metronidazole has been researched along with Lymphoma, Large B-Cell, Diffuse in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Lymphoma, Large B-Cell, Diffuse: Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kono, Y | 1 |
| Kusumoto, C | 1 |
| Kiguchi, T | 1 |
| Okada, H | 1 |
| Takashima, M | 1 |
| Kakimoto, T | 1 |
| Saito, H | 1 |
| Misaki, S | 1 |
| Onishi, Y | 1 |
| Kasugai, T | 1 |
| Akuta, K | 1 |
| Kasahara, H | 1 |
| Yamamoto, K | 1 |
| Doi, Y | 1 |
| Ujiie, H | 1 |
| Sugahara, H | 1 |
| Hoshida, Y | 1 |
| Sakoda, H | 1 |
1 review available for metronidazole and Lymphoma, Large B-Cell, Diffuse
| Article | Year |
|---|---|
Gastrointestinal: Rapid emergence of double-expressor lymphoma after Helicobacter pylori eradication therapy.
Topics: Aged; Amoxicillin; Anti-Bacterial Agents; Endoscopy, Digestive System; Follow-Up Studies; Gastric Mu | 2021 |
1 other study available for metronidazole and Lymphoma, Large B-Cell, Diffuse
| Article | Year |
|---|---|
Synchronous tumor with diffuse large B-cell lymphoma and ameboma.
Topics: Abdominal Pain; Aged; Amebicides; Antibodies, Monoclonal, Murine-Derived; Antigens, Protozoan; Antin | 2011 |