metronidazole has been researched along with Intestinal Diseases in 25 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Intestinal Diseases: Pathological processes in any segment of the INTESTINE from DUODENUM to RECTUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tablets of 500 mg metronidazole were given to 24 patients with intestinal diseases and to 10 healthy volunteers." | 3.66 | Pharmacokinetics of metronidazole in patients with enteric disease compared to normal volunteers. ( Bergan, T; Bjerke, PE; Fausa, O, 1981) |
| "Metronidazole (M) has potent bactericidal activity against anaerobic bacteria." | 2.65 | Prospective, randomized comparison of metronidazole and clindamycin, each with gentamicin, for the treatment of serious intra-abdominal infection. ( , 1983) |
| "Metronidazole is an antibiotic used to treat intra-abdominal anaerobic bacterial infections and is also commonly used in preoperative treatment for colorectal surgery." | 1.37 | [Marked efficacy of metronidazole for the intestinal pseudoobstruction associated with systemic sclerosis]. ( Azuma, N; Fujita, K; Hashimoto, N; Hino, T; Iizuka, M; Kitano, M; Matsui, K; Morimoto, M; Nishioka, A; Okabe, M; Sano, H; Sekiguchi, M, 2011) |
| "The diagnosis of non-dysenteric intestinal amoebiasis could be made in only one patient, who had relapse of symptoms within 6 weeks of antiamoebic therapy and therefore the relapse did not meet criteria for the diagnosis of non-dysenteric intestinal amoebiasis." | 1.30 | Does non-dysenteric intestinal amoebiasis exist? ( Anand, AC; Kher, SK; Reddy, PS; Saiprasad, GS, 1997) |
| "A patient had Crohn's disease in relapse with multiple small bowel fistulae and mesenteric abscesses." | 1.30 | Relative sensitivity of Tc-99m WBC versus In-111 WBC in a patient with Crohn's disease on steroids. ( Broekelschen, P; Challa, S; Lyons, KP; Milne, N, 1997) |
| "Treatment with metronidazole in most cases improved symptoms." | 1.28 | [Intestinal spirochetosis in HIV infection: prevalence, isolation and morphology of spirochetes]. ( Arasteh, K; Gelderblom, HR; Grosse, G; Heise, W; Käsbohrer, A; Koch, MA; L'age, M; Pauli, G; Schönberg, A, 1990) |
| "Three cases of intestinal amebiasis with varying clinical pictures are presented." | 1.26 | [Diagnosis of intestinal amebiasis]. ( Blum, AL; Giger, M; Gyr, K; Reichlin, B, 1981) |
| "Pneumatosis cystoides intestinalis was a sequal in two patients." | 1.26 | Bypass enteropathy: an inflammatory process in the excluded segment with systemic complications. ( Ament, ME; Drenick, EJ; Finegold, SM; Passaro, E, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (36.00) | 18.7374 |
| 1990's | 8 (32.00) | 18.2507 |
| 2000's | 4 (16.00) | 29.6817 |
| 2010's | 4 (16.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tahan, S | 1 |
| Melli, LC | 1 |
| Mello, CS | 1 |
| Rodrigues, MS | 1 |
| Bezerra Filho, H | 1 |
| de Morais, MB | 1 |
| Suarez-Peñaranda, JM | 1 |
| Macías-García, F | 1 |
| Llovo, J | 1 |
| Forteza, J | 1 |
| Madisch, A | 1 |
| Azuma, N | 1 |
| Nishioka, A | 1 |
| Iizuka, M | 1 |
| Matsui, K | 1 |
| Fujita, K | 1 |
| Hino, T | 1 |
| Okabe, M | 1 |
| Morimoto, M | 1 |
| Sekiguchi, M | 1 |
| Kitano, M | 1 |
