metronidazole has been researched along with Parasitemia in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Parasitemia: The presence of parasites (especially malarial parasites) in the blood. (Dorland, 27th ed)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 2 (100.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Cross, RM | 1 |
Flanigan, DL | 1 |
Monastyrskyi, A | 1 |
LaCrue, AN | 1 |
Sáenz, FE | 1 |
Maignan, JR | 1 |
Mutka, TS | 1 |
White, KL | 1 |
Shackleford, DM | 1 |
Bathurst, I | 1 |
Fronczek, FR | 1 |
Wojtas, L | 1 |
Guida, WC | 1 |
Charman, SA | 1 |
Burrows, JN | 1 |
Kyle, DE | 1 |
Manetsch, R | 1 |
Giannini, G | 1 |
Battistuzzi, G | 1 |
2 other studies available for metronidazole and Parasitemia
Article | Year |
---|---|
Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of Plasmodium.
Topics: Animals; Antimalarials; Humans; Inhibitory Concentration 50; Malaria; Mice; Microsomes, Liver; Paras | 2014 |
Exploring in vitro and in vivo Hsp90 inhibitors activity against human protozoan parasites.
Topics: Animals; Antiprotozoal Agents; Cell Line, Tumor; Disease Models, Animal; HSP90 Heat-Shock Proteins; | 2015 |