Page last updated: 2024-09-27

Chromosome Instability Syndromes

Disorders resulting from defective DNA REPAIR processes or the associated cellular responses to DNA DAMAGE.

Synonyms(4)

Synonym
DNA Repair-Deficiency Disorders
Deficient DNA Repair
Chromosome Instability Syndromes
DNA Repair-Deficiency

Research

Studies (34)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's7 (20.59)18.1394
2010's21 (61.76)28.8240
2020's6 (17.65)9.53
DrugIndicatedRelationship StrengthStudiesTrials
adenine0low10
thymine0low10
toluene0low10
alachlor0low10
methyl methanesulfonate0low10
metronidazole0low10
temozolomide0low10
thalidomide0low10
mitomycin0low10
cytarabine0low10
phenylbutyramide0low10
benzotrichloride0low10
diglycidyl resorcinol ether0low10
indazoles0low20
ethylnitrosourea0low10
deoxycytidine0low10
chromium0low10
camptothecin0low20
paclitaxel0low10
lovastatin0low10
irinotecan0low10
metronidazole monosuccinate0low10
docetaxel anhydrous0low10
singlet oxygen0low10
carboplatin0low20
dactinomycin0low10
melphalan0low10
5-hydroxy-2'-deoxycytidine0low10
isomethyleugenol0low10
sulfur0low10
emerin0low10
ic 866210low10
nu 70260low10
rucaparib0low20
nutlin 10low10
alpha-synuclein0low10
olaparib0low30
niraparib0low20
piperidines0low20
cyclosporine0low10
deoxyguanosine0low20
guanine0low10
dacarbazine0low10
8-hydroxyguanine0low10
8-hydroxy-2'-deoxyguanosine0low20
bmn 6730low20

