metronidazole has been researched along with Liver Diseases, Alcoholic in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Liver Diseases, Alcoholic: Liver diseases associated with ALCOHOLISM. It usually refers to the coexistence of two or more subentities, i.e., ALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; and ALCOHOLIC CIRRHOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to test the effect of gut manipulation by either novel synbiotics or by metronidazole on either endotoxemia or the severity of liver damage in the course of acute pancreatitis from alcohol ingestion." | 7.73 | Experimental acute alcohol pancreatitis-related liver damage and endotoxemia: synbiotics but not metronidazole have a protective effect. ( Barreto, R; Fesce, E; Gelosa, F; Lorenzetti, A; Marotta, F; Naito, Y; Wu, CC; Yoshioka, M, 2005) |
| " Acute reversible cerebellar ataxia with confusion secondary to prolonged metronidazole use has been reported rarely as a cause of encephalopathy in patients with ALD." | 3.83 | Metronidazole-Induced Encephalopathy in Alcoholic Liver Disease: A Diagnostic and Therapeutic Challenge. ( Contractor, Q; Jain, SS; Mohite, AR; Pawar, SV; Rathi, PM; Sonthalia, N; Surude, RG, 2016) |
| "The aim of this study was to test the effect of gut manipulation by either novel synbiotics or by metronidazole on either endotoxemia or the severity of liver damage in the course of acute pancreatitis from alcohol ingestion." | 3.73 | Experimental acute alcohol pancreatitis-related liver damage and endotoxemia: synbiotics but not metronidazole have a protective effect. ( Barreto, R; Fesce, E; Gelosa, F; Lorenzetti, A; Marotta, F; Naito, Y; Wu, CC; Yoshioka, M, 2005) |
| "Metronidazole (7." | 1.27 | Pharmacokinetics of metronidazole in patients with alcoholic liver disease. ( Chang, CW; Evans, R; Lau, AH; Seligsohn, R, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sonthalia, N | 1 |
| Pawar, SV | 1 |
| Mohite, AR | 1 |
| Jain, SS | 1 |
| Surude, RG | 1 |
| Rathi, PM | 1 |
| Contractor, Q | 1 |
| Marotta, F | 1 |
| Barreto, R | 1 |
| Wu, CC | 1 |
| Naito, Y | 1 |
| Gelosa, F | 1 |
| Lorenzetti, A | 1 |
| Yoshioka, M | 1 |
| Fesce, E | 1 |
| Farrell, G | 1 |
| Zaluzny, L | 1 |
| Baird-Lambert, J | 1 |
| Cvejic, M | 1 |
| Buchanan, N | 1 |
| Lau, AH | 1 |
| Evans, R | 1 |
| Chang, CW | 1 |
| Seligsohn, R | 1 |
4 other studies available for metronidazole and Liver Diseases, Alcoholic
| Article | Year |
|---|---|
Metronidazole-Induced Encephalopathy in Alcoholic Liver Disease: A Diagnostic and Therapeutic Challenge.
Topics: Anti-Infective Agents; Cerebellar Ataxia; Confusion; Dysarthria; Humans; Liver Diseases, Alcoholic; | 2016 |
Experimental acute alcohol pancreatitis-related liver damage and endotoxemia: synbiotics but not metronidazole have a protective effect.
Topics: Acute Disease; Animals; Bacterial Translocation; Bifidobacterium; Ceruletide; Disease Models, Animal | 2005 |
Impaired elimination of metronidazole in decompensated chronic liver disease.
Topics: Adult; Aged; Antipyrine; Female; Half-Life; Hepatitis, Chronic; Humans; Liver Diseases, Alcoholic; M | 1983 |
Pharmacokinetics of metronidazole in patients with alcoholic liver disease.
Topics: Adult; Female; Half-Life; Humans; Liver Diseases, Alcoholic; Male; Metronidazole; Middle Aged | 1987 |