Page last updated: 2024-10-31

metronidazole and Local Neoplasm Recurrence

metronidazole has been researched along with Local Neoplasm Recurrence in 12 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Research Excerpts

ExcerptRelevanceReference
"We describe the case of a 54-year-old woman with relapse of multiple myeloma 3 years after myeloablative allogeneic stem cell transplant who developed abdominal pain and bloody diarrhea following 7 months of lenalidomide therapy."7.83Ischemic colitis diagnosed by magnetic resonance imaging during lenalidomide treatment in a patient with relapsed multiple myeloma. ( Bucalossi, A; Cioffi Squitieri, N; Guerrini, S; Mazzei, FG; Mazzei, MA; Volterrani, L, 2016)
"Metronidazole gel was applied to the surface of ulcerated tumors once or twice daily."6.68Use of metronidazole gel to control malodor in advanced and recurrent breast cancer. ( Kubota, M; Kuge, S; Makuuchi, H; Mitomi, T; Ninomiya, S; Ohta, M; Okumura, A; Sawamura, S; Tajima, T; Tokuda, Y, 1996)
"We describe the case of a 54-year-old woman with relapse of multiple myeloma 3 years after myeloablative allogeneic stem cell transplant who developed abdominal pain and bloody diarrhea following 7 months of lenalidomide therapy."3.83Ischemic colitis diagnosed by magnetic resonance imaging during lenalidomide treatment in a patient with relapsed multiple myeloma. ( Bucalossi, A; Cioffi Squitieri, N; Guerrini, S; Mazzei, FG; Mazzei, MA; Volterrani, L, 2016)
"The patient received treatment with anti-tetanus globulin and metronidazole; sound insulation and shielding were also performed in a dark room."2.72Non-surgical treatment of tetanus infection associated with breast cancer skin ulcer: a case report and literature review. ( Aisaka, W; Narimatsu, E; Nomura, K; Okamoto, H; Sakawaki, E; Sakawaki, S; Takeyama, Y; Uemura, S; Yamaoka, A, 2021)
"Metronidazole gel was applied to the surface of ulcerated tumors once or twice daily."2.68Use of metronidazole gel to control malodor in advanced and recurrent breast cancer. ( Kubota, M; Kuge, S; Makuuchi, H; Mitomi, T; Ninomiya, S; Ohta, M; Okumura, A; Sawamura, S; Tajima, T; Tokuda, Y, 1996)
"Endoscopy after ER detected no new gastric cancers in these patients."1.30Effect of Helicobacter pylori eradication on subsequent development of cancer after endoscopic resection of early gastric cancer. ( Haruma, K; Kajiyama, G; Mashiba, H; Mukai, T; Okamoto, S; Sasaki, N; Sumii, K; Taniyama, K; Uemura, N; Yamaguchi, S, 1997)
"In combined treatment of the laryngeal cancer patients after a summary focal dose of 32 Gy and 1."1.27[The results of metronidazole use in radiation and combined treatment of patients with laryngeal cancer]. ( Andreev, VG; Mardynskiĭ, IuS, 1985)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19905 (41.67)18.7374
1990's3 (25.00)18.2507
2000's0 (0.00)29.6817
2010's2 (16.67)24.3611
2020's2 (16.67)2.80

Authors

AuthorsStudies
Ekdahl, L1
Eoh, KJ1
Thumuluru, KM1
Butler-Manuel, SA1
Tae Kim, Y1
Lönnerfors, C1
Falconer, H1
Persson, J1
Nomura, K1
Sakawaki, E1
Sakawaki, S1
Yamaoka, A1
Aisaka, W1
Okamoto, H1
Takeyama, Y1
Uemura, S1
Narimatsu, E1
Kiziltan, HS1
Gunes Bayir, A1
Taspinar, O1
Yucesan, G1
Tastekin, D1
Sonmez, FC1
Coban, G1
Kilic, G1
Eris, AH1
Aydin, T1
Akcakaya, A1
Mayadagli, A1
Guerrini, S1
Bucalossi, A1
Cioffi Squitieri, N1
Mazzei, FG1
Volterrani, L1
Mazzei, MA1
Orr, LE1
Puthawala, A1
Syed, AM1
Fleming, PA1
Stewart, DJ1
Cripps, MC1
Lamothe, A1
Laframboise, G1
Odell, P1
Gerin-Lajoie, J1
Kuge, S1
Tokuda, Y1
Ohta, M1
Okumura, A1
Kubota, M1
Ninomiya, S1
Sawamura, S1
Makuuchi, H1
Tajima, T1
Mitomi, T1
Uemura, N1
Mukai, T1
Okamoto, S1
Yamaguchi, S1
Mashiba, H1
Taniyama, K1
Sasaki, N1
Haruma, K1
Sumii, K1
Kajiyama, G1
Lee, DJ1
Wharam, MD1
Kashima, H1
Order, SE1
Isaev, IG1
Beibutov, SM1
Dar'ialova, SL1
Poliakov, PIu1
Kiseleva, ES1
Zimina, ES1
Zel'vin, BM1
Andreev, VG1
Mardynskiĭ, IuS1

