metronidazole has been researched along with Pancreatitis in 28 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Pancreatitis: INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pancreatitis is a very rare adverse effect of metronidazole with only six cases of metronidazole-induced pancreatitis reported in the English literature so far." | 8.82 | Metronidazole-induced pancreatitis. A case report and review of literature. ( Casey, KJ; Nigwekar, SU, 2004) |
| "This case provides the eighth report of Metronidazole induced pancreatitis." | 7.76 | Metronidazole-induced pancreatitis. ( Hogan, A; Mealy, K; O'Halloran, E, 2010) |
| "We present the first case of metronidazole-related acute pancreatitis during a relapse of ulcerative colitis." | 7.74 | Acute pancreatitis as a possible consequence of metronidazole during a relapse of ulcerative colitis. ( Ekonomou, IA; Giannoulis, EK; Giannoulis, KE; Savopoulos, CG; Tsesmeli, NE; Vretou, EE, 2007) |
| "Use of metronidazole has been suggested to be associated with an increased risk of acute pancreatitis in case reports." | 7.73 | Metronidazole and risk of acute pancreatitis: a population-based case-control study. ( Jacobsen, J; Nørgaard, M; Pedersen, L; Ratanajamit, C; Skriver, MV; Sørensen, HT, 2005) |
| "The aim of this study was to test the effect of gut manipulation by either novel synbiotics or by metronidazole on either endotoxemia or the severity of liver damage in the course of acute pancreatitis from alcohol ingestion." | 7.73 | Experimental acute alcohol pancreatitis-related liver damage and endotoxemia: synbiotics but not metronidazole have a protective effect. ( Barreto, R; Fesce, E; Gelosa, F; Lorenzetti, A; Marotta, F; Naito, Y; Wu, CC; Yoshioka, M, 2005) |
| "Recurrent acute pancreatitis associated with metronidazole developed in a 49-year-old woman who was taking the drug as treatment for vaginal trichomoniasis." | 7.71 | Metronidazole-induced pancreatitis in a patient with recurrent vaginal trichomoniasis. ( Feola, DJ; Thornton, AC, 2002) |
| "Very few cases of metronidazole-associated pancreatitis have been reported, and the long-term sequelae are unknown." | 7.70 | Metronidazole-associated pancreatitis. ( Heinrich, KA; Sura, ME; Suseno, M, 2000) |
| "A 45-year-old woman in the period 1988-1995 suffered three episodes of acute pancreatitis associated with the use of metronidazole." | 7.69 | [Acute pancreatitis caused by metronidazole]. ( de Jongh, FE; Ottervanger, JP; Stuiver, PC, 1996) |
| "Two case reports of metronidazole-induced pancreatitis raised the question of how often this reaction occurs." | 7.68 | How often does metronidazole induce pancreatitis? ( Friedman, GD; Selby, JV, 1990) |
| "We present a case of a 22-yr-old female who developed acute pancreatitis coincident with metronidazole therapy, with documented recurrence when inadvertently rechallenged on two separate occasions." | 7.67 | Metronidazole-induced pancreatitis. ( Burakoff, R; Celifarco, A; Warschauer, C, 1989) |
| "Pancreatitis is a very rare adverse effect of metronidazole with only six cases of metronidazole-induced pancreatitis reported in the English literature so far." | 4.82 | Metronidazole-induced pancreatitis. A case report and review of literature. ( Casey, KJ; Nigwekar, SU, 2004) |
| "This case provides the eighth report of Metronidazole induced pancreatitis." | 3.76 | Metronidazole-induced pancreatitis. ( Hogan, A; Mealy, K; O'Halloran, E, 2010) |
| "We present the first case of metronidazole-related acute pancreatitis during a relapse of ulcerative colitis." | 3.74 | Acute pancreatitis as a possible consequence of metronidazole during a relapse of ulcerative colitis. ( Ekonomou, IA; Giannoulis, EK; Giannoulis, KE; Savopoulos, CG; Tsesmeli, NE; Vretou, EE, 2007) |
