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metronidazole and Agranulocytosis

metronidazole has been researched along with Agranulocytosis in 9 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Agranulocytosis: A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).

Research Excerpts

ExcerptRelevanceReference
"Metronidazole was withdrawn and agranulocytosis improved within three days."5.27[Drug-induced agranulocytosis. Discussion of the responsibility of metronidazole]. ( Brioche, MI; Gouin, F; Martin, C; Ruperti, A; Saux, P, 1985)
"Metronidazole was withdrawn and agranulocytosis improved within three days."1.27[Drug-induced agranulocytosis. Discussion of the responsibility of metronidazole]. ( Brioche, MI; Gouin, F; Martin, C; Ruperti, A; Saux, P, 1985)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19909 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Smith, JA1
Guerre, J1
Gaudric, M1
Tual, JL1
McKendrick, MW1
Geddes, AM1
Bergan, T1
Windle, R1
Macpherson, S1
Bell, PR1
Levrat, R1
Joliot, AY1
Vital Durand, D1
Martin, D1
Martin, C1
Ruperti, A1
Saux, P1
Brioche, MI1
Gouin, F1
Lefebvre, Y1
Hesseltine, HC1
Taylor, JA1

Other Studies

9 other studies available for metronidazole and Agranulocytosis

ArticleYear
Neutropenia associated with metronidazole therapy.
    Canadian Medical Association journal, 1980, Aug-09, Volume: 123, Issue:3

    Topics: Agranulocytosis; Female; Humans; Leukocyte Count; Metronidazole; Middle Aged; Neutropenia

1980
[Early neutropenia during treatment by metronidazole].
    La Nouvelle presse medicale, 1979, Feb-24, Volume: 8, Issue:9

    Topics: Adult; Agranulocytosis; Drug Hypersensitivity; Female; Humans; Metronidazole; Neutropenia

1979
Neutropenia associated with metronidazole.
    British medical journal, 1979, Sep-29, Volume: 2, Issue:6193

    Topics: Aged; Agranulocytosis; Bacterial Infections; Humans; Male; Metronidazole; Neutropenia

1979
Neutropenia associated with metronidazole.
    British medical journal, 1979, Nov-10, Volume: 2, Issue:6199

    Topics: Agranulocytosis; Azathioprine; Drug Therapy, Combination; Humans; Metronidazole; Neutropenia

1979
Neutropenia associated with metronidazole.
    British medical journal, 1979, Nov-10, Volume: 2, Issue:6199

    Topics: Agranulocytosis; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Humans; Metronidazole;

1979
[Prolonged neutropenia during treatment with metronidazole].
    La Nouvelle presse medicale, 1978, Oct-07, Volume: 7, Issue:34

    Topics: Agranulocytosis; Female; Humans; Metronidazole; Middle Aged; Neutropenia

1978
[Drug-induced agranulocytosis. Discussion of the responsibility of metronidazole].
    Annales francaises d'anesthesie et de reanimation, 1985, Volume: 4, Issue:6

    Topics: Adult; Agranulocytosis; Anti-Bacterial Agents; Bone Marrow Examination; Drug Therapy, Combination; F

1985
The peripheral white blood cells and metronidazole.
    JAMA, 1965, Oct-04, Volume: 194, Issue:1

    Topics: Adolescent; Adult; Aged; Agranulocytosis; Female; Humans; Leukocyte Count; Leukocytes; Lymphocytes;

1965
Metronidazole and transient leukopenia.
    JAMA, 1965, Dec-20, Volume: 194, Issue:12

    Topics: Aged; Agranulocytosis; Bone Marrow Examination; Humans; Leukemia; Leukocyte Count; Male; Metronidazo

1965