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metronidazole and Skin Diseases, Infectious

metronidazole has been researched along with Skin Diseases, Infectious in 10 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Skin Diseases, Infectious: Skin diseases caused by bacteria, fungi, parasites, or viruses.

Research Excerpts

ExcerptRelevanceReference
"Metronidazole also has been used either alone or in combination, most frequently with amoxicillin, to treat many other anaerobic infections: head and neck, pleuropulmonary, genital tract, bone and joint, skin and soft tissue, and cases of fusobacterial septicemia (necrobacillosis)."1.27The therapeutic use of metronidazole in anaerobic infection: six years' experience in a London hospital. ( Eykyn, SJ, 1983)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19909 (90.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Little, K1
Eykyn, SJ1
Adams, EB1
MacLeod, IN1
Beaune, J1
Llorca, G1
Gonin, A1
Brun, Y1
Fleurette, J1
Neidhart, JP1
Sunarwan, I1
Jones, BM1
Geary, I1
Lee, ME1
Duerden, BI1
Cockerill, FR1
Rosenblatt, JE1
Lee, DT1
Gay, JD1
Feingold, DS1
Wagner, RF1
Reznikov, M1
Hakendorf, PH1
Matthews, DB1
Müller, E1
Sturm, G1

Reviews

1 review available for metronidazole and Skin Diseases, Infectious

ArticleYear
Antibacterial therapy.
    Journal of the American Academy of Dermatology, 1986, Volume: 14, Issue:4

    Topics: Anti-Bacterial Agents; Anti-Infective Agents, Local; Cephalosporins; Clindamycin; Drug Combinations;

1986

Other Studies

9 other studies available for metronidazole and Skin Diseases, Infectious

ArticleYear
What is causing this patient's multiple skin abscesses?
    JAAPA : official journal of the American Academy of Physician Assistants, 2018, Volume: 31, Issue:11

    Topics: Abscess; Adolescent; Colitis, Ulcerative; Cyclosporine; Dermatologic Agents; Female; Gastrointestina

2018
The therapeutic use of metronidazole in anaerobic infection: six years' experience in a London hospital.
    Surgery, 1983, Volume: 93, Issue:1 Pt 2

    Topics: Adult; Aged; Bacterial Infections; Bone Diseases; Empyema; Female; Fusobacterium Infections; Gastroi

1983
Invasive amebiasis. I. Amebic dysentery and its complications.
    Medicine, 1977, Volume: 56, Issue:4

    Topics: Adult; Amebiasis; Amebicides; Child, Preschool; Colonic Diseases; Entamoeba histolytica; Granuloma;

1977
[Necrotic phlegmon of the hand, starting point for a septicemia caused by Aeromonas hydrophila. Demonstration of the ichthyological origin of the infection].
    La Nouvelle presse medicale, 1978, Apr-08, Volume: 7, Issue:14

    Topics: Aeromonas; Animals; Bacterial Infections; Cellulitis; Chloramphenicol; Doxycycline; Drug Therapy, Co

1978
A case of cutaneous amoebiasis.
    Dermatologica, 1975, Volume: 151, Issue:4

    Topics: Acetanilides; Amebiasis; Amebicides; Colostomy; Entamoebiasis; Furans; Humans; Male; Metronidazole;

1975
Comparison of the in vitro activities of fenticonazole, other imidazoles, metronidazole, and tetracycline against organisms associated with bacterial vaginosis and skin infections.
    Antimicrobial agents and chemotherapy, 1989, Volume: 33, Issue:6

    Topics: Antifungal Agents; Bacteria; Female; Humans; Imidazoles; Metronidazole; Microbial Sensitivity Tests;

1989
Comparison of clindamycin, metronidazole, and penicillin for the treatment of experimental infections in mice caused by beta-lactamase-producing Bacteroides intermedius.
    Diagnostic microbiology and infectious disease, 1986, Volume: 5, Issue:1

    Topics: Abscess; Animals; Bacteroides; Bacteroides Infections; beta-Lactamases; Clindamycin; Male; Metronida

1986
Response of a 'susceptible' Escherichia coli to metronidazole therapy: an investigation using experimental subcutaneous abscesses.
    Chemotherapy, 1985, Volume: 31, Issue:1

    Topics: Abscess; Animals; Bacteroides fragilis; Bacteroides Infections; Drug Resistance, Microbial; Escheric

1985
[Protozoan infections of the skin].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1974, Volume: 25, Issue:6

    Topics: Amphotericin B; Antimony; Female; Germany, West; Humans; Leishmania; Leishmaniasis, Mucocutaneous; M

1974