Loa loa Filariasis

Synonym
Loa loa Filariasis
Loaiasis
Loa loa Infection

Excerpt	Reference
"Loa loa infection is endemic in limited areas of West-Central Africa."	( Angheben, A; Bisoffi, Z; Bottieau, E; Bouchaud, O; Buonfrate, D; Calleri, G; Clerinx, J; Gobbi, F; Guerriero, M; Herrera-Ávila, JP; Neumayr, A; Rodari, P; Rojo-Marcos, G; Rothe, C; Salvador, F; Treviño, B; Zammarchi, L, 2018)
"Loa loa filariasis is usually found in the forest areas of Central and West Africa."	( Barro-Traoré, F; Bougma, R; Bougouma, C; Drabo, F; Kaboret, N; Korsaga-Somé, N; Niamba, P; Ouédraogo, M; Ouédraogo, MS; Ouédraogo, NA; Tapsoba, GP; Traoré, A; Traoré, F; Zida, A, 2020)

Excerpt	Reference
"Loa loa infections have emerged as a serious public health problem in patients co-infected with Onchocerca volvulus or Wuchereria bancrofti because of severe adverse neurological reactions after treatment with ivermectin."	( Carlow, CK; Ettwiller, L; Evans, TC; Poole, CB; Tanner, NA; Wanji, S, 2015)

Excerpt	Reference
"In order to reduce the endemicity of loaiasis, mass treatment with ivermectin could be envisaged immediately."	( Noireau, F, 1990)
"Microfilaricidal treatment of loaiasis is sometimes followed by severe adverse reactions."	( Chippaux, JP; Ducorps, M; Gardon-Wendel, N; Nkinin, SW, 1998)
"Accurate diagnosis of Loa loa infection is essential to the success of mass drug administration efforts to eliminate onchocerciasis and lymphatic filariasis, due to the risk of fatal encephalopathic reactions to ivermectin occurring among highly microfilaremic Loa-infected individuals living in areas co-endemic for multiple filarial species."	( Fink, DL; Kamgno, J; Nutman, TB, 2011)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	107 (25.12)	23.3326
1990's	79 (18.54)	12.5806
2000's	72 (16.90)	18.1394
2010's	111 (26.06)	28.8240
2020's	57 (13.38)	9.53

Drug	Relationship Strength	Studies	Trials
quinacrine	low	1	0
salicylic acid	low	1	0
acetaminophen	low	1	0
albendazole	medium	24	7
amodiaquine	medium	1	1
chloroquine	medium	1	1
diazepam	low	1	0
ddt	low	3	0
diethylcarbamazine	medium	88	4
diphenhydramine	low	1	0
ketoprofen	low	1	0
mebendazole	medium	9	2
metronidazole	low	1	0
temefos	low	1	0
prednisolone	low	1	0
prednisone	low	3	0
dehydroepiandrosterone	low	1	0
galactose	low	1	0
ampicillin	low	1	0
isoprene	low	1	0
methylprednisolone	low	1	0
betamethasone	low	1	0
oleanolic acid	low	1	0
malondialdehyde	low	1	0
dehydroepiandrosterone sulfate	low	1	0
sabinene	low	1	0
trolamine salicylate	low	2	0
melarsonic acid	low	1	0
levamisole	medium	2	1
flubendazole	low	2	0
artesunic acid	medium	1	1
imatinib mesylate	low	1	0
trimethoprim, sulfamethoxazole drug combination	low	2	0
dieldrin	low	5	0
quinine	medium	1	1
bilirubin	medium	1	1
arsenic	low	1	0
cefotaxime	low	1	0
rehmannic acid	low	1	0
beta-escin	low	1	0
bay 44-4400	low	1	0
loa	medium	316	9
furapyrimidone	low	1	0
losartan potassium	low	1	0
dextrothyroxine	medium	103	9
aldrin	low	3	0
eye	low	6	0

