metronidazole has been researched along with Breast Neoplasms in 24 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Breast Neoplasms: Tumors or cancer of the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Since the dermatitis caused by metronidazole gel was also distinguished, the redness was improved when the application was stopped." | 7.96 | [A Case of Dermatitis Caused by Metronidazole Gel That Needed to Be Differentiated from Breast Cancer Skin Metastasis]. ( Asano, Y; Hirakawa, K; Ishihara, S; Kashiwagi, S; Kawano, Y; Kouhashi, R; Morisaki, T; Noda, S; Ohira, M; Onoda, N; Takashima, T; Tauchi, Y; Yabumoto, A, 2020) |
| "The aim of our study was to evaluate the impact of metronidazole (MTZ) on cytotoxicity and DNA synthesis in MCF-7 (estrogen receptor positive) and MDA-MB-231 (estrogen receptor negative) breast cancer cell lines." | 7.79 | Metronidazole affects breast cancer cell lines. ( Car, H; Konończuk, J; Miltyk, W; Prokopiuk, S; Sadowska, A; Sawicka, D; Surażyński, A, 2013) |
| "A 78-year-old patient with an ulcerous, purulent, exophytic fist-sized breast carcinoma (FIGO IVd) and a pulmonary metastasis who refused radiation, chemotherapy and operation, was treated with oral tamoxifen and metronidazole daily and with local antiseptics." | 7.69 | Influence of metronidazole and tamoxifen in a case of otherwise untreated ulcerous breast carcinoma. ( de la Motte, S; Heirler, F; Popp, W, 1995) |
| "Metronidazole gel was applied to the surface of ulcerated tumors once or twice daily." | 6.68 | Use of metronidazole gel to control malodor in advanced and recurrent breast cancer. ( Kubota, M; Kuge, S; Makuuchi, H; Mitomi, T; Ninomiya, S; Ohta, M; Okumura, A; Sawamura, S; Tajima, T; Tokuda, Y, 1996) |
| "Metronidazole (Flagyl) was introduced into The United States in the 1960's for the treatment of trichomoniasis (1)." | 5.27 | Occurrence of three cases of carcinoma in individuals with Crohn's disease treated with metronidazole. ( Ayuyang, HQ; Ellis, LD; Krause, JR, 1985) |
| " Since the dermatitis caused by metronidazole gel was also distinguished, the redness was improved when the application was stopped." | 3.96 | [A Case of Dermatitis Caused by Metronidazole Gel That Needed to Be Differentiated from Breast Cancer Skin Metastasis]. ( Asano, Y; Hirakawa, K; Ishihara, S; Kashiwagi, S; Kawano, Y; Kouhashi, R; Morisaki, T; Noda, S; Ohira, M; Onoda, N; Takashima, T; Tauchi, Y; Yabumoto, A, 2020) |
| "The aim of our study was to evaluate the impact of metronidazole (MTZ) on cytotoxicity and DNA synthesis in MCF-7 (estrogen receptor positive) and MDA-MB-231 (estrogen receptor negative) breast cancer cell lines." | 3.79 | Metronidazole affects breast cancer cell lines. ( Car, H; Konończuk, J; Miltyk, W; Prokopiuk, S; Sadowska, A; Sawicka, D; Surażyński, A, 2013) |
| "A 78-year-old patient with an ulcerous, purulent, exophytic fist-sized breast carcinoma (FIGO IVd) and a pulmonary metastasis who refused radiation, chemotherapy and operation, was treated with oral tamoxifen and metronidazole daily and with local antiseptics." | 3.69 | Influence of metronidazole and tamoxifen in a case of otherwise untreated ulcerous breast carcinoma. ( de la Motte, S; Heirler, F; Popp, W, 1995) |
