metronidazole has been researched along with Tooth Mobility in 12 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Tooth Mobility: Horizontal and, to a lesser degree, axial movement of a tooth in response to normal forces, as in occlusion. It refers also to the movability of a tooth resulting from loss of all or a portion of its attachment and supportive apparatus, as seen in periodontitis, occlusal trauma, and periodontosis. (From Jablonski, Dictionary of Dentistry, 1992, p507 & Boucher's Clinical Dental Terminology, 4th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "No statistically significant difference is observed between both the groups and a combination of Ciprofloxacin, Minocycline and Tinidazole antibacterial drugs can be used on teeth pulpally involved with physiologic root resorption." | 5.16 | In vivo evaluation of lesion sterilization and tissue repair in primary teeth pulp therapy using two antibiotic drug combinations. ( Anantharaj, A; Jaya, AR; Praveen, P; Rani, PS; Venkataraghavan, K, 2012) |
| " With only partial compliance to local debridement, chlorhexidine oral rinses, and systemic metronidazole therapy, alveolar bone loss resulted in tooth mobility necessitating extraction of 2 involved teeth." | 3.70 | Rapid progression of bone loss in HIV-associated necrotizing ulcerative stomatitis. ( McKaig, R; Patton, LL, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 4 (33.33) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jaya, AR | 1 |
| Praveen, P | 1 |
| Anantharaj, A | 1 |
| Venkataraghavan, K | 1 |
| Rani, PS | 1 |
| Neering, SH | 1 |
| Adyani-Fard, S | 1 |
| Klocke, A | 1 |
| Rüttermann, S | 1 |
| Flemmig, TF | 1 |
| Beikler, T | 1 |
| Agrawal, N | 1 |
| Kallury, A | 1 |
| Khurana, R | 1 |
| Jain, V | 1 |
| Agarwal, K | 1 |
| Paramkusam, G | 1 |
| Meduri, V | 1 |
| Gangeshetty, N | 1 |
| Kargül, B | 1 |
| Tanboga, I | 1 |
| Altinok, B | 1 |
| Seremidi, K | 1 |
| Gizani, S | 1 |
| Madianos, P | 1 |
| Schacher, B | 1 |
| Baron, F | 1 |
| Ludwig, B | 1 |
| Valesky, E | 1 |
| Noack, B | 1 |
| Eickholz, P | 1 |
| Sixou, JL | 1 |
| Robert, JC | 1 |
| Bonnaure-Mallet, M | 1 |
| Patton, LL | 1 |
| McKaig, R | 1 |
| Loesche, WJ | 1 |
| Giordano, JR | 1 |
| Soehren, S | 1 |
| Kaciroti, N | 1 |
| Groselj, D | 1 |
| Grabec, I | 1 |
| Bodur, A | 1 |
| Bodur, H | 1 |
| Bal, B | 1 |
| Baloş, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Observational Study on Cytokine Production by Leukocytes of Papillon-Lefèvre Syndrome Patients and Healthy Probands in Whole Blood Cultures[NCT01116934] | 17 participants (Actual) | Observational | 2006-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Concentrations of IL-8, IL-6, IP-10, interferon (IFN)-gamma, and IL-1 beta, in plasma/RPMI samples were determined by enzyme linked immunosorbent assay (ELISA) according to the manufacturers' instructions (NCT01116934)
Timeframe: 2006
| Intervention | pg/ml (Median) | ||||
|---|---|---|---|---|---|
| interleukin-1 beta | interleukin-6 | interferon-inducible protein-10 | interferon gamma | interleukin-8 | |
| Healthy Controls | 896.21 | 45734 | 11563 | 3317.4 | 44390 |
| Papillon-Lefèvre Syndrome (PLS) Patients | 1100.00 | 65559 | 12902.5 | 3704.5 | 50520 |
1 review available for metronidazole and Tooth Mobility
| Article | Year |
|---|---|
Pyoderma gangrenosum with oral involvement - case report and review of the literature.
Topics: Adult; Anti-Infective Agents; Chlorhexidine; Dapsone; Drug Therapy, Combination; Female; Glucocortic | 2010 |
2 trials available for metronidazole and Tooth Mobility
| Article | Year |
|---|---|
In vivo evaluation of lesion sterilization and tissue repair in primary teeth pulp therapy using two antibiotic drug combinations.
Topics: Anti-Bacterial Agents; Child; Ciprofloxacin; Dental Pulp Necrosis; Double-Blind Method; Drug Combina | 2012 |
The nonsurgical treatment of patients with periodontal disease: results after five years.
Topics: Age Factors; Alveolar Bone Loss; Anti-Bacterial Agents; Bacteria, Anaerobic; Bacterial Infections; D | 2002 |
9 other studies available for metronidazole and Tooth Mobility
| Article | Year |
|---|---|
Periodontitis associated with plasminogen deficiency: a case report.
Topics: Adolescent; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Combined Modality Therapy; Conju | 2015 |
Interdisciplinary management of aggressive periodontitis.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Combined Modality Therapy; Conn | 2015 |
Conventional endodontic treatment of primary molars using metronidazole as an intra-canal medicament: a pilot study.
Topics: Abscess; Alveolar Bone Loss; Anti-Infective Agents; Child; Dental Fistula; Dental Pulp Diseases; Fem | 2010 |
Therapeutic management of a case of generalised aggressive periodontitis in an 8-year old child: 18-month results.
Topics: Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Alveolar Bone Loss; Amoxicillin; An | 2012 |
Periodontal therapy in siblings with Papillon-Lefèvre syndrome and tinea capitis: a report of two cases.
Topics: Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Ch | 2006 |
Loss of deciduous teeth and germs of permanent incisors in a 4-year-old child. An atypic prepubertal periodontitis? A clinical, microbiological, immunological and ultrastructural study.
Topics: Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Anti-Bacterial Agents; Basement Mem | 1997 |
Rapid progression of bone loss in HIV-associated necrotizing ulcerative stomatitis.
Topics: Adult; AIDS-Related Opportunistic Infections; Alveolar Bone Loss; Anti-Infective Agents; Anti-Infect | 1998 |
Statistical modeling of tooth mobility after treating adult periodontitis.
Topics: Adult; Anti-Bacterial Agents; Chronic Disease; Colony Count, Microbial; Dental Plaque Index; Electro | 2002 |
Generalized aggressive periodontitis in a prepubertal patient: a case report.
Topics: Actinobacillus Infections; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Alveolar | 2001 |