metronidazole has been researched along with Hemolysis in 12 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Hemolysis: The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Netropsin was tested at concentrations ranging from 3." | 1.51 | Efficacy of netropsin dihydrochloride against the viability, cytopathogenicity and hemolytic activity of Trichomonas vaginalis clinical isolates. ( Abou Gamra, MM; Ezz Eldin, HM; Kamel, HH; Taha Zahran, FM, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Salahuddin, A | 1 |
| Inam, A | 1 |
| van Zyl, RL | 1 |
| Heslop, DC | 1 |
| Chen, CT | 1 |
| Avecilla, F | 1 |
| Agarwal, SM | 1 |
| Azam, A | 1 |
| Kuznetsova, DA | 1 |
| Gaynanova, GA | 1 |
| Vasileva, LA | 1 |
| Sibgatullina, GV | 1 |
| Samigullin, DV | 1 |
| Sapunova, AS | 1 |
| Voloshina, AD | 1 |
| Galkina, IV | 1 |
| Petrov, KA | 1 |
| Zakharova, LY | 1 |
| Filippi, M | 1 |
| Nguyen, DV | 1 |
| Garello, F | 1 |
| Perton, F | 1 |
| Bégin-Colin, S | 1 |
| Felder-Flesch, D | 1 |
| Power, L | 1 |
| Scherberich, A | 1 |
| Bitencourt, FG | 1 |
| de Brum Vieira, P | 1 |
| Meirelles, LC | 1 |
| Rigo, GV | 1 |
| da Silva, EF | 1 |
| Gnoatto, SCB | 1 |
| Tasca, T | 3 |
| Abou Gamra, MM | 1 |
| Kamel, HH | 1 |
| Ezz Eldin, HM | 1 |
| Taha Zahran, FM | 1 |
| Innocente, AM | 1 |
| Vieira, Pde B | 1 |
| Frasson, AP | 2 |
| Casanova, BB | 1 |
| Gosmann, G | 1 |
| Gnoatto, SC | 1 |
| Guo, ZH | 1 |
| Yin, Y | 1 |
| Wang, C | 1 |
| Wang, PF | 1 |
| Zhang, XT | 1 |
| Wang, ZC | 1 |
| Zhu, HL | 1 |
| van Bunderen, CC | 1 |
| Bomers, MK | 1 |
| Wesdorp, E | 1 |
| Peerbooms, P | 1 |
| Veenstra, J | 1 |
| Scopel, M | 1 |
| dos Santos, O | 1 |
| Abraham, WR | 1 |
| Henriques, AT | 1 |
| Macedo, AJ | 1 |
| Flynn, MJ | 1 |
| Slots, J | 1 |
| Pohunek, M | 1 |
| Frintová, K | 1 |
| Dailey, DC | 1 |
| Chang, TH | 1 |
| Alderete, JF | 1 |
1 review available for metronidazole and Hemolysis
| Article | Year |
|---|---|
Clostridium perfringens septicaemia with massive intravascular haemolysis: a case report and review of the literature.
Topics: Aged; Amoxicillin; Anti-Bacterial Agents; Cholangitis; Clostridium Infections; Clostridium perfringe | 2010 |
11 other studies available for metronidazole and Hemolysis
| Article | Year |
|---|---|
Synthesis and evaluation of 7-chloro-4-(piperazin-1-yl)quinoline-sulfonamide as hybrid antiprotozoal agents.
Topics: Amino Acid Sequence; Antiprotozoal Agents; Cell Survival; Chloroquine; Crystallography, X-Ray; Dihyd | 2013 |
Mitochondria-targeted cationic liposomes modified with alkyltriphenylphosphonium bromides loaded with hydrophilic drugs: preparation, cytotoxicity and colocalization assay.
Topics: Antineoplastic Agents; Benzopyrans; Bromides; Cations; Cell Line, Tumor; Drug Carriers; Drug Screeni | 2019 |
Metronidazole-functionalized iron oxide nanoparticles for molecular detection of hypoxic tissues.
Topics: Animals; Anthracenes; Cell Culture Techniques; Cell Hypoxia; Cell Proliferation; Cell Survival; Eryt | 2019 |
Anti-Trichomonas vaginalis activity of ursolic acid derivative: a promising alternative.
Topics: Animals; Antitrichomonal Agents; Cell Death; Cell Line, Tumor; Chlorocebus aethiops; Drug Resistance | 2018 |
Efficacy of netropsin dihydrochloride against the viability, cytopathogenicity and hemolytic activity of Trichomonas vaginalis clinical isolates.
Topics: Animals; Anti-Bacterial Agents; Dogs; Drug Resistance; Female; Hemolysis; Humans; Madin Darby Canine | 2019 |
Anti-Trichomonas vaginalis activity from triterpenoid derivatives.
Topics: Antitrichomonal Agents; Betulinic Acid; Drug Resistance; Erythrocytes; Female; HeLa Cells; Hemolysis | 2014 |
Design, synthesis and molecular docking of salicylic acid derivatives containing metronidazole as a new class of antimicrobial agents.
Topics: Anti-Infective Agents; Binding Sites; Crystallography, X-Ray; Drug Design; Erythrocytes; Gram-Negati | 2015 |
Anti-Trichomonas vaginalis activity of marine-associated fungi from the South Brazilian Coast.
Topics: Animals; Antiprotozoal Agents; Brazil; Chlorocebus aethiops; Drug Resistance; Erythrocytes; Fungi; H | 2013 |
Beta-hemolytic streptococci in advanced periodontitis.
Topics: Adolescent; Adult; Age Factors; Aged; Ciprofloxacin; Colony Count, Microbial; Cross-Sectional Studie | 1993 |
Metronidazole and facultative anaerobes.
Topics: Bacteria; Culture Media; Drug Resistance, Microbial; Hemolysis; Metronidazole; Microbial Sensitivity | 1978 |
Characterization of Trichomonas vaginalis haemolysis.
Topics: Animals; Calcium; Hemolysis; Humans; Hydrogen-Ion Concentration; Iodoacetamide; Magnesium; Metronida | 1990 |