| "Twenty-seven patients with metastatic adenocarcinoma of the breast refractory to other chemotherapy were treated with mitomycin-C plus metronidazole." | 3.67 | Mitomycin-C plus metronidazole in advanced carcinoma of the breast. ( Crook, AF; Heringer, R; Lefebvre, B; Maroun, JA; Stewart, DJ, 1985) |
| "The patient received treatment with anti-tetanus globulin and metronidazole; sound insulation and shielding were also performed in a dark room." | 2.72 | Non-surgical treatment of tetanus infection associated with breast cancer skin ulcer: a case report and literature review. ( Aisaka, W; Narimatsu, E; Nomura, K; Okamoto, H; Sakawaki, E; Sakawaki, S; Takeyama, Y; Uemura, S; Yamaoka, A, 2021) |
| "Metronidazole gel was applied to the surface of ulcerated tumors once or twice daily." | 2.68 | Use of metronidazole gel to control malodor in advanced and recurrent breast cancer. ( Kubota, M; Kuge, S; Makuuchi, H; Mitomi, T; Ninomiya, S; Ohta, M; Okumura, A; Sawamura, S; Tajima, T; Tokuda, Y, 1996) |
| "Metronidazole therapy was associated with substantial nausea and vomiting but no neurotoxicity was observed." | 2.65 | Randomized trial of radiotherapy versus radiotherapy plus metronidazole for the treatment metastatic cancer to brain. A Southwest Oncology Group study. ( Eyre, HJ; Frank, J; LoBuglio, AF; Mansfield, CM; McCracken, JD; Ohlsen, JD; Weatherall, TJ, 1984) |
| " In the present study, plasma concentration of MTZ was measured in a breast cancer patient using MTZ ointment for cancerous malodor and basic research was also conducted with the objective of investigating the safety of topical MTZ from a pharmacokinetic perspective." | 1.39 | Investigation of the safety of topical metronidazole from a pharmacokinetic perspective. ( Hasegawa, S; Iida, J; Ike, H; Ito, K; Kagaya, H; Kudo, T; Sato, T; Shimada, K; Yamagishi, S; Yatsuno, Y, 2013) |
| "Risk of breast cancer in women was assessed for eight pharmaceuticals that produce mammary tumors in experimental animals, using nested case-control analyses in two cohorts with prescription records in a comprehensive medical care program." | 1.35 | Pharmaceuticals that cause mammary gland tumors in animals: findings in women. ( Chan, J; Friedman, GD; Habel, LA; Jiang, SF; Quesenberry, CP; Udaltsova, N, 2009) |
| "Non puerperal mastitis is an inflammatory disease that resembles carcinoma, the course is insidious and frequently this entity is misdiagnosed." | 1.29 | [Non-puerperal mastitis. Clinical study of 30 patients]. ( Moreno, G; Paredes López, A, 1995) |
| "Metronidazole, 1." | 1.27 | Feasibility study of combining metronidazole with chemotherapy. ( Bélanger, R; Crook, AF; Heringer, R; Hopkins, HS; Hugenholtz, H; Maroun, JA; Richard, MT; Stewart, DJ; Yan, RC; Young, V, 1983) |
| "Metronidazole (Flagyl) was introduced into The United States in the 1960's for the treatment of trichomoniasis (1)." | 1.27 | Occurrence of three cases of carcinoma in individuals with Crohn's disease treated with metronidazole. ( Ayuyang, HQ; Ellis, LD; Krause, JR, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (41.67) | 18.7374 |
| 1990's | 6 (25.00) | 18.2507 |
| 2000's | 2 (8.33) | 29.6817 |
