metronidazole has been researched along with Enteric Fever in 9 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Young children are very susceptible to typhoid fever, emphasizing the need for vaccination in under five age groups." | 2.79 | Evaluation of immune responses to an oral typhoid vaccine, Ty21a, in children from 2 to 5 years of age in Bangladesh. ( Bhuiyan, TR; Choudhury, FK; Khanam, F; Lundgren, A; Qadri, F; Sack, DA; Saha, A; Salma, U; Sayeed, MA; Svennerholm, AM, 2014) |
| "Typhoid intestinal perforation is a common complication of typhoid fever in our environment." | 1.35 | Typhoid intestinal disease: 32 perforations in 1 patient. ( Abdur-Rahman, LO; Adeniran, JO; Nasir, AA; Odi, TO; Omotayo, JA, 2008) |
| "The postoperative complications were suppuration of the wall (n = 4), intestinal fistula (n = 3), evisceration, and residual abscess." | 1.29 | [Typhoid perforations: experiences in a surgical setting in Cameroon. Apropos of 49 cases]. ( Ibile, A; Malonga, E; Masso-Misse, P; Yao, JG, 1994) |
| "Forty cases of typhoid ileal perforation were treated surgically in three years." | 1.29 | Typhoid perforation treated with and without metronidazole along with chloramphenicol, gentamycin. ( Ahmad, G; Dab, RH; Javaid, K; Rathore, AH, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bhuiyan, TR | 1 |
| Choudhury, FK | 1 |
| Khanam, F | 1 |
| Saha, A | 1 |
| Sayeed, MA | 1 |
| Salma, U | 1 |
| Lundgren, A | 1 |
| Sack, DA | 1 |
| Svennerholm, AM | 1 |
| Qadri, F | 1 |
| Duggal, S | 1 |
| Mahajan, RK | 1 |
| Biswas, NK | 1 |
| Chandel, DS | 1 |
| Duggal, N | 1 |
| Hans, C | 1 |
| Nasir, AA | 1 |
| Adeniran, JO | 1 |
| Abdur-Rahman, LO | 1 |
| Odi, TO | 1 |
| Omotayo, JA | 1 |
| Yao, JG | 1 |
| Masso-Misse, P | 1 |
| Ibile, A | 1 |
| Malonga, E | 1 |
| Javaid, K | 1 |
| Dab, RH | 1 |
| Rathore, AH | 1 |
| Ahmad, G | 1 |
| Moralejo, ML | 1 |
| Montero, MJ | 1 |
| Fuertes, A | 1 |
| de Las Heras, JA | 1 |
| Jiménez, A | 1 |
| Thomas, SS | 1 |
| Mammen, KJ | 1 |
| Eggleston, FC | 1 |
| Geddes, AM | 1 |
| Sirol, J | 1 |
| Vedy, J | 1 |
| Sabrié, A | 1 |
1 review available for metronidazole and Enteric Fever
| Article | Year |
|---|---|
[Liver abscess due to Salmonella typhi].
Topics: Aged; Aged, 80 and over; Ceftriaxone; Combined Modality Therapy; Drainage; Drug Therapy, Combination | 2002 |
1 trial available for metronidazole and Enteric Fever
| Article | Year |
|---|---|
Evaluation of immune responses to an oral typhoid vaccine, Ty21a, in children from 2 to 5 years of age in Bangladesh.
Topics: Administration, Oral; Albendazole; Anthelmintics; Antibodies, Bacterial; Bangladesh; Child, Preschoo | 2014 |
7 other studies available for metronidazole and Enteric Fever
| Article | Year |
|---|---|
Splenic abscess due to Salmonella enterica Serotype typhi in a young adult.
Topics: Abdominal Abscess; Anti-Bacterial Agents; Ceftriaxone; Humans; Male; Metronidazole; Ofloxacin; Salmo | 2008 |
Typhoid intestinal disease: 32 perforations in 1 patient.
Topics: Anti-Infective Agents; Antiprotozoal Agents; Child, Preschool; Ciprofloxacin; Colectomy; Female; Gen | 2008 |
[Typhoid perforations: experiences in a surgical setting in Cameroon. Apropos of 49 cases].
Topics: Adult; Aged; Ampicillin; Anastomosis, Surgical; Cameroon; Chloramphenicol; Colon; Combined Modality | 1994 |
Typhoid perforation treated with and without metronidazole along with chloramphenicol, gentamycin.
Topics: Adolescent; Child; Chloramphenicol; Drug Therapy, Combination; Female; Gentamicins; Humans; Ileal Di | 1996 |
Typhoid perforation: further experience with end-to-side ileotransverse colostomy.
Topics: Adult; Colostomy; Female; Humans; India; Intestinal Perforation; Male; Metronidazole; Postoperative | 1990 |
Imported infections. Unexplained fever.
Topics: Africa; Asia; Brucellosis; Chloramphenicol; Chloroquine; Fever; Humans; Leishmaniasis, Visceral; Liv | 1974 |
[Noma or forgotten ugliness. Clinical study and pathogenesis apropos of 6 cases at Fort-Lamy (Chad)].
Topics: Anti-Bacterial Agents; Chad; Child; Child, Preschool; Female; Humans; Leishmaniasis, Mucocutaneous; | 1972 |