metronidazole has been researched along with Vaginal Diseases in 30 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Vaginal Diseases: Pathological processes of the VAGINA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Adjunctive metronidazole therapy did not improve pregnancy outcome." | 5.10 | Periodontal disease and preterm birth: results of a pilot intervention study. ( Cliver, SP; Geurs, NC; Goldenberg, RL; Hauth, JC; Hodgkins, PM; Jeffcoat, MK; Reddy, MS, 2003) |
| "A multi-centre double-blind, placebo-controlled clinical trial was performed to determine the minimum number of doses of metronidazole required for effective prophylaxis of vaginal cuff abscess following hysterectomy." | 5.06 | A comparison of single-dose and multi-dose metronidazole prophylaxis for hysterectomy. ( Haverkorn, MJ, 1987) |
| "Some workers have suggested that the recurrence of symptoms may in fact be reinfection by male consorts, but no controlled studies have been undertaken to confirm this." | 2.66 | Should male consorts of women with bacterial vaginosis be treated? ( Alaksen, K; Bymose, B; Erkkola, R; Jerve, F; Moi, H; Nelleman, G; Tornqvist, E, 1989) |
| " Bacterial vaginosis responds readily to treatment with metronidazole at a dosage of 400 mg twice daily for seven days, although a proportion of patients suffer a recurrence of symptoms." | 2.38 | Bacterial vaginosis. ( Levett, PN, 1989) |
| "The term "metastatic" Crohn's disease is used to define the cutaneous lesions, distant from the gastrointestinal tract and separated from other ulcerations by normal skin, showing granulomatous histology." | 1.27 | [Cutaneous Crohn disease]. ( Bakos, L; Kuhl, IC; Wissbluth, ML; Zampese, MS, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (76.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (20.00) | 29.6817 |
| 2010's | 1 (3.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Popa, D | 1 |
| Laszlo, M | 1 |
| Ciobanu, L | 1 |
| Ucenic, E | 1 |
| Mihalache, M | 1 |
| Pascu, O | 1 |
| Mendling, W | 1 |
| Poli, A | 1 |
| Magnani, P | 1 |
| El-Gizawy, SA | 1 |
| Aglan, NI | 1 |
| SVENDSEN, EK | 1 |
| Jeffcoat, MK | 1 |
| Hauth, JC | 1 |
| Geurs, NC | 1 |
| Reddy, MS | 1 |
| Cliver, SP | 1 |
| Hodgkins, PM | 1 |
| Goldenberg, RL | 1 |
| French, L | 1 |
| Horton, J | 1 |
| Matousek, M | 1 |
| Kazy, Z | 1 |
| Puhó, E | 1 |
| Czeizel, AE | 1 |
| Balsdon, MJ | 1 |
| Vapinov, B | 1 |
| Tsankova, M | 1 |
| Velev, R | 1 |
| Georgiev, S | 1 |
| Willmott, FE | 1 |
| Hofstetter, A | 1 |
| Schmiedt, E | 1 |
| Weissenbacher, ER | 1 |
| Frank, S | 1 |
| Mengel, MB | 1 |
| Berg, AO | 1 |
| Weaver, CH | 1 |
| Herman, DJ | 1 |
| Herman, SJ | 1 |
| Hughes, VL | 1 |
| Koepsell, TD | 1 |
| Moi, H | 1 |
| Erkkola, R | 1 |
| Jerve, F | 1 |
| Nelleman, G | 1 |
| Bymose, B | 1 |
| Alaksen, K | 1 |
| Tornqvist, E | 1 |
| Levett, PN | 1 |
| Edelman, DA | 1 |
| North, BB | 1 |
| Jones, BM | 1 |
| Geary, I | 1 |
| Lee, ME | 1 |
| Duerden, BI | 1 |
| Haverkorn, MJ | 1 |
| Secor, RM | 1 |
| Andersch, B | 1 |
| Forssman, L | 1 |
| Lincoln, K | 1 |
| Torstensson, P | 1 |
| Symonds, J | 1 |
| Biswas, AK | 1 |
| Fox, GN | 1 |
| Zampese, MS | 1 |
| Bakos, L | 1 |
| Kuhl, IC | 1 |
| Wissbluth, ML | 1 |
| Plosker, GL | 1 |
| Bistoletti, P | 1 |
| Fredricsson, B | 1 |
| Hagström, B | 1 |
| Nord, CE | 1 |
| Dennerstein, GJ | 1 |
| Valent, M | 1 |
| Valentová, M | 1 |
| Klobusický, M | 1 |
| Penza, J | 1 |
| Rankin, JS | 1 |
| Drazancić, A | 1 |
| Krstulović, B | 1 |
| Ivić, J | 1 |
| Robinson, SC | 1 |
| Oller, LZ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Controlled, Multicenter, Randomized Parallel Group Pilot Study With 2 Treatment Arms in Non-pregnant Women With Acute Symptomatic Bacterial Vaginosis (BV)[NCT02042287] | Phase 4 | 32 participants (Actual) | Interventional | 2014-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for metronidazole and Vaginal Diseases
| Article | Year |
|---|---|
Clinical effects of nifuratel in vulvovaginal infections. A meta-analysis of metronidazole-controlled trials.
Topics: Antifungal Agents; Antitrichomonal Agents; Female; Humans; Metronidazole; Nifuratel; Randomized Cont | 2002 |
Abnormal vaginal discharge: what does and does not work in treating underlying causes.
Topics: Anti-Bacterial Agents; Antifungal Agents; Candidiasis, Vulvovaginal; Clindamycin; Female; Humans; Me | 2004 |
Gardnerella vaginalis and its clinical syndrome.
Topics: Amoxicillin; Ampicillin; Culture Media; Female; Gardnerella vaginalis; Gentian Violet; Haemophilus; | 1982 |
Bacterial vaginosis.
Topics: Bacterial Infections; Diagnosis, Differential; Female; Humans; Metronidazole; Recurrence; Vaginal Di | 1989 |
Bacterial vaginosis: a comprehensive review.
Topics: Anti-Bacterial Agents; Diagnosis, Differential; Female; Gardnerella vaginalis; Haemophilus Infection | 1988 |
Vaginitis: diagnosis and treatment.
Topics: Adult; Candidiasis; Clinical Laboratory Techniques; Diagnosis, Differential; Female; Haemophilus Inf | 1972 |
Infectious vaginopathies in pregnancy.
Topics: Antifungal Agents; Candidiasis, Vulvovaginal; Female; Glucocorticoids; Gonorrhea; Haemophilus Infect | 1970 |
9 trials available for metronidazole and Vaginal Diseases
| Article | Year |
|---|---|
Formulation and evaluation of metronidazole acid gel for vaginal contraception.
Topics: Acetic Acid; Administration, Intravaginal; Adult; Bacterial Infections; Body Fluids; Contraception; | 2003 |
Periodontal disease and preterm birth: results of a pilot intervention study.
Topics: Adult; Anti-Infective Agents; Dental Scaling; Double-Blind Method; Feasibility Studies; Female; Huma | 2003 |
[Klion D - possibilities of prophylaxis and treatment during pregnancy].
Topics: Administration, Intravaginal; Animals; Anti-Infective Agents; Cerclage, Cervical; Drug Therapy, Comb | 2001 |
The effectiveness of single-dose metronidazole therapy for patients and their partners with bacterial vaginosis.
Topics: Adult; Bacterial Infections; Clinical Trials as Topic; Double-Blind Method; Drug Administration Sche | 1989 |
Should male consorts of women with bacterial vaginosis be treated?
Topics: Adolescent; Adult; Bacterial Infections; Double-Blind Method; Female; Gardnerella vaginalis; Haemoph | 1989 |
Treatment of bacterial vaginosis with intravaginal sponges containing metronidazole.
Topics: Administration, Intravaginal; Adolescent; Adult; Bacterial Infections; Delayed-Action Preparations; | 1989 |
A comparison of single-dose and multi-dose metronidazole prophylaxis for hysterectomy.
Topics: Abscess; Adolescent; Adult; Aged; Aged, 80 and over; Cellulitis; Clinical Trials as Topic; Double-Bl | 1987 |
Treatment of bacterial vaginosis with an acid cream: a comparison between the effect of lactate-gel and metronidazole.
Topics: Adult; Bacteria, Anaerobic; Bacterial Infections; Female; Gardnerella vaginalis; Haemophilus Infecti | 1986 |
Comparison of oral and vaginal metronidazole therapy for nonspecific bacterial vaginosis.
Topics: Administration, Oral; Adolescent; Adult; Bacterial Infections; Female; Humans; Metronidazole; Middle | 1986 |
14 other studies available for metronidazole and Vaginal Diseases
| Article | Year |
|---|---|
Self-Administered Home Series Fecal "Minitransplants" for Recurrent Clostridium difficile Infection on a Rectal Remnant.
Topics: Aged; Anti-Infective Agents; Clostridioides difficile; Colectomy; Enterocolitis, Pseudomembranous; F | 2015 |
[Experiences with methronidazole--Flagyl--in the treatment of trichomoniasis].
Topics: Disease; Female; Humans; Imidazoles; Metronidazole; Trichomonas Infections; Vagina; Vaginal Diseases | 1962 |
Effect of vaginal metronidazole + miconazole treatment during pregnancy for gestational age and birth weight in a population-based study.
Topics: Administration, Intravaginal; Adult; Antifungal Agents; Birth Weight; Case-Control Studies; Female; | 2005 |
Genital yeasts in female patients attending a VD clinic.
Topics: Adolescent; Adult; Age Factors; Anti-Bacterial Agents; Candida albicans; Candidiasis, Vulvovaginal; | 1975 |
[Urethritis syndrome and atypical germ flora of the exterior female genitalia (author's transl)].
Topics: Candidiasis, Vulvovaginal; Cervix Uteri; Chronic Disease; Female; Humans; Male; Metronidazole; Mycop | 1976 |
Comparison of the in vitro activities of fenticonazole, other imidazoles, metronidazole, and tetracycline against organisms associated with bacterial vaginosis and skin infections.
Topics: Antifungal Agents; Bacteria; Female; Humans; Imidazoles; Metronidazole; Microbial Sensitivity Tests; | 1989 |
Amoxycillin, augmentin and metronidazole in bacterial vaginosis associated with Gardnerella vaginalis.
Topics: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Clavulanic Acids; Drug Combinations; Fem | 1986 |
Single-dose therapy for genitourinary infections.
Topics: Acute Disease; Anti-Bacterial Agents; Antifungal Agents; Candidiasis, Vulvovaginal; Cystitis; Drug A | 1987 |
[Cutaneous Crohn disease].
Topics: Aged; Crohn Disease; Female; Humans; Metronidazole; Skin Diseases; Vaginal Diseases; Vulvar Diseases | 1986 |
Possible interaction between ethanol and vaginally administered metronidazole.
Topics: Administration, Intravaginal; Adult; Drug Interactions; Ethanol; Female; Humans; Metronidazole; Vagi | 1987 |
Incidence of trichomonadosis and vaginal mycosis.
Topics: Czechoslovakia; Female; Humans; Metronidazole; Mycoses; Trichomonas Vaginitis; Vaginal Diseases | 1973 |
[Vaginal trichomoniasis and cervix uteri changes].
Topics: Antitrichomonal Agents; Biopsy; Carcinoma; Cervix Uteri; Colposcopy; Diagnosis, Differential; Female | 1969 |
Clinical trial of a broad-spectrum antimicrobial preparation in vaginits.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Antifungal Agents; Candi | 1969 |
Prevention of post-metronidazole candidosis with amphotericin B pessaries.
Topics: Adolescent; Adult; Aged; Amphotericin B; Candida; Candidiasis; Female; Humans; Metronidazole; Middle | 1969 |