Protein Targets (453)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Avidin0022
Chain A, Avidin0022
Chain B, Avidin0022
Microtubule-associated protein tau3003
Olfactory receptor 51E20011
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE110011
Chain A, MTA/SAH nucleosidase0101
Chain A, Ribosome-inactivating protein alpha-trichosanthin0011
Chain A, Ricin A chain0011
Chain A, Ribosome-inactivating protein 30011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
RAR-related orphan receptor gamma120012
TDP1 protein140014
AR protein130013
nuclear receptor subfamily 1, group I, member 39009
cytochrome P450 family 3 subfamily A polypeptide 4110011
glucocorticoid receptor [Homo sapiens]120012
estrogen-related nuclear receptor alpha160016
pregnane X nuclear receptor9009
estrogen nuclear receptor alpha170017
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a8008
nuclear factor erythroid 2-related factor 2 isoform 26006
heat shock protein beta-14004
importin subunit beta-1 isoform 12002
snurportin-12002
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 11001
lamin isoform A-delta109009
Voltage-dependent calcium channel gamma-2 subunit8008
Bile salt export pump011011
Cyclin-dependent kinase 10202
Heat shock protein HSP 90-beta0101
Glutamate receptor 28008
Xanthine dehydrogenase/oxidase0101
TAR DNA-binding protein 433003
Protein mono-ADP-ribosyltransferase PARP150404
Leucine-rich repeat serine/threonine-protein kinase 20202
ATPase family AAA domain-containing protein 54004
Ataxin-25005
interleukin 85005
Nrf21001
glp-1 receptor, partial3003
thioredoxin reductase5005
SMAD family member 23003
SMAD family member 33003
GLI family zinc finger 3100010
estrogen receptor 2 (ER beta)7007
progesterone receptor7007
retinoic acid nuclear receptor alpha variant 1130013
retinoid X nuclear receptor alpha100010
farnesoid X nuclear receptor8008
peroxisome proliferator-activated receptor delta7007
peroxisome proliferator activated receptor gamma100010
vitamin D (1,25- dihydroxyvitamin D3) receptor100010
thyroid stimulating hormone receptor4004
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
Histone H2A.x7007
Caspase-73003
cellular tumor antigen p53 isoform a3003
chromobox protein homolog 15005
caspase-33003
thyroid hormone receptor beta isoform 2110011
nuclear factor erythroid 2-related factor 2 isoform 1100010
Cellular tumor antigen p53112013
Nuclear receptor ROR-gamma5005
Chain A, Hyaluronidase, phage associated0101
acetylcholinesterase2002
thioredoxin glutathione reductase3003
IDH13003
euchromatic histone-lysine N-methyltransferase 28008
lethal(3)malignant brain tumor-like protein 1 isoform I1001
geminin110011
lethal factor (plasmid)6006
Polyphenol oxidase 20101
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Alpha-2B adrenergic receptor0011
Spike glycoprotein7007
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
thyroid stimulating hormone receptor8008
aryl hydrocarbon receptor4004
interferon gamma precursor0002
Poly [ADP-ribose] polymerase tankyrase-10426
Poly [ADP-ribose] polymerase 108818
Potassium voltage-gated channel subfamily H member 20101
Protein mono-ADP-ribosyltransferase PARP140235
Protein mono-ADP-ribosyltransferase PARP100347
Protein mono-ADP-ribosyltransferase PARP80033
Protein mono-ADP-ribosyltransferase PARP160145
Protein mono-ADP-ribosyltransferase PARP120336
Poly [ADP-ribose] polymerase 207817
Protein mono-ADP-ribosyltransferase PARP40347
Protein mono-ADP-ribosyltransferase PARP303712
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, 2-oxoglutarate Oxygenase3003
Chain A, Ferritin light chain3003
Chain A, Cruzipain3003
DNA topoisomerase 0101
15-lipoxygenase, partial4004
ATAD5 protein, partial1001
Fumarate hydratase5005
NFKB1 protein, partial1001
PPM1D protein5005
Thrombopoietin1001
aldehyde dehydrogenase 1 family, member A17007
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
regulator of G-protein signaling 41001
EWS/FLI fusion protein110011
polyprotein5005
67.9K protein7007
glucocerebrosidase2002
putative alpha-glucosidase1001
alpha-galactosidase1001
Bloom syndrome protein isoform 13003
lysosomal alpha-glucosidase preproprotein1001
peripheral myelin protein 22 isoform 11001
hemoglobin subunit beta1001
cytochrome P450 2C19 precursor1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
huntingtin isoform 22002
ras-related protein Rab-9A1001
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor0011
serine/threonine-protein kinase mTOR isoform 12002
DNA polymerase iota isoform a (long)3003
nuclear receptor ROR-gamma isoform 14004
survival motor neuron protein isoform d6006
cytochrome P450 3A4 isoform 15005
M-phase phosphoprotein 81001
muscleblind-like protein 1 isoform 13003
histone acetyltransferase KAT2A isoform 12002
relaxin receptor 1 isoform 11001
Gamma-aminobutyric acid receptor subunit pi5005
Telomerase reverse transcriptase0101
Serine/threonine-protein kinase Chk10011
Histone deacetylase 30101
