metronidazole has been researched along with Critical Illness in 11 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Critical Illness: A disease or state in which death is possible or imminent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Data on the impact of combination therapy (intravenous metronidazole [IV MTZ] plus oral vancomycin [PO VAN]) on clinical outcomes in intensive care unit (ICU) patients with severe non-fulminant Clostridioides difficile infection (CDI), including NAP1-positive samples, are lacking." | 7.96 | Evaluation of Addition of Intravenous Metronidazole to Oral Vancomycin Therapy in Critically Ill Patients with Non-Fulminant Severe Clostridioides difficile Infection. ( Banoub, M; Blackman, AL; Claeys, KC; Heil, EL; Kristie Johnson, J; Leekha, S; Vega, AD, 2020) |
| "Data on the impact of combination therapy (intravenous metronidazole [IV MTZ] plus oral vancomycin [PO VAN]) on clinical outcomes in intensive care unit (ICU) patients with severe non-fulminant Clostridioides difficile infection (CDI), including NAP1-positive samples, are lacking." | 3.96 | Evaluation of Addition of Intravenous Metronidazole to Oral Vancomycin Therapy in Critically Ill Patients with Non-Fulminant Severe Clostridioides difficile Infection. ( Banoub, M; Blackman, AL; Claeys, KC; Heil, EL; Kristie Johnson, J; Leekha, S; Vega, AD, 2020) |
| " Nonetheless, there is a lack in pharmacokinetics information for this population, and dosing criteria may vary between healthcare centers." | 1.91 | Model-informed precision dosing of antimicrobial drugs in pediatrics: experiences from a pilot scale program. ( Arriaga-García, FJ; Medellín-Garibay, SE; Milán-Segovia, RDC; Pérez-González, LF; Rodríguez-Báez, AS; Romano-Moreno, S; Velarde-Salcedo, R, 2023) |
| "Bacteremia was infrequently detected, but isolated pathogens were multidrug resistant." | 1.56 | Prevalence, Etiology, and Outcome of Sepsis among Critically Ill Patients in Malawi. ( Charles, A; Kadyaudzu, C; Onofrey, L; Prin, M; Purcell, L, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 5 (45.45) | 2.80 |
| Authors | Studies |
|---|---|
| Velarde-Salcedo, R | 1 |
| Pérez-González, LF | 1 |
| Rodríguez-Báez, AS | 1 |
| Arriaga-García, FJ | 1 |
| Milán-Segovia, RDC | 1 |
| Romano-Moreno, S | 1 |
| Medellín-Garibay, SE | 1 |
| Manthey, CF | 1 |
| Dranova, D | 1 |
| Christner, M | 1 |
| Drolz, A | 1 |
| Kluge, S | 1 |
| Lohse, AW | 1 |
| Fuhrmann, V | 1 |
| Vega, AD | 1 |
| Heil, EL | 2 |
| Blackman, AL | 1 |
| Banoub, M | 2 |
| Kristie Johnson, J | 1 |
| Leekha, S | 2 |
| Claeys, KC | 2 |
| Prin, M | 1 |
| Onofrey, L | 1 |
| Purcell, L | 1 |
| Kadyaudzu, C | 1 |
| Charles, A | 1 |
| Ito, H | 1 |
| Vega, A | 1 |
| Blackman, A | 1 |
| Johnson, JK | 1 |
| Carter, C | 1 |
| Viveash, S | 1 |
| Rokas, KE | 1 |
| Johnson, JW | 1 |
| Beardsley, JR | 1 |
| Ohl, CA | 1 |
| Luther, VP | 1 |
| Williamson, JC | 1 |
| Koo, JS | 1 |
| Choi, WS | 1 |
| Park, DW | 1 |
| Yildiz, T | 1 |
| Gündeş, S | 1 |
| Willke, A | 1 |
| Solak, M | 1 |
| Toker, K | 1 |
| Grundfest-Broniatowski, S | 1 |
| Quader, M | 1 |
| Alexander, F | 1 |
| Walsh, RM | 1 |
| Lavery, I | 1 |
| Milsom, J | 1 |
1 review available for metronidazole and Critical Illness
| Article | Year |
|---|---|
Clostridium difficile colitis in the critically ill.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; APACHE; Colectomy; Combined Modal | 1996 |
10 other studies available for metronidazole and Critical Illness
| Article | Year |
|---|---|
Model-informed precision dosing of antimicrobial drugs in pediatrics: experiences from a pilot scale program.
Topics: Anti-Bacterial Agents; Bayes Theorem; Child; Clindamycin; Critical Illness; Fluconazole; Humans; Lin | 2023 |
Initial therapy affects duration of diarrhoea in critically ill patients with Clostridioides difficile infection (CDI).
Topics: Aged; Anti-Infective Agents; Clostridioides difficile; Clostridium Infections; Cohort Studies; Criti | 2019 |
Evaluation of Addition of Intravenous Metronidazole to Oral Vancomycin Therapy in Critically Ill Patients with Non-Fulminant Severe Clostridioides difficile Infection.
Topics: Administration, Oral; Aged; Anti-Bacterial Agents; APACHE; Clostridium Infections; Cohort Studies; C | 2020 |
Prevalence, Etiology, and Outcome of Sepsis among Critically Ill Patients in Malawi.
Topics: Adult; Anti-Bacterial Agents; Antifungal Agents; Bacteremia; Burkholderia Infections; Candida glabra | 2020 |
Critique of "Evaluation of Addition of Intravenous Metronidazole to Oral Vancomycin Therapy in Critically Ill Patients with Non-Fulminant Severe Clostridioides difficile Infection".
Topics: Clostridioides; Clostridium Infections; Critical Illness; Humans; Metronidazole; Vancomycin | 2020 |
Reply to Letters to the Editor.
Topics: Anti-Infective Agents; Clostridioides; Clostridium Infections; Critical Illness; Humans; Metronidazo | 2020 |
Nursing a critically ill tetanus patient in an intensive care unit in Zambia.
Topics: Analgesics, Opioid; Anti-Infective Agents; Anticonