metronidazole has been researched along with Age-Related Osteoporosis in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ghidini, G | 1 |
| Manfredi, M | 1 |
| Giovannacci, I | 1 |
| Mergoni, G | 1 |
| Sarraj, A | 1 |
| Mureddu, M | 1 |
| Giunta, G | 1 |
| Bonanini, M | 1 |
| Meleti, M | 1 |
| Vescovi, P | 1 |
| Beglinger, Ch | 1 |
1 review available for metronidazole and Age-Related Osteoporosis
| Article | Year |
|---|---|
[Treatment of Crohn's disease].
Topics: Acute Disease; Adjuvants, Immunologic; Adrenal Cortex Hormones; Algorithms; Aminosalicylic Acids; An | 2003 |
1 other study available for metronidazole and Age-Related Osteoporosis
| Article | Year |
|---|---|
Medication-related osteonecrosis of the jaw: risk factors in patients under biphosphonate versus patients under antiresorptive-antiangiogenic drugs.
Topics: Aged; Aged, 80 and over; Amoxicillin-Potassium Clavulanate Combination; Angiogenesis Inhibitors; Ant | 2017 |