| "Use of metronidazole has been suggested to be associated with an increased risk of acute pancreatitis in case reports." | 3.73 | Metronidazole and risk of acute pancreatitis: a population-based case-control study. ( Jacobsen, J; Nørgaard, M; Pedersen, L; Ratanajamit, C; Skriver, MV; Sørensen, HT, 2005) |
| "The aim of this study was to test the effect of gut manipulation by either novel synbiotics or by metronidazole on either endotoxemia or the severity of liver damage in the course of acute pancreatitis from alcohol ingestion." | 3.73 | Experimental acute alcohol pancreatitis-related liver damage and endotoxemia: synbiotics but not metronidazole have a protective effect. ( Barreto, R; Fesce, E; Gelosa, F; Lorenzetti, A; Marotta, F; Naito, Y; Wu, CC; Yoshioka, M, 2005) |
| "Recurrent acute pancreatitis associated with metronidazole developed in a 49-year-old woman who was taking the drug as treatment for vaginal trichomoniasis." | 3.71 | Metronidazole-induced pancreatitis in a patient with recurrent vaginal trichomoniasis. ( Feola, DJ; Thornton, AC, 2002) |
| "Very few cases of metronidazole-associated pancreatitis have been reported, and the long-term sequelae are unknown." | 3.70 | Metronidazole-associated pancreatitis. ( Heinrich, KA; Sura, ME; Suseno, M, 2000) |
| "A 45-year-old woman in the period 1988-1995 suffered three episodes of acute pancreatitis associated with the use of metronidazole." | 3.69 | [Acute pancreatitis caused by metronidazole]. ( de Jongh, FE; Ottervanger, JP; Stuiver, PC, 1996) |
| "Two case reports of metronidazole-induced pancreatitis raised the question of how often this reaction occurs." | 3.68 | How often does metronidazole induce pancreatitis? ( Friedman, GD; Selby, JV, 1990) |
| "We present a case of a 22-yr-old female who developed acute pancreatitis coincident with metronidazole therapy, with documented recurrence when inadvertently rechallenged on two separate occasions." | 3.67 | Metronidazole-induced pancreatitis. ( Burakoff, R; Celifarco, A; Warschauer, C, 1989) |
| "The penetrance of mezlocillin, metronidazole and trimethoprim-sulfamethoxazole into the pancreatic juice of humans was measured in ten patients convalescing from acute pancreatitis at the time of endoscopic retrograde cholangiopancreatography." | 3.67 | Assessment of antimicrobial penetrance into the pancreatic juice in humans. ( Bawdon, RE; Cushing, RD; Ledgerwood, AM; Lucas, CE; Sugawa, C; Wallace, JR, 1986) |
| "One of them also had primary sclerosing cholangitis." | 2.42 | [Pancreatitis accompanying inflammatory bowel diseases, and our observations]. ( Aleksandrova, A; Nedin, D, 2004) |
| "Although it is rare, acute pancreatitis must be considered when evaluating patients presenting with abdominal pain and/or ascites in the postpartum period." | 1.33 | Ascites in the puerperium: a missed diagnosis of acute postpartum pancreatitis. ( Fakokunde, A; Gyang, A; Kalu, E; Whitlow, B, 2005) |
| "Pancreatitis is generally regarded to be an extra-intestinal complication of Crohn's disease unless the duodenum is directly involved." | 1.29 | Crohn's disease associated with pancreatitis of unknown etiology: a case report. ( Arakawa, S; Omata, F; Takahashi, H; Ueno, F, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (17.86) | 18.7374 |
| 1990's | 6 (21.43) | 18.2507 |
| 2000's | 11 (39.29) | 29.6817 |
| 2010's | 5 (17.86) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Qian, C | 1 |
| Abourizk, N | 1 |
| Rizk, MA | 1 |
| Kim, J | 1 |
| Smith, DL | 1 |
| Westra, KC | 1 |
| McLaughlin, JP | 1 |
| Apelt, N | 1 |
| Thompson, E | 1 |
| Brown, E | 1 |
| Schindel, D | 1 |
| Pezzilli, R | 1 |