| Hashimoto, N | 1 |
| Sano, H | 1 |
| Day, AS | 1 |
| Lemberg, DA | 1 |
| Rozynek, E | 1 |
| Dzierzanowska-Fangrat, K | 1 |
| Celińska-Cedro, D | 1 |
| Jóźwiak, P | 1 |
| Madaliński, K | 1 |
| Dzierzanowska, D | 1 |
| van Mook, WN | 1 |
| Koek, GH | 1 |
| van der Ven, AJ | 1 |
| Ceelen, TL | 1 |
| Bos, RP | 1 |
| Reichlin, B | 1 |
| Gyr, K | 1 |
| Giger, M | 1 |
| Blum, AL | 1 |
| McEvoy, B | 1 |
| Kelly, DG | 1 |
| Phillips, SF | 1 |
| Kelly, KA | 1 |
| Weinstein, WM | 1 |
| Gilchrist, MJ | 1 |
| Bergan, T | 1 |
| Bjerke, PE | 1 |
| Fausa, O | 1 |
| Tan, E | 1 |
| Hart, LL | 1 |
| Anand, AC | 1 |
| Reddy, PS | 1 |
| Saiprasad, GS | 1 |
| Kher, SK | 1 |
| Lyons, KP | 2 |
| Challa, S | 2 |
| Broekelschen, P | 2 |
| Milne, N | 2 |
| Kovachev, L | 1 |
| Presolski, I | 1 |
| Tsvetkov, I | 1 |
| Trenschel, R | 1 |
| Peceny, R | 1 |
| Runde, V | 1 |
| Elmaagacli, A | 1 |
| Dermoumi, H | 1 |
| Heintschel von Heinegg, E | 1 |
| Müller, KD | 1 |
| Schaefer, UW | 1 |
| Beelen, DW | 1 |
| Hilmer, R | 1 |
| Goulston, K | 1 |
| Drenick, EJ | 1 |
| Ament, ME | 1 |
| Finegold, SM | 1 |
| Passaro, E | 1 |
| Grassi, M | 1 |
| Fontana, M | 1 |
| Mammucari, S | 1 |
| Nocchi, S | 1 |
| Messina, B | 1 |
| Mennuni, G | 1 |
| Diacinti, D | 1 |
| Winslet, MC | 1 |
| Youngs, D | 1 |
| Burdon, DW | 1 |
| Keighley, MR | 1 |
| Käsbohrer, A | 1 |
| Gelderblom, HR | 1 |
| Arasteh, K | 1 |
| Heise, W | 1 |
| Grosse, G | 1 |
| L'age, M | 1 |
| Schönberg, A | 1 |
| Koch, MA | 1 |
| Pauli, G | 1 |
| Leigh, DA | 1 |
| Powell, SJ | 1 |
3 reviews available for metronidazole and Intestinal Diseases
| Article | Year |
|---|---|
[Diagnostics and therapy of chronic diarrhea in elderly people].
Topics: Age Factors; Aged; Aged, 80 and over; Anti-Infective Agents; Anti-Inflammatory Agents; Antidiarrheal | 2008 |
Human intestinal spirochaetosis: any clinical significance?
Topics: Anti-Infective Agents; Brachyspira; Colon; Humans; Immunocompetence; Intestinal Diseases; Metronidaz | 2004 |
Metronidazole/neomycin as preoperative bowel preparation.
Topics: Drug Therapy, Combination; Humans; Intestinal Diseases; Intestines; Metronidazole; Neomycin; Premedi | 1993 |
4 trials available for metronidazole and Intestinal Diseases
| Article | Year |
|---|---|
Effectiveness of trimethoprim-sulfamethoxazole and metronidazole in the treatment of small intestinal bacterial overgrowth in children living in a slum.
Topics: Anti-Infective Agents; Area Under Curve; Bacterial Infections; Breath Tests; Child; Humans; Hydrogen | 2013 |
Prospective, randomized comparison of metronidazole and clindamycin, each with gentamicin, for the treatment of serious intra-abdominal infection.
Topics: Abdomen; Abscess; Adolescent; Adult; Aged; Anti-Bacterial Agents; Appendicitis; Bacterial Infections | 1983 |
Fungal colonization and invasive fungal infections following allogeneic BMT using metronidazole, ciprofloxacin and fluconazole or ciprofloxacin and fluconazole as intestinal decontamination.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Antifungal Agents; Aspergillosis; | 2000 |
Short-term chemoprophylaxis with ceftizoxime vs. five-day aminoglycoside with metronidazole in 'contaminated' lower gastrointestinal surgery.
