metronidazole has been researched along with Infections, Soft Tissue in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anjani, QK | 1 |
| Sabri, AHB | 1 |
| Domínguez-Robles, J | 1 |
| Moreno-Castellanos, N | 1 |
| Utomo, E | 1 |
| Wardoyo, LAH | 1 |
| Larrañeta, E | 1 |
| Donnelly, RF | 1 |
| van Hulsteijn, LT | 1 |
| Mieog, JS | 1 |
| Zwartbol, MH | 1 |
| Merkus, JW | 1 |
| van Nieuwkoop, C | 1 |
| van Kuilenburg, JT | 1 |
| van Niekerk, J | 1 |
| Sinnige, H | 1 |
| de Jager, CP | 1 |
| Tamm, TI | 1 |
4 other studies available for metronidazole and Infections, Soft Tissue
| Article | Year |
|---|---|
Metronidazole nanosuspension loaded dissolving microarray patches: An engineered composite pharmaceutical system for the treatment of skin and soft tissue infection.
Topics: Anti-Bacterial Agents; Bacteroides fragilis; Humans; Metronidazole; Pharmaceutical Preparations; Sof | 2022 |
Appendicitis Presenting As Cellulitis of the Right Leg.
Topics: Aged; Anti-Bacterial Agents; Appendicitis; Cefuroxime; Cellulitis; Emergency Service, Hospital; Esch | 2017 |
A woman with a swollen neck.
Topics: Aged; Anti-Bacterial Agents; Cefuroxime; Female; Humans; Ludwig's Angina; Metronidazole; Neck; Neck | 2009 |
[Local treatment in anaerobic infections of soft tissues].
Topics: Bacteria, Anaerobic; Bacterial Infections; Chloramphenicol; Drug Therapy, Combination; Follow-Up Stu | 1996 |