metronidazole has been researched along with Acquired Immunodeficiency Syndrome in 15 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Acquired Immunodeficiency Syndrome: An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The knowledge of adverse effects of antibiotics was greatest for tooth discoloration which is related to tetracycline." | 3.80 | Antibiotics prescription in Nigerian dental healthcare services. ( Azodo, CC; Ojehanon, PI, 2014) |
| "Testing the effects of STD control on AIDS prevention is feasible in this Ugandan setting." | 2.69 | A randomized, community trial of intensive sexually transmitted disease control for AIDS prevention, Rakai, Uganda. ( Berkley, S; Brookmeyer, R; Gray, RH; Kelly, R; Kiwanuka, N; Li, C; Lutalo, T; McNairn, D; Nalugoda, F; Paxton, L; Quinn, TC; Serwadda, D; Sewankambo, NK; Wabwire-Mangen, F; Wawer, MJ, 1998) |
| "An elderly bisexual male AIDS patient, whose CD4 cell count was 128/mm3 and HIV-RNA was 3." | 1.30 | Amebic liver abscess in an elderly AIDS patient. ( Kimura, K; Ohnishi, K, 1999) |
| "A 30-year-old Japanese homosexual AIDS patient was admitted to hospital because of Kaposi's sarcoma and mild diarrhea on February 4, 1993." | 1.29 | Symptomatic amebic colitis in a Japanese homosexual AIDS patient. ( Murata, M; Ohnishi, K; Okuzawa, E, 1994) |
| "A 30-year-old man with AIDS presented with symptoms of fever, epigastric pain and weight loss, together with histological findings of Helicobacter pylori-induced gastritis." | 1.28 | Severe Helicobacter pylori infection in a patient with AIDS. ( Blackwell, N; Khoo, SH, 1991) |
| "Treatment with metronidazole in most cases improved symptoms." | 1.28 | [Intestinal spirochetosis in HIV infection: prevalence, isolation and morphology of spirochetes]. ( Arasteh, K; Gelderblom, HR; Grosse, G; Heise, W; Käsbohrer, A; Koch, MA; L'age, M; Pauli, G; Schönberg, A, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 10 (66.67) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sherley, M | 1 |
| Martin, SJ | 1 |
| Azodo, CC | 1 |
| Ojehanon, PI | 1 |
| Dillingham, RA | 1 |
| Pinkerton, R | 1 |
| Leger, P | 1 |
| Severe, P | 1 |
| Guerrant, RL | 1 |
| Pape, JW | 1 |
| Fitzgerald, DW | 1 |
| Ribas, A | 1 |
| Martínez-Girón, R | 1 |
| Ponte-Mittelbrum, C | 1 |
| Alonso-Cuervo, R | 1 |
| Iglesias-Llaca, F | 1 |
| Ohnishi, K | 2 |
| Murata, M | 1 |
| Okuzawa, E | 1 |
| Arranz-Caso, JA | 1 |
| Albarrán-Hernández, F | 1 |
| Cuadrado-Gómez, LM | 1 |
| Gonzalez-Palacios, R | 1 |
| He, Q | 1 |
| Leitch, GJ | 1 |
| Visvesvara, GS | 1 |
| Wallace, S | 1 |
| Ebrahimzadeh, A | 1 |
| Bottone, EJ | 1 |
| Wawer, MJ | 1 |
| Gray, RH | 1 |
| Sewankambo, NK | 1 |
| Serwadda, D | 1 |
| Paxton, L | 1 |
| Berkley, S | 1 |
| McNairn, D | 1 |
| Wabwire-Mangen, F | 1 |
| Li, C | 1 |
| Nalugoda, F | 1 |
| Kiwanuka, N | 1 |
| Lutalo, T | 1 |
| Brookmeyer, R | 1 |
| Kelly, R | 1 |
| Quinn, TC | 1 |
| Kimura, K | 1 |
| Garavelli, PL | 2 |
| Blanshard, C | 1 |
| Gazzard, BG | 1 |
| Khoo, SH | 1 |
| Blackwell, N | 1 |
| Käsbohrer, A | 1 |
| Gelderblom, HR | 1 |
| Arasteh, K | 1 |
| Heise, W | 1 |
| Grosse, G | 1 |
| L'age, M | 1 |
| Schönberg, A | 1 |
| Koch, MA | 1 |
| Pauli, G | 1 |
| Orsi, P | 1 |
| Scaglione, L | 1 |
1 trial available for metronidazole and Acquired Immunodeficiency Syndrome
| Article | Year |
|---|---|
A randomized, community trial of intensive sexually transmitted disease control for AIDS prevention, Rakai, Uganda.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adolescent; Adult; Anti-Infective Agents; | 1998 |
14 other studies available for metronidazole and Acquired Immunodeficiency Syndrome
| Article | Year |
|---|---|
Multiple simultaneous infections in a patient with well-controlled HIV: when Occam's razor fails.
