metronidazole has been researched along with Nutrition Disorders in 7 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Nutrition Disorders: Disorders caused by nutritional imbalance, either overnutrition or undernutrition.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The first reported isolation from human noma lesions of F." | 1.30 | Isolation of Fusobacterium necrophorum from cancrum oris (noma). ( Enwonwu, CO; Falkler, WA; Idigbe, EO, 1999) |
| " The results indicate that a predicted drug cumulation would occur in malnourished children with the ordinary dosage regimen (30 mg/kg/day)." | 1.29 | A new dosing regimen for metronidazole in malnourished children. ( Cravioto, J; Lares-Asseff, I; Pérez-Ortíz, B; Santiago, P, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 5 (71.43) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gregg, CR | 1 |
| Harris, PR | 1 |
| Figueroa-Colon, R | 1 |
| Lares-Asseff, I | 1 |
| Cravioto, J | 1 |
| Santiago, P | 1 |
| Pérez-Ortíz, B | 1 |
| Ostrosky-Wegman, P | 1 |
| Gonsebatt, ME | 1 |
| Falkler, WA | 1 |
| Enwonwu, CO | 1 |
| Idigbe, EO | 1 |
| Sullivan, PB | 1 |
| Lunn, PG | 1 |
| Northrop-Clewes, C | 1 |
| Crowe, PT | 1 |
| Marsh, MN | 1 |
| Neale, G | 1 |
| Goldberg, A | 1 |
| Krasner, N | 1 |
| Dow, J | 1 |
| MacDonald, CM | 1 |
| Moore, MR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacokinetics of Antimicrobials and Carriage of Antimicrobial Resistance Amongst Hospitalised Children With Severe Acute Malnutrition[NCT02746276] | Phase 2 | 81 participants (Actual) | Interventional | 2016-04-01 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metronidazole and Nutrition Disorders
| Article | Year |
|---|---|
Enteric bacterial flora and bacterial overgrowth syndrome.
Topics: Aged; Aged, 80 and over; Anti-Infective Agents; Bacterial Infections; Diagnostic Techniques, Digesti | 2002 |
6 other studies available for metronidazole and Nutrition Disorders
| Article | Year |
|---|---|
Rectal prolapse in children associated with Clostridium difficile infection.
Topics: Child, Preschool; Clostridioides difficile; Enterocolitis, Pseudomembranous; Female; Humans; Metroni | 1995 |
A new dosing regimen for metronidazole in malnourished children.
Topics: Biotransformation; Child, Preschool; Computer Simulation; Female; Humans; Infant; Male; Metabolic Cl | 1993 |
Environmental toxicants in developing countries.
Topics: Animal Population Groups; Animals; Antiparasitic Agents; Brain Diseases; Carcinogens; Chromosome Abe | 1996 |
Isolation of Fusobacterium necrophorum from cancrum oris (noma).
Topics: Adolescent; Anti-Bacterial Agents; Bacteroidaceae Infections; Child; Child, Preschool; Clindamycin; | 1999 |
Persistent diarrhea and malnutrition--the impact of treatment on small bowel structure and permeability.
Topics: Anti-Bacterial Agents; Antifungal Agents; Blood Proteins; Body Weight; Cell Membrane Permeability; C | 1992 |
Clinical and experimental studies on alcoholism.
Topics: Alcohol Deterrents; Alcoholism; Animals; Disulfiram; Ethanol; Fenfluramine; Humans; Liver Diseases; | 1973 |