| 2010's | 4 (16.67) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Nomura, K | 1 |
| Sakawaki, E | 1 |
| Sakawaki, S | 1 |
| Yamaoka, A | 1 |
| Aisaka, W | 1 |
| Okamoto, H | 1 |
| Takeyama, Y | 1 |
| Uemura, S | 1 |
| Narimatsu, E | 1 |
| Ishihara, S | 1 |
| Kashiwagi, S | 1 |
| Asano, Y | 1 |
| Kawano, Y | 1 |
| Kouhashi, R | 1 |
| Yabumoto, A | 1 |
| Tauchi, Y | 1 |
| Morisaki, T | 1 |
| Noda, S | 1 |
| Takashima, T | 1 |
| Onoda, N | 1 |
| Hirakawa, K | 1 |
| Ohira, M | 1 |
| Sadowska, A | 1 |
| Prokopiuk, S | 1 |
| Miltyk, W | 1 |
| Surażyński, A | 1 |
| Konończuk, J | 1 |
| Sawicka, D | 1 |
| Car, H | 1 |
| Friedman, GD | 1 |
| Jiang, SF | 1 |
| Udaltsova, N | 1 |
| Chan, J | 1 |
| Quesenberry, CP | 1 |
| Habel, LA | 1 |
| Qian, Y | 1 |
| Zhang, HJ | 1 |
| Zhang, H | 1 |
| Xu, C | 1 |
| Zhao, J | 1 |
| Zhu, HL | 1 |
| Guy, SD | 1 |
| Worth, LJ | 1 |
| Thursky, KA | 1 |
| Francis, PA | 1 |
| Slavin, MA | 1 |
| Iida, J | 1 |
| Kudo, T | 1 |
| Shimada, K | 1 |
| Yatsuno, Y | 1 |
| Yamagishi, S | 1 |
| Hasegawa, S | 1 |
| Ike, H | 1 |
| Sato, T | 1 |
| Kagaya, H | 1 |
| Ito, K | 1 |
| Lo, SF | 1 |
| Hsu, MY | 1 |
| Hu, WY | 1 |
| Ashford, RF | 1 |
| Plant, GT | 1 |
| Maher, J | 1 |
| Pickering, D | 1 |
| Coe, MA | 1 |
| Drury, A | 1 |
| Goold, MA | 1 |
| Teare, EL | 1 |
| Sparrow, G | 1 |
| Minton, M | 1 |
| Rubens, RD | 1 |
| Simmons, NA | 1 |
| Aubrey, C | 1 |
| Eyre, HJ | 1 |
| Ohlsen, JD | 1 |
| Frank, J | 1 |
| LoBuglio, AF | 1 |
| McCracken, JD | 1 |
| Weatherall, TJ | 1 |
| Mansfield, CM | 1 |
| Stewart, DJ | 2 |
| Maroun, JA | 2 |
| Young, V | 1 |
| Crook, AF | 2 |
| Hopkins, HS | 1 |
| Yan, RC | 1 |
| Richard, MT | 1 |
| Hugenholtz, H | 1 |
| Bélanger, R | 1 |
| Heringer, R | 2 |
| Lowenthal, RM | 1 |
| Cooper, DA | 1 |
| Paredes López, A | 1 |
| Moreno, G | 1 |
| Fairbairn, K | 1 |
| Heirler, F | 1 |
| de la Motte, S | 1 |
| Popp, W | 1 |
| Kuge, S | 1 |
| Tokuda, Y | 1 |
| Ohta, M | 1 |
| Okumura, A | 1 |
| Kubota, M | 1 |
| Ninomiya, S | 1 |
| Sawamura, S | 1 |
| Makuuchi, H | 1 |
| Tajima, T | 1 |
| Mitomi, T | 1 |
| Munzenrider, JE | 1 |
| Beard, CM | 1 |
| Noller, KL | 1 |
| O'Fallon, WM | 1 |
| Kurland, LT | 1 |
| Dockerty, MB | 1 |
| Bower, M | 1 |
| Stein, R | 1 |
| Evans, TR | 1 |
| Hedley, A | 1 |
| Pert, P | 1 |
| Coombes, RC | 1 |
| Krause, JR | 1 |
| Ayuyang, HQ | 1 |
| Ellis, LD | 1 |
| Khanna, AK | 1 |
| Khanna, A | 1 |
| Asthana, AK | 1 |
| Lefebvre, B | 1 |
4 reviews available for metronidazole and Breast Neoplasms
| Article | Year |
|---|---|
Non-surgical treatment of tetanus infection associated with breast cancer skin ulcer: a case report and literature review.
Topics: Breast Neoplasms; Female; Humans; Lymphatic Metastasis; Metronidazole; Middle Aged; Neoplasm Recurre | 2021 |
Legionella pneumophila lung abscess associated with immune suppression.
Topics: Adult; Anti-Bacterial Agents; Antineoplastic Combined Chemotherapy Protocols; Australia; Azithromyci | 2011 |
Using wound bed preparation to heal a malignant fungating wound: a single case study.
Topics: Adult; Bandages, Hydrocolloid; Breast Neoplasms; Carboxymethylcellulose Sodium; Clinical Protocols; | 2007 |
Recent advances in radiotherapy.
