metronidazole has been researched along with Erythema in 31 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Erythema: Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of disease processes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to prepare a topical water-in-oil type microemulsion containing metronidazole and to compare its effectiveness with a commercial gel product in the treatment of rosacea." | 9.16 | Preparation and evaluation of topical microemulsion system containing metronidazole for remission in rosacea. ( Adişen, E; Çelebi, N; Erel, A; Kayiş, A; Tirnaksiz, F, 2012) |
| "A phase 4, open-label, multicenter, community-based study was conducted in subjects with mild to moderately severe papulopustular rosacea of various etiologies and locations to identify subgroups particularly responsive to twice-daily application of metronidazole topical gel 0." | 9.12 | The CLEAR trial: results of a large community-based study of metronidazole gel in rosacea. ( Del Rosso, JQ; Wolf, JE, 2007) |
| "75% metronidazole gel in improving principal signs of rosacea (inflammatory lesions and erythema)." | 9.10 | A comparison of 15% azelaic acid gel and 0.75% metronidazole gel in the topical treatment of papulopustular rosacea: results of a randomized trial. ( Elewski, BE; Fleischer, AB; Pariser, DM, 2003) |
| "The capacity of topical metronidazole to reduce erythema severity scores in rosacea has been attributed to its anti-inflammatory activity." | 9.09 | Topical metronidazole does not abate UVB-induced erythema. ( Brusati, C; Guarrera, M; Rebora, A, 2001) |
| "The papules and pustules of rosacea can be effectively treated with topical metronidazole." | 9.09 | Once-daily topical metronidazole cream formulations in the treatment of the papules and pustules of rosacea. ( Baker, MD; Dahl, MV; Jarratt, M; Kaplan, D; Tuley, MR, 2001) |
| "Eighty-one patients with rosacea were treated with either I% metronidazole cream or the cream base as a placebo for two months." | 9.05 | Treatment of rosacea with i% metronidazole cream. A double-blind study. ( Nielsen, PG, 1983) |
| "The aim of this study was to prepare a topical water-in-oil type microemulsion containing metronidazole and to compare its effectiveness with a commercial gel product in the treatment of rosacea." | 5.16 | Preparation and evaluation of topical microemulsion system containing metronidazole for remission in rosacea. ( Adişen, E; Çelebi, N; Erel, A; Kayiş, A; Tirnaksiz, F, 2012) |
| "Thirty women with mild or moderate erythema of rosacea on their facial cheeks were randomly assigned to use one of the following for 28 days: the rosacea treatment system (RTS); RTS minus metronidazole (RTS-M); or metronidazole 0." | 5.15 | Efficacy of a novel rosacea treatment system: an investigator-blind, randomized, parallel-group study. ( Leyden, JJ, 2011) |
| "A phase 4, open-label, multicenter, community-based study was conducted in subjects with mild to moderately severe papulopustular rosacea of various etiologies and locations to identify subgroups particularly responsive to twice-daily application of metronidazole topical gel 0." | 5.12 | The CLEAR trial: results of a large community-based study of metronidazole gel in rosacea. ( Del Rosso, JQ; Wolf, JE, 2007) |
| "75% metronidazole gel in improving principal signs of rosacea (inflammatory lesions and erythema)." | 5.10 | A comparison of 15% azelaic acid gel and 0.75% metronidazole gel in the topical treatment of papulopustular rosacea: results of a randomized trial. ( Elewski, BE; Fleischer, AB; Pariser, DM, 2003) |
| "The papules and pustules of rosacea can be effectively treated with topical metronidazole." | 5.09 | Once-daily topical metronidazole cream formulations in the treatment of the papules and pustules of rosacea. ( Baker, MD; Dahl, MV; Jarratt, M; Kaplan, D; Tuley, MR, 2001) |
