metronidazole has been researched along with Seizures in 19 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Five patients had apparently drug-induced seizures while simultaneously receiving theophylline and either imipenem (three patients), ciprofloxacin (one patient), or ciprofloxacin and metronidazole (one patient)." | 7.68 | Seizures in patients simultaneously receiving theophylline and imipenem or ciprofloxacin or metronidazole. ( Allen, N; Semel, JD, 1991) |
| "Metronidazole (MNZ) is a widely used drug for protozoan and anaerobic infections." | 7.01 | [A case of irreversible metronidazole encephalopathy during liver abscess treatment]. ( Aoki, Y; Hirosawa, T; Imai, Y; Kashimura, H; Konno, N; Munakata, A; Nihei, T; Okawara, K; Takahashi, S; Usami, Y, 2023) |
| "Cerebellar syndrome or seizures are less frequently reported." | 5.35 | [Metronidazole-related polyneuritis, convulsive seizures, and cerebellar syndrome. Contribution of MRI]. ( Corpechot, C; Ferroir, JP; Freudenreich, A; Khalil, A, 2009) |
| "Generalised convulsive seizures occurred on four occasions, associated with paresthesia of the four limbs, but without loss of motor or reflex activity, though some distal hypoesthesia was detected." | 5.26 | [Convulsive seizures and polyneuritis in a patient with lupus treated with metronidazole (author's transl)]. ( Betous, F; Herreman, G; Krainik, F; Mundler, B; Nicolas, MO, 1981) |
| "Afebrile seizures associated with rotavirus gastroenteritis, respiratory syncytial virus bronchiolitis, influenza infection, asthma, blood transfusions, and intake of a number of drugs (including theophylline, cephalosporins, metronidazole, and acyclovir) with therapeutic drug levels are uncommonly encountered in clinical practice." | 4.85 | Common causes of uncommon seizures. ( Boustany, RM; El-Bitar, MK, 2009) |
| "Five patients had apparently drug-induced seizures while simultaneously receiving theophylline and either imipenem (three patients), ciprofloxacin (one patient), or ciprofloxacin and metronidazole (one patient)." | 3.68 | Seizures in patients simultaneously receiving theophylline and imipenem or ciprofloxacin or metronidazole. ( Allen, N; Semel, JD, 1991) |
| "Metronidazole (MNZ) is a widely used drug for protozoan and anaerobic infections." | 3.01 | [A case of irreversible metronidazole encephalopathy during liver abscess treatment]. ( Aoki, Y; Hirosawa, T; Imai, Y; Kashimura, H; Konno, N; Munakata, A; Nihei, T; Okawara, K; Takahashi, S; Usami, Y, 2023) |
| "Related neurological adverse effects to metronidazole are rarely encountered in clinical practice despite its wide use as an antibacterial or antiparasitic agent." | 1.56 | Neurological complications during treatment of liver abscess: think of metronidazole toxicity. ( Arora, N; Babbar, N; Pannu, AK; Saroch, A; Sharma, N; Wasti, KP, 2020) |
| "Cerebral actinomycosis is rare and difficult to diagnose." | 1.37 | [Cerebral actinomycosis pseudotumor: a case report]. ( Battikh, R; Ben Abdelhafidh, N; Bougrine, F; Bouziani, A; M'Sadek, F; Madhi, W; Othmani, S; Yedeas, M, 2011) |
| "Cerebellar syndrome or seizures are less frequently reported." | 1.35 | [Metronidazole-related polyneuritis, convulsive seizures, and cerebellar syndrome. Contribution of MRI]. ( Corpechot, C; Ferroir, JP; Freudenreich, A; Khalil, A, 2009) |
| "We report convulsions induced by short-term metronidazole therapy used in conventional doses for Clostridium difficile colitis in an elderly patient with chronic renal failure." | 1.31 | Convulsions induced by metronidazole treatment for Clostridium difficile-associated disease in chronic renal failure. ( Beloosesky, Y; Grinblat, J; Grosman, B; Marmelstein, V, 2000) |
| "Generalised convulsive seizures occurred on four occasions, associated with paresthesia of the four limbs, but without loss of motor or reflex activity, though some distal hypoesthesia was detected." | 1.26 | [Convulsive seizures and polyneuritis in a patient with lupus treated with metronidazole (author's transl)]. ( Betous, F; Herreman, G; Krainik, F; Mundler, B; Nicolas, MO, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (31.58) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 4 (21.05) | 24.3611 |
| 2020's | 2 (10.53) | 2.80 |
| Authors | Studies |
|---|---|
| Usami, Y | 1 |
| Munakata, A | 1 |
| Takahashi, S | 1 |
| Konno, N | 1 |
| Imai, Y | 1 |
| Okawara, K | 1 |
| Hirosawa, T | 1 |
| Aoki, Y | 1 |
| Kashimura, H | 1 |
| Nihei, T | 1 |
| Arora, N | 1 |
| Wasti, KP | 1 |
| Babbar, N | 1 |
| Saroch, A | 1 |
| Pannu, AK | 1 |
| Sharma, N | 1 |
| Carter, C | 1 |
| Viveash, S | 1 |
| Ueno, T | 1 |
| Ito, M | 1 |
| Arai, A | 1 |
| Suzuki, C | 1 |
| Tomiyama, M | 1 |
| Ferroir, JP | 2 |
| Corpechot, C | 1 |
| Freudenreich, A | 1 |
| Khalil, A | 1 |
| El-Bitar, MK | 1 |
| Boustany, RM | 1 |
| Battikh, R | 1 |
| M'Sadek, F | 1 |
| Bougrine, F | 1 |
| Madhi, W | 1 |
| Ben Abdelhafidh, N | 1 |
| Bouziani, A | 1 |
| Yedeas, M | 1 |
| Othmani, S | 1 |
| Khan, SA | 1 |
| Dutta, P | 1 |
| Chowdhury, P | 1 |
| Borah, J | 1 |
| Topno, R | 1 |
| Mahanta, J | 1 |
| Karpova, MN | 1 |
| Karganov, MY | 1 |
| Klishina, NY | 1 |
| Khlebnikova, NN | 1 |
| Kryzhanovskii, GN | 1 |
| Roy, S | 1 |
| Ellenbogen, JM | 1 |
| Bailes, J | 1 |
| Willis, J | 1 |
| Priebe, C | 1 |
| Strub, R | 1 |
| Halloran, TJ | 1 |
| Herreman, G | 1 |
| Krainik, F | 1 |
| Betous, F | 1 |
| Nicolas, MO | 1 |
| Mundler, B | 1 |
| Beloosesky, Y | 1 |
| Grosman, B | 1 |
| Marmelstein, V | 1 |
| Grinblat, J | 1 |
| Frytak, S | 1 |
| Moertel, CH | 1 |
| Childs, DS | 1 |
| Semel, JD | 1 |
| Allen, N | 1 |
| Sopeña, B | 1 |
| Fernández Rodríguez, C | 1 |
| Ledo, L | 1 |
| Rodríguez, D | 1 |
| Roger, V | 1 |
| Mahieux, F | 1 |
| Guillard, A | 1 |
| Moulin, B | 1 |
| Dhib, M | 1 |
| Heudes, AM | 1 |
| Godin, M | 1 |
| Fillastre, JP | 1 |
2 reviews available for metronidazole and Seizures
| Article | Year |
|---|---|
[A case of irreversible metronidazole encephalopathy during liver abscess treatment].