ATP-binding cassette sub-family C member 30909
Multidrug resistance-associated protein 40909
Type-2 restriction enzyme ScaI0101
Deoxyribonuclease-2-alpha0101
Tyrosyl-DNA phosphodiesterase 20101
Deoxyribonuclease-10101
Type-2 restriction enzyme PstI0101
Type-2 restriction enzyme EcoRI0101
Prothrombin0001
DNA ligase0101
Interferon beta9009
Integrin beta-31102
Integrin alpha-IIb1001
Heterogeneous nuclear ribonucleoprotein A10011
DNA topoisomerase 10117
DNA topoisomerase 2-alpha0101
Gamma-aminobutyric acid receptor subunit beta-15005
Gamma-aminobutyric acid receptor subunit delta5005
Gamma-aminobutyric acid receptor subunit gamma-25005
Gamma-aminobutyric acid receptor subunit alpha-55005
Gamma-aminobutyric acid receptor subunit alpha-35005
Gamma-aminobutyric acid receptor subunit gamma-15005
Gamma-aminobutyric acid receptor subunit alpha-25005
Type-2 restriction enzyme BamHI0101
Gamma-aminobutyric acid receptor subunit alpha-45005
Gamma-aminobutyric acid receptor subunit gamma-35005
Gamma-aminobutyric acid receptor subunit alpha-65005
Somatostatin receptor type 10101
Somatostatin receptor type 20101
Somatostatin receptor type 40101
Somatostatin receptor type 30101
Somatostatin receptor type 50101
5-hydroxytryptamine receptor 2B0202
Type-2 restriction enzyme HindIII0101
D(1A) dopamine receptor2002
Histone deacetylase 40101
Ribonuclease pancreatic0101
Gamma-aminobutyric acid receptor subunit alpha-15005
Gamma-aminobutyric acid receptor subunit beta-35005
Gamma-aminobutyric acid receptor subunit beta-25005
Inositol monophosphatase 12002
DNA topoisomerase 2-beta0001
DNA topoisomerase 10102
Histone deacetylase 10202
DNA topoisomerase 10101
Integrase 0101
Histone deacetylase 70101
GABA theta subunit5005
Histone deacetylase 20202
Canalicular multispecific organic anion transporter 10909
DNA topoisomerase type IB small subunit 0011
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Histone deacetylase 80101
Gamma-aminobutyric acid receptor subunit epsilon5005
Tyrosyl-DNA phosphodiesterase 10101
Histone deacetylase 60202
Histone deacetylase 90101
Histone deacetylase 50101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain A, Putative fructose-1,6-bisphosphate aldolase3003
phosphopantetheinyl transferase5005
G4004
cytochrome P450 2D68008
vitamin D3 receptor isoform VDRA4004
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
DNA polymerase kappa isoform 13003
HLA class I histocompatibility antigen, B alpha chain 4004
Inositol hexakisphosphate kinase 14004
cytochrome P450 2C9, partial4004
ATP-dependent phosphofructokinase2002
endonuclease IV1001
USP1 protein, partial4004
LMP1 [Human herpesvirus 4]0002
thyroid hormone receptor beta isoform a6006
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
peripheral myelin protein 225005
nuclear receptor coactivator 3 isoform a0101
Thymidine kinase 2, mitochondrial0101
Thymidine kinase, cytosolic0203
Thymidine kinase0101
Thymidylate synthase0001
Cytochrome P450 3A40202
Thymidine kinase0101
Deoxycytidine kinase0003
Probable deoxycytidylate deaminase0002
Cytidine deaminase0103
E3 ubiquitin-protein ligase Mdm20303
Enoyl-[acyl-carrier-protein] reductase [NADH] 0101
Thymidine kinase0101
Deoxynucleoside kinase0101
hypoxia-inducible factor 1 alpha subunit5005
activating transcription factor 64004
Matrix metalloproteinase-90101
Isocitrate lyase0101
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
caspase 7, apoptosis-related cysteine protease6006
caspase-36006
RAD510101
v-jun sarcoma virus 17 oncogene homolog (avian)2002
caspase-1 isoform alpha precursor1001
ATP-dependent translocase ABCB10205
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 10101
Caspase-71001
Growth factor receptor-bound protein 20101
Pantothenate synthetase0101
Discoidin domain-containing receptor 20101
Growth factor receptor-bound protein 2 0101
Reverse transcriptase/RNaseH 0112
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase0011
Thymidine kinase 2 0101
AAA family ATPase 0001
AAA family ATPase 0001
Sterol O-acyltransferase 10101
histone deacetylase 9 isoform 31001
nuclear receptor subfamily 1, group I, member 24004
Serum paraoxonase/arylesterase 10202
Kinesin-like protein KIF110101
Nucleotide-binding oligomerization domain-containing protein 20202
pregnane X receptor3003
Purine nucleoside phosphorylase0202
Hypoxanthine-guanine phosphoribosyltransferase0001
Ricin0101
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase0011
Purine nucleoside phosphorylase 0012
Shiga toxin subunit A0101
Guanine deaminase0001
DNA-dependent protein kinase catalytic subunit0202
DNA-dependent protein kinase catalytic subunit 0101
Chain A, Cell Division Protein Kinase 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, Cell Division Protein Kinase 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, Cell Division Protein Kinase 20101
DNA repair and recombination protein RadA0011
Heat shock protein HSP 90-alpha0011
