Page last updated: 2024-10-31

metronidazole and Acne

metronidazole has been researched along with Acne in 13 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Research Excerpts

ExcerptRelevanceReference
"In order to investigate the effect of blue light combined with metronidazole by NFJI in the treatment of acne, the 251 enrolled patients were randomly assigned into the blue light group, metronidazole (MNZ) group, and MNZ + blue light group, and then received 6-weeks' treatment."9.69Therapeutic efficacy of metronidazole by needle-free jet injection combined with blue light therapy in Moderate-to-Severe facial acne vulgaris. ( Chen, F; Gao, L; Huang, X; Jiang, L; Lao, Y; Li, N; Lu, J; Lv, L; Yan, W; Yang, F; Yi, L; Zhang, B, 2023)
"An analytical method for the simultaneous determination of 6 antibiotics (minocycline, oxytetracycline, tetracycline hydrochloride, chlorotetracycline hydrochloride, doxycycline hydrochloride and chloramphenicol) and metronidazole in acne removal products of cosmetic was established using high performance liquid chromatography (HPLC)."7.78[Simultaneous determination of 6 antibiotics and metronidazole in acne removal products bt high performance liquid chromatography]. ( Li, Y; Lu, J; Pang, Y; Wang, C, 2012)
"Metronidazole's activity has been established in both acneiform rosacea and acne vulgaris."7.70Metronidazole, its bioactive metabolites and acne. ( Bannatyne, RM, 1999)
"Metronidazole is clinically effective in treating not only rosacea but also acne inflammation."7.68The inhibition of free radical generation by human neutrophils through the synergistic effects of metronidazole with palmitoleic acid: a possible mechanism of action of metronidazole in rosacea and acne. ( Akamatsu, H; Asada, Y; Nishijima, S; Niwa, Y; Oguchi, M; Takahashi, M; Ushijima, T, 1990)
"An analytical method for the simultaneous determination of 6 antibiotics (minocycline, oxytetracycline, tetracycline hydrochloride, chlorotetracycline hydrochloride, doxycycline hydrochloride and chloramphenicol) and metronidazole in acne removal products of cosmetic was established using high performance liquid chromatography (HPLC)."3.78[Simultaneous determination of 6 antibiotics and metronidazole in acne removal products bt high performance liquid chromatography]. ( Li, Y; Lu, J; Pang, Y; Wang, C, 2012)
"Metronidazole's activity has been established in both acneiform rosacea and acne vulgaris."3.70Metronidazole, its bioactive metabolites and acne. ( Bannatyne, RM, 1999)
"Metronidazole is clinically effective in treating not only rosacea but also acne inflammation."3.68The inhibition of free radical generation by human neutrophils through the synergistic effects of metronidazole with palmitoleic acid: a possible mechanism of action of metronidazole in rosacea and acne. ( Akamatsu, H; Asada, Y; Nishijima, S; Niwa, Y; Oguchi, M; Takahashi, M; Ushijima, T, 1990)
"Acne vulgaris is a pervasive inflammatory disorder of the skin, with multiple etiologies and treatment options."1.40Acne vulgaris in the context of complex medical co-morbities: the management of severe acne vulgaris in a female with retinitis pigmentosa - utilizing pulse dye laser in conjunction with medical therapy. ( Keck, L; Shariff, A; Zlotoff, B, 2014)
"Antibiotics used for the treatment of acne significantly inhibited ROS generated by neutrophils, when compared to other antibiotics."1.30The possible role of reactive oxygen species generated by neutrophils in mediating acne inflammation. ( Akamatsu, H; Horio, T, 1998)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19903 (23.08)18.7374
1990's6 (46.15)18.2507
2000's1 (7.69)29.6817
2010's2 (15.38)24.3611
2020's1 (7.69)2.80

Authors

AuthorsStudies
Yi, L1
Gao, L1
Lv, L1
Zhang, B1
Chen, F1
Yang, F1
Yan, W1
Jiang, L1
Li, N1
Lao, Y1
Lu, J2
Huang, X1
Shariff, A1
Keck, L1
Zlotoff, B1
Pang, Y1
Li, Y1
Wang, C1
Forssman, T1
Tong, D1
Peters, W1
Barnetson, RS1
Akamatsu, H2
Horio, T1
Thiboutot, DM1
Bannatyne, RM1
Carne, S1
Gamborg Nielsen, P1
Oguchi, M1
Nishijima, S1
Asada, Y1
Takahashi, M1
Ushijima, T1
Niwa, Y1
Mirtschink, S1
Barth, J1
Hübner, U1
Curreli, A1
Massidda, B1
Leo, P1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
"Zinc Sulfate in the Treatment of Rosacea: A Randomized, Controlled Trial. Prospective, Double Blind, Randomized, Controlled Trial Comparing the Effects of Supplemental Zinc Sulfate and Placebo on the Severity of Rosacea."[NCT00395226]65 participants (Actual)Interventional2006-07-31Terminated (stopped due to Difficulty recruiting subjects)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Severity of Facial Rosacea After 90 Days of Treatment

