Page last updated: 2024-08-05 15:14:11

adrenergic agonist

An agent that selectively binds to and activates adrenergic receptors.

ChEBI ID: 37886

Members (3)

MemberDefinitionClass
brimonidinebrimonidine
dipivefrinThe dipivalate ester of (+-)-epinephrine (racepinephrine). A pro-drug of epinephrine, the hydrochloride is used topically as eye drops to reduce intra-ocular pressure in the treatment of open-angle glaucoma or ocular hypertension.dipivefrin
dipivefrin hydrochlorideThe hydrochloride salt of dipivefrin. It is used topically as eye drops to reduce intra-ocular pressure in the treatment of open-angle glaucoma or ocular hypertension.dipivefrin hydrochloride

Research

Studies (188)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199074 (39.36)18.7374
1990's62 (32.98)18.2507
2000's23 (12.23)29.6817
2010's19 (10.11)24.3611
2020's10 (5.32)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials39 (18.66%)5.53%
Reviews9 (4.31%)6.00%
Case Studies27 (12.92%)4.05%
Observational0 (0.00%)0.25%
Other134 (64.11%)84.16%

Protein Targets (73)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency22.387211
15-lipoxygenase, partialHomo sapiens (human)Potency15.848911
acetylcholinesteraseHomo sapiens (human)Potency26.024122
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency15.848911
arylsulfatase AHomo sapiens (human)Potency0.015111
ATAD5 protein, partialHomo sapiens (human)Potency0.651311
beta-2 adrenergic receptorHomo sapiens (human)Potency0.766033
Bloom syndrome protein isoform 1Homo sapiens (human)Potency0.005622
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency16.206513
Chain A, Beta-lactamaseEscherichia coli K-12Potency9.333612
Chain A, Ferritin light chainEquus caballus (horse)Potency42.239522
Chain A, HADH2 proteinHomo sapiens (human)Potency25.118911
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency14.467212
Chain B, HADH2 proteinHomo sapiens (human)Potency25.118911
chromobox protein homolog 1Homo sapiens (human)Potency39.810711
cytochrome P450 2D6Homo sapiens (human)Potency21.876111
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency39.810711
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency8.123524
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency4.897511
DNA polymerase eta isoform 1Homo sapiens (human)Potency28.183811
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency58.654412
endonuclease IVEscherichia coliPotency7.943311
estrogen nuclear receptor alphaHomo sapiens (human)Potency30.106512
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency33.491511
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency17.368212
flap endonuclease 1Homo sapiens (human)Potency9.466211
GABA theta subunitRattus norvegicus (Norway rat)Potency8.123512
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency8.123512
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency8.123512
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency8.123512
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency8.123512
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency8.123512
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency8.123512
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency8.123512
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency8.123512
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency8.123512
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency8.123512
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency8.123512
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency8.123512
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency8.123512
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency8.123512
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency8.123512
glp-1 receptor, partialHomo sapiens (human)Potency1.377723
GLS proteinHomo sapiens (human)Potency7.079511
lamin isoform A-delta10Homo sapiens (human)Potency7.550612
Microtubule-associated protein tauHomo sapiens (human)Potency29.947824
mitogen-activated protein kinase 1Homo sapiens (human)Potency39.810711
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency11.904812
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency1.995311
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency25.099911
phosphopantetheinyl transferaseBacillus subtilisPotency56.234111
regulator of G-protein signaling 4Homo sapiens (human)Potency9.496912
TDP1 proteinHomo sapiens (human)Potency9.034922
thioredoxin reductaseRattus norvegicus (Norway rat)Potency11.976045
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency10.963422
transient receptor potential cation channel subfamily V member 1Homo sapiens (human)Potency31.622811
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency36.426112

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)IC502.551011
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)Ki1.458011
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)IC502.551011
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)Ki1.458011
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)Ki0.740011
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)Ki0.740011
Alpha-1D adrenergic receptorHomo sapiens (human)IC501.720011
Alpha-1D adrenergic receptorHomo sapiens (human)Ki0.846011
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)Ki0.740011
Alpha-2A adrenergic receptorHomo sapiens (human)IC500.150522
Alpha-2A adrenergic receptorHomo sapiens (human)Ki0.029434
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)Ki0.030011
Alpha-2B adrenergic receptorHomo sapiens (human)IC500.525022
Alpha-2B adrenergic receptorHomo sapiens (human)Ki0.160323
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)Ki0.041022
Alpha-2C adrenergic receptorHomo sapiens (human)IC500.003011
Alpha-2C adrenergic receptorHomo sapiens (human)Ki0.015623
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)Ki0.030011
MPI proteinHomo sapiens (human)IC5050.000012

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Alpha-1A adrenergic receptorBos taurus (cattle)EC501.132011
Alpha-1B adrenergic receptor Cricetulus griseus (Chinese hamster)EC500.943011
Alpha-2A adrenergic receptorHomo sapiens (human)EC505.701244
Alpha-2B adrenergic receptorHomo sapiens (human)EC5011.400022
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)EC500.055011
Alpha-2C adrenergic receptorHomo sapiens (human)EC505.702844
beta-2 adrenergic receptorHomo sapiens (human)EC507.130011
G protein-activated inward rectifier potassium channel 1Rattus norvegicus (Norway rat)EC500.082011