metronidazole has been researched along with Aging in 9 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole was first introduced for the treatment of trichomoniasis." | 2.38 | Clinical pharmacokinetics of metronidazole and other nitroimidazole anti-infectives. ( Danziger, LH; Lam, NP; Lau, AH; Piscitelli, SC; Wilkes, L, 1992) |
| "Linking haemodynamic (HD) and pharmacokinetic (PK) parameters provides much insight into interrelations between circulatory system and drug disposition." | 1.46 | Models describing metronidazole pharmacokinetics in relation to hemodynamics in turkeys. ( Grabowski, T; Pasławska, U; Poźniak, B; Świtała, M, 2017) |
| " The dosage of metronidazole was about 10 or 20 mg/kg b." | 1.27 | Disposition kinetics of metronidazole in children. ( Amon, I; Amon, K; Franke, G; Nagel, F; Scharp, H, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Grabowski, T | 1 |
| Pasławska, U | 1 |
| Poźniak, B | 1 |
| Świtała, M | 1 |
| Turnbull, IR | 1 |
| Wlzorek, JJ | 1 |
| Osborne, D | 1 |
| Hotchkiss, RS | 1 |
| Coopersmith, CM | 1 |
| Buchman, TG | 1 |
| Thadepalli, H | 1 |
| Chuah, SK | 1 |
| Vidad, A | 1 |
| Gollapudi, S | 1 |
| Amon, I | 1 |
| Amon, K | 1 |
| Scharp, H | 1 |
| Franke, G | 1 |
| Nagel, F | 1 |
| Ludwig, E | 1 |
| Csiba, A | 1 |
| Magyar, T | 1 |
| Szöcs, G | 1 |
| Graber, H | 1 |
| Brandt, LJ | 1 |
| Kosche, KA | 1 |
| Greenwald, DA | 1 |
| Berkman, D | 1 |
| Kim, JJ | 1 |
| Reddy, R | 1 |
| Lee, M | 1 |
| Kim, JG | 1 |
| El-Zaatari, FA | 1 |
| Osato, MS | 1 |
| Graham, DY | 1 |
| Kwon, DH | 1 |
| Lau, AH | 1 |
| Lam, NP | 1 |
| Piscitelli, SC | 1 |
| Wilkes, L | 1 |
| Danziger, LH | 1 |
| Loft, S | 1 |
| Egsmose, C | 1 |
| Sonne, J | 1 |
| Poulsen, HE | 1 |
| Døssing, M | 1 |
| Andreasen, PB | 1 |
1 review available for metronidazole and Aging
| Article | Year |
|---|---|
Clinical pharmacokinetics of metronidazole and other nitroimidazole anti-infectives.
Topics: Aged; Aging; Anti-Infective Agents; Biological Availability; Child, Preschool; Drug Interactions; Fe | 1992 |
8 other studies available for metronidazole and Aging
| Article | Year |
|---|---|
Models describing metronidazole pharmacokinetics in relation to hemodynamics in turkeys.
Topics: Aging; Animals; Anti-Infective Agents; Body Weight; Hemodynamics; Metronidazole; Models, Biological; | 2017 |
Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture.
Topics: Age Factors; Aging; Animals; Cecum; Ceftriaxone; Disease Susceptibility; Drug Therapy, Combination; | 2003 |
Efficacy of telithromycin in the treatment of experimental Bacteroides fragilis intraabdominal abscess in the senescent mice.
Topics: Abdominal Abscess; Age Factors; Aging; Animals; Anti-Bacterial Agents; Bacteroides fragilis; Bactero | 2004 |
Disposition kinetics of metronidazole in children.
Topics: Adolescent; Aging; Body Weight; Child; Child, Preschool; Drug Administration Schedule; Female; Human | 1983 |
Age-associated pharmacokinetic changes of metronidazole.
Topics: Adult; Aged; Aging; Erythrocytes; Female; Humans; Kinetics; Male; Metronidazole | 1983 |
Clostridium difficile-associated diarrhea in the elderly.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anti-Bacterial Agents; Child; Clostridioides diff | 1999 |
Analysis of metronidazole, clarithromycin and tetracycline resistance of Helicobacter pylori isolates from Korea.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Clarithromycin; Drug Resistance, Microbial; Femal | 2001 |
Metronidazole elimination is preserved in the elderly.
Topics: Adult; Aged; Aged, 80 and over; Aging; Female; Humans; Male; Metronidazole | 1990 |