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metronidazole and Aging

metronidazole has been researched along with Aging in 9 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Metronidazole was first introduced for the treatment of trichomoniasis."2.38Clinical pharmacokinetics of metronidazole and other nitroimidazole anti-infectives. ( Danziger, LH; Lam, NP; Lau, AH; Piscitelli, SC; Wilkes, L, 1992)
"Linking haemodynamic (HD) and pharmacokinetic (PK) parameters provides much insight into interrelations between circulatory system and drug disposition."1.46Models describing metronidazole pharmacokinetics in relation to hemodynamics in turkeys. ( Grabowski, T; Pasławska, U; Poźniak, B; Świtała, M, 2017)
" The dosage of metronidazole was about 10 or 20 mg/kg b."1.27Disposition kinetics of metronidazole in children. ( Amon, I; Amon, K; Franke, G; Nagel, F; Scharp, H, 1983)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19902 (22.22)18.7374
1990's3 (33.33)18.2507
2000's3 (33.33)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Grabowski, T1
Pasławska, U1
Poźniak, B1
Świtała, M1
Turnbull, IR1
Wlzorek, JJ1
Osborne, D1
Hotchkiss, RS1
Coopersmith, CM1
Buchman, TG1
Thadepalli, H1
Chuah, SK1
Vidad, A1
Gollapudi, S1
Amon, I1
Amon, K1
Scharp, H1
Franke, G1
Nagel, F1
Ludwig, E1
Csiba, A1
Magyar, T1
Szöcs, G1
Graber, H1
Brandt, LJ1
Kosche, KA1
Greenwald, DA1
Berkman, D1
Kim, JJ1
Reddy, R1
Lee, M1
Kim, JG1
El-Zaatari, FA1
Osato, MS1
Graham, DY1
Kwon, DH1
Lau, AH1
Lam, NP1
Piscitelli, SC1
Wilkes, L1
Danziger, LH1
Loft, S1
Egsmose, C1
Sonne, J1
Poulsen, HE1
Døssing, M1
Andreasen, PB1

Reviews

1 review available for metronidazole and Aging

ArticleYear
Clinical pharmacokinetics of metronidazole and other nitroimidazole anti-infectives.
    Clinical pharmacokinetics, 1992, Volume: 23, Issue:5

    Topics: Aged; Aging; Anti-Infective Agents; Biological Availability; Child, Preschool; Drug Interactions; Fe

1992

Other Studies

8 other studies available for metronidazole and Aging

ArticleYear
Models describing metronidazole pharmacokinetics in relation to hemodynamics in turkeys.
    Research in veterinary science, 2017, Volume: 112

    Topics: Aging; Animals; Anti-Infective Agents; Body Weight; Hemodynamics; Metronidazole; Models, Biological;

2017
Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture.
    Shock (Augusta, Ga.), 2003, Volume: 19, Issue:4

    Topics: Age Factors; Aging; Animals; Cecum; Ceftriaxone; Disease Susceptibility; Drug Therapy, Combination;

2003
Efficacy of telithromycin in the treatment of experimental Bacteroides fragilis intraabdominal abscess in the senescent mice.
    Le infezioni in medicina, 2004, Volume: 12, Issue:1

    Topics: Abdominal Abscess; Age Factors; Aging; Animals; Anti-Bacterial Agents; Bacteroides fragilis; Bactero

2004
Disposition kinetics of metronidazole in children.
    European journal of clinical pharmacology, 1983, Volume: 24, Issue:1

    Topics: Adolescent; Aging; Body Weight; Child; Child, Preschool; Drug Administration Schedule; Female; Human

1983
Age-associated pharmacokinetic changes of metronidazole.
    International journal of clinical pharmacology, therapy, and toxicology, 1983, Volume: 21, Issue:2

    Topics: Adult; Aged; Aging; Erythrocytes; Female; Humans; Kinetics; Male; Metronidazole

1983
Clostridium difficile-associated diarrhea in the elderly.
    The American journal of gastroenterology, 1999, Volume: 94, Issue:11

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anti-Bacterial Agents; Child; Clostridioides diff

1999
Analysis of metronidazole, clarithromycin and tetracycline resistance of Helicobacter pylori isolates from Korea.
    The Journal of antimicrobial chemotherapy, 2001, Volume: 47, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Clarithromycin; Drug Resistance, Microbial; Femal

2001
Metronidazole elimination is preserved in the elderly.
    Human & experimental toxicology, 1990, Volume: 9, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Aging; Female; Humans; Male; Metronidazole

1990