metronidazole has been researched along with Acne in 13 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In order to investigate the effect of blue light combined with metronidazole by NFJI in the treatment of acne, the 251 enrolled patients were randomly assigned into the blue light group, metronidazole (MNZ) group, and MNZ + blue light group, and then received 6-weeks' treatment." | 9.69 | Therapeutic efficacy of metronidazole by needle-free jet injection combined with blue light therapy in Moderate-to-Severe facial acne vulgaris. ( Chen, F; Gao, L; Huang, X; Jiang, L; Lao, Y; Li, N; Lu, J; Lv, L; Yan, W; Yang, F; Yi, L; Zhang, B, 2023) |
| "An analytical method for the simultaneous determination of 6 antibiotics (minocycline, oxytetracycline, tetracycline hydrochloride, chlorotetracycline hydrochloride, doxycycline hydrochloride and chloramphenicol) and metronidazole in acne removal products of cosmetic was established using high performance liquid chromatography (HPLC)." | 7.78 | [Simultaneous determination of 6 antibiotics and metronidazole in acne removal products bt high performance liquid chromatography]. ( Li, Y; Lu, J; Pang, Y; Wang, C, 2012) |
| "Metronidazole's activity has been established in both acneiform rosacea and acne vulgaris." | 7.70 | Metronidazole, its bioactive metabolites and acne. ( Bannatyne, RM, 1999) |
| "Metronidazole is clinically effective in treating not only rosacea but also acne inflammation." | 7.68 | The inhibition of free radical generation by human neutrophils through the synergistic effects of metronidazole with palmitoleic acid: a possible mechanism of action of metronidazole in rosacea and acne. ( Akamatsu, H; Asada, Y; Nishijima, S; Niwa, Y; Oguchi, M; Takahashi, M; Ushijima, T, 1990) |
| "An analytical method for the simultaneous determination of 6 antibiotics (minocycline, oxytetracycline, tetracycline hydrochloride, chlorotetracycline hydrochloride, doxycycline hydrochloride and chloramphenicol) and metronidazole in acne removal products of cosmetic was established using high performance liquid chromatography (HPLC)." | 3.78 | [Simultaneous determination of 6 antibiotics and metronidazole in acne removal products bt high performance liquid chromatography]. ( Li, Y; Lu, J; Pang, Y; Wang, C, 2012) |
| "Metronidazole's activity has been established in both acneiform rosacea and acne vulgaris." | 3.70 | Metronidazole, its bioactive metabolites and acne. ( Bannatyne, RM, 1999) |
| "Metronidazole is clinically effective in treating not only rosacea but also acne inflammation." | 3.68 | The inhibition of free radical generation by human neutrophils through the synergistic effects of metronidazole with palmitoleic acid: a possible mechanism of action of metronidazole in rosacea and acne. ( Akamatsu, H; Asada, Y; Nishijima, S; Niwa, Y; Oguchi, M; Takahashi, M; Ushijima, T, 1990) |
| "Acne vulgaris is a pervasive inflammatory disorder of the skin, with multiple etiologies and treatment options." | 1.40 | Acne vulgaris in the context of complex medical co-morbities: the management of severe acne vulgaris in a female with retinitis pigmentosa - utilizing pulse dye laser in conjunction with medical therapy. ( Keck, L; Shariff, A; Zlotoff, B, 2014) |
| "Antibiotics used for the treatment of acne significantly inhibited ROS generated by neutrophils, when compared to other antibiotics." | 1.30 | The possible role of reactive oxygen species generated by neutrophils in mediating acne inflammation. ( Akamatsu, H; Horio, T, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (23.08) | 18.7374 |
| 1990's | 6 (46.15) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Yi, L | 1 |
| Gao, L | 1 |
| Lv, L | 1 |
| Zhang, B | 1 |
| Chen, F | 1 |
| Yang, F | 1 |
| Yan, W | 1 |
| Jiang, L | 1 |
| Li, N | 1 |
| Lao, Y | 1 |
| Lu, J | 2 |
| Huang, X | 1 |
| Shariff, A | 1 |
| Keck, L | 1 |
| Zlotoff, B | 1 |
| Pang, Y | 1 |
| Li, Y | 1 |
| Wang, C | 1 |
| Forssman, T | 1 |
| Tong, D | 1 |
| Peters, W | 1 |
| Barnetson, RS | 1 |
| Akamatsu, H | 2 |
| Horio, T | 1 |
