metronidazole has been researched along with Hepatitis C, Chronic in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Hepatitis C, Chronic: INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead to LIVER CIRRHOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Leukocytosis is a sign of severe CDI and is predictive for a complicated course." | 1.39 | [Case report. Leukocytosis in the course of Clostridium difficile infection]. ( Defosse, JM; Sakka, SG; Wappler, F; Weber, KS, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Weber, KS | 1 |
| Defosse, JM | 1 |
| Wappler, F | 1 |
| Sakka, SG | 1 |
| Marchioretto, MA | 1 |
| Ecclissato, C | 1 |
| da Silva, CM | 1 |
| Cassiano, NM | 1 |
| Calafatti, SA | 1 |
| Mendonça, S | 1 |
| Ribeiro, ML | 1 |
| Bernasconi, GC | 1 |
| Degger, MF | 1 |
| Piovesan, H | 1 |
| Pedrazzoli, J | 1 |
2 other studies available for metronidazole and Hepatitis C, Chronic
| Article | Year |
|---|---|
[Case report. Leukocytosis in the course of Clostridium difficile infection].
Topics: Aged; Anti-Bacterial Agents; Clostridioides difficile; Colon; Colonoscopy; Diabetes Mellitus, Type 2 | 2013 |
Plasma hydroxy-metronidazole/metronidazole ratio in hepatitis C virus-induced liver disease.
Topics: Adult; Anti-Infective Agents; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid | 2005 |