Page last updated: 2024-12-06

pyrazolo(3,4-d)pyrimidine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID67499
SCHEMBL ID7771
MeSH IDM0062497

Synonyms (29)

Synonym
nsc82206
271-80-7
nsc-82206
pyrazolo(3,4-d)pyrimidine
nsc 82206
1h-pyrazolo(3,4-d)pyrimidine
1h-pyrazolo[3,4-d]pyrimidine
1h-pyrazolo[3, 4-d]pyrimidine
A22570
AKOS006281904
pyrazolo[3,4-d]pyrimidine
BL007573
2h-pyrazolo[3,4-d]pyrimidine
271-78-3
SCHEMBL7771
MB03781
QUKPALAWEPMWOS-UHFFFAOYSA-N
J-504737
mfcd06407902
TS-01613
2,4,8,9-tetrazabicyclo[4.3.0]nona-1,3,5,7-tetraene
DTXSID60181566
CS-0045912
5h-pyrazolo[3,4-d]pyrimidine
AMY15861
SY009465
Z1198168658
F87671
mfcd18814987

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" Pharmacokinetic analysis revealed that KKC080106 has good bioavailability and enters the brain after oral and intravenous administration, in both rats and mice."( A novel pyrazolo [3,4-d] pyrimidine, KKC080106, activates the Nrf2 pathway and protects nigral dopaminergic neurons.
Cheong, CS; Han, SH; Hwang, O; Kim, DJ; Kim, HR; Lee, JA; Shin, N; Son, HJ, 2020
)
0.56

Dosage Studied

ExcerptRelevanceReference
" When mice were dosed orally, A-420983 inhibited TCR-mediated c-jun and ZAP-70 phosphorylation in CD4+ T cells and suppressed the disease course of established EAE."( Suppression of CD4+ T cell activation by a novel inhibitor of Src family kinases.
Dixon, KF; Hirst, GC; Jia, Y; McRae, BL; Mohan, S; Presky, DH; Roux, A; Tracey, DE; Wallace, C, 2005
)
0.33
" Especially, compounds 6c, 6g, and 6i inhibited Sclerotinia by 100% at the concentration of 50 mg/L and by 83, 83, and 82% at the dosage of 10 mg/L, respectively."( Synthesis and antifungal activities of novel 5-amino-6-arylamino-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one derivatives.
Lin, CR; Wang, HQ; Wang, YY; Zhou, WP, 2008
)
0.35
" This novel compound dosed as a single agent is able to produce significant growth inhibition of neuroblastoma xenografts in vivo."( Reversal of oncogene transformation and suppression of tumor growth by the novel IGF1R kinase inhibitor A-928605.
Bell, RL; Buchanan, FG; Davidsen, SK; Donawho, C; Grudzien, MM; Hubbard, RD; Johnson, EF; Jung, PM; Meulbroek, JA; Pappano, WN; Sheppard, GS; Soni, NB; Wang, J; Wang, YC; Zhang, Q, 2009
)
0.35
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (73)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's23 (31.51)29.6817
2010's42 (57.53)24.3611
2020's8 (10.96)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.96

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.96 (24.57)
Research Supply Index4.33 (2.92)
Research Growth Index4.71 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.96)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews4 (5.33%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other71 (94.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]