loureirin a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

loureirin A: a biologically active component of longxuejie, prepared from Dracaena cochinchinensis; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Dracaena	genus	A plant genus of the family Asparagaceae. The common name of dragon's blood is also used for CROTON and Daemonorops (ARECACEAE).[MeSH]	Asparagaceae	A family of flowering subshrubs and shrubs in the class Magnoliopsida.[MeSH]

Cross-References

ID Source	ID
PubMed CID	5319081
CHEMBL ID	253779
SCHEMBL ID	7187176
MeSH ID	M0560282

Synonyms (19)

Synonym
loureirin a
LMPK12120602
CHEMBL253779
3-(2,4-dimethoxyphenyl)-1-(4-hydroxyphenyl)propan-1-one
S3241
SCHEMBL7187176
RSAIVLRELNGZEY-UHFFFAOYSA-N
3-(2,4-dimethoxyphenyl)-1-(4-hydroxyphenyl)propan-1-on
119425-89-7
AC-34430
CS-7883
AKOS030573608
HY-N1505
FT-0715269
mfcd10566607
ZB1869
AS-78728
loureirina
DTXSID201318286

Research Excerpts

Overview

Loureirin A is a major active component of Draconis sanguis, a traditional Chinese medicine. It is used to promote blood circulation and remove stasis in Chinese traditional medicine.

Excerpt	Reference	Relevance
"Loureirin A is a major active component of Draconis sanguis, a traditional Chinese medicine. "	( Effect of loureirin A against Candida albicans biofilms. Hu, DD; Hu, GH; Jiang, YY; Lin, MY; Su, J; Wang, Y; Yan, L; Yuan, ZL; Zhang, RL; Zhong, H, 2019)	2.36
"Loureirin A is a flavonoid extracted from Dragon׳s Blood that has been used to promote blood circulation and remove stasis in Chinese traditional medicine. "	( Antiplatelet activity of loureirin A by attenuating Akt phosphorylation: In vitro studies. Da, XW; Hao, HZ; He, AD; Liang, ML; Liu, G; Ming, ZY; Wang, DC; Xiang, JZ; Xie, W; Yao, GQ; Yin, Z; Zhou, YJ, 2015)	2.16

Pharmacokinetics

Excerpt	Reference	Relevance
"A sensitive HPLC-ESI-MS method for the simultaneous determination of loureirin A (LA) and loureirin B (LB) in rat plasma and tissues was developed, and the pharmacokinetic and tissue distribution characteristics of LA and LB were investigated after gavage administration."	( An HPLC-ESI-MS method for analysis of loureirin A and B in dragon's blood and application in pharmacokinetics and tissue distribution in rats. Chen, Z; Zhao, H, 2013)	0.9
" The analytical method was successfully applied to a pharmacokinetic study of the multi-components after oral administration of Sanjie Zhentong Capsule in rats."	( Simultaneous determination of ten bioactive constituents of Sanjie Zhentong Capsule in rat plasma by ultra-high-performance liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study. Hu, JH; Huang, W; Li, D; Li, J; Pan, Y; Wang, Y; Wang, ZZ; Xiao, W, 2017)	0.46

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (23)

Assay ID	Title	Year	Journal	Article
AID1198782	Binding affinity to human serum albumin assessed as entropy change at 305K by thermodynamic analysis	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID470666	Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay	2009	Journal of natural products, Sep, Volume: 72, Issue:9	Cytotoxic constituents of Soymida febrifuga from Myanmar.
AID1198784	Binding affinity to human serum albumin assessed as induction of protein conformational changes by synchronous fluorescence spectroscopy	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID1198781	Binding affinity to human serum albumin assessed as entropy change at 300K by thermodynamic analysis	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID1198780	Binding affinity to human serum albumin assessed as enthalpy change at 300K by thermodynamic analysis	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID1198785	Binding affinity to human serum albumin assessed as induction of protein conformational changes by measuring reduction in intensity along with red shift in peak 1 by three-dimensional fluorescence spectroscopy	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID1198774	Binding affinity to human serum albumin assessed as quenching constant at 305K by fluorescence spectroscopy	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID1198783	Binding affinity to human serum albumin assessed as entropy change at 310K by thermodynamic analysis	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID470663	Cytotoxicity against human A549 cells after 72 hrs by MTT assay	2009	Journal of natural products, Sep, Volume: 72, Issue:9	Cytotoxic constituents of Soymida febrifuga from Myanmar.
AID470661	Cytotoxicity against human PANC1 cells in nutrient-deprived condition after 24 hrs by WST8 assay	2009	Journal of natural products, Sep, Volume: 72, Issue:9	Cytotoxic constituents of Soymida febrifuga from Myanmar.
AID1198775	Binding affinity to human serum albumin assessed as quenching constant at 310K by fluorescence spectroscopy	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID1198779	Binding affinity to human serum albumin assessed as binding constant at 310K by Stem-Volmer plot	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID470662	Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay	2009	Journal of natural products, Sep, Volume: 72, Issue:9	Cytotoxic constituents of Soymida febrifuga from Myanmar.
AID1198777	Binding affinity to human serum albumin assessed as binding constant at 300K by Stem-Volmer plot	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID311534	Antibacterial activity against Helicobacter pylori ATCC 43504 by agar dilution method	2007	Journal of natural products, Oct, Volume: 70, Issue:10	Anti-Helicobacter pylori and thrombin inhibitory components from Chinese dragon's blood, Dracaena cochinchinensis.
AID1198771	Binding affinity to human serum albumin assessed as Stem-Volmer quenching constant at 305K by fluorescence spectroscopy	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID1198778	Binding affinity to human serum albumin assessed as binding constant at 305K by Stem-Volmer plot	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID1198776	Binding affinity to human serum albumin by UV-vis spectrophotometry	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID470665	Cytotoxicity against mouse Colon 26-L5 cells after 72 hrs by MTT assay	2009	Journal of natural products, Sep, Volume: 72, Issue:9	Cytotoxic constituents of Soymida febrifuga from Myanmar.
AID1198770	Binding affinity to human serum albumin assessed as Stem-Volmer quenching constant at 300K by fluorescence spectroscopy	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID1198772	Binding affinity to human serum albumin assessed as Stem-Volmer quenching constant at 310K by fluorescence spectroscopy	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID1198773	Binding affinity to human serum albumin assessed as quenching constant at 300K by fluorescence spectroscopy	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.
AID470664	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	2009	Journal of natural products, Sep, Volume: 72, Issue:9	Cytotoxic constituents of Soymida febrifuga from Myanmar.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (17)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (11.76)	29.6817
2010's	12 (70.59)	24.3611
2020's	3 (17.65)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.15