| "Eighty-one patients with rosacea were treated with either I% metronidazole cream or the cream base as a placebo for two months." | 5.05 | Treatment of rosacea with i% metronidazole cream. A double-blind study. ( Nielsen, PG, 1983) |
| "The use of mesoderm therapy combined with compound glycyrrhizic acid has a therapeutic effect on facial rosacea and improves patient satisfaction." | 4.31 | Therapeutic effects of mesoderm introduction of compound glycyrrhizin injection on the treatment of rosacea. ( Chen, Y; Li, S; Liu, J; Zhao, X, 2023) |
| "Rosacea is a chronic skin disorder involving central facial erythema secondary to vascular instability and cutaneous inflammation." | 3.01 | Neurogenic Rosacea Treatment: A Literature Review. ( Gold, MH; Ivanic, MG; Javadi, SS; Norden, A; Oulee, A; Wu, JJ, 2023) |
| "Rosacea is a chronic and relapsing facial dermatosis that encompasses a wide spectrum of clinical phenotypes (transient/persistent erythema, telangiectasias, papules/pustules, edema, phymatous changes, and ocular symptoms) often with uncomfortable symptoms such as flushing, pain, burning, edema, and dryness." | 2.82 | Advances in pharmacotherapy for rosacea: what is the current state of the art? ( Dall'Oglio, F; Gerbino, C; Micali, G; Nasca, MR, 2022) |
| "Numerous methods for the treatment of rosacea are defined by the diversity of etiologic and pathogenic factors of dermatosis, its stage and clinical form." | 2.79 | [Angioprotectors in the treatment of rosacea]. ( Katsitadze, A; Tchitanava, L; Tsiskarishvili, NI; Tsiskarishvili, NV; Tsiskarishvili, Ts, 2014) |
| "Rosacea is a chronic skin disease of unknown etiology, affecting the central areas of the face skin (cheeks, chin, nose, forehead) and is characterized by periods of remission and exacerbation." | 2.78 | [New possibilities in the treatment of early stages of rosacea]. ( Katsitadze, A; Tsiskarishvili, NV; Tsiskarishvili, Ts, 2013) |
| "Rosacea is a common, recurrent, inflammatory dermatologic disorder characterized by the presence of facial erythema, visible blood vessels, papules, and pustules." | 2.72 | A look at the safety of metronidazole 1% gel: cumulative irritation, contact sensitization, phototoxicity, and photoallergy potential. ( Beutner, KR; Calvarese, B; Lemke, S, 2006) |
| "For the treatment of rosacea, the interdisciplinary guideline committee, with representatives of the German Dermatological Society (DDG), the Professional Association of German Dermatologists (BVDD), the German Opthalmological Society (DOG), the Society for Dermopharmacy (GD), the Swiss Society for Dermatology and Venereology (SGDV) and the German Rosacea Aid e." | 1.72 | S2k guideline: Rosacea. ( Bernhard, D; Clanner-Engelshofen, BM; Dargatz, S; Flaig, MJ; Gieler, U; Kinberger, M; Klövekorn, W; Kuna, AC; Läuchli, S; Lehmann, P; Nast, A; Pleyer, U; Reinholz, M; Schaller, M; Schöfer, H; Schwennesen, T; Steinhoff, M; Werner, RN; Zierhut, M, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (12.90) | 18.7374 |
| 1990's | 4 (12.90) | 18.2507 |
| 2000's | 11 (35.48) | 29.6817 |
| 2010's | 7 (22.58) | 24.3611 |
| 2020's | 5 (16.13) | 2.80 |
| Authors | Studies |
|---|---|
| Clanner-Engelshofen, BM | 1 |
| Bernhard, D | 1 |
| Dargatz, S | 1 |
| Flaig, MJ | 1 |
| Gieler, U | 1 |
| Kinberger, M | 1 |
| Klövekorn, W | 1 |
| Kuna, AC | 1 |
| Läuchli, S | 1 |
| Lehmann, P | 1 |
| Nast, A | 1 |
| Pleyer, U | 1 |
| Schaller, M | 2 |
| Schöfer, H | 1 |
| Steinhoff, M | 1 |
| Schwennesen, T | 1 |
| Werner, RN | 1 |
| Zierhut, M | 1 |
| Reinholz, M | 1 |
| Dall'Oglio, F | 1 |
| Nasca, MR | 1 |
| Gerbino, C | 1 |
| Micali, G | 1 |
| Li, S | 1 |
| Zhao, X | 1 |
| Chen, Y | 1 |
| Liu, J | 1 |
| Ivanic, MG | 1 |
| Oulee, A | 1 |
| Norden, A | 1 |
| Javadi, SS | 1 |
| Gold, MH | 1 |
| Wu, JJ | 1 |
| Hedberg, ML | 1 |
| Chibnall, RJ | 1 |
| Compton, LA | 1 |
| Del Rosso, JQ | 2 |
| Thiboutot, D | 1 |
| Gallo, R | 1 |
| Webster, G | 1 |
| Tanghetti, E | 1 |
| Eichenfield, LF | 1 |
| Stein-Gold, L | 1 |
| Berson, D | 1 |
| Zaenglein, A | 1 |
| Tsiskarishvili, NV | 2 |
| Katsitadze, A | 2 |
| Tsiskarishvili, Ts | 2 |
| Tchitanava, L | 1 |
| Tsiskarishvili, NI | 1 |
| Mayor-Ibarguren, A | 1 |
| Maseda-Pedrero, R | 1 |
| Feito-Rodríguez, M | 1 |
| Ortiz, PG | 1 |
| Hansen, SH | 1 |
| Shah, VP | 1 |
| Menné, T | 1 |
| Benfeldt, E | 1 |
| Draelos, ZD | 1 |
| Colón, LE | 1 |
| Preston, N | 1 |
| Johnson, LA | 1 |
| Gottschalk, RW | 1 |
| Leyden, JJ | 1 |
| Tirnaksiz, F | 1 |
| Kayiş, A | 1 |
| Çelebi, N | 1 |
| Adişen, E | 1 |
| Erel, A | 1 |
| Sander, CA | 1 |
| Plewig, G | 1 |
| Elewski, BE | 1 |
| Fleischer, AB | 1 |
| Pariser, DM | 1 |
| Utikal, J | 1 |
| Poenitz, N | 1 |
| Kurzen, H | 1 |
| Goerdt, S | 1 |
| De Aloe, G | 1 |
| Rubegni, P | 1 |
| Risulo, M | 1 |
| Sbano, P | 1 |
| Poggiali, S | 1 |
| Fimiani, M | 1 |
| Beutner, KR | 1 |
| Lemke, S | 1 |
| Calvarese, B | 1 |
| Weber, TM | 1 |
| Ceilley, RI | 1 |
| Buerger, A | 1 |
| Kolbe, L | 1 |
| Trookman, NS | 1 |
| Rizer, RL | 1 |
| Schoelermann, A | 1 |
| Wolf, JE | 1 |
| Nielsen, PG | 1 |
| Watsky, KL | 1 |
| Lehrnbecher, T | 1 |
| Kontny, HU | 1 |
| Jeschke, R | 1 |
| Guarrera, M | 1 |
| Brusati, C | 1 |
| Rebora, A | 1 |
| Dahl, MV | 1 |
| Jarratt, M | 1 |
| Kaplan, D | 1 |
| Tuley, MR | 1 |
| Baker, MD | 1 |
| Walfish, AE | 1 |
| Sapadin, AN | 1 |
| Veien, NK | 1 |
| Munkvad, JM | 1 |
| Nielsen, AO | 1 |
| Niordson, AM | 1 |
| Stahl, D | 1 |
| Thormann, J | 1 |
| Kanwar, AJ | 1 |
| Sharma, R | 1 |
| Rajagopalan, M | 1 |
| Kaur, S | 1 |
| Aronson, IK | 1 |
| Rumsfield, JA | 1 |
| West, DP | 1 |
| Alexander, J | 1 |
| Fischer, JH | 1 |
| Paloucek, FP | 1 |
| Bleicher, PA | 1 |
| Charles, JH | 1 |
| Sober, AJ | 1 |
| Wishart, JM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Evaluation of the Cosmetic Appearance of Metronidazole Gel (MetroGel®) 1%[NCT00668655] | 30 participants (Actual) | Observational | 2008-02-29 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for metronidazole and Erythema
| Article | Year |
|---|---|
Advances in pharmacotherapy for rosacea: what is the current state of the art?
Topics: Dermatologic Agents; Erythema; Guidelines as Topic; Humans; Metronidazole; Quality of Life; Rosacea | 2022 |
Neurogenic Rosacea Treatment: A Literature Review.
Topics: Anti-Bacterial Agents; Brimonidine Tartrate; Erythema; Humans; Metronidazole; Rosacea | 2023 |
Symptomatic vulvar demodicosis: A case report and review of the literature.
Topics: Administration, Oral; Administration, Topical; Adult; Animals; Antiparasitic Agents; Antiprotozoal A | 2020 |
15 trials available for metronidazole and Erythema
| Article | Year |
|---|---|
[Angioprotectors in the treatment of rosacea].
Topics: Administration, Topical; Adrenal Cortex Hormones; Adult; Anti-Bacterial Agents; Ascorbic Acid; Derma | 2014 |
The appearance of facial foundation cosmetics applied after metronidazole gel 1%.
Topics: Administration, Cutaneous; Adult; Aged; Cosmetics; Dermatologic Agents; Erythema; Female; Gels; Huma | 2011 |
Efficacy of a novel rosacea treatment system: an investigator-blind, randomized, parallel-group study.
Topics: Administration, Cutaneous; Dermatologic Agents; Erythema; Female; Gels; Humans; Metronidazole; Middl | 2011 |
Preparation and evaluation of topical microemulsion system containing metronidazole for remission in rosacea.
Topics: Administration, Topical; Adult; Double-Blind Method; Emulsions; Erythema; Female; Humans; Male; Metr | 2012 |
[New possibilities in the treatment of early stages of rosacea].
Topics: Administration, Topical; Adrenergic beta-Antagonists; Adult; Anti-Bacterial Agents; Erythema; Female | 2013 |
A comparison of 15% azelaic acid gel and 0.75% metronidazole gel in the topical treatment of papulopustular rosacea: results of a randomized trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Dermatologic Agents; Dicarboxylic Acids; Do | 2003 |
A look at the safety of metronidazole 1% gel: cumulative irritation, contact sensitization, phototoxicity, and photoallergy potential.