Topics: Aged, 80 and over; Anti-Bacterial Agents; Brain Diseases; Female; Humans; Liver Abscess; Metronidazo | 2023 |
Common causes of uncommon seizures.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antiviral Agents; Asthma; Brain; Bronchiolitis; Child; | 2009 |
17 other studies available for metronidazole and Seizures
| Article | Year |
|---|---|
Neurological complications during treatment of liver abscess: think of metronidazole toxicity.
Topics: Antiprotozoal Agents; Humans; Liver Abscess, Amebic; Magnetic Resonance Imaging; Male; Metronidazole | 2020 |
Nursing a critically ill tetanus patient in an intensive care unit in Zambia.
Topics: Analgesics, Opioid; Anti-Infective Agents; Anticonvulsants; Back Pain; Critical Care Nursing; Critic | 2017 |
Convulsive seizures caused by metronidazole-induced encephalopathy.
Topics: Abdominal Abscess; Anti-Infective Agents; Brain Diseases; Cerebellar Nuclei; Humans; Magnetic Resona | 2019 |
[Metronidazole-related polyneuritis, convulsive seizures, and cerebellar syndrome. Contribution of MRI].
Topics: Aged; Cerebellar Diseases; Cerebellum; Epilepsies, Myoclonic; Humans; Liver Transplantation; Magneti | 2009 |
[Cerebral actinomycosis pseudotumor: a case report].
Topics: Actinomycosis; Adrenal Cortex Hormones; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacteria | 2011 |
Co-infection of arboviruses presenting as Acute Encephalitis Syndrome.
Topics: Acute Disease; Adult; Anti-Infective Agents; Brain; Consciousness; Encephalitis; Encephalitis Virus, | 2011 |
Contribution of protein synthesis to mechanisms of antiepileptic system activity in kindling.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Epilepsy; Kindling, Neurologic; Metronidazole; Mic | 2002 |
Seizures, frontal lobe mass, and remote history of periodontal abscess.
Topics: Actinomyces; Actinomycosis; Anti-Infective Agents; Brain Abscess; Corpus Callosum; Craniotomy; Dose- | 2005 |
Encephalopathy with metronidazole in a child.
Topics: Brain Diseases; Child; Coma; Humans; Male; Metronidazole; Seizures | 1983 |
Convulsions associated with high cumulative doses of metronidazole.
Topics: Humans; Male; Metronidazole; Middle Aged; Seizures | 1982 |
[Convulsive seizures and polyneuritis in a patient with lupus treated with metronidazole (author's transl)].
Topics: Abscess; Adult; Biopsy; Female; Humans; Lupus Erythematosus, Discoid; Male; Metronidazole; Middle Ag | 1981 |
Convulsions induced by metronidazole treatment for Clostridium difficile-associated disease in chronic renal failure.
Topics: Aged; Anti-Infective Agents; Enterocolitis, Pseudomembranous; Female; Humans; Kidney Failure, Chroni | 2000 |
Neurologic toxicity associated with high-dose metronidazole therapy.
Topics: Adenocarcinoma; Aged; Animals; Dogs; Female; Humans; Metronidazole; Middle Aged; Neoplasm Metastasis | 1978 |
Seizures in patients simultaneously receiving theophylline and imipenem or ciprofloxacin or metronidazole.
Topics: Aged; Ciprofloxacin; Drug Interactions; Drug Therapy, Combination; Epilepsies, Partial; Female; Huma | 1991 |
[Convulsions induced by a metronidazole-chloroquine combination].
Topics: Chloroquine; Humans; Male; Metronidazole; Middle Aged; Seizures | 1990 |
[Polyneuritis, convulsive crises, and cerebellar syndrome, complications of treatment with metronidazole].
Topics: Cerebellar Diseases; Female; Humans; Metronidazole; Middle Aged; Polyneuropathies; Seizures | 1985 |
[Neurotoxic risk of metronidazole in severe renal insufficiency].
Topics: Acute Kidney Injury; Adult; Confusion; Female; Humans; Metronidazole; Renal Dialysis; Seizures | 1988 |