metronidazole has been researched along with Pruritus in 15 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Pruritus: An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A phase 4, open-label, multicenter, community-based study was conducted in subjects with mild to moderately severe papulopustular rosacea of various etiologies and locations to identify subgroups particularly responsive to twice-daily application of metronidazole topical gel 0." | 9.12 | The CLEAR trial: results of a large community-based study of metronidazole gel in rosacea. ( Del Rosso, JQ; Wolf, JE, 2007) |
| "We investigated the effects of 1-4% ointments of metronidazole and tinidazole (derivatives of nitroimidazole) on models of inflammatory dermatitis evoked by antigen, hapten and monoclonal anti-dinitrophenol (DNP) IgE antibody in mice." | 7.72 | Effects of metronidazole and tinidazole ointments on models for inflammatory dermatitis in mice. ( Ito, Y; Nishimuta, K, 2003) |
| "A phase 4, open-label, multicenter, community-based study was conducted in subjects with mild to moderately severe papulopustular rosacea of various etiologies and locations to identify subgroups particularly responsive to twice-daily application of metronidazole topical gel 0." | 5.12 | The CLEAR trial: results of a large community-based study of metronidazole gel in rosacea. ( Del Rosso, JQ; Wolf, JE, 2007) |
| "We investigated the effects of 1-4% ointments of metronidazole and tinidazole (derivatives of nitroimidazole) on models of inflammatory dermatitis evoked by antigen, hapten and monoclonal anti-dinitrophenol (DNP) IgE antibody in mice." | 3.72 | Effects of metronidazole and tinidazole ointments on models for inflammatory dermatitis in mice. ( Ito, Y; Nishimuta, K, 2003) |
| "Treatment with metronidazole per os or tinidazole per os was successful; the pruritic symptoms in one patient improved markedly." | 1.33 | [Giardia lamblia--cause of urticaria and pruritus or accidental association?]. ( Domula, E; Herrmann, J; Nenoff, P; Willing, U, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (33.33) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Neema, S | 1 |
| Subramaniyan, R | 1 |
| Kinra, P | 1 |
| Wang, GJ | 1 |
| Gao, XY | 1 |
| Wu, Y | 1 |
| He, HQ | 1 |
| Yu, Y | 1 |
| Qin, HH | 1 |
| Shen, WT | 1 |
| Rose, AE | 1 |
| Patel, U | 1 |
| Chu, J | 1 |
| Patel, R | 1 |
| Meehan, S | 1 |
| Latkowski, JA | 1 |
| Moraes, ME | 1 |
| Cunha, GH | 1 |
| Bezerra, MM | 1 |
| Fechine, FV | 1 |
| Pontes, AV | 1 |
| Andrade, WS | 1 |
| Frota Bezerra, FA | 1 |
| Moraes, MO | 1 |
| Cavalcanti, PP | 1 |
| Nishimuta, K | 1 |
| Ito, Y | 1 |
| Nenoff, P | 1 |
| Domula, E | 1 |
| Willing, U | 1 |
| Herrmann, J | 1 |
| Sharma, JB | 1 |
| Mittal, S | 1 |
| Raina, U | 1 |
| Chanana, C | 1 |
| Wolf, JE | 1 |
| Del Rosso, JQ | 1 |
| Weart, CW | 1 |
| Hyman, LC | 1 |
| Hamrick, HJ | 1 |
| Moore, GW | 1 |
| Rodríguez Hernández, J | 1 |
| Canut Blasco, A | 1 |
| Brezmes Valdivieso, MF | 1 |
| de Fuentes, I | 1 |
| Bañuls, J | 1 |
| Ramon, D | 1 |
| Aniz, E | 1 |
| Jorda, E | 1 |
| Torres, V | 1 |
| Camacho-Martínez, F | 1 |
| Juergens, UR | 1 |
| Predel, HG | 1 |
| Vetter, H | 1 |
| Liechti, R | 1 |
1 review available for metronidazole and Pruritus
| Article | Year |
|---|---|
Erythrodermic lichen planus.
Topics: Aged; Chills; Dermatitis, Exfoliative; Glucocorticoids; Humans; Immunologic Factors; Itraconazole; L | 2011 |
5 trials available for metronidazole and Pruritus
| Article | Year |
|---|---|
Evaluation of the efficacy and tolerance of artemether emulsion for the treatment of papulopustular rosacea: a randomized pilot study.
Topics: Adult; Artemether; Drug Administration Schedule; Emulsions; Female; Humans; Male; Metronidazole; Mid | 2019 |
Efficacy of the Mentha crispa in the treatment of women with Trichomonas vaginalis infection.
Topics: Adult; Antitrichomonal Agents; Double-Blind Method; Dyspareunia; Dysuria; Female; Humans; Male; Ment | 2012 |
Comparative efficacy of two regimens in syndromic management of lower genital infections.
Topics: Administration, Intravaginal; Adult; Anti-Infective Agents, Local; Azithromycin; Clotrimazole; Drug | 2006 |
The CLEAR trial: results of a large community-based study of metronidazole gel in rosacea.
Topics: Administration, Cutaneous; Adult; Anti-Infective Agents; Erythema; Female; Follow-Up Studies; Gels; | 2007 |
[MK-915, a newreparation for the oral treatment of trichomonas colpitis].
Topics: Adult; Alkaline Phosphatase; Antifungal Agents; Aspartate Aminotransferases; Bilirubin; Blood Cell C | 1970 |
9 other studies available for metronidazole and Pruritus
| Article | Year |
|---|---|
Demodex induced facial frictional melanoses.
Topics: Anti-Infective Agents; Antiparasitic Agents; Drug Therapy, Combination; Facial Dermatoses; Female; F | 2020 |
Effects of metronidazole and tinidazole ointments on models for inflammatory dermatitis in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens; Antipruritics; Capillary Permeability; D | 2003 |
[Giardia lamblia--cause of urticaria and pruritus or accidental association?].
Topics: Adult; Animals; Antiprotozoal Agents; Chronic Disease; Dermatitis, Atopic; Diagnosis, Differential; | 2006 |
Serum sickness associated with metronidazole.
Topics: Adult; Female; Humans; Metronidazole; Pruritus; Serum Sickness; Vaginitis | 1983 |
Giardiasis causing urticaria in a child.
Topics: Child, Preschool; Feces; Female; Giardia; Giardiasis; Humans; Metronidazole; Pruritus; Urticaria; Wa | 1983 |
[Clinico-epidemiological implications of autochthonous infection caused by Entamoeba histolytica].
Topics: Adult; Animals; Antiprotozoal Agents; Dysentery, Amebic; Entamoebiasis; Female; Follow-Up Studies; H | 1995 |
Papular pruritic eruption with human immunodeficiency virus infection.
Topics: Adult; Dermatitis; Female; HIV Infections; Humans; Metronidazole; Pruritus; Zidovudine | 1991 |
Localized trichorrhexis nodosa.
Topics: Adult; Clonidine; Face; Female; Hair Diseases; Humans; Male; Metronidazole; Pruritus; Pruritus Vulva | 1989 |
[Urticaria, pruritus].
Topics: Giardiasis; Humans; Intestinal Diseases, Parasitic; Male; Metronidazole; Middle Aged; Pruritus; Urti | 1989 |