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	20.15 (24.57)
Research Supply Index	2.89 (2.92)
Research Growth Index	5.40 (4.65)
Search Engine Demand Index	15.26 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (20.15)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	17 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
4-hydroxybenzoic acid 4-hydroxybenzoic acid : A monohydroxybenzoic acid that is benzoic acid carrying a hydroxy substituent at C-4 of the benzene ring.	2.05	1	monohydroxybenzoic acid	algal metabolite; plant metabolite
fluorouracil Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.	2.05	1	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic
metronidazole Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.. metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.	2.03	1	C-nitro compound; imidazoles; primary alcohol	antiamoebic agent; antibacterial drug; antimicrobial agent; antiparasitic agent; antitrichomonal drug; environmental contaminant; prodrug; radiosensitizing agent; xenobiotic
flavone flavone: RN given refers to unlabeled cpd; structure given in first source. flavone : The simplest member of the class of flavones that consists of 4H-chromen-4-one bearing a phenyl substituent at position 2.	2.07	1	flavones	metabolite; nematicide
malondialdehyde Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.	2.25	1	dialdehyde	biomarker
amoxicillin Amoxicillin: A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.. amoxicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group.	2.03	1	penicillin allergen; penicillin	antibacterial drug
pinocembrin pinocembrin : A dihydroxyflavanone in which the two hydroxy groups are located at positions 5 and 7. A natural product found in Piper sarmentosum and Cryptocarya chartacea.	2.05	1	(2S)-flavan-4-one; dihydroxyflavanone	antineoplastic agent; antioxidant; metabolite; neuroprotective agent; vasodilator agent
fibrinogen Fibrinogen: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.. D-iditol : The D-enantiomer of iditol.	2.11	1	iditol	fungal metabolite
mci 9038 [no description available]	2.03	1	peptide
verticine verticine: structure	2.15	1	alkaloid
peiminine peiminine: isolated from Fritillaria verticillata; structure given in first source; RN given refers to (3beta,5alpha)-isomer	2.15	1	alkaloid
loureirin b loureirin B: component of dragon's blood resin	3.59	8
ginsenoside rg1 [no description available]	2.15	1	12beta-hydroxy steroid; 3beta-hydroxy-4,4-dimethylsteroid; beta-D-glucoside; ginsenoside; tetracyclic triterpenoid	neuroprotective agent; pro-angiogenic agent
notoginsenoside r1 notoginsenoside R1 : A ginsenoside found in Panax notoginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside and beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position.	2.15	1	12beta-hydroxy steroid; 3beta-hydroxy-4,4-dimethylsteroid; 3beta-hydroxy steroid; beta-D-glucoside; disaccharide derivative; ginsenoside; tetracyclic triterpenoid	antioxidant; apoptosis inducer; neuroprotective agent; phytoestrogen; plant metabolite
resveratrol trans-resveratrol : A resveratrol in which the double bond has E configuration.	2.46	2	resveratrol	antioxidant; phytoalexin; plant metabolite; quorum sensing inhibitor; radical scavenger
chalcone trans-chalcone : The trans-isomer of chalcone.	2.11	1	chalcone	EC 3.2.1.1 (alpha-amylase) inhibitor
stilbenes Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene.	2.51	2	stilbene
ginsenosides ginsenoside : Triterpenoid saponins with a dammarane-like skeleton originally isolated from ginseng (Panax) species. Use of the term has been extended to include semi-synthetic derivatives.	2.15	1
pterostilbene [no description available]	2.77	3	diether; methoxybenzenes; stilbenol	anti-inflammatory agent; antineoplastic agent; antioxidant; apoptosis inducer; hypoglycemic agent; neuroprotective agent; neurotransmitter; plant metabolite; radical scavenger
4',7-dihydroxyflavone 4',7-dihydroxyflavone: inducer of nod gene. 4',7-dihydroxyflavone : A dihydroxyflavone in which the two hydroxy substituents are located at positions 4' and 7.	2.15	1	dihydroxyflavone	metabolite
cochinchinenin cochinchinenin: isolated from Dracaena cochinchinensis; structure in first source	7.11	1
3-deoxysappanchalcone 3-deoxysappanchalcone: Anti-allergic from the roots and heartwood of Caesalpinia sappan; structure in first source. 2'-O-methylisoliquiritigenin : A member of the class of chalcones that is isoliquiritigenin in which one of the hydroxy groups at position 2' is replaced by a methoxy group.	2.44	2	chalcones; monomethoxybenzene; phenols	metabolite
2',4'-dihydroxychalcone 2',4'-dihydroxychalcone: RN given refers to (E)-isomer; RN for cpd without isomeric designation not available 6/89; structure given in first source	2.05	1
pinostilbene pinostilbene: structure in first source. 3-methoxy-4',5-dihydroxy-trans-stilbene : A stilbenoid that is trans-resveratrol in which one of the meta-hydroxy groups is converted to the corresponding methyl ether.	2.05	1	stilbenol
2,4,2'-trihydroxychalcone 2,4,2'-trihydroxychalcone: structure in first source	2.05	1
3,5-dihydroxy-4'-methoxystilbene 4'-methoxyresveratrol: has anti-inflammatory effects in cell culture model	2.03	1
ginsenoside rb1 [no description available]	2.15	1	ginsenoside; glycoside; tetracyclic triterpenoid	anti-inflammatory drug; anti-obesity agent; apoptosis inhibitor; neuroprotective agent; plant metabolite; radical scavenger
peimisine peimisine: isolated from Fritillaria ussuriensis	2.15	1

Condition	Relationship Strength	Studies
Candida Infection [description not available]	2.21	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.21	1
Candidiasis Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)	2.21	1
Arthritis, Degenerative [description not available]	2.25	1
Osteoarthritis A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.	7.25	1
Disease Resistance The capacity of an organism to defend itself against pathological processes or the agents of those processes. This most often involves innate immunity whereby the organism responds to pathogens in a generic way. The term disease resistance is used most frequently when referring to plants.	2.08	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.11	1

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