metronidazole has been researched along with Autoimmune Thrombocytopenia in 9 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "pylori infection and idiopathic thrombocytopenic purpura (ITP)." | 2.42 | [Evaluation of the efficacy of an Helicobacter pylori eradication treatment for idiopathic thrombocytopenic purpura patients]. ( Hirashima, N; Ito, K; Kato, A; Kato, H; Kondo, H; Matsunaga, S; Nukaya, H; Sakakibara, K; Sakamoto, T; Tanaka, Y, 2004) |
| "pylori-positive chronic idiopathic thrombocytopenic purpura (ITP)." | 1.33 | [Successful platelet recovery after the second eradication of Helicobacter pylori with metronidazole in two patients with chronic idiopathic thrombocytopenic purpura]. ( Hatao, K; Takahashi, T; Yamada, K, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amiri, M | 1 |
| Sato, R | 1 |
| Murakami, K | 1 |
| Okimoto, T | 1 |
| Watanabe, K | 1 |
| Kodama, M | 1 |
| Fujioka, T | 1 |
| Selgrad, M | 1 |
| Bornschein, J | 1 |
| Malfertheiner, P | 1 |
| Shigeto, N | 1 |
| Shimizu, S | 1 |
| Kato, A | 1 |
| Kato, H | 1 |
| Hirashima, N | 1 |
| Sakamoto, T | 1 |
| Nukaya, H | 1 |
| Ito, K | 1 |
| Matsunaga, S | 1 |
| Kondo, H | 1 |
| Tanaka, Y | 1 |
| Sakakibara, K | 1 |
| Konno, M | 1 |
| Takahashi, T | 1 |
| Hatao, K | 1 |
| Yamada, K | 1 |
| McCaulley, ME | 1 |
| García Pérez, A | 1 |
| Valverde de La Osa, J | 1 |
| Giménez Samper, M | 1 |
| Alonso García, I | 1 |
4 reviews available for metronidazole and Autoimmune Thrombocytopenia
| Article | Year |
|---|---|
[Helicobacter pylori: an infection with local complications and systemic effects].
Topics: Amoxicillin; Anemia, Iron-Deficiency; Anti-Bacterial Agents; Asthma; Clarithromycin; Cross-Sectional | 2011 |
[Eradication of Helicobacter pylori for idiopathic thrombocytopenic purpura].
Topics: Aged; Anti-Infective Agents; Clarithromycin; Drug Therapy, Combination; Female; Helicobacter Infecti | 2004 |
[Evaluation of the efficacy of an Helicobacter pylori eradication treatment for idiopathic thrombocytopenic purpura patients].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Amoxicillin; Anti-Infective Agents; Clarithromycin; D | 2004 |
[Helicobacter pylori eradication therapy for children].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Amoxicillin; Anemia, Iron-Deficiency; Anti-Bacterial Agents | 2005 |
5 other studies available for metronidazole and Autoimmune Thrombocytopenia
| Article | Year |
|---|---|
Impact of Helicobacter pylori Eradication Therapy on Platelet Counts in Patients With Chronic Idiopathic Thrombocytopenic Purpura.
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Clarithromycin; Drug Therapy, Combination; Fema | 2015 |
Development of corpus atrophic gastritis may be associated with Helicobacter pylori-related idiopathic thrombocytopenic purpura.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Clarithrom | 2011 |
[Successful platelet recovery after the second eradication of Helicobacter pylori with metronidazole in two patients with chronic idiopathic thrombocytopenic purpura].
Topics: Aged; Aged, 80 and over; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Clarithromycin; | 2006 |
Immune thrombocytopenia and ulcerative colitis: response to nonoperative therapy.
Topics: Adult; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Drug Ther | 1996 |
[Resolution of an autoimmune thrombocytopenic purpura after eradicating treatment of Helicobacter pylori].
Topics: Adult; Amoxicillin; Anti-Ulcer Agents; Autoimmune Diseases; Bismuth; Drug Therapy, Combination; Fema | 1999 |