Compounds > loureirin a
Page last updated: 2024-12-11

loureirin a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

loureirin A: a biologically active component of longxuejie, prepared from Dracaena cochinchinensis; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
DracaenagenusA plant genus of the family Asparagaceae. The common name of dragon's blood is also used for CROTON and Daemonorops (ARECACEAE).[MeSH]AsparagaceaeA family of flowering subshrubs and shrubs in the class Magnoliopsida.[MeSH]

Cross-References

ID SourceID
PubMed CID5319081
CHEMBL ID253779
SCHEMBL ID7187176
MeSH IDM0560282

Synonyms (19)

Synonym
loureirin a
LMPK12120602
CHEMBL253779
3-(2,4-dimethoxyphenyl)-1-(4-hydroxyphenyl)propan-1-one
S3241
SCHEMBL7187176
RSAIVLRELNGZEY-UHFFFAOYSA-N
3-(2,4-dimethoxyphenyl)-1-(4-hydroxyphenyl)propan-1-on
119425-89-7
AC-34430
CS-7883
AKOS030573608
HY-N1505
FT-0715269
mfcd10566607
ZB1869
AS-78728
loureirina
DTXSID201318286

Research Excerpts

Overview

Loureirin A is a major active component of Draconis sanguis, a traditional Chinese medicine. It is used to promote blood circulation and remove stasis in Chinese traditional medicine.

ExcerptReferenceRelevance
"Loureirin A is a major active component of Draconis sanguis, a traditional Chinese medicine. "( Effect of loureirin A against Candida albicans biofilms.
Hu, DD; Hu, GH; Jiang, YY; Lin, MY; Su, J; Wang, Y; Yan, L; Yuan, ZL; Zhang, RL; Zhong, H, 2019)		2.36
"Loureirin A is a flavonoid extracted from Dragon׳s Blood that has been used to promote blood circulation and remove stasis in Chinese traditional medicine. "( Antiplatelet activity of loureirin A by attenuating Akt phosphorylation: In vitro studies.
Da, XW; Hao, HZ; He, AD; Liang, ML; Liu, G; Ming, ZY; Wang, DC; Xiang, JZ; Xie, W; Yao, GQ; Yin, Z; Zhou, YJ, 2015)		2.16

Pharmacokinetics

ExcerptReferenceRelevance
"A sensitive HPLC-ESI-MS method for the simultaneous determination of loureirin A (LA) and loureirin B (LB) in rat plasma and tissues was developed, and the pharmacokinetic and tissue distribution characteristics of LA and LB were investigated after gavage administration."( An HPLC-ESI-MS method for analysis of loureirin A and B in dragon's blood and application in pharmacokinetics and tissue distribution in rats.
Chen, Z; Zhao, H, 2013)		0.9
" The analytical method was successfully applied to a pharmacokinetic study of the multi-components after oral administration of Sanjie Zhentong Capsule in rats."( Simultaneous determination of ten bioactive constituents of Sanjie Zhentong Capsule in rat plasma by ultra-high-performance liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study.
Hu, JH; Huang, W; Li, D; Li, J; Pan, Y; Wang, Y; Wang, ZZ; Xiao, W, 2017)		0.46
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (23)

