metronidazole has been researched along with Anal Fistula in 33 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate, in a prospective, open-label study, the influence of antibiotics and azathioprine on the clinical outcome of perianal fistulas in patients with Crohn's disease." | 9.10 | Antibiotics and azathioprine for the treatment of perianal fistulas in Crohn's disease. ( Dejaco, C; Harrer, M; Miehsler, W; Reinisch, W; Vogelsang, H; Waldhoer, T, 2003) |
| "To evaluate combination therapy with azathioprine and metronidazole in German Shepherd Dogs with perianal fistulae." | 7.70 | Management of perianal fistulae in five dogs using azathioprine and metronidazole prior to surgery. ( Beck, JA; Hunt, GB; Malik, R; Tisdall, PL, 1999) |
| "Remission and response of perianal fistulas were defined as closure of all fistulas and closure of at least 50% of fistulas that were draining at baseline, respectively." | 6.74 | Ciprofloxacin or metronidazole for the treatment of perianal fistulas in patients with Crohn's disease: a randomized, double-blind, placebo-controlled pilot study. ( Bernstein, CN; Bitton, A; Cockeram, A; Feagan, BG; Mahadevan, U; Sandborn, WJ; Thia, KT; Wong, C, 2009) |
| "To evaluate, in a prospective, open-label study, the influence of antibiotics and azathioprine on the clinical outcome of perianal fistulas in patients with Crohn's disease." | 5.10 | Antibiotics and azathioprine for the treatment of perianal fistulas in Crohn's disease. ( Dejaco, C; Harrer, M; Miehsler, W; Reinisch, W; Vogelsang, H; Waldhoer, T, 2003) |
| "Fifty-two patients (median age 36 yr) with draining perianal fistulas were treated with ciprofloxacin (N = 49) or metronidazole (N = 3) for a median duration of 7 wk." | 3.74 | NOD2/CARD15 gene variants are linked to failure of antibiotic treatment in perianal fistulating Crohn's disease. ( Angelberger, S; Dejaco, C; Lichtenberger, C; Miehsler, W; Reinisch, W; Schaeffeler, E; Schwab, M; Teml, A; Vogelsang, H; Waldhoer, T; Wehkamp, J, 2008) |
| "To evaluate combination therapy with azathioprine and metronidazole in German Shepherd Dogs with perianal fistulae." | 3.70 | Management of perianal fistulae in five dogs using azathioprine and metronidazole prior to surgery. ( Beck, JA; Hunt, GB; Malik, R; Tisdall, PL, 1999) |
| "Remission and response of perianal fistulas were defined as closure of all fistulas and closure of at least 50% of fistulas that were draining at baseline, respectively." | 2.74 | Ciprofloxacin or metronidazole for the treatment of perianal fistulas in patients with Crohn's disease: a randomized, double-blind, placebo-controlled pilot study. ( Bernstein, CN; Bitton, A; Cockeram, A; Feagan, BG; Mahadevan, U; Sandborn, WJ; Thia, KT; Wong, C, 2009) |
| "Metronidazole was orally administered for the first 2 weeks." | 2.74 | Long-term prospective evaluation of topically applied 0.1% tacrolimus ointment for treatment of perianal sinuses in dogs. ( Hauptman, JG; Stanley, BJ, 2009) |
| "Perianal fistulas are common in Crohn's disease and often have a poor prognosis, with permanent sphincter and perineal tissue destruction." | 2.44 | Perianal fistulizing Crohn's disease: a call to action. ( Kamm, MA; Ng, SC, 2008) |
