metronidazole has been researched along with Agranulocytosis in 9 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Agranulocytosis: A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).
Excerpt | Relevance | Reference |
---|---|---|
"Metronidazole was withdrawn and agranulocytosis improved within three days." | 5.27 | [Drug-induced agranulocytosis. Discussion of the responsibility of metronidazole]. ( Brioche, MI; Gouin, F; Martin, C; Ruperti, A; Saux, P, 1985) |
"Metronidazole was withdrawn and agranulocytosis improved within three days." | 1.27 | [Drug-induced agranulocytosis. Discussion of the responsibility of metronidazole]. ( Brioche, MI; Gouin, F; Martin, C; Ruperti, A; Saux, P, 1985) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 9 (100.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Smith, JA | 1 |
Guerre, J | 1 |
Gaudric, M | 1 |
Tual, JL | 1 |
McKendrick, MW | 1 |
Geddes, AM | 1 |
Bergan, T | 1 |
Windle, R | 1 |
Macpherson, S | 1 |
Bell, PR | 1 |
Levrat, R | 1 |
Joliot, AY | 1 |
Vital Durand, D | 1 |
Martin, D | 1 |
Martin, C | 1 |
Ruperti, A | 1 |
Saux, P | 1 |
Brioche, MI | 1 |
Gouin, F | 1 |
Lefebvre, Y | 1 |
Hesseltine, HC | 1 |
Taylor, JA | 1 |
9 other studies available for metronidazole and Agranulocytosis
Article | Year |
---|---|
Neutropenia associated with metronidazole therapy.
Topics: Agranulocytosis; Female; Humans; Leukocyte Count; Metronidazole; Middle Aged; Neutropenia | 1980 |
[Early neutropenia during treatment by metronidazole].
Topics: Adult; Agranulocytosis; Drug Hypersensitivity; Female; Humans; Metronidazole; Neutropenia | 1979 |
Neutropenia associated with metronidazole.
Topics: Aged; Agranulocytosis; Bacterial Infections; Humans; Male; Metronidazole; Neutropenia | 1979 |
Neutropenia associated with metronidazole.
Topics: Agranulocytosis; Azathioprine; Drug Therapy, Combination; Humans; Metronidazole; Neutropenia | 1979 |
Neutropenia associated with metronidazole.
Topics: Agranulocytosis; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Humans; Metronidazole; | 1979 |
[Prolonged neutropenia during treatment with metronidazole].
Topics: Agranulocytosis; Female; Humans; Metronidazole; Middle Aged; Neutropenia | 1978 |
[Drug-induced agranulocytosis. Discussion of the responsibility of metronidazole].
Topics: Adult; Agranulocytosis; Anti-Bacterial Agents; Bone Marrow Examination; Drug Therapy, Combination; F | 1985 |
The peripheral white blood cells and metronidazole.
Topics: Adolescent; Adult; Aged; Agranulocytosis; Female; Humans; Leukocyte Count; Leukocytes; Lymphocytes; | 1965 |
Metronidazole and transient leukopenia.
Topics: Aged; Agranulocytosis; Bone Marrow Examination; Humans; Leukemia; Leukocyte Count; Male; Metronidazo | 1965 |