Assay IDTitleYearJournalArticle
AID1198782Binding affinity to human serum albumin assessed as entropy change at 305K by thermodynamic analysis2015European journal of medicinal chemistry, Mar-26, Volume: 93Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID470666Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay2009Journal of natural products, Sep, Volume: 72, Issue:9
Cytotoxic constituents of Soymida febrifuga from Myanmar.
AID1198784Binding affinity to human serum albumin assessed as induction of protein conformational changes by synchronous fluorescence spectroscopy2015European journal of medicinal chemistry, Mar-26, Volume: 93Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID1198781Binding affinity to human serum albumin assessed as entropy change at 300K by thermodynamic analysis2015European journal of medicinal chemistry, Mar-26, Volume: 93Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID1198780Binding affinity to human serum albumin assessed as enthalpy change at 300K by thermodynamic analysis2015European journal of medicinal chemistry, Mar-26, Volume: 93Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID1198785Binding affinity to human serum albumin assessed as induction of protein conformational changes by measuring reduction in intensity along with red shift in peak 1 by three-dimensional fluorescence spectroscopy2015European journal of medicinal chemistry, Mar-26, Volume: 93Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID1198774Binding affinity to human serum albumin assessed as quenching constant at 305K by fluorescence spectroscopy2015European journal of medicinal chemistry, Mar-26, Volume: 93Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID1198783Binding affinity to human serum albumin assessed as entropy change at 310K by thermodynamic analysis2015European journal of medicinal chemistry, Mar-26, Volume: 93Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID470663Cytotoxicity against human A549 cells after 72 hrs by MTT assay2009Journal of natural products, Sep, Volume: 72, Issue:9
Cytotoxic constituents of Soymida febrifuga from Myanmar.
AID470661Cytotoxicity against human PANC1 cells in nutrient-deprived condition after 24 hrs by WST8 assay2009Journal of natural products, Sep, Volume: 72, Issue:9
Cytotoxic constituents of Soymida febrifuga from Myanmar.
AID1198775Binding affinity to human serum albumin assessed as quenching constant at 310K by fluorescence spectroscopy2015European journal of medicinal chemistry, Mar-26, Volume: 93Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID1198779Binding affinity to human serum albumin assessed as binding constant at 310K by Stem-Volmer plot2015European journal of medicinal chemistry, Mar-26, Volume: 93Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID470662Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay2009Journal of natural products, Sep, Volume: 72, Issue:9
Cytotoxic constituents of Soymida febrifuga from Myanmar.
AID1198777Binding affinity to human serum albumin assessed as binding constant at 300K by Stem-Volmer plot2015European journal of medicinal chemistry, Mar-26, Volume: 93Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID311534Antibacterial activity against Helicobacter pylori ATCC 43504 by agar dilution method2007Journal of natural products, Oct, Volume: 70, Issue:10
Anti-Helicobacter pylori and thrombin inhibitory components from Chinese dragon's blood, Dracaena cochinchinensis.
AID1198771Binding affinity to human serum albumin assessed as Stem-Volmer quenching constant at 305K by fluorescence spectroscopy2015European journal of medicinal chemistry, Mar-26, Volume: 93Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID1198778Binding affinity to human serum albumin assessed as binding constant at 305K by Stem-Volmer plot2015European journal of medicinal chemistry, Mar-26, Volume: 93Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID1198776Binding affinity to human serum albumin by UV-vis spectrophotometry2015European journal of medicinal chemistry, Mar-26, Volume: 93Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID470665Cytotoxicity against mouse Colon 26-L5 cells after 72 hrs by MTT assay2009Journal of natural products, Sep, Volume: 72, Issue:9
Cytotoxic constituents of Soymida febrifuga from Myanmar.
AID1198770Binding affinity to human serum albumin assessed as Stem-Volmer quenching constant at 300K by fluorescence spectroscopy2015European journal of medicinal chemistry, Mar-26, Volume: 93Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID1198772Binding affinity to human serum albumin assessed as Stem-Volmer quenching constant at 310K by fluorescence spectroscopy2015European journal of medicinal chemistry, Mar-26, Volume: 93Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID1198773Binding affinity to human serum albumin assessed as quenching constant at 300K by fluorescence spectroscopy2015European journal of medicinal chemistry, Mar-26, Volume: 93Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID470664Cytotoxicity against human HeLa cells after 72 hrs by MTT assay2009Journal of natural products, Sep, Volume: 72, Issue:9
Cytotoxic constituents of Soymida febrifuga from Myanmar.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (17)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (11.76)29.6817
2010's12 (70.59)24.3611
2020's3 (17.65)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.15

