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metronidazole and Anemia, Aplastic

metronidazole has been researched along with Anemia, Aplastic in 3 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Anemia, Aplastic: A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.

Research Excerpts

ExcerptRelevanceReference
"Emphysematous gastritis is a life-threatening disease."2.42Emphysematous gastritis and severe aplastic anemia. ( Cantalapiedra, A; Del Villar, R; García-Frade, LJ; Gutierrez, O; Peñarrubia, MJ; Sales, R; Tabuyo, MI, 2003)
"Metronidazole is known to cause hematologic adverse effects, including a reversible mild neutropenia; in rare circumstances, thrombocytopenia has been associated with metronidazole treatment."1.56A Case of Aplastic Anemia Associated With Long-Term Metronidazole Use. ( Koura, D; Sam, AM; Saunders, IM; Taplitz, R, 2020)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19901 (33.33)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Sam, AM1
Saunders, IM1
Taplitz, R1
Koura, D1
Gutierrez, O1
Cantalapiedra, A1
Tabuyo, MI1
Del Villar, R1
Peñarrubia, MJ1
Sales, R1
García-Frade, LJ1
Bromiker, R1
Korman, SH1
Or, R1
Hardan, I1
Naparstek, E1
Cohen, P1
Ben-Shahar, M1
Engelhard, D1

Reviews

1 review available for metronidazole and Anemia, Aplastic

ArticleYear
Emphysematous gastritis and severe aplastic anemia.
    The hematology journal : the official journal of the European Haematology Association, 2003, Volume: 4, Issue:1

    Topics: Anemia, Aplastic; Antilymphocyte Serum; Cholelithiasis; Cyclosporine; Emphysema; Female; Gastritis;

2003

Other Studies

2 other studies available for metronidazole and Anemia, Aplastic

ArticleYear
A Case of Aplastic Anemia Associated With Long-Term Metronidazole Use.
    Journal of pharmacy practice, 2020, Volume: 33, Issue:4

    Topics: Anemia, Aplastic; Anti-Bacterial Agents; Humans; Metronidazole; Thrombocytopenia

2020
Severe giardiasis in two patients undergoing bone marrow transplantation.
    Bone marrow transplantation, 1989, Volume: 4, Issue:6

    Topics: Adult; Anemia, Aplastic; Animals; Bone Marrow Transplantation; Gastrointestinal Diseases; Giardia; G

1989