metronidazole has been researched along with Dermal Sinus in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report on a 16-month-old child with tetraplegia secondary to intramedullary abscesses because of a dermoid cyst infection associated with a dermal sinus." | 1.37 | Recovery after tetraplegia caused by dermal sinus infection: intramedullary abscess and tetraparesis. ( Brochard, S; Dam Hieu, P; Houx, L; Peudenier, S; Rémy-Néris, O, 2011) |
| "Total excision of dermal sinus tract, dermoid cyst, and the intramedullary abscess by means of a L2-S3 laminectomy, followed by antibiotic therapy resulted in good functional recovery." | 1.35 | Infected lumbar dermoid cyst presenting with tetraparesis secondary to holocord central lesion. ( Cekinmez, M; Erdogan, B; Sener, L; Tufan, K, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alsubaie, S | 1 |
| Dolgum, S | 1 |
| Binkhamis, K | 1 |
| Alweijri, I | 1 |
| Bugshan, A | 1 |
| Alzamil, F | 1 |
| Tufan, K | 1 |
| Cekinmez, M | 1 |
| Sener, L | 1 |
| Erdogan, B | 1 |
| Houx, L | 1 |
| Brochard, S | 1 |
| Peudenier, S | 1 |
| Dam Hieu, P | 1 |
| Rémy-Néris, O | 1 |
3 other studies available for metronidazole and Dermal Sinus
| Article | Year |
|---|---|
Finegoldia magna causing intramedullary thoracic spinal cord abscess in an infant.
Topics: Abscess; Anti-Bacterial Agents; Ceftriaxone; Female; Firmicutes; Gram-Positive Bacterial Infections; | 2019 |
Infected lumbar dermoid cyst presenting with tetraparesis secondary to holocord central lesion.
Topics: Abscess; Cefotaxime; Child; Dermoid Cyst; Drug Therapy, Combination; Follow-Up Studies; Gram-Negativ | 2008 |
Recovery after tetraplegia caused by dermal sinus infection: intramedullary abscess and tetraparesis.
Topics: Anti-Infective Agents; Bacteroidaceae Infections; Brain Abscess; Cefotaxime; Humans; Infant; Magneti | 2011 |