| Slim, R | 1 |
| Ben Salem, C | 1 |
| Zamy, M | 1 |
| Fathallah, N | 1 |
| Raynaud, JJ | 1 |
| Bouraoui, K | 1 |
| Biour, M | 1 |
| O'Halloran, E | 1 |
| Hogan, A | 1 |
| Mealy, K | 1 |
| Osada, J | 1 |
| Wereszczynska-Siemiatkowska, U | 1 |
| Dabrowski, A | 1 |
| Dabrowska, MI | 1 |
| Koike, Y | 1 |
| Kanai, T | 1 |
| Saeki, K | 1 |
| Nakamura, Y | 1 |
| Nakano, M | 1 |
| Mikami, Y | 1 |
| Yamagishi, Y | 1 |
| Nakamoto, N | 1 |
| Ebinuma, H | 1 |
| Hibi, T | 1 |
| Feola, DJ | 1 |
| Thornton, AC | 1 |
| Nigwekar, SU | 1 |
| Casey, KJ | 1 |
| Nedin, D | 1 |
| Aleksandrova, A | 1 |
| Nørgaard, M | 1 |
| Ratanajamit, C | 1 |
| Jacobsen, J | 1 |
| Skriver, MV | 1 |
| Pedersen, L | 1 |
| Sørensen, HT | 1 |
| Gyang, A | 1 |
| Kalu, E | 1 |
| Fakokunde, A | 1 |
| Whitlow, B | 1 |
| Marotta, F | 1 |
| Barreto, R | 1 |
| Wu, CC | 1 |
| Naito, Y | 1 |
| Gelosa, F | 1 |
| Lorenzetti, A | 1 |
| Yoshioka, M | 1 |
| Fesce, E | 1 |
| Tsesmeli, NE | 1 |
| Giannoulis, KE | 1 |
| Savopoulos, CG | 1 |
| Vretou, EE | 1 |
| Ekonomou, IA | 1 |
| Giannoulis, EK | 1 |
| Loulergue, P | 1 |
| Mir, O | 1 |
| Romero Ganuza, FJ | 1 |
| Gianotti, L | 1 |
| Munda, R | 1 |
| Gennari, R | 1 |
| Pyles, R | 1 |
| Alexander, JW | 1 |
| Omata, F | 1 |
| Arakawa, S | 1 |
| Takahashi, H | 1 |
| Ueno, F | 1 |
| de Jongh, FE | 1 |
| Ottervanger, JP | 1 |
| Stuiver, PC | 1 |
| Liu, S | 1 |
| Chen, F | 1 |
| Chen, H | 1 |
| Sura, ME | 1 |
| Heinrich, KA | 1 |
| Suseno, M | 1 |
| Romero, Y | 1 |
| Yebra, M | 1 |
| Lacoma, F | 1 |
| Manzano, L | 1 |
| Friedman, GD | 1 |
| Selby, JV | 1 |
| Plotnick, BH | 1 |
| Cohen, I | 1 |
| Tsang, T | 1 |
| Cullinane, T | 1 |
| Celifarco, A | 1 |
| Warschauer, C | 1 |
| Burakoff, R | 1 |
| Donaldson, RM | 1 |
| Sanford, KA | 1 |
| Mayle, JE | 1 |
| Dean, HA | 1 |
| Greenbaum, DS | 1 |
| Wallace, JR | 1 |
| Cushing, RD | 1 |
| Bawdon, RE | 1 |
| Sugawa, C | 1 |
| Lucas, CE | 1 |
| Ledgerwood, AM | 1 |
4 reviews available for metronidazole and Pancreatitis
| Article | Year |
|---|---|
Metronidazole-induced pancreatitis. A case report and review of literature.
Topics: Diagnostic Errors; Female; Humans; Metronidazole; Middle Aged; Pancreatitis; Pancreatitis, Alcoholic | 2004 |
[Pancreatitis accompanying inflammatory bowel diseases, and our observations].
Topics: Acute Disease; Amylases; Anti-Infective Agents; Anti-Inflammatory Agents; Bulgaria; Cholangitis, Scl | 2004 |
[Pancreatitis associated with metronidazole].
Topics: Abdominal Injuries; Acute Disease; Adult; Anti-Bacterial Agents; Cervical Vertebrae; Clostridium Inf | 2008 |
Effect of different regimens of gut decontamination on bacterial translocation and mortality in experimental acute pancreatitis.
Topics: Acute Disease; Animals; Anti-Bacterial Agents; Decontamination; Erythromycin; Gram-Negative Bacteria | 1995 |
2 trials available for metronidazole and Pancreatitis
| Article | Year |
|---|---|
Effect of different regimens of gut decontamination on bacterial translocation and mortality in experimental acute pancreatitis.
Topics: Acute Disease; Animals; Anti-Bacterial Agents; Decontamination; Erythromycin; Gram-Negative Bacteria | 1995 |
[An evaluation of nonsurgical treatment for severe acute pancreatitis].
Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Bacterial Agents; Cefazolin; Cephalosporins; Combined M | 1995 |
23 other studies available for metronidazole and Pancreatitis
| Article | Year |
|---|---|
A rare case of metronidazole induced recurrent pancreatitis.
Topics: Adult; Anti-Infective Agents; Female; Humans; Metronidazole; Pancreatitis; Recurrence | 2021 |
In trauma, expect the unexpected: a rare case of post-traumatic pancreatitis associated with salmonellosis and enterocolitis.
Topics: Abdomen; Adolescent; Anti-Bacterial Agents; Ceftriaxone; Clostridioides difficile; Enterocolitis, Ps | 2018 |
Antibiotic prophylaxis in severe acute pancreatitis: do we need more meta-analytic studies?
Topics: Acute Disease; Antibiotic Prophylaxis; Carbapenems; Cefuroxime; Ciprofloxacin; Humans; Meta-Analysis | 2009 |
Secnidazole-induced acute pancreatitis: a new side-effect for an old drug?
Topics: Acute Disease; Anti-Infective Agents; Female; Humans; Metronidazole; Pancreatitis; Young Adult | 2010 |
Metronidazole-induced pancreatitis.
Topics: Adult; Anti-Infective Agents; Female; Humans; Metronidazole; Pancreatitis; Treatment Outcome | 2010 |
Platelet activation in acute pancreatitis.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; beta-Thromboglobulin; Blood Platelets; Ciprof | 2012 |
MyD88-dependent interleukin-10 production from regulatory CD11b⁺Gr-1(high) cells suppresses development of acute cerulein pancreatitis in mice.
Topics: Ampicillin; Animals; Anti-Bacterial Agents; CD11b Antigen; CD4-Positive T-Lymphocytes; Ceruletide; F | 2012 |
Metronidazole-induced pancreatitis in a patient with recurrent vaginal trichomoniasis.
Topics: Female; Humans; Metronidazole; Middle Aged; Pancreatitis; Trichomonas Vaginitis | 2002 |
Metronidazole and risk of acute pancreatitis: a population-based case-control study.
Topics: Acute Disease; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Case-Control Studies; Denmark; D | 2005 |
Ascites in the puerperium: a missed diagnosis of acute postpartum pancreatitis.
Topics: Abdominal Pain; Acute Disease; Adult; Anti-Infective Agents; Ascites; Clarithromycin; Diagnosis, Dif | 2005 |
Experimental acute alcohol pancreatitis-related liver damage and endotoxemia: synbiotics but not metronidazole have a protective effect.
Topics: Acute Disease; Animals; Bacterial Translocation; Bifidobacterium; Ceruletide; Disease Models, Animal | 2005 |
Acute pancreatitis as a possible consequence of metronidazole during a relapse of ulcerative colitis.
Topics: Acute Disease; Adult; Colitis, Ulcerative; Gastrointestinal Agents; Humans; Male; Metronidazole; Pan | 2007 |
Metronidazole-induced pancreatitis during HIV infection.
Topics: Acute Disease; Adult; Anti-Infective Agents; Enterocolitis, Pseudomembranous; HIV Infections; Homose | 2008 |
Crohn's disease associated with pancreatitis of unknown etiology: a case report.
Topics: Acute Disease; Adult; Crohn Disease; Humans; Male; Metronidazole; Pancreatitis; Parenteral Nutrition | 1993 |
[Acute pancreatitis caused by metronidazole].
Topics: Acute Disease; Female; Humans; Metronidazole; Middle Aged; Pancreatitis | 1996 |
Metronidazole-associated pancreatitis.
Topics: Anti-Infective Agents; Female; Humans; Metronidazole; Middle Aged; Oxidation-Reduction; Pancreatitis | 2000 |
Metronidazole and pancreatitis.
Topics: Acute Disease; Amylases; Crohn Disease; Female; Humans; Metronidazole; Middle Aged; Pancreatitis | 1992 |
How often does metronidazole induce pancreatitis?
Topics: Adult; California; Confidence Intervals; Drug Prescriptions; Female; Humans; Male; Metronidazole; Mi | 1990 |
Metronidazole-induced pancreatitis.
Topics: Acute Disease; Adult; Amylases; Female; Humans; Lipase; Metronidazole; Pancreatitis; Recurrence | 1985 |
Metronidazole-induced pancreatitis.
Topics: Acute Disease; Adult; Female; Humans; Metronidazole; Pancreatitis; Radiography | 1989 |
Excessive drug challenge.
Topics: Acute Disease; Female; Humans; Metronidazole; Pancreatitis | 1989 |
Metronidazole-associated pancreatitis.
Topics: Adult; Contraceptives, Oral, Combined; Female; Gardnerella vaginalis; Haemophilus Infections; Humans | 1988 |
Assessment of antimicrobial penetrance into the pancreatic juice in humans.
Topics: Acute Disease; Cholangiopancreatography, Endoscopic Retrograde; Chromatography, High Pressure Liquid | 1986 |