metronidazole has been researched along with Abscess, Pulmonary in 21 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this randomized study, the efficacy of metronidazole was compared with clindamycin in the treatment of patients with anaerobic lung abscess or necrotizing pneumonia." | 5.05 | Metronidazole vs clindamycin treatment of anerobic pulmonary infection. Failure of metronidazole therapy. ( Perlino, CA, 1981) |
| "Pulmonary abscess has been rarely reported as a complication of other bronchoscopic procedures such as endobronchial ultrasound-guided needle biopsy, however, to our knowledge this is the first reported case of pulmonary abscess complicating peripheral lung cryobiopsy." | 1.43 | Pulmonary Abscess as a Complication of Transbronchial Lung Cryobiopsy. ( Edell, ES; Kern, RM; Maldonado, F; Midthun, DE; Skalski, JH, 2016) |
| "Treatment with metronidazole (1." | 1.33 | [Amoebic infections of the lung and pleura]. ( Alaoui Yazidi, A; Bahlaoui, A; Bakhatar, A; El Biaze, M; El Meziane, A; Loudadssi, F; Rachid, H; Yassine, N, 2005) |
| "Pleuropulmonary amebiasis is a very rare complication of liver amebiasis." | 1.31 | An amebic lung abscess: report of a case. ( Hanawa, T; Kuwabara, M; Matsubara, Y; Matsui, T; Teramoto, K; Yamashita, N, 2001) |
| "Metronidazole also has been used either alone or in combination, most frequently with amoxicillin, to treat many other anaerobic infections: head and neck, pleuropulmonary, genital tract, bone and joint, skin and soft tissue, and cases of fusobacterial septicemia (necrobacillosis)." | 1.27 | The therapeutic use of metronidazole in anaerobic infection: six years' experience in a London hospital. ( Eykyn, SJ, 1983) |
| "Anaerobic infections are reviewed with emphasis on management." | 1.25 | Management of anaerobic infections. ( Bartlett, JG; Chow, AW; Finegold, SM; Flora, DJ; Gorbach, SL; Harder, EJ; Tally, FP, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (38.10) | 18.7374 |
| 1990's | 2 (9.52) | 18.2507 |
| 2000's | 8 (38.10) | 29.6817 |
| 2010's | 3 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Skalski, JH | 1 |
| Kern, RM | 1 |
| Midthun, DE | 1 |
| Edell, ES | 1 |
| Maldonado, F | 1 |
| Briongos-Figuero, LS | 1 |
| Bachiller-Luque, P | 1 |
| Pastor-Mancisidor, L | 1 |
| Carreres-Rodríguez, A | 1 |
| Mena-Martín, FJ | 1 |
| Neghina, R | 1 |
| Neghina, AA | 1 |
| Merkler, C | 1 |
| Marincu, I | 1 |
| Iacobiciu, I | 1 |
| Guy, SD | 1 |
| Worth, LJ | 1 |
| Thursky, KA | 1 |
| Francis, PA | 1 |
| Slavin, MA | 1 |
| Spitzer, C | 1 |
| Foltys, H | 1 |
| Lemmen, SW | 1 |
| Block, F | 1 |
| Rachid, H | 1 |
| Alaoui Yazidi, A | 1 |
| Loudadssi, F | 1 |
| El Biaze, M | 1 |
| Bakhatar, A | 1 |
| Yassine, N | 1 |
| El Meziane, A | 1 |
| Bahlaoui, A | 1 |
| Peltola, V | 1 |
| Svedström, E | 1 |
| Waris, M | 1 |
| Heikkinen, T | 1 |
| Ruuskanen, O | 1 |
| Eykyn, SJ | 1 |
| Perlino, CA | 1 |
| Baldwin, L | 1 |
| Henderson, A | 1 |
| Wright, M | 1 |
| Whitby, M | 1 |
| Dechan, J | 1 |
| De Soyza, A | 1 |
| Higgins, B | 1 |
| Gould, K | 1 |
| Okomé-Nkoumou, M | 1 |
| Kombila, M | 1 |
| Teramoto, K | 1 |
| Yamashita, N | 1 |
| Kuwabara, M | 1 |
| Hanawa, T | 1 |
| Matsui, T | 1 |
| Matsubara, Y | 1 |
| West, SD | 1 |
| Brunskill, NJ | 1 |
| Abeysundere, RL | 1 |
| Hodson, ME | 1 |
| Szawatkowski, M | 1 |
| Noone, P | 1 |
| Sanders, CV | 1 |
| Hanna, BJ | 1 |
| Lewis, AC | 1 |
| Galgiani, JN | 1 |
| Busch, DF | 1 |
| Brass, C | 1 |
| Rumans, LW | 1 |
| Mangels, JI | 1 |
| Stevens, DA | 1 |
| Holmberg, R | 1 |
| Finegold, SM | 1 |
| Bartlett, JG | 1 |
| Chow, AW | 1 |
| Flora, DJ | 1 |
| Gorbach, SL | 1 |
| Harder, EJ | 1 |
| Tally, FP | 1 |
| Kolesov, AP | 1 |
| Koroliuk, AM | 1 |
| Kochetkov, AV | 1 |
| Kocherovets, VI | 1 |
| Stolbovoĭ, AV | 1 |
2 reviews available for metronidazole and Abscess, Pulmonary
| Article | Year |
|---|---|
Legionella pneumophila lung abscess associated with immune suppression.