Modified Rosacea Severity Scoring System evaluating four signs of rosacea, flushing (transient erythema or redness), erythema (redness), papules and pustules and telangiectasia (spider-veins) ranges from 0 (best, absent) to 12 (worst, severe on all items) (NCT00395226)
Timeframe: 90 days

Interventionunits on scale 0 to 12 (Mean)
Placebo (Lactose)4.9
Zinc Sulfate5.1

Reviews

1 review available for metronidazole and Acne

ArticleYear
Acne and rosacea. New and emerging therapies.
    Dermatologic clinics, 2000, Volume: 18, Issue:1

    Topics: Acne Vulgaris; Aged; Anti-Bacterial Agents; Helicobacter Infections; Helicobacter pylori; Humans; Is

2000

Trials

3 trials available for metronidazole and Acne

ArticleYear
Therapeutic efficacy of metronidazole by needle-free jet injection combined with blue light therapy in Moderate-to-Severe facial acne vulgaris.
    Journal of cosmetic dermatology, 2023, Volume: 22, Issue:2

    Topics: Acne Vulgaris; Humans; Injections, Jet; Metronidazole; Phototherapy; Treatment Outcome

2023
Evaluation of 0.75% metronidazole gel in acne--a double-blind study.
    Clinical and experimental dermatology, 1994, Volume: 19, Issue:3

    Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Double-Blind Method; Drug Administration

1994
Topical metronidazole gel. Use in acne vulgaris.
    International journal of dermatology, 1991, Volume: 30, Issue:9

    Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Benzoyl Peroxide; Drug Therapy, Combinati

1991

Other Studies

9 other studies available for metronidazole and Acne

ArticleYear
Acne vulgaris in the context of complex medical co-morbities: the management of severe acne vulgaris in a female with retinitis pigmentosa - utilizing pulse dye laser in conjunction with medical therapy.
    Dermatology online journal, 2014, Mar-17, Volume: 20, Issue:3

    Topics: Acne Vulgaris; Administration, Cutaneous; Adult; Androstenes; Anti-Infective Agents, Local; Combined

2014
[Simultaneous determination of 6 antibiotics and metronidazole in acne removal products bt high performance liquid chromatography].
    Se pu = Chinese journal of chromatography, 2012, Volume: 30, Issue:6

    Topics: Acne Vulgaris; Anti-Bacterial Agents; Anti-Infective Agents; Chromatography, High Pressure Liquid; C

2012
Antibiotic resistance in acne patients under antibiotic treatment in comparison to an untreated control group with retrospective assessment of therapy.
    Current problems in dermatology, 1995, Volume: 22

    Topics: Acne Vulgaris; Adult; Anti-Bacterial Agents; Case-Control Studies; Drug Resistance, Microbial; Eryth

1995
The possible role of reactive oxygen species generated by neutrophils in mediating acne inflammation.
    Dermatology (Basel, Switzerland), 1998, Volume: 196, Issue:1

    Topics: Acne Vulgaris; Anti-Bacterial Agents; Humans; Inflammation; Linoleic Acid; Metronidazole; Neutrophil

1998
Metronidazole, its bioactive metabolites and acne.
    Current medical research and opinion, 1999, Volume: 15, Issue:4

    Topics: Acne Vulgaris; Anti-Bacterial Agents; Humans; Metronidazole; Microbial Sensitivity Tests; Propioniba

1999
Letter: Metronidazole and acne.
    Lancet (London, England), 1976, Aug-14, Volume: 2, Issue:7981

    Topics: Acne Vulgaris; Humans; Metronidazole

1976
The inhibition of free radical generation by human neutrophils through the synergistic effects of metronidazole with palmitoleic acid: a possible mechanism of action of metronidazole in rosacea and acne.
    Archives of dermatological research, 1990, Volume: 282, Issue:7

    Topics: Acne Vulgaris; Drug Synergism; Fatty Acids, Monounsaturated; Free Radicals; Humans; Inflammation; Me

1990
[Case report of the facial pyoderma disease picture].
    Dermatologische Monatschrift, 1986, Volume: 172, Issue:5

    Topics: Acne Vulgaris; Adult; Facial Dermatoses; Female; Humans; Metronidazole; Pyoderma

1986
[Action of topical metronidazole on hypertrichosis].
    Atti della Accademia medica lombarda, 1973, Volume: 28, Issue:1-4

    Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Drug Evaluation; Female; Humans; Hypertri

1973