| " Moreover, long-term use of glucocorticosteroids is associated with serious and sometimes irreversible side effects." | 2.42 | An historical overview of the treatment of Crohn's disease: why do we need biological therapies? ( Rutgeerts, PJ, 2004) |
| "He had urinary infection and severe ileocolitis." | 2.39 | Management of rectourethral fistulas in Crohn's disease. ( Bucci, L; Frizelle, FA; Santoro, GA, 1995) |
| "Asymptomatic perianal fistulas in a patient with Crohn's disease do not require treatment." | 2.38 | Perianal inflammatory conditions in inflammatory bowel disease. ( Gordon, PH; Stein, BL, 1993) |
| "Metronidazole is a nitroimidazole antibiotic used in treating anaerobic bacteria and protozoal infections." | 1.56 | Reversible optic neuropathy secondary to metronidazole. ( Anwyll, N; Gerry, P; Gormley, J, 2020) |
| "Fistulas were treated with antibiotics in 59." | 1.38 | Genital fistulas in female Crohn's disease patients.: clinical characteristics and response to therapy. ( Bermejo, F; de la Poza, G; Gisbert, JP; López-Sanroman, A; Marín-Jimenez, I; Muriel, A; Opio, V; Taxonera, C, 2012) |
| "CD-associated perianal fistulas are mainly complex." | 1.38 | Endoscopic ultrasound for perianal Crohn's disease: disease and fistula characteristics, and impact on therapy. ( Assulin, Y; Beer-Gabel, M; Chowers, Y; Lahat, A, 2012) |
| "Nevertheless, patients with perianal fistulas and CARD15 mutations showed worse response to antibiotics." | 1.37 | CARD15 mutations and perianal fistulating Crohn's disease: correlation and predictive value of antibiotic response. ( Andrade, P; Donato, MM; Ferreira, M; Freire, P; Portela, F; Sofia, C, 2011) |
| "Recto-urethral fistulas due to Crohn's disease are very uncommon." | 1.35 | [Urethral fistula due to Crohn's disease: case report of successful conservative management]. ( Borovicka, J; Engeler, DS; Hetzer, FH; Meyer, D; Schmid, HP; Schwab, C, 2008) |
| "He had urinary infection and severe ileocolitis." | 1.30 | [Treatment of recto-urethral fistulas in Crohn's disease]. ( Aiello, C; Bucci, L; Cerbone, V; de Werra, C; Gentile, M; Santoro, GA, 1997) |
| "For the prophylaxis of a post-surgical recurrence, only salicylates are established." | 1.30 | [Conservative therapy of fistulas of the anorectal area in Crohn disease]. ( Brucks, U; Malfertheiner, P; Peitz, U, 1999) |
| "Pancreatitis is generally regarded to be an extra-intestinal complication of Crohn's disease unless the duodenum is directly involved." | 1.29 | Crohn's disease associated with pancreatitis of unknown etiology: a case report. ( Arakawa, S; Omata, F; Takahashi, H; Ueno, F, 1993) |
| "The mean age at diagnosis of Crohn's disease was 11." | 1.28 | Perianal complications of pediatric Crohn's disease. ( Bilik, R; Griffiths, AM; Palder, SB; Shandling, B; Sherman, P, 1991) |
| "This meningorectal fistula is the first of its kind to our knowledge to be demonstrated by microbiologic, radiologic, and pathologic studies." | 1.26 | Meningorectal fistula as a cause of polymicrobial anaerobic meningitis. ( Berelowitz, BA; Breyer, MD; Malinoff, H; Walsh, TJ; Weinstein, RA, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.06) | 18.7374 |
| 1990's | 9 (27.27) | 18.2507 |
| 2000's | 14 (42.42) | 29.6817 |
| 2010's | 6 (18.18) | 24.3611 |
| 2020's | 2 (6.06) | 2.80 |
