metronidazole has been researched along with Anemia, Aplastic in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Anemia, Aplastic: A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Emphysematous gastritis is a life-threatening disease." | 2.42 | Emphysematous gastritis and severe aplastic anemia. ( Cantalapiedra, A; Del Villar, R; García-Frade, LJ; Gutierrez, O; Peñarrubia, MJ; Sales, R; Tabuyo, MI, 2003) |
| "Metronidazole is known to cause hematologic adverse effects, including a reversible mild neutropenia; in rare circumstances, thrombocytopenia has been associated with metronidazole treatment." | 1.56 | A Case of Aplastic Anemia Associated With Long-Term Metronidazole Use. ( Koura, D; Sam, AM; Saunders, IM; Taplitz, R, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Sam, AM | 1 |
| Saunders, IM | 1 |
| Taplitz, R | 1 |
| Koura, D | 1 |
| Gutierrez, O | 1 |
| Cantalapiedra, A | 1 |
| Tabuyo, MI | 1 |
| Del Villar, R | 1 |
| Peñarrubia, MJ | 1 |
| Sales, R | 1 |
| García-Frade, LJ | 1 |
| Bromiker, R | 1 |
| Korman, SH | 1 |
| Or, R | 1 |
| Hardan, I | 1 |
| Naparstek, E | 1 |
| Cohen, P | 1 |
| Ben-Shahar, M | 1 |
| Engelhard, D | 1 |
1 review available for metronidazole and Anemia, Aplastic
| Article | Year |
|---|---|
Emphysematous gastritis and severe aplastic anemia.
Topics: Anemia, Aplastic; Antilymphocyte Serum; Cholelithiasis; Cyclosporine; Emphysema; Female; Gastritis; | 2003 |
2 other studies available for metronidazole and Anemia, Aplastic
| Article | Year |
|---|---|
A Case of Aplastic Anemia Associated With Long-Term Metronidazole Use.
Topics: Anemia, Aplastic; Anti-Bacterial Agents; Humans; Metronidazole; Thrombocytopenia | 2020 |
Severe giardiasis in two patients undergoing bone marrow transplantation.
Topics: Adult; Anemia, Aplastic; Animals; Bone Marrow Transplantation; Gastrointestinal Diseases; Giardia; G | 1989 |