metronidazole has been researched along with Local Neoplasm Recurrence in 12 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We describe the case of a 54-year-old woman with relapse of multiple myeloma 3 years after myeloablative allogeneic stem cell transplant who developed abdominal pain and bloody diarrhea following 7 months of lenalidomide therapy." | 7.83 | Ischemic colitis diagnosed by magnetic resonance imaging during lenalidomide treatment in a patient with relapsed multiple myeloma. ( Bucalossi, A; Cioffi Squitieri, N; Guerrini, S; Mazzei, FG; Mazzei, MA; Volterrani, L, 2016) |
| "Metronidazole gel was applied to the surface of ulcerated tumors once or twice daily." | 6.68 | Use of metronidazole gel to control malodor in advanced and recurrent breast cancer. ( Kubota, M; Kuge, S; Makuuchi, H; Mitomi, T; Ninomiya, S; Ohta, M; Okumura, A; Sawamura, S; Tajima, T; Tokuda, Y, 1996) |
| "We describe the case of a 54-year-old woman with relapse of multiple myeloma 3 years after myeloablative allogeneic stem cell transplant who developed abdominal pain and bloody diarrhea following 7 months of lenalidomide therapy." | 3.83 | Ischemic colitis diagnosed by magnetic resonance imaging during lenalidomide treatment in a patient with relapsed multiple myeloma. ( Bucalossi, A; Cioffi Squitieri, N; Guerrini, S; Mazzei, FG; Mazzei, MA; Volterrani, L, 2016) |
| "The patient received treatment with anti-tetanus globulin and metronidazole; sound insulation and shielding were also performed in a dark room." | 2.72 | Non-surgical treatment of tetanus infection associated with breast cancer skin ulcer: a case report and literature review. ( Aisaka, W; Narimatsu, E; Nomura, K; Okamoto, H; Sakawaki, E; Sakawaki, S; Takeyama, Y; Uemura, S; Yamaoka, A, 2021) |
| "Metronidazole gel was applied to the surface of ulcerated tumors once or twice daily." | 2.68 | Use of metronidazole gel to control malodor in advanced and recurrent breast cancer. ( Kubota, M; Kuge, S; Makuuchi, H; Mitomi, T; Ninomiya, S; Ohta, M; Okumura, A; Sawamura, S; Tajima, T; Tokuda, Y, 1996) |
| "Endoscopy after ER detected no new gastric cancers in these patients." | 1.30 | Effect of Helicobacter pylori eradication on subsequent development of cancer after endoscopic resection of early gastric cancer. ( Haruma, K; Kajiyama, G; Mashiba, H; Mukai, T; Okamoto, S; Sasaki, N; Sumii, K; Taniyama, K; Uemura, N; Yamaguchi, S, 1997) |
| "In combined treatment of the laryngeal cancer patients after a summary focal dose of 32 Gy and 1." | 1.27 | [The results of metronidazole use in radiation and combined treatment of patients with laryngeal cancer]. ( Andreev, VG; Mardynskiĭ, IuS, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (41.67) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Ekdahl, L | 1 |
| Eoh, KJ | 1 |
| Thumuluru, KM | 1 |
| Butler-Manuel, SA | 1 |
| Tae Kim, Y | 1 |
| Lönnerfors, C | 1 |
| Falconer, H | 1 |
| Persson, J | 1 |
| Nomura, K | 1 |
| Sakawaki, E | 1 |
| Sakawaki, S | 1 |
| Yamaoka, A | 1 |
| Aisaka, W | 1 |
| Okamoto, H | 1 |
| Takeyama, Y | 1 |
| Uemura, S | 1 |
| Narimatsu, E | 1 |
| Kiziltan, HS | 1 |
| Gunes Bayir, A | 1 |
| Taspinar, O | 1 |
| Yucesan, G | 1 |
| Tastekin, D | 1 |
| Sonmez, FC | 1 |
| Coban, G | 1 |
| Kilic, G | 1 |
| Eris, AH | 1 |
| Aydin, T | 1 |
| Akcakaya, A | 1 |
| Mayadagli, A | 1 |
| Guerrini, S | 1 |
| Bucalossi, A | 1 |
| Cioffi Squitieri, N | 1 |
| Mazzei, FG | 1 |
| Volterrani, L | 1 |
| Mazzei, MA | 1 |
| Orr, LE | 1 |
| Puthawala, A | 1 |
| Syed, AM | 1 |
| Fleming, PA | 1 |
| Stewart, DJ | 1 |
| Cripps, MC | 1 |
| Lamothe, A | 1 |
| Laframboise, G | 1 |
| Odell, P | 1 |
| Gerin-Lajoie, J | 1 |
| Kuge, S | 1 |
| Tokuda, Y | 1 |
| Ohta, M | 1 |
| Okumura, A | 1 |
| Kubota, M | 1 |
| Ninomiya, S | 1 |
| Sawamura, S | 1 |
| Makuuchi, H | 1 |
| Tajima, T | 1 |
| Mitomi, T | 1 |
| Uemura, N | 1 |
| Mukai, T | 1 |
| Okamoto, S | 1 |
| Yamaguchi, S | 1 |
| Mashiba, H | 1 |
| Taniyama, K | 1 |
| Sasaki, N | 1 |
| Haruma, K | 1 |
| Sumii, K | 1 |
| Kajiyama, G | 1 |
| Lee, DJ | 1 |
| Wharam, MD | 1 |
| Kashima, H | 1 |
| Order, SE | 1 |
| Isaev, IG | 1 |
| Beibutov, SM | 1 |
| Dar'ialova, SL | 1 |
| Poliakov, PIu | 1 |
| Kiseleva, ES | 1 |
| Zimina, ES | 1 |
| Zel'vin, BM | 1 |
| Andreev, VG | 1 |
| Mardynskiĭ, IuS | 1 |
1 review available for metronidazole and Local Neoplasm Recurrence
| Article | Year |
|---|---|
Non-surgical treatment of tetanus infection associated with breast cancer skin ulcer: a case report and literature review.
Topics: Breast Neoplasms; Female; Humans; Lymphatic Metastasis; Metronidazole; Middle Aged; Neoplasm Recurre | 2021 |
3 trials available for metronidazole and Local Neoplasm Recurrence
| Article | Year |
|---|---|
Doxorubicin plus metronidazole in the treatment of recurrent or metastatic squamous cell carcinoma of the head and neck.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous | 1993 |
Use of metronidazole gel to control malodor in advanced and recurrent breast cancer.
Topics: Administration, Topical; Aged; Bacteria, Anaerobic; Bacterial Infections; Breast Neoplasms; Female; | 1996 |
[Metronidazole in the radiotherapy of malignant neoplasms].
Topics: Clinical Trials as Topic; Combined Modality Therapy; Humans; Metronidazole; Neoplasm Recurrence, Loc | 1986 |
8 other studies available for metronidazole and Local Neoplasm Recurrence
| Article | Year |
|---|---|
A combination of second trimester oral metronidazole and no sexual intercourse during second and third trimester may reduce late miscarriage and premature delivery after fertility sparing radical trachelectomy.
Topics: Abortion, Spontaneous; Coitus; Female; Fertility Preservation; Humans; Metronidazole; Neoplasm Recur | 2021 |
Radioprotectant and Cytotoxic Effects of Spirulina in Relapsed Verrucous Vulvar Cancer: A Case Report.
Topics: Aged, 80 and over; Anti-Infective Agents; Biological Products; Carcinoma, Verrucous; Chemoradiothera | 2015 |
Ischemic colitis diagnosed by magnetic resonance imaging during lenalidomide treatment in a patient with relapsed multiple myeloma.
Topics: Anti-Infective Agents; Antineoplastic Combined Chemotherapy Protocols; Colitis, Ischemic; Combined M | 2016 |
Metronidazole and interstitial implantation in the treatment of extensive recurrent head and neck cancers.
Topics: Brachytherapy; Carcinoma, Squamous Cell; Drug Administration Schedule; Humans; Metronidazole; Middle | 1981 |
Effect of Helicobacter pylori eradication on subsequent development of cancer after endoscopic resection of early gastric cancer.
Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Biopsy; Clarithromycin; Combined Modality Therapy; Dose | 1997 |
Short course high fractional dose irradiation in advanced and recurrent head and neck cancer.
Topics: Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Male; Metronidazole; Mucous Membr | 1979 |
[Radiation therapy of esophageal carcinoma using dynamic dose fractionation in combination with metronidazole and local hyperthermia].
Topics: Chemical Fractionation; Combined Modality Therapy; Dose-Response Relationship, Radiation; Esophageal | 1988 |
[The results of metronidazole use in radiation and combined treatment of patients with laryngeal cancer].
Topics: Adult; Combined Modality Therapy; Follow-Up Studies; Humans; Laryngeal Neoplasms; Laryngectomy; Metr | 1985 |