| Authors | Studies |
|---|---|
| Sosa Solís, AM | 1 |
| Fernández Antuña, L | 1 |
| Royo Cuadra, Y | 1 |
| Castellarnau Figueras, E | 1 |
| Anwyll, N | 1 |
| Gerry, P | 1 |
| Gormley, J | 1 |
| Ghahramani, L | 1 |
| Minaie, MR | 1 |
| Arasteh, P | 1 |
| Hosseini, SV | 1 |
| Izadpanah, A | 1 |
| Bananzadeh, AM | 1 |
| Ahmadbeigi, M | 1 |
| Hooshanginejad, Z | 1 |
| Arroyo, A | 1 |
| Moya, P | 1 |
| Rodríguez-Prieto, MA | 1 |
| Alcaide, MJ | 1 |
| Aguilar, MM | 1 |
| Bellón, M | 1 |
| Pérez-Vázquez, MT | 1 |
| Candela, F | 1 |
| Calpena, R | 1 |
| Blaker, JJ | 1 |
| Pratten, J | 1 |
| Ready, D | 1 |
| Knowles, JC | 1 |
| Forbes, A | 1 |
| Day, RM | 1 |
| Thia, KT | 1 |
| Mahadevan, U | 1 |
| Feagan, BG | 1 |
| Wong, C | 1 |
| Cockeram, A | 1 |
| Bitton, A | 1 |
| Bernstein, CN | 1 |
| Sandborn, WJ | 1 |
| Iesalnieks, I | 1 |
| Glass, H | 1 |
| Kilger, A | 1 |
| Ott, C | 1 |
| Klebl, F | 1 |
| Agha, A | 1 |
| Schlitt, HJ | 1 |
| Strauch, U | 1 |
| Stanley, BJ | 1 |
| Hauptman, JG | 1 |
| Freire, P | 1 |
| Portela, F | 1 |
| Donato, MM | 1 |
| Ferreira, M | 1 |
| Andrade, P | 1 |
| Sofia, C | 1 |
| Pomazkin, VI | 1 |
| de la Poza, G | 1 |
| López-Sanroman, A | 1 |
| Taxonera, C | 1 |
| Marín-Jimenez, I | 1 |
| Gisbert, JP | 1 |
| Bermejo, F | 1 |
| Opio, V | 1 |
| Muriel, A | 1 |
| Lahat, A | 1 |
| Assulin, Y | 1 |
| Beer-Gabel, M | 1 |
| Chowers, Y | 1 |
| Zimmerman, DD | 1 |
| Delemarre, JB | 1 |
| Gosselink, MP | 1 |
| Hop, WC | 1 |
| Briel, JW | 1 |
| Schouten, WR | 1 |
| Dejaco, C | 2 |
| Harrer, M | 1 |
| Waldhoer, T | 2 |
| Miehsler, W | 2 |
| Vogelsang, H | 2 |
| Reinisch, W | 2 |
| Rutgeerts, PJ | 1 |
| Dignass, AU | 1 |
| Atienza, P | 1 |
| Kamm, MA | 1 |
| Ng, SC | 1 |
| Angelberger, S | 1 |
| Wehkamp, J | 1 |
| Lichtenberger, C | 1 |
| Schaeffeler, E | 1 |
| Schwab, M | 1 |
| Teml, A | 1 |
| Schwab, C | 1 |
| Meyer, D | 1 |
| Hetzer, FH | 1 |
| Borovicka, J | 1 |
| Schmid, HP | 1 |
| Engeler, DS | 1 |
| Walsh, TJ | 1 |
| Weinstein, RA | 1 |
| Malinoff, H | 1 |
| Breyer, MD | 1 |
| Berelowitz, BA | 1 |
| Stein, BL | 1 |
| Gordon, PH | 1 |
| Omata, F | 1 |
| Arakawa, S | 1 |
| Takahashi, H | 1 |
| Ueno, F | 1 |
| Santoro, GA | 2 |
| Bucci, L | 2 |
| Frizelle, FA | 1 |
| Aiello, C | 1 |
| Cerbone, V | 1 |
| de Werra, C | 1 |
| Gentile, M | 1 |
| Lehrnbecher, T | 1 |
| Kontny, HU | 1 |
| Jeschke, R | 1 |
| Peitz, U | 1 |
| Brucks, U | 1 |
| Malfertheiner, P | 1 |
| Patrlj, L | 1 |
| Kocman, B | 1 |
| Martinac, M | 1 |
| Jadrijevic, S | 1 |
| Sosa, T | 1 |
| Sebecic, B | 1 |
| Brkljacic, B | 1 |
| Tisdall, PL | 1 |
| Hunt, GB | 1 |
| Beck, JA | 1 |
| Malik, R | 1 |
| Arseneau, KO | 1 |
| Cohn, SM | 1 |
| Cominelli, F | 1 |
| Connors, AF | 1 |
| Nadler, LH | 1 |
| Palder, SB | 1 |
| Shandling, B | 1 |
| Bilik, R | 1 |
| Griffiths, AM | 1 |
| Sherman, P | 1 |
| Malchow, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective Longitudinal Study on the Effect of Tight Control Management on Perianal Crohn's Disease[NCT03861689] | 40 participants (Anticipated) | Interventional | 2019-07-01 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for metronidazole and Anal Fistula
| Article | Year |
|---|---|
An historical overview of the treatment of Crohn's disease: why do we need biological therapies?