| Thiboutot, DM | 1 |
| Bannatyne, RM | 1 |
| Carne, S | 1 |
| Gamborg Nielsen, P | 1 |
| Oguchi, M | 1 |
| Nishijima, S | 1 |
| Asada, Y | 1 |
| Takahashi, M | 1 |
| Ushijima, T | 1 |
| Niwa, Y | 1 |
| Mirtschink, S | 1 |
| Barth, J | 1 |
| Hübner, U | 1 |
| Curreli, A | 1 |
| Massidda, B | 1 |
| Leo, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| "Zinc Sulfate in the Treatment of Rosacea: A Randomized, Controlled Trial. Prospective, Double Blind, Randomized, Controlled Trial Comparing the Effects of Supplemental Zinc Sulfate and Placebo on the Severity of Rosacea."[NCT00395226] | 65 participants (Actual) | Interventional | 2006-07-31 | Terminated (stopped due to Difficulty recruiting subjects) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Modified Rosacea Severity Scoring System evaluating four signs of rosacea, flushing (transient erythema or redness), erythema (redness), papules and pustules and telangiectasia (spider-veins) ranges from 0 (best, absent) to 12 (worst, severe on all items) (NCT00395226)
Timeframe: 90 days
| Intervention | units on scale 0 to 12 (Mean) |
|---|---|
| Placebo (Lactose) | 4.9 |
| Zinc Sulfate | 5.1 |
1 review available for metronidazole and Acne
| Article | Year |
|---|---|
Acne and rosacea. New and emerging therapies.
Topics: Acne Vulgaris; Aged; Anti-Bacterial Agents; Helicobacter Infections; Helicobacter pylori; Humans; Is | 2000 |
3 trials available for metronidazole and Acne
| Article | Year |
|---|---|
Therapeutic efficacy of metronidazole by needle-free jet injection combined with blue light therapy in Moderate-to-Severe facial acne vulgaris.
Topics: Acne Vulgaris; Humans; Injections, Jet; Metronidazole; Phototherapy; Treatment Outcome | 2023 |
Evaluation of 0.75% metronidazole gel in acne--a double-blind study.
Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Double-Blind Method; Drug Administration | 1994 |
Topical metronidazole gel. Use in acne vulgaris.
Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Benzoyl Peroxide; Drug Therapy, Combinati | 1991 |
9 other studies available for metronidazole and Acne
| Article | Year |
|---|---|
Acne vulgaris in the context of complex medical co-morbities: the management of severe acne vulgaris in a female with retinitis pigmentosa - utilizing pulse dye laser in conjunction with medical therapy.
Topics: Acne Vulgaris; Administration, Cutaneous; Adult; Androstenes; Anti-Infective Agents, Local; Combined | 2014 |
[Simultaneous determination of 6 antibiotics and metronidazole in acne removal products bt high performance liquid chromatography].
Topics: Acne Vulgaris; Anti-Bacterial Agents; Anti-Infective Agents; Chromatography, High Pressure Liquid; C | 2012 |
Antibiotic resistance in acne patients under antibiotic treatment in comparison to an untreated control group with retrospective assessment of therapy.
Topics: Acne Vulgaris; Adult; Anti-Bacterial Agents; Case-Control Studies; Drug Resistance, Microbial; Eryth | 1995 |
The possible role of reactive oxygen species generated by neutrophils in mediating acne inflammation.
Topics: Acne Vulgaris; Anti-Bacterial Agents; Humans; Inflammation; Linoleic Acid; Metronidazole; Neutrophil | 1998 |
Metronidazole, its bioactive metabolites and acne.
Topics: Acne Vulgaris; Anti-Bacterial Agents; Humans; Metronidazole; Microbial Sensitivity Tests; Propioniba | 1999 |
Letter: Metronidazole and acne.
Topics: Acne Vulgaris; Humans; Metronidazole | 1976 |
The inhibition of free radical generation by human neutrophils through the synergistic effects of metronidazole with palmitoleic acid: a possible mechanism of action of metronidazole in rosacea and acne.
Topics: Acne Vulgaris; Drug Synergism; Fatty Acids, Monounsaturated; Free Radicals; Humans; Inflammation; Me | 1990 |
[Case report of the facial pyoderma disease picture].
Topics: Acne Vulgaris; Adult; Facial Dermatoses; Female; Humans; Metronidazole; Pyoderma | 1986 |
[Action of topical metronidazole on hypertrichosis].
Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Drug Evaluation; Female; Humans; Hypertri | 1973 |