metronidazole has been researched along with Trypanosomiasis in 7 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Trypanosomiasis: Infection with protozoa of the genus TRYPANOSOMA.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (57.14) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| ADRIAENSSENS, K | 1 |
| SANTANA, ET | 1 |
| Bouteille, B | 1 |
| Chauviere, G | 1 |
| Ogunbanwo, JA | 1 |
| Agbonlahor, DE | 1 |
| Adamu, A | 1 |
| Dalyop, P | 1 |
| Elesha, SO | 1 |
| Fagbenro-Beyioku, AF | 1 |
| Takada, S | 1 |
| Cuckler, AC | 1 |
| Malanga, CM | 1 |
| Conroy, J | 1 |
| Shapero, M | 1 |
| Jefferies, HS | 1 |
| Ryan, DM | 1 |
1 review available for metronidazole and Trypanosomiasis
| Article | Year |
|---|---|
[Use of megazol for the treatment of trypanosomiasis].
Topics: Acetanilides; Animals; Anti-Infective Agents; Disease Models, Animal; Drug Evaluation, Preclinical; | 1999 |
6 other studies available for metronidazole and Trypanosomiasis
| Article | Year |
|---|---|
[Metronidazole in a case of sleeping sickness caused by Trypanosoma rhodesiense].
Topics: Animals; Black People; Humans; Imidazoles; Metronidazole; Trypanosoma brucei rhodesiense; Trypanosom | 1961 |
[USE OF METRONIDAZOL (RP 8823) IN CHAGAS' DISEASE].
Topics: Chagas Disease; Drug Therapy; Humans; Metronidazole; Trypanosomiasis; United States | 1964 |
Effects of anti-protozoal drugs and histopathological studies on trypanosome species.
Topics: Animals; Chloroquine; Female; Humans; Male; Metronidazole; Parasitic Sensitivity Tests; Phenanthrene | 2001 |
[Drugs used against protozoan infections in man].
Topics: Amebiasis; Aminoquinolines; Antiprotozoal Agents; Humans; Malaria; Metronidazole; Pneumonia, Pneumoc | 1990 |
Therapeutic efficacy of new nitroimidazoles for experimental trichomoniasis, amebiasis, and trypanosomiasis.
Topics: Amebiasis; Animals; Antiprotozoal Agents; Disease Models, Animal; Entamoeba histolytica; Female; Imi | 1970 |
Laboratory evaluation of panidazole (1-(2'-( -pyridyl) ethyl-2-methyl)-5-nitroimidazole), a new amoebicide.
Topics: Amebiasis; Amebicides; Animals; Antitrichomonal Agents; Cecal Diseases; Cricetinae; Emetine; Entamoe | 1972 |