Topics: Aminoglycosides; Bacterial Infections; Ceftizoxime; Drug Administration Schedule; Humans; Incidence; | 1990 |
18 other studies available for metronidazole and Intestinal Diseases
| Article | Year |
|---|---|
Histopathological diagnosis of intestinal spirochetosis in a nonimmunocompromised patient.
Topics: Aged; Anti-Infective Agents; Colonoscopy; Diarrhea; Feces; Humans; Immunocompetence; Intestinal Dise | 2010 |
[Marked efficacy of metronidazole for the intestinal pseudoobstruction associated with systemic sclerosis].
Topics: Female; Humans; Intestinal Diseases; Metronidazole; Middle Aged; Scleroderma, Systemic; Tomography, | 2011 |
Reduced sepsis with enteral antibiotics in children with intestinal failure.
Topics: Anti-Infective Agents; Child; Enteral Nutrition; Humans; Intestinal Absorption; Intestinal Diseases; | 2011 |
Primary resistance of Helicobacter pylori to antimicrobial agents in Polish children.
Topics: Adolescent; Amoxicillin; Anti-Bacterial Agents; Child; Clarithromycin; DNA, Bacterial; Drug Resistan | 2002 |
[Diagnosis of intestinal amebiasis].
Topics: Acetanilides; Adult; Amebiasis; Amoeba; Colon, Sigmoid; Dysentery, Amebic; Emetine; Feces; Female; F | 1981 |
Transfer of bioactive substances in breast milk.
Topics: Amoxicillin; Breast Feeding; Candidiasis; Dermatitis, Atopic; Female; Humans; Infant; Intestinal Dis | 1984 |
Dysfunction of the continent ileostomy: clinical features and bacteriology.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Female; Humans; Ileostomy; Intestinal Diseases; Inte | 1983 |
Pharmacokinetics of metronidazole in patients with enteric disease compared to normal volunteers.
Topics: Adult; Biological Availability; Female; Humans; Ileostomy; Intestinal Absorption; Intestinal Disease | 1981 |
Does non-dysenteric intestinal amoebiasis exist?
Topics: Abdominal Pain; Adolescent; Adult; Aged; Animals; Antibodies, Protozoan; Child; Colonic Diseases, Fu | 1997 |
Relative sensitivity of Tc-99m WBC versus In-111 WBC in a patient with Crohn's disease on steroids.
Topics: Abdominal Abscess; Adult; Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammator | 1997 |
Relative sensitivity of Tc-99m WBC versus In-111 WBC in a patient with Crohn disease and steroid use.
Topics: Abdominal Abscess; Adult; Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammator | 1997 |
[Decontamination in colorectal surgery].
Topics: Aged; Anti-Infective Agents; Antibiotic Prophylaxis; Cause of Death; Cephalosporins; Colorectal Surg | 1998 |
Drugs used in treatment of large bowel disease.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antidiarrheals; Azathioprine; Cathartics; Colitis, U | 1979 |
Bypass enteropathy: an inflammatory process in the excluded segment with systemic complications.
Topics: Adult; Albumins; Arthritis; Body Weight; Dermatitis; Diarrhea; Female; Humans; Ileum; Inflammation; | 1977 |
[A case of intestinal giardiasis associated with immunoglobulin deficiency and intestinal lymph node hyperplasia].
Topics: Adult; gamma-Globulins; Giardiasis; Humans; Hyperplasia; Immunoglobulins; Intestinal Diseases; Intes | 1990 |
[Intestinal spirochetosis in HIV infection: prevalence, isolation and morphology of spirochetes].
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; AIDS-Related Complex; Endoscopy; Homosexuality; Hum | 1990 |
Letter: Bacteroides infections.
Topics: Bacteroides; Bacteroides Infections; Clindamycin; Culture Media; Drug Evaluation; Drug Resistance, M | 1973 |
Latest developments in the treatment of amebiasis.
Topics: Amebiasis; Amebicides; Anti-Bacterial Agents; Chemical Phenomena; Chemistry; Chloroquine; Dysentery, | 1972 |