Topics: Dermatitis, Contact; Dermatitis, Photoallergic; Dermatitis, Phototoxic; Dermatologic Agents; Erythem | 2006 |
Skin tolerance, efficacy, and quality of life of patients with red facial skin using a skin care regimen containing Licochalcone A.
Topics: Adult; Aged; Chalcones; Drug Therapy, Combination; Erythema; Face; Female; Humans; Male; Metronidazo | 2006 |
The CLEAR trial: results of a large community-based study of metronidazole gel in rosacea.
Topics: Administration, Cutaneous; Adult; Anti-Infective Agents; Erythema; Female; Follow-Up Studies; Gels; | 2007 |
Treatment of rosacea with i% metronidazole cream. A double-blind study.
Topics: Administration, Topical; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Erythema; Femal | 1983 |
Topical metronidazole does not abate UVB-induced erythema.
Topics: Administration, Cutaneous; Adult; Anti-Infective Agents; Erythema; Female; Humans; Male; Metronidazo | 2001 |
Once-daily topical metronidazole cream formulations in the treatment of the papules and pustules of rosacea.
Topics: Administration, Topical; Adult; Aged; Anti-Infective Agents; Dose-Response Relationship, Drug; Drug | 2001 |
Topical metronidazole in the treatment of perioral dermatitis.
Topics: Administration, Cutaneous; Administration, Oral; Adolescent; Adult; Dermatitis; Double-Blind Method; | 1991 |
Evaluation of topical metronidazole gel in acne rosacea.
Topics: Administration, Topical; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Erythema; Femal | 1987 |
Topical metronidazole therapy for rosacea.
Topics: Adult; Double-Blind Method; Drug Evaluation; Erythema; Female; Humans; Male; Metronidazole; Random A | 1987 |
13 other studies available for metronidazole and Erythema
| Article | Year |
|---|---|
S2k guideline: Rosacea.
Topics: Brimonidine Tartrate; Dermatologic Agents; Erythema; Humans; Ivermectin; Metronidazole; Rosacea | 2022 |
Therapeutic effects of mesoderm introduction of compound glycyrrhizin injection on the treatment of rosacea.
Topics: Erythema; Glycyrrhizic Acid; Humans; Metronidazole; Quality of Life; Rosacea | 2023 |
Consensus recommendations from the American Acne & Rosacea Society on the management of rosacea, part 5: a guide on the management of rosacea.
Topics: Administration, Cutaneous; Administration, Oral; Adrenergic alpha-2 Receptor Agonists; Anti-Infectiv | 2014 |
Periorificial Lesions in a Young Girl.
Topics: Adrenal Cortex Hormones; Age of Onset; Child; Contraindications; Dermatitis, Perioral; Drug Substitu | 2016 |
The effect of irritant dermatitis on cutaneous bioavailability of a metronidazole formulation, investigated by microdialysis and dermatopharmacokinetic method.
Topics: Administration, Cutaneous; Adult; Analysis of Variance; Area Under Curve; Biological Availability; D | 2008 |
Demodex abscesses: clinical and therapeutic challenges.
Topics: Administration, Oral; Animals; Anti-Infective Agents; Diagnosis, Differential; Erythema; Facial Derm | 2003 |
[Persistent facial erythema and edema].
Topics: Administration, Topical; Anti-Bacterial Agents; Anti-Infective Agents; Diagnosis, Differential; Edem | 2005 |
Erythema annulare centrifugum successfully treated with metronidazole.
Topics: Adult; Chronic Disease; Dermatologic Agents; Erythema; Humans; Male; Metronidazole | 2005 |
Acute generalized exanthematous pustulosis induced by metronidazole: the role of patch testing.
Topics: Adult; Anti-Infective Agents; Drug Eruptions; Edema; Erythema; Exanthema; Humans; Male; Metronidazol | 1999 |
Metastatic Crohn's disease in a 9-year-old boy.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Azathioprine; Child; Crohn Disease; Erythema; Human | 1999 |
Fixed drug eruption due to doxycycline and metronidazole.
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Doxycycline; Drug Eruptions; Erythema; Female; | 2002 |
Fixed drug eruption due to tinidazole with cross-reactivity with metronidazole.
Topics: Adult; Drug Eruptions; Drug Interactions; Erythema; Humans; Male; Metronidazole; Nitroimidazoles; Ti | 1990 |
Reticulosarcoma of the vulva complicating dermatomyositis treated by immunosuppression.
Topics: Adult; Azathioprine; Dermatomyositis; Erythema; Female; Humans; Immunosuppressive Agents; Lymphoma, | 1973 |