Topics: Breast Neoplasms; Bromodeoxyuridine; Carcinoid Tumor; Elementary Particles; Fast Neutrons; Hot Tempe | 1977 |
3 trials available for metronidazole and Breast Neoplasms
| Article | Year |
|---|---|
Randomized trial of radiotherapy versus radiotherapy plus metronidazole for the treatment metastatic cancer to brain. A Southwest Oncology Group study.
Topics: Age Factors; Brain Neoplasms; Breast Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; | 1984 |
Use of metronidazole gel to control malodor in advanced and recurrent breast cancer.
Topics: Administration, Topical; Aged; Bacteria, Anaerobic; Bacterial Infections; Breast Neoplasms; Female; | 1996 |
A double-blind study of the efficacy of metronidazole gel in the treatment of malodorous fungating tumours.
Topics: Administration, Topical; Aged; Aged, 80 and over; Bacteria, Anaerobic; Bacterial Infections; Breast | 1992 |
17 other studies available for metronidazole and Breast Neoplasms
| Article | Year |
|---|---|
[A Case of Dermatitis Caused by Metronidazole Gel That Needed to Be Differentiated from Breast Cancer Skin Metastasis].
Topics: Aged; Axilla; Breast Neoplasms; Dermatitis; Female; Humans; Metronidazole; Trastuzumab | 2020 |
Metronidazole affects breast cancer cell lines.
Topics: Breast Neoplasms; Cell Survival; DNA; Dose-Response Relationship, Drug; Estrogens; Female; Humans; M | 2013 |
Pharmaceuticals that cause mammary gland tumors in animals: findings in women.
Topics: Adult; Aged; Antifungal Agents; Antiprotozoal Agents; Breast Neoplasms; Case-Control Studies; Diuret | 2009 |
Synthesis, molecular modeling, and biological evaluation of cinnamic acid metronidazole ester derivatives as novel anticancer agents.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cinnamates; Crystallograph | 2010 |
Investigation of the safety of topical metronidazole from a pharmacokinetic perspective.
Topics: Administration, Topical; Animals; Anti-Infective Agents; Anticoagulants; Breast Neoplasms; Carcinoma | 2013 |
Metronidazole in smelly tumours.
Topics: Bacterial Infections; Breast Neoplasms; Female; Humans; Metronidazole; Middle Aged; Odorants; Qualit | 1980 |
Metronidazole in smelly tumours.
Topics: Administration, Oral; Breast Neoplasms; Female; Humans; Metronidazole; Odorants | 1980 |
Feasibility study of combining metronidazole with chemotherapy.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Carcinoma, Sq | 1983 |
Complete regression of locally-advanced breast cancer with chemotherapy.
Topics: Aged; Breast Neoplasms; Carcinoma; Drug Therapy, Combination; Female; Humans; Metronidazole; Tobramy | 1981 |
[Non-puerperal mastitis. Clinical study of 30 patients].
Topics: Adenocarcinoma; Adult; Aged; Breast Neoplasms; Diagnosis, Differential; Erythromycin; Female; Humans | 1995 |
A challenge that requires further research. Management of fungating breast lesions.
Topics: Breast Neoplasms; Combined Modality Therapy; Female; Humans; Metronidazole; Patient Care Team; Psych | 1994 |
Influence of metronidazole and tamoxifen in a case of otherwise untreated ulcerous breast carcinoma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Humans; Metronidazol | 1995 |
Lack of evidence for cancer due to use of metronidazole.
Topics: Adolescent; Adult; Aged; Breast Neoplasms; Female; Humans; Lung Neoplasms; Metronidazole; Middle Age | 1979 |
Management of smelly tumours.
Topics: Administration, Topical; Bacteroides Infections; Bandages; Breast Neoplasms; Fatty Acids, Volatile; | 1990 |
Occurrence of three cases of carcinoma in individuals with Crohn's disease treated with metronidazole.
Topics: Adenoma, Bile Duct; Adult; Bile Duct Neoplasms; Breast Neoplasms; Carcinoma; Crohn Disease; Female; | 1985 |
Postirradiation ulcer and topical metronidazole.
Topics: Breast Neoplasms; Carcinoma, Squamous Cell; Female; Humans; Metronidazole; Middle Aged; Radiation In | 1988 |
Mitomycin-C plus metronidazole in advanced carcinoma of the breast.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Blood Cell Count; Breas | 1985 |