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lipid As

Glycophospholipids that are the components of endotoxins held responsible for the toxicity of Gram-negative bacteria. Lipid A is the innermost of the three regions of the lipopolysaccharide (LPS) molecule, and its hydrophobic nature allows it to anchor the LPS to the outer membrane. Four acyl chains attached directly to two (1->6)-linked glucosamine sugars are beta-hydroxy acyl chains usually between 10 and 16 carbons in length. Two additional acyl chains are often attached to the beta-hydroxy group.

ChEBI ID: 25051

Members (3)

MemberDefinitionRole
3-deoxy-2-octulosonic acid(2)-lipid iv(a)Lipid IVA glycosylated with two 3-deoxy-D-manno-octulosonic acid (KDO) residues.(KDO)2-lipid IVA
eritoranA lipid A derivative used for the treatment of severe sepsis.eritoran
kdo2-lipid a(Kdo)2-lipid A (E. coli)

Research

Studies (99)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-19900 (0.00)18.7374
1990's7 (7.07)18.2507
2000's18 (18.18)29.6817
2010's70 (70.71)24.3611
2020's4 (4.04)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials6 (6.06%)5.53%
Reviews16 (16.16%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other77 (77.78%)84.16%