Protein Targets (618)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
RAR-related orphan receptor gamma	11	0	0	11
ATAD5 protein, partial	5	0	0	5
GLS protein	4	0	0	4
Microtubule-associated protein tau	5	0	0	5
Smad3	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	9	0	0	9
thyroid stimulating hormone receptor	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	11	0	0	11
progesterone receptor	13	0	0	13
EWS/FLI fusion protein	6	0	0	6
retinoic acid nuclear receptor alpha variant 1	13	0	0	13
retinoid X nuclear receptor alpha	11	0	0	11
estrogen-related nuclear receptor alpha	14	0	0	14
estrogen nuclear receptor alpha	19	0	0	19
peroxisome proliferator activated receptor gamma	9	0	0	9
aryl hydrocarbon receptor	10	0	0	10
chromobox protein homolog 1	10	0	0	10
thyroid hormone receptor beta isoform 2	13	0	0	13
peripheral myelin protein 22	5	0	0	5
cytochrome P450 3A4 isoform 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	3	2	1	6
ATP-binding cassette sub-family C member 3	0	12	0	12
Multidrug resistance-associated protein 4	0	13	0	14
Solute carrier family 22 member 6	0	4	0	4
Carbonic anhydrase 12	0	2	0	2
UDP-glucuronosyltransferase 1A9	0	0	0	1
Bile salt export pump	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	9	0	0	9
Bile salt export pump	0	17	0	17
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	5	0	5
Carbonic anhydrase 2	0	5	0	5
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	0	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Carbonic anhydrase 3	0	2	0	2
Cytochrome P450 3A4	0	2	0	3
Cytochrome P450 2D6	0	3	0	3
Cytochrome P450 2C9	0	5	0	5
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	3	2	1	6
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	3	2	1	6
Gamma-aminobutyric acid receptor subunit gamma-2	3	2	1	6
UDP-glucuronosyltransferase 1-6	0	0	0	1
Glutamate receptor 2	9	0	0	9
Gamma-aminobutyric acid receptor subunit alpha-5	3	2	1	6
Gamma-aminobutyric acid receptor subunit alpha-3	3	2	1	6
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	1
Carbonic anhydrase 4	0	2	0	2
Prostaglandin G/H synthase 1	0	4	0	4
Carbonic anhydrase 6	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	3	2	1	6
Gamma-aminobutyric acid receptor subunit alpha-2	3	2	1	6
Gamma-aminobutyric acid receptor subunit alpha-4	3	2	1	6
Gamma-aminobutyric acid receptor subunit gamma-3	3	2	1	6
Gamma-aminobutyric acid receptor subunit alpha-6	3	2	1	6
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Prostaglandin G/H synthase 2	0	4	0	5
Carbonic anhydrase 7	0	2	0	2
Nuclear receptor ROR-gamma	3	0	0	3
Cytochrome P450 2J2	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	3	2	1	6
Gamma-aminobutyric acid receptor subunit beta-3	3	2	1	6
Gamma-aminobutyric acid receptor subunit beta-2	3	2	1	6
Carbonic anhydrase 9	0	2	0	2
GABA theta subunit	3	2	1	6
Canalicular multispecific organic anion transporter 1	0	10	0	10
Carbonic anhydrase 15	0	2	0	2
Carbonic anhydrase 13	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	3	2	1	6
Carbonic anhydrase 14	0	2	0	2
Carbonic anhydrase 5B, mitochondrial	0	2	0	2
toxin B	0	0	0	1
Telomerase reverse transcriptase	0	1	0	1
Amyloid-beta precursor protein	0	3	0	3
Reverse transcriptase/RNaseH	0	1	0	1
Chain A, Beta-lactamase	4	0	0	4
Luciferase	6	0	0	6
glp-1 receptor, partial	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	7	0	0	7
Fumarate hydratase	5	0	0	5
TDP1 protein	15	0	0	15
GLI family zinc finger 3	15	0	0	15
AR protein	16	0	0	16
caspase 7, apoptosis-related cysteine protease	2	0	0	2
glucocorticoid receptor [Homo sapiens]	14	0	0	14
farnesoid X nuclear receptor	10	0	0	10
pregnane X nuclear receptor	14	0	0	14
polyprotein	5	0	0	5
67.9K protein	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	12	0	0	12
caspase-3	2	0	0	2
IDH1	7	0	0	7
euchromatic histone-lysine N-methyltransferase 2	10	0	0	10
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	12	0	0	12
v-jun sarcoma virus 17 oncogene homolog (avian)	8	0	0	8
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
Histone H2A.x	5	0	0	5
cellular tumor antigen p53 isoform a	3	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 2	6	0	0	6
transcriptional regulator ERG isoform 3	1	0	0	1
histone deacetylase 9 isoform 3	2	0	0	2
heat shock protein beta-1	5	0	0	5
mitogen-activated protein kinase 1	7	0	0	7
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
geminin	15	0	0	15
Vif	0	0	0	1
survival motor neuron protein isoform d	3	0	0	3
muscleblind-like protein 1 isoform 1	3	0	0	3
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
lamin isoform A-delta10	9	0	0	9
neuropeptide S receptor isoform A	2	0	0	2
Interferon beta	11	0	0	11
Cellular tumor antigen p53	10	0	0	10
Integrin beta-3	2	0	0	2
Integrin alpha-IIb	2	0	0	2
Methionine aminopeptidase	0	2	0	2
Fatty-acid amide hydrolase 1	0	2	0	2
Inositol monophosphatase 1	3	0	0	3
ATPase family AAA domain-containing protein 5	6	0	0	6
Ataxin-2	9	0	0	9
Chain A, Histamine N-methyltransferase	0	1	0	1
Chain A, Histamine N-methyltransferase	0	1	0	1
Chain A, Histamine N-methyltransferase	0	1	0	1
Chain A, Histamine N-methyltransferase	0	1	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	12	0	0	12
cytochrome P450 2D6	6	0	0	6
Spike glycoprotein	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
lysosomal alpha-glucosidase preproprotein	1	0	0	1
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Transmembrane protease serine 2	0	1	2	3
Procathepsin L	0	1	2	3
Replicase polyprotein 1a	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Replicase polyprotein 1ab	0	3	2	5
Cytochrome P450 2C8	0	0	0	2
Nuclear receptor subfamily 4 group A member 2	0	0	2	2
Spike glycoprotein	7	1	2	10
Angiotensin-converting enzyme 2	0	1	2	3
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	6	0	0	6
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, Cruzipain	4	0	0	4
Beta-lactamase	0	0	0	2
acid sphingomyelinase	1	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	0	2
Metallo-beta-lactamase VIM-11	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	2
DNA polymerase beta	2	0	0	2
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	5	0	0	5
DNA polymerase kappa isoform 1	4	0	0	4
60 kDa heat shock protein, mitochondrial	0	1	0	1
Beta-lactamase OXA-7	0	0	0	1
Solute carrier family 15 member 1	0	3	0	3
Solute carrier family 15 member 1	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	2	0	2
Thiosulfate sulfurtransferase	0	1	0	1
Metallo-beta-lactamase VIM-13	0	0	0	2
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase Toho-1	0	0	0	2
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
60 kDa chaperonin	0	1	0	1
Metallo-beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	2	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
10 kDa chaperonin	0	1	0	1
Metallo-b-lactamase	0	0	0	2
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	2
Histamine H3 receptor	0	0	0	3
Beta-lactamase class B VIM-2	0	0	0	2
Beta-lactamase VIM-1	0	0	0	2
ATP-dependent phosphofructokinase	4	0	0	4
pregnane X receptor	4	0	0	4
thyroid hormone receptor beta isoform a	3	0	0	3
galanin receptor type 3	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	9	0	0	9
Glucocorticoid receptor	0	8	2	15
Glycine receptor subunit alpha-1	0	8	0	8
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
ORF73	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
phosphopantetheinyl transferase	3	0	0	3
USP1 protein, partial	5	0	0	5
vitamin D3 receptor isoform VDRA	5	0	0	5
caspase-1 isoform alpha precursor	1	0	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	4
Solute carrier organic anion transporter family member 1B1	0	2	0	4
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Albumin	0	2	3	6
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	1	0	2
B2 metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 6	0	3	0	3
Solute carrier family 22 member 7	0	2	0	3
Beta-lactamase	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	3	0	3
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 11	0	1	0	2
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 7	0	1	0	1
thioredoxin reductase	7	0	0	7
PPM1D protein	4	0	0	4
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
flap endonuclease 1	5	0	0	5
Dihydrofolate reductase	0	1	0	1
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	1	2	3
Major prion protein	0	0	2	2
Histidine-rich protein PFHRP-II	0	3	0	4
Muscarinic acetylcholine receptor M2	0	5	0	5
Muscarinic acetylcholine receptor M4	0	5	0	5
Muscarinic acetylcholine receptor M5	0	5	0	5
Alpha-2A adrenergic receptor	0	3	0	3
Spike glycoprotein	0	1	0	1
Muscarinic acetylcholine receptor M1	0	5	0	5