Topics: Adult; Anti-Bacterial Agents; Antineoplastic Combined Chemotherapy Protocols; Australia; Azithromyci | 2011 |
[Bacterial meningitis as a complication of Fusobacterium necroforum infection in adults].
Topics: Adult; Anti-Bacterial Agents; Blood Glucose; Cerebrospinal Fluid Proteins; Diagnosis, Differential; | 2003 |
1 trial available for metronidazole and Abscess, Pulmonary
| Article | Year |
|---|---|
Metronidazole vs clindamycin treatment of anerobic pulmonary infection. Failure of metronidazole therapy.
Topics: Adult; Bacterial Infections; Clindamycin; Clinical Trials as Topic; Female; Humans; Lung Abscess; Lu | 1981 |
18 other studies available for metronidazole and Abscess, Pulmonary
| Article | Year |
|---|---|
Pulmonary Abscess as a Complication of Transbronchial Lung Cryobiopsy.
Topics: Anti-Bacterial Agents; Biopsy; Bronchoscopy; Humans; Levofloxacin; Lung; Lung Abscess; Lung Diseases | 2016 |
[Cerebellar syndrome induced by metronidazole: a rare side effect].
Topics: Anti-Bacterial Agents; Brain Abscess; Cefotaxime; Cephalosporins; Cerebellar Ataxia; Diagnosis, Diff | 2016 |
A case report of pulmonary amoebiasis with Entamoeba histolytica diagnosed in western Romania.
Topics: Antiprotozoal Agents; Entamoeba histolytica; Entamoebiasis; Humans; Lung Abscess; Lung Diseases, Par | 2008 |
[Amoebic infections of the lung and pleura].
Topics: Adult; Animals; Antiprotozoal Agents; Drainage; Entamoeba histolytica; Entamoebiasis; Humans; Liver | 2005 |
Pulmonary abscess of viral-bacterial etiology in a neonate.
Topics: Anti-Infective Agents; Cefuroxime; Cephalexin; Escherichia coli Infections; Female; Humans; Infant, | 2007 |
The therapeutic use of metronidazole in anaerobic infection: six years' experience in a London hospital.
Topics: Adult; Aged; Bacterial Infections; Bone Diseases; Empyema; Female; Fusobacterium Infections; Gastroi | 1983 |
Spontaneous Clostridium perfringens lung abscess unresponsive to penicillin.
Topics: Clostridium Infections; Clostridium perfringens; Humans; Injections, Intravenous; Lung Abscess; Male | 1993 |
Combination of medical and surgical therapy for pleuropneumonia in a horse.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Antitrichomonal Agents; Cep | 1997 |
An unusual case of pulmonary abscess.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Brain Abscess; Cefaclor; Cephalosporins; Diagnosis, Diffe | 2000 |
[Pulmonary amebiasis and tuberculosis association. Two case reports in Libreville, Gabon].
Topics: Adult; Alcoholism; Amebiasis; Anti-Infective Agents; Antitubercular Agents; Causality; Drug Therapy, | 2000 |
An amebic lung abscess: report of a case.
Topics: Amebiasis; Anti-Infective Agents; Humans; Lung Abscess; Male; Metronidazole; Middle Aged; Pneumonect | 2001 |
Complications associated with influenza infection.
Topics: Acute Kidney Injury; Alphainfluenzavirus; Drug Therapy, Combination; Humans; Imipenem; Influenza, Hu | 2002 |
Pleuropulmonary lung infection by anaerobic bacteria.
Topics: Adult; Bacteroides fragilis; Bacteroides Infections; Chloramphenicol; Empyema; Humans; Lung Abscess; | 1978 |
Metronidazole in the treatment of anaerobic infections.
Topics: Adult; Anaerobiosis; Bacteroides Infections; Female; Humans; Lung Abscess; Male; Metronidazole; Midd | 1979 |
Bacteroides fragilis endocarditis, bacteremia and other infections treated with oral or intravenous metronidazole.
Topics: Abscess; Administration, Oral; Adult; Anti-Bacterial Agents; Bacteroides fragilis; Bacteroides Infec | 1978 |
[Extraintestinal amebiasis. A case with abscess in the liver and spread to the lungs].
Topics: Adult; Humans; Liver Abscess, Amebic; Lung Abscess; Lung Diseases, Parasitic; Male; Metronidazole; R | 1977 |
Management of anaerobic infections.
Topics: Anaerobiosis; Anti-Bacterial Agents; Bacterial Infections; Bacteroides Infections; Bone Diseases; Br | 1975 |
[Clinical picture, diagnosis and treatment of anaerobic abscess of the lung and pleurisy].
Topics: Adult; Aged; Bacteria, Anaerobic; Chloramphenicol; Combined Modality Therapy; Female; Humans; Lincom | 1985 |