metronidazole has been researched along with Injuries, Spinal Cord in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ohnmacht, J | 1 |
| Yang, Y | 1 |
| Maurer, GW | 1 |
| Barreiro-Iglesias, A | 1 |
| Tsarouchas, TM | 1 |
| Wehner, D | 1 |
| Sieger, D | 1 |
| Becker, CG | 1 |
| Becker, T | 1 |
| Romero Ganuza, FJ | 1 |
| Zhang, YP | 1 |
| Onifer, SM | 1 |
| Burke, DA | 1 |
| Shields, CB | 1 |
1 review available for metronidazole and Injuries, Spinal Cord
| Article | Year |
|---|---|
[Pancreatitis associated with metronidazole].
Topics: Abdominal Injuries; Acute Disease; Adult; Anti-Bacterial Agents; Cervical Vertebrae; Clostridium Inf | 2008 |
2 other studies available for metronidazole and Injuries, Spinal Cord
| Article | Year |
|---|---|
Spinal motor neurons are regenerated after mechanical lesion and genetic ablation in larval zebrafish.
Topics: Animals; Dexamethasone; Immunity, Innate; Immunosuppressive Agents; Larva; Macrophages; Metronidazol | 2016 |
A topical mixture for preventing, abolishing, and treating autophagia and self-mutilation in laboratory rats.
Topics: Administration, Topical; Animal Welfare; Animals; Female; Kainic Acid; Lumbosacral Region; Metronida | 2001 |