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.15 (24.57)
Research Supply Index2.89 (2.92)
Research Growth Index5.40 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.15)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
4-hydroxybenzoic acid
4-hydroxybenzoic acid : A monohydroxybenzoic acid that is benzoic acid carrying a hydroxy substituent at C-4 of the benzene ring.		2.0510monohydroxybenzoic acidalgal metabolite;
plant metabolite
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		2.0510nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
metronidazole
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.. metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.		2.0310C-nitro compound;
imidazoles;
primary alcohol		antiamoebic agent;
antibacterial drug;
antimicrobial agent;
antiparasitic agent;
antitrichomonal drug;
environmental contaminant;
prodrug;
radiosensitizing agent;
xenobiotic
flavone
flavone: RN given refers to unlabeled cpd; structure given in first source. flavone : The simplest member of the class of flavones that consists of 4H-chromen-4-one bearing a phenyl substituent at position 2.		2.0710flavonesmetabolite;
nematicide
malondialdehyde
Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.		2.2510dialdehydebiomarker
amoxicillin
Amoxicillin: A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.. amoxicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group.		2.0310penicillin allergen;
penicillin		antibacterial drug
pinocembrin
pinocembrin : A dihydroxyflavanone in which the two hydroxy groups are located at positions 5 and 7. A natural product found in Piper sarmentosum and Cryptocarya chartacea.		2.0510(2S)-flavan-4-one;
dihydroxyflavanone		antineoplastic agent;
antioxidant;
metabolite;
neuroprotective agent;
vasodilator agent
fibrinogen
Fibrinogen: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.. D-iditol : The D-enantiomer of iditol.		2.1110iditolfungal metabolite
mci 9038
[no description available]		2.0310peptide
verticine
verticine: structure		2.1510alkaloid
peiminine
peiminine: isolated from Fritillaria verticillata; structure given in first source; RN given refers to (3beta,5alpha)-isomer		2.1510alkaloid
loureirin b
loureirin B: component of dragon's blood resin		3.5980
ginsenoside rg1
[no description available]		2.151012beta-hydroxy steroid;
3beta-hydroxy-4,4-dimethylsteroid;
beta-D-glucoside;
ginsenoside;
tetracyclic triterpenoid		neuroprotective agent;
pro-angiogenic agent
notoginsenoside r1
notoginsenoside R1 : A ginsenoside found in Panax notoginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside and beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position.		2.151012beta-hydroxy steroid;
3beta-hydroxy-4,4-dimethylsteroid;
3beta-hydroxy steroid;
beta-D-glucoside;
disaccharide derivative;
ginsenoside;
tetracyclic triterpenoid		antioxidant;
apoptosis inducer;
neuroprotective agent;
phytoestrogen;
plant metabolite
resveratrol
trans-resveratrol : A resveratrol in which the double bond has E configuration.		2.4620resveratrolantioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger
chalcone
trans-chalcone : The trans-isomer of chalcone.		2.1110chalconeEC 3.2.1.1 (alpha-amylase) inhibitor
stilbenes
Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene.		2.5120stilbene
ginsenosides
ginsenoside : Triterpenoid saponins with a dammarane-like skeleton originally isolated from ginseng (Panax) species. Use of the term has been extended to include semi-synthetic derivatives.		2.1510
pterostilbene
[no description available]		2.7730diether;
methoxybenzenes;
stilbenol		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
hypoglycemic agent;
neuroprotective agent;
neurotransmitter;
plant metabolite;
radical scavenger
4',7-dihydroxyflavone
4',7-dihydroxyflavone: inducer of nod gene. 4',7-dihydroxyflavone : A dihydroxyflavone in which the two hydroxy substituents are located at positions 4' and 7.		2.1510dihydroxyflavonemetabolite
cochinchinenin
cochinchinenin: isolated from Dracaena cochinchinensis; structure in first source		7.1110
3-deoxysappanchalcone
3-deoxysappanchalcone: Anti-allergic from the roots and heartwood of Caesalpinia sappan; structure in first source. 2'-O-methylisoliquiritigenin : A member of the class of chalcones that is isoliquiritigenin in which one of the hydroxy groups at position 2' is replaced by a methoxy group.		2.4420chalcones;
monomethoxybenzene;
phenols		metabolite
2',4'-dihydroxychalcone
2',4'-dihydroxychalcone: RN given refers to (E)-isomer; RN for cpd without isomeric designation not available 6/89; structure given in first source		2.0510
pinostilbene
pinostilbene: structure in first source. 3-methoxy-4',5-dihydroxy-trans-stilbene : A stilbenoid that is trans-resveratrol in which one of the meta-hydroxy groups is converted to the corresponding methyl ether.		2.0510stilbenol
2,4,2'-trihydroxychalcone
2,4,2'-trihydroxychalcone: structure in first source		2.0510
3,5-dihydroxy-4'-methoxystilbene
4'-methoxyresveratrol: has anti-inflammatory effects in cell culture model		2.0310
ginsenoside rb1
[no description available]		2.1510ginsenoside;
glycoside;
tetracyclic triterpenoid		anti-inflammatory drug;
anti-obesity agent;
apoptosis inhibitor;
neuroprotective agent;
plant metabolite;
radical scavenger
peimisine
peimisine: isolated from Fritillaria ussuriensis		2.1510
ConditionIndicatedRelationship StrengthStudiesTrials
Candida Infection
[description not available]		02.2110
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.2110
Candidiasis
Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)		02.2110
Arthritis, Degenerative
[description not available]		02.2510
Osteoarthritis
A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.		07.2510
Disease Resistance
The capacity of an organism to defend itself against pathological processes or the agents of those processes. This most often involves innate immunity whereby the organism responds to pathogens in a generic way. The term disease resistance is used most frequently when referring to plants.		02.0810
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.1110