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	0	1
Alpha-2B adrenergic receptor	0	3	0	3
Alpha-2C adrenergic receptor	0	3	0	3
DNA ligase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	5	0	5
Serine/threonine-protein kinase mTOR	0	1	0	1
Beta-secretase 1	0	1	0	1
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	5	0	5
Sigma intracellular receptor 2	0	1	0	1
Phosphoethanolamine N-methyltransferase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	1	2
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
interleukin 8	2	0	0	2
SMAD family member 2	6	0	0	6
SMAD family member 3	6	0	0	6
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
estrogen receptor 2 (ER beta)	8	0	0	8
G	7	0	0	7
peroxisome proliferator-activated receptor delta	5	0	0	5
thyroid stimulating hormone receptor	6	0	0	6
activating transcription factor 6	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
Caspase-7	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
caspase-3	2	0	0	2
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
lethal factor (plasmid)	2	0	0	2
HLA class I histocompatibility antigen, B alpha chain	7	0	0	7
Androgen receptor	0	6	0	6
Inositol hexakisphosphate kinase 1	7	0	0	7
cytochrome P450 2C9, partial	7	0	0	7
Sex hormone-binding globulin	0	0	1	1
Beta-glucuronidase	0	1	0	1
Corticosteroid-binding globulin	0	2	0	2
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Alpha-synuclein	1	0	0	1
TAR DNA-binding protein 43	2	0	0	2
G-protein coupled bile acid receptor 1	0	0	4	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	1	0	2
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Steryl-sulfatase	0	0	0	1
Multidrug resistance-associated protein 1	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	2
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	2
ATP-binding cassette sub-family C member 11	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Chain A, Ferritin light chain	1	0	0	1
endonuclease IV	1	0	0	1
nonstructural protein 1	2	0	0	2
glucocerebrosidase	1	0	0	1
Bloom syndrome protein isoform 1	1	0	0	1
peripheral myelin protein 22 isoform 1	2	0	0	2
M-phase phosphoprotein 8	2	0	0	2
Gamma-aminobutyric acid	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Fatty acid-binding protein, liver	0	2	0	2
Alpha-1-acid glycoprotein 1	0	0	0	1
Albumin	0	0	1	1
ATP-dependent translocase ABCB1	0	2	1	5
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	2	4
Translocator protein	0	1	1	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
5-hydroxytryptamine receptor 1A	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
acetylcholinesterase	3	0	0	3
thyrotropin-releasing hormone receptor	1	0	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Thrombopoietin	1	0	0	1
regulator of G-protein signaling 4	3	0	0	3
cytochrome P450 2D6 isoform 1	1	0	0	1
huntingtin isoform 2	2	0	0	2
muscarinic acetylcholine receptor M1	2	0	0	2
5-hydroxytryptamine receptor 4	0	2	0	2
Aldo-keto reductase family 1 member B1	0	4	0	4
Angiotensin-converting enzyme	0	2	0	2
Sodium-dependent noradrenaline transporter	0	4	0	4
5-hydroxytryptamine receptor 2A	0	4	0	4
5-hydroxytryptamine receptor 2C	0	2	0	2
Histamine H1 receptor	0	0	1	2
Histamine H1 receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Histamine H2 receptor	1	0	0	2
Histamine N-methyltransferase	0	0	0	1
Sodium channel protein type 5 subunit alpha	0	2	0	2
Solute carrier family 22 member 1	0	3	0	4
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Calcium release-activated calcium channel protein 1	0	1	0	1
Protein orai-2	0	1	0	1
Protein orai-3	0	1	0	1
Histamine H4 receptor	0	1	0	1
Solute carrier family 22 member 2	0	3	0	3
Ultraspiracle	0	2	0	2
20-hydroxy-ecdysone receptor	0	2	0	2
eyes absent homolog 2 isoform a	1	0	0	1
Ecdysone receptor	0	1	0	1
Protein ultraspiracle	0	1	0	1
Ecdysone receptor	0	1	0	1
Ultraspiracle	0	1	0	1
20-hydroxy-ecdysone receptor	0	1	0	1
Ultraspiracle protein	0	1	0	1
20-hydroxy-ecdysone receptor	0	1	0	1
relaxin receptor 1 isoform 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	5	0	0	5
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Tyrosine-protein kinase ABL1	0	3	1	4
Mast/stem cell growth factor receptor Kit	0	1	1	2
Breakpoint cluster region protein	0	0	1	1
Platelet-derived growth factor receptor alpha	0	1	1	2
