metronidazole has been researched along with Adiadochokinesis in 10 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "He had a 50-day-history of amebic dysentery and had been treated with 1,500 mg metronidazole per day." | 5.33 | [MRI and SPECT findings in a case of metronidazole-induced reversible acute cerebellar ataxia]. ( Ohta, S; Santa, Y; Takase, K; Yoshimura, T, 2005) |
| " Acute reversible cerebellar ataxia with confusion secondary to prolonged metronidazole use has been reported rarely as a cause of encephalopathy in patients with ALD." | 3.83 | Metronidazole-Induced Encephalopathy in Alcoholic Liver Disease: A Diagnostic and Therapeutic Challenge. ( Contractor, Q; Jain, SS; Mohite, AR; Pawar, SV; Rathi, PM; Sonthalia, N; Surude, RG, 2016) |
| "He had a 50-day-history of amebic dysentery and had been treated with 1,500 mg metronidazole per day." | 1.33 | [MRI and SPECT findings in a case of metronidazole-induced reversible acute cerebellar ataxia]. ( Ohta, S; Santa, Y; Takase, K; Yoshimura, T, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jiménez, MT | 1 |
| Gándara, PS | 1 |
| Espay, AJ | 1 |
| Muir, RT | 1 |
| Mercado, M | 1 |
| Walter, VR | 1 |
| Singhal, N | 1 |
| Kwan, P | 1 |
| Kucharczyk, W | 1 |
| Stall, NM | 1 |
| Carlen, PL | 1 |
| Yamamoto, Y | 1 |
| Asai, N | 1 |
| Furuhashi, A | 1 |
| Ono, T | 1 |
| Yamagishi, Y | 1 |
| Mikamo, H | 1 |
| Kazaoka, Y | 1 |
| Briongos-Figuero, LS | 1 |
| Bachiller-Luque, P | 1 |
| Pastor-Mancisidor, L | 1 |
| Carreres-Rodríguez, A | 1 |
| Mena-Martín, FJ | 1 |
| Sonthalia, N | 1 |
| Pawar, SV | 1 |
| Mohite, AR | 1 |
| Jain, SS | 1 |
| Surude, RG | 1 |
| Rathi, PM | 1 |
| Contractor, Q | 1 |
| Patel, K | 1 |
| Green-Hopkins, I | 1 |
| Lu, S | 1 |
| Tunkel, AR | 1 |
| Moosa, AN | 1 |
| Perkins, D | 1 |
| Heaney, CJ | 1 |
| Campeau, NG | 1 |
| Lindell, EP | 1 |
| Takase, K | 1 |
| Santa, Y | 1 |
| Ohta, S | 1 |
| Yoshimura, T | 1 |
| Kusumi, RK | 1 |
| Plouffe, JF | 1 |
| Wyatt, RH | 1 |
| Fass, RJ | 1 |
1 review available for metronidazole and Adiadochokinesis
| Article | Year |
|---|---|
Cerebellar ataxia following prolonged use of metronidazole: case report and literature review.
Topics: Anti-Infective Agents; Cerebellar Ataxia; Cerebellum; Female; Humans; Magnetic Resonance Imaging; Ma | 2008 |
9 other studies available for metronidazole and Adiadochokinesis
| Article | Year |
|---|---|
Teaching NeuroImages: The dentate sign in subacute cerebellar ataxia: Metronidazole neurotoxicity.
Topics: Aged; Cerebellar Ataxia; Cerebellar Nuclei; Female; Humans; Metronidazole | 2020 |
Ataxia and Parkinsonism in Metronidazole Neurotoxicity.
Topics: Ataxia; Brain Diseases; Cerebellar Ataxia; Humans; Magnetic Resonance Imaging; Metronidazole; Neurot | 2021 |
Metronidazole-induced encephalopathy caused by hyperbaric oxygen therapy in a patient with mandibular osteomyelitis.
Topics: Aged; Anti-Bacterial Agents; Cerebellar Ataxia; Cerebellar Nuclei; Chemoradiotherapy; Drug Therapy, | 2019 |
[Cerebellar syndrome induced by metronidazole: a rare side effect].
Topics: Anti-Bacterial Agents; Brain Abscess; Cefotaxime; Cephalosporins; Cerebellar Ataxia; Diagnosis, Diff | 2016 |
Metronidazole-Induced Encephalopathy in Alcoholic Liver Disease: A Diagnostic and Therapeutic Challenge.
Topics: Anti-Infective Agents; Cerebellar Ataxia; Confusion; Dysarthria; Humans; Liver Diseases, Alcoholic; | 2016 |
Neurological picture. MRI of metronidazole induced cerebellar ataxia.
Topics: Anti-Infective Agents; Brain; Cerebellar Ataxia; Cerebellum; Humans; Magnetic Resonance Imaging; Mal | 2010 |
MR imaging and diffusion-weighted imaging changes in metronidazole (Flagyl)-induced cerebellar toxicity.
Topics: Abdominal Abscess; Abdominal Neoplasms; Aged; Amoxicillin; Anti-Infective Agents; Carcinoid Tumor; C | 2003 |
[MRI and SPECT findings in a case of metronidazole-induced reversible acute cerebellar ataxia].
Topics: Acute Disease; Aged; Antiprotozoal Agents; Brain; Cerebellar Ataxia; Cysteine; Dysentery, Amebic; Hu | 2005 |
Central nervous system toxicity associated with metronidazole therapy.
Topics: Blood-Brain Barrier; Brain Diseases; Cerebellar Ataxia; Female; Humans; Metronidazole; Middle Aged; | 1980 |