Topics: Acquired Immunodeficiency Syndrome; Aftercare; AIDS-Related Opportunistic Infections; Anti-Retrovira | 2017 |
Antibiotics prescription in Nigerian dental healthcare services.
Topics: Acquired Immunodeficiency Syndrome; Amoxicillin; Anaphylaxis; Anti-Bacterial Agents; Antibiotic Prop | 2014 |
High early mortality in patients with chronic acquired immunodeficiency syndrome diarrhea initiating antiretroviral therapy in Haiti: a case-control study.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Anti-HIV Agents; Anti-Infective Agents; Case- | 2009 |
Immunosupression, flagellated protozoa in the human airways and metronidazole: observations on the state of the art.
Topics: Acquired Immunodeficiency Syndrome; Adult; Animals; Antiprotozoal Agents; Eukaryota; Flagella; Human | 2007 |
Symptomatic amebic colitis in a Japanese homosexual AIDS patient.
Topics: Acquired Immunodeficiency Syndrome; Adult; Animals; Antibodies, Protozoan; Blood; Dysentery, Amebic; | 1994 |
Metronidazole treatment in a patient with AIDS and visceral leishmaniasis.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Humans; Leishmania | 1995 |
Effects of nifedipine, metronidazole, and nitric oxide donors on spore germination and cell culture infection of the microsporidia Encephalitozoon hellem and Encephalitozoon intestinalis.
Topics: Acquired Immunodeficiency Syndrome; Animals; Antitrichomonal Agents; Calcium Channel Blockers; Cells | 1996 |
Persistent diarrhea caused by Isospora belli: therapeutic response to pyrimethamine and sulfadiazine.
Topics: Acquired Immunodeficiency Syndrome; Animals; Anti-Infective Agents; Antitrichomonal Agents; Diarrhea | 1996 |
Amebic liver abscess in an elderly AIDS patient.
Topics: Acquired Immunodeficiency Syndrome; Aged; Anti-HIV Agents; Anti-Infective Agents; Humans; Liver Absc | 1999 |
The therapy of blastocystosis.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Aged; Aged, 80 and over; Animals; Anti-Infect | 1991 |
Microsporidiosis in HIV-1-infected individuals.
Topics: Acquired Immunodeficiency Syndrome; Diarrhea; Drug Administration Schedule; Giardiasis; HIV-1; Human | 1991 |
Severe Helicobacter pylori infection in a patient with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; Ampicillin; Animals; Biopsy; Drug Therapy, Combination; G | 1991 |
[Intestinal spirochetosis in HIV infection: prevalence, isolation and morphology of spirochetes].
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; AIDS-Related Complex; Endoscopy; Homosexuality; Hum | 1990 |
Blastocystis hominis infection during AIDS.
Topics: Acquired Immunodeficiency Syndrome; Aged; Animals; Humans; Male; Metronidazole; Protozoan Infections | 1988 |