G2/mitotic-specific cyclin-B10101
Indoleamine 2,3-dioxygenase 10112
Cyclin-A20101
Cyclin-dependent kinase 20101
Nitric oxide synthase, brain0101
RAC-alpha serine/threonine-protein kinase0101
Cyclin-A10101
Chain A, Acetylcholinesterase0101
Solute carrier family 22 member 20101
Solute carrier family 22 member 1 0101
Solute carrier family 22 member 30101
Interstitial collagenase0101
Acetylcholinesterase0101
Muscarinic acetylcholine receptor M40202
Alpha-2C adrenergic receptor0202
Acetylcholinesterase0303
Liver carboxylesterase 10001
Multidrug and toxin extrusion protein 20101
Multidrug and toxin extrusion protein 10101
Chain A, Antigen Cd11a (p180)0101
Chain A, Beta-lactamase2002
Smad32002
PINK11001
isocitrate dehydrogenase 1, partial1001
Parkin1001
thyrotropin-releasing hormone receptor1001
potassium voltage-gated channel subfamily H member 2 isoform d2002
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
bcl-2-related protein A10101
urokinase plasminogen activator surface receptor precursor3003
3-hydroxy-3-methylglutaryl-coenzyme A reductase0101
Integrin beta-20101
Intercellular adhesion molecule 10101
Aldo-keto reductase family 1 member B10202
Neutrophil elastase0101
Insulin receptor 0101
Androgen receptor0202
Integrin alpha-L0112
Substance-K receptor0404
Sodium-dependent noradrenaline transporter 0202
Adenosine receptor A10202
Prostaglandin G/H synthase 20101
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
Sodium-dependent dopamine transporter 0202
Lanosterol 14-alpha demethylase0202
Rap guanine nucleotide exchange factor 41001
Acyl-CoA:cholesterol acyltransferase 0101
Solute carrier organic anion transporter family member 1B10303
GLS protein1001
Large neutral amino acids transporter small subunit 1 0101
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
Disintegrin and metalloproteinase domain-containing protein 171001
Thioredoxin reductase 0101
mitogen-activated protein kinase 11001
Flavodoxin0001
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Cytochrome P450 1A2 0012
5-hydroxytryptamine receptor 2A0202
Sodium-dependent dopamine transporter0202
D(2) dopamine receptor0202
Poly [ADP-ribose] polymerase tankyrase-20314
Protein mono-ADP-ribosyltransferase PARP110022
Phosphatidylinositol 3-kinase regulatory subunit alpha0101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform0101
Serine/threonine-protein kinase mTOR0101
Serine-protein kinase ATM0101
Serine/threonine-protein kinase ATR0101
Cytochrome P450 1A20101
Cholinesterase0101
Cytochrome P450 2D60101
Protein mono-ADP-ribosyltransferase PARP60101
Histamine H3 receptor0101
Genome polyprotein 0101
Luciferase1001
NPC intracellular cholesterol transporter 1 precursor1001
Tyrosine-protein kinase ABL10202
Epidermal growth factor receptor0101
Tubulin alpha-1A chain0012
Tubulin beta chain0011
Tubulin beta-4A chain0113
Receptor tyrosine-protein kinase erbB-20101
Tyrosine-protein kinase Fyn0101
Integrin alpha-V 0101
Tubulin beta chain0113
60 kDa chaperonin0101
Tubulin alpha-3C chain0113
Botulinum neurotoxin type A 0101
Apoptosis regulator Bcl-20101
60 kDa heat shock protein, mitochondrial0101
Fibroblast growth factor receptor 10101
Proto-oncogene tyrosine-protein kinase Src0101
UDP-glucuronosyltransferase 2B70101
UDP-glucuronosyltransferase 1-60101
ATP-dependent translocase ABCB10101
UDP-glucuronosyltransferase 1A1 0101
UDP-glucuronosyltransferase 1A40101
Cholecystokinin receptor type A0202
Melanocortin receptor 50202
UDP-glucuronosyltransferase 2B10 0101
Delta-type opioid receptor0202
10 kDa heat shock protein, mitochondrial0101
Tubulin alpha-1B chain0113
Tubulin alpha-4A chain0113
Tubulin beta-4B chain0113
Bcl-2-like protein 10101
Tyrosine-protein kinase Mer0101
Tubulin beta-3 chain0214
Tubulin beta-2A chain0113
Thiosulfate sulfurtransferase0101
Beta-tubulin 0101
Tubulin beta-8 chain0113
60 kDa chaperonin 0101
Tubulin beta-2B chain0013
Tubulin alpha-3E chain0113
Tubulin alpha-1A chain0113
10 kDa chaperonin 0101
Similar to alpha-tubulin isoform 1 0013
Similar to alpha-tubulin isoform 1 0002
Tubulin alpha-1C chain0113
Tubulin beta-6 chain0113
Tubulin beta-2B chain0113
Tubulin beta-1 chain0113
Solute carrier organic anion transporter family member 1B30202
tyrosine-protein kinase Yes1001
GDH/6PGL endoplasmic bifunctional protein0101
Protein mono-ADP-ribosyltransferase PARP90011
polyadenylate-binding protein 10101
Carbonic anhydrase 120101
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Tyrosine-protein kinase ABL20101
Carbonic anhydrase 90101
Cereblon isoform 40202
arylsulfatase A1001
Prostaglandin G/H synthase 10101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Prostaglandin G/H synthase 20101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
DNA-binding protein Ikaros0001
DNA damage-binding protein 10112
Protein cereblon0214
Thymidine phosphorylase0101
polyunsaturated fatty acid lipoxygenase ALOX121001
Endolysin0011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]