Reviews

1 review available for metronidazole and Local Neoplasm Recurrence

ArticleYear
Non-surgical treatment of tetanus infection associated with breast cancer skin ulcer: a case report and literature review.
    BMC infectious diseases, 2021, Jan-07, Volume: 21, Issue:1

    Topics: Breast Neoplasms; Female; Humans; Lymphatic Metastasis; Metronidazole; Middle Aged; Neoplasm Recurre

2021

Trials

3 trials available for metronidazole and Local Neoplasm Recurrence

ArticleYear
Doxorubicin plus metronidazole in the treatment of recurrent or metastatic squamous cell carcinoma of the head and neck.
    American journal of clinical oncology, 1993, Volume: 16, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous

1993
Use of metronidazole gel to control malodor in advanced and recurrent breast cancer.
    Japanese journal of clinical oncology, 1996, Volume: 26, Issue:4

    Topics: Administration, Topical; Aged; Bacteria, Anaerobic; Bacterial Infections; Breast Neoplasms; Female;

1996
[Metronidazole in the radiotherapy of malignant neoplasms].
    Meditsinskaia radiologiia, 1986, Volume: 31, Issue:7

    Topics: Clinical Trials as Topic; Combined Modality Therapy; Humans; Metronidazole; Neoplasm Recurrence, Loc

1986

Other Studies

8 other studies available for metronidazole and Local Neoplasm Recurrence

ArticleYear
A combination of second trimester oral metronidazole and no sexual intercourse during second and third trimester may reduce late miscarriage and premature delivery after fertility sparing radical trachelectomy.
    European journal of obstetrics, gynecology, and reproductive biology, 2021, Volume: 265

    Topics: Abortion, Spontaneous; Coitus; Female; Fertility Preservation; Humans; Metronidazole; Neoplasm Recur

2021
Radioprotectant and Cytotoxic Effects of Spirulina in Relapsed Verrucous Vulvar Cancer: A Case Report.
    Alternative therapies in health and medicine, 2015, Volume: 21 Suppl 2

    Topics: Aged, 80 and over; Anti-Infective Agents; Biological Products; Carcinoma, Verrucous; Chemoradiothera

2015
Ischemic colitis diagnosed by magnetic resonance imaging during lenalidomide treatment in a patient with relapsed multiple myeloma.
    Tumori, 2016, Nov-11, Volume: 102, Issue:Suppl. 2

    Topics: Anti-Infective Agents; Antineoplastic Combined Chemotherapy Protocols; Colitis, Ischemic; Combined M

2016
Metronidazole and interstitial implantation in the treatment of extensive recurrent head and neck cancers.
    Cancer, 1981, Jul-01, Volume: 48, Issue:1

    Topics: Brachytherapy; Carcinoma, Squamous Cell; Drug Administration Schedule; Humans; Metronidazole; Middle

1981
Effect of Helicobacter pylori eradication on subsequent development of cancer after endoscopic resection of early gastric cancer.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1997, Volume: 6, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Biopsy; Clarithromycin; Combined Modality Therapy; Dose

1997
Short course high fractional dose irradiation in advanced and recurrent head and neck cancer.
    International journal of radiation oncology, biology, physics, 1979, Volume: 5, Issue:10

    Topics: Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Male; Metronidazole; Mucous Membr

1979
[Radiation therapy of esophageal carcinoma using dynamic dose fractionation in combination with metronidazole and local hyperthermia].
    Radiobiologia, radiotherapia, 1988, Volume: 29, Issue:1

    Topics: Chemical Fractionation; Combined Modality Therapy; Dose-Response Relationship, Radiation; Esophageal

1988
[The results of metronidazole use in radiation and combined treatment of patients with laryngeal cancer].
    Meditsinskaia radiologiia, 1985, Volume: 30, Issue:4

    Topics: Adult; Combined Modality Therapy; Follow-Up Studies; Humans; Laryngeal Neoplasms; Laryngectomy; Metr

1985