Cytochrome P450 3A5	0	0	0	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Epidermal growth factor receptor	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	0	1
Aldo-keto reductase family 1 member B1	0	3	0	3
UDP-glucuronosyltransferase 2B7	0	0	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Caspase-1	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	1
Caspase-3	0	1	0	1
Caspase-4	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
Guanine nucleotide-binding protein G	1	0	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Lactoylglutathione lyase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	0	1	1
dopamine D1 receptor	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Alkaline phosphatase, placental type	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	2	0	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Vitamin D3 receptor	0	1	1	2
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
GALC protein	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
Proto-oncogene tyrosine-protein kinase Src	0	2	0	2
Vascular endothelial growth factor receptor 2	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Calmodulin-domain protein kinase 1	0	1	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Phosphotyrosine protein phosphatase	0	1	0	1
Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]	0	0	1	1
serine/threonine-protein kinase PLK1	2	0	0	2
Aldo-keto reductase family 1 member B10	0	2	0	2
Glycogen phosphorylase, muscle form	0	1	0	1
Pancreatic alpha-amylase	0	1	0	3
Phospholipase A2	0	1	0	1
DNA polymerase beta	0	1	0	1
DNA polymerase beta	0	1	0	1
Receptor-type tyrosine-protein phosphatase C	0	1	0	1
Receptor-type tyrosine-protein phosphatase F	0	1	0	1
DNA topoisomerase 1	0	0	0	1
DNA topoisomerase 2-alpha	0	0	0	1
Tissue factor	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 2	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	3	0	5
Receptor-type tyrosine-protein phosphatase alpha	0	1	0	1
Liver carboxylesterase 1	0	1	0	1
Receptor-type tyrosine-protein phosphatase epsilon	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 6	0	1	0	1
M-phase inducer phosphatase 2	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Signal transducer and activator of transcription 3	0	1	0	1
Dual specificity protein phosphatase 3	0	1	0	1
Transcription factor p65	0	2	0	2
Tyrosine-protein phosphatase non-receptor type 11	0	1	0	1
Nuclear factor erythroid 2-related factor 2	0	0	1	1
Env polyprotein	0	0	1	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Prolyl hydroxylase EGLN2	0	0	1	1
Egl nine homolog 1	0	0	1	1
Prolyl hydroxylase EGLN3	0	0	1	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Transmembrane prolyl 4-hydroxylase	0	0	1	1
Protease	0	1	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
thioredoxin glutathione reductase	1	0	0	1
nuclear receptor ROR-gamma isoform 1	2	0	0	2
N	0	1	0	1
NPYLR7B	0	0	1	1
arylsulfatase A	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
tumor susceptibility gene 101 protein	1	0	0	1
Glutathione reductase, mitochondrial	0	1	0	1
Major prion protein	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
DNA-directed RNA polymerase subunit alpha	0	1	0	1
DNA-directed RNA polymerase subunit omega	0	1	0	1
DNA-directed RNA polymerase subunit beta'	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Acidic phospholipase A2 2	0	1	0	1
Acetylcholinesterase	0	2	0	2
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Trypanothione reductase	0	2	0	2
D(3) dopamine receptor	0	2	0	2
D(1A) dopamine receptor	1	0	0	1
Aldehyde oxidase 1	0	1	0	1
Cholinesterase	0	1	0	1
Aldehyde oxidase	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	2
Solute carrier family 22 member 1	0	2	0	2
Solute carrier family 22 member 2	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Bcl-2-like protein 1	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Polyphenol oxidase 2	0	1	0	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
polyadenylate-binding protein 1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(3)

Research Excerpts

Overview

Context

Treatment

Research

Studies (426)

Protein Targets (618)

Loa loa Filariasis

Synonyms(3)

Research Excerpts

Overview

Context

Treatment

Research

Studies (426)

Drugs Studied (54)

Protein Targets (618)