Topics: Anti-Infective Agents; Biological Therapy; Ciprofloxacin; Crohn Disease; Glucocorticoids; Humans; Im | 2004 |
[Refractory perineal fistulas in Crohn's disease].
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Antibodies, Monoclonal; Ciprofloxacin; Crohn Diseas | 2007 |
Perianal fistulizing Crohn's disease: a call to action.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Crohn Disease; Endosonography; Gastrointestinal Age | 2008 |
Perianal inflammatory conditions in inflammatory bowel disease.
Topics: Abscess; Adult; Colitis, Ulcerative; Combined Modality Therapy; Crohn Disease; Female; Humans; Male; | 1993 |
Management of rectourethral fistulas in Crohn's disease.
Topics: Adult; Crohn Disease; Follow-Up Studies; Humans; Male; Metronidazole; Perineum; Rectal Fistula; Scro | 1995 |
4 trials available for metronidazole and Anal Fistula
| Article | Year |
|---|---|
Antibiotic therapy for prevention of fistula in-ano after incision and drainage of simple perianal abscess: A randomized single blind clinical trial.
Topics: Abscess; Anti-Bacterial Agents; Antibiotic Prophylaxis; Anus Diseases; Ciprofloxacin; Drainage; Huma | 2017 |
Ciprofloxacin or metronidazole for the treatment of perianal fistulas in patients with Crohn's disease: a randomized, double-blind, placebo-controlled pilot study.
Topics: Adult; Anti-Infective Agents; Ciprofloxacin; Crohn Disease; Double-Blind Method; Female; Humans; Mal | 2009 |
Long-term prospective evaluation of topically applied 0.1% tacrolimus ointment for treatment of perianal sinuses in dogs.
Topics: Administration, Oral; Administration, Topical; Anal Sacs; Animals; Dietary Proteins; Dog Diseases; D | 2009 |
Antibiotics and azathioprine for the treatment of perianal fistulas in Crohn's disease.
Topics: Adjuvants, Immunologic; Adolescent; Adult; Aged; Anti-Bacterial Agents; Anus Diseases; Azathioprine; | 2003 |
24 other studies available for metronidazole and Anal Fistula
| Article | Year |
|---|---|
Perianal disease as the first manifestation in paediatric Crohn's disease.
Topics: Abscess; Adalimumab; Anemia, Hypochromic; Azathioprine; Child; Crohn Disease; Fissure in Ano; Gastro | 2020 |
Reversible optic neuropathy secondary to metronidazole.
Topics: Adult; Crohn Disease; Electroretinography; Evoked Potentials, Visual; Humans; Male; Metronidazole; O | 2020 |
Photodynamic therapy for the treatment of complex anal fistula.
Topics: Adolescent; Adult; Aged; Aminolevulinic Acid; Anti-Infective Agents; Antibiotic Prophylaxis; Combine | 2017 |
Assessment of antimicrobial microspheres as a prospective novel treatment targeted towards the repair of perianal fistulae.
Topics: Animals; Anti-Infective Agents; Biocompatible Materials; Drug Delivery Systems; Humans; Metronidazol | 2008 |
[Perianal fistulas in Crohn's disease: treatment results at an interdisciplinary unit].
Topics: Abscess; Adolescent; Adult; Anti-Infective Agents; Anti-Inflammatory Agents; Antibodies, Monoclonal; | 2009 |
CARD15 mutations and perianal fistulating Crohn's disease: correlation and predictive value of antibiotic response.
Topics: Adult; Anti-Bacterial Agents; Ciprofloxacin; Crohn Disease; Drug Therapy, Combination; Female; Genet | 2011 |
[Results of one-stage reconstruction of anal sphincter in surgical treatment of fistulas-in-ano combined with fecal incontinence].
Topics: Adult; Anal Canal; Antibiotic Prophylaxis; Ceftriaxone; Fecal Incontinence; Female; Follow-Up Studie | 2011 |
Genital fistulas in female Crohn's disease patients.: clinical characteristics and response to therapy.
Topics: Adalimumab; Adolescent; Adult; Age Factors; Anti-Infective Agents; Anti-Inflammatory Agents; Antibod | 2012 |
Endoscopic ultrasound for perianal Crohn's disease: disease and fistula characteristics, and impact on therapy.
Topics: Abscess; Adolescent; Adrenal Cortex Hormones; Adult; Aged; Anti-Infective Agents; Anti-Inflammatory | 2012 |
Smoking affects the outcome of transanal mucosal advancement flap repair of trans-sphincteric fistulas.
Topics: Adult; Aged; Anti-Infective Agents; Cefuroxime; Female; Follow-Up Studies; Humans; Male; Metronidazo | 2003 |
[Management of perianal fistulizing Crohn's disease: a conservative approach].
Topics: Anti-Infective Agents; Ciprofloxacin; Combined Modality Therapy; Crohn Disease; Fecal Incontinence; | 2005 |
NOD2/CARD15 gene variants are linked to failure of antibiotic treatment in perianal fistulating Crohn's disease.
Topics: Adult; Alleles; Anti-Infective Agents; beta-Defensins; Ciprofloxacin; Crohn Disease; Female; Genetic | 2008 |
[Urethral fistula due to Crohn's disease: case report of successful conservative management].
Topics: Azathioprine; Ciprofloxacin; Crohn Disease; Cystoscopy; Cystostomy; Diagnosis, Differential; Drug Th | 2008 |
Meningorectal fistula as a cause of polymicrobial anaerobic meningitis.
Topics: Female; Fistula; Humans; Meninges; Meningitis; Metronidazole; Middle Aged; Radiotherapy; Rectal Fist | 1982 |
Crohn's disease associated with pancreatitis of unknown etiology: a case report.
Topics: Acute Disease; Adult; Crohn Disease; Humans; Male; Metronidazole; Pancreatitis; Parenteral Nutrition | 1993 |
[Treatment of recto-urethral fistulas in Crohn's disease].
Topics: Adult; Anti-Infective Agents; Crohn Disease; Follow-Up Studies; Humans; Immunosuppressive Agents; Ma | 1997 |
Metastatic Crohn's disease in a 9-year-old boy.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Azathioprine; Child; Crohn Disease; Erythema; Human | 1999 |
[Conservative therapy of fistulas of the anorectal area in Crohn disease].
Topics: Crohn Disease; Humans; Immunosuppressive Agents; Metronidazole; Postoperative Complications; Prognos | 1999 |
Fibrin glue-antibiotic mixture in the treatment of anal fistulae: experience with 69 cases.
Topics: Adult; Cefotaxime; Cephalosporins; Drug Therapy, Combination; Electrocoagulation; Female; Fibrin Tis | 2000 |
Management of perianal fistulae in five dogs using azathioprine and metronidazole prior to surgery.
Topics: Administration, Oral; Animals; Anti-Infective Agents; Azathioprine; Dog Diseases; Dogs; Female; Immu | 1999 |
Cost-utility of initial medical management for Crohn's disease perianal fistulae.
Topics: Adult; Antibodies, Monoclonal; Crohn Disease; Drug Costs; Drug Therapy, Combination; Female; Gastroi | 2001 |
Fistula-in-ano in Crohn's disease.
Topics: Chemotherapy, Adjuvant; Crohn Disease; Humans; Metronidazole; Rectal Fistula | 1991 |
Perianal complications of pediatric Crohn's disease.
Topics: Abscess; Adolescent; Anus Diseases; Child; Child, Preschool; Crohn Disease; Female; Fissure in Ano; | 1991 |
[Fistulas in Crohn disease--conservative versus operative treatment. The internist viewpoint].
Topics: Adolescent; Adult; Child; Combined Modality Therapy; Crohn Disease; Female; Humans; Intestinal Fistu | 1985 |