Page last updated: 2024-10-31

metronidazole and Deafness

metronidazole has been researched along with Deafness in 3 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Deafness: A general term for the complete loss of the ability to hear from both ears.

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19903 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hibberd, AD2
Nicoll, RJ2
Macbeth, WA2
Blake, P1
Butt, WE1

Other Studies

3 other studies available for metronidazole and Deafness

ArticleYear
Deafness is an adverse reaction to the prophylactic use of metronidazole.
    The New Zealand medical journal, 1984, Feb-22, Volume: 97, Issue:750

    Topics: Aged; Bacterial Infections; Cecal Neoplasms; Deafness; Female; Humans; Metronidazole; Premedication

1984
Ototoxicity of metronidazole.
    The New Zealand medical journal, 1984, Apr-11, Volume: 97, Issue:753

    Topics: Deafness; Humans; Metronidazole

1984
Ototoxicity of metronidazole.
    The New Zealand medical journal, 1984, Apr-25, Volume: 97, Issue:754

    Topics: Deafness; Humans; Metronidazole

1984