Page last updated: 2024-08-05 13:14:22
lipid As
Glycophospholipids that are the components of endotoxins held responsible for the toxicity of Gram-negative bacteria. Lipid A is the innermost of the three regions of the lipopolysaccharide (LPS) molecule, and its hydrophobic nature allows it to anchor the LPS to the outer membrane. Four acyl chains attached directly to two (1->6)-linked glucosamine sugars are beta-hydroxy acyl chains usually between 10 and 16 carbons in length. Two additional acyl chains are often attached to the beta-hydroxy group.
ChEBI ID: 25051
Members (3)
| Member | Definition | Role |
|---|---|---|
| 3-deoxy-2-octulosonic acid(2)-lipid iv(a) | Lipid IVA glycosylated with two 3-deoxy-D-manno-octulosonic acid (KDO) residues. | (KDO)2-lipid IVA |
| eritoran | A lipid A derivative used for the treatment of severe sepsis. | eritoran |
| kdo2-lipid a | (Kdo)2-lipid A (E. coli) |
Research
Studies (99)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (7.07) | 18.2507 |
| 2000's | 18 (18.18) | 29.6817 |
| 2010's | 70 (70.71) | 24.3611 |
| 2020's | 4 (4.04) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 6 (6.06%) | 5.53% |
| Reviews | 16 (16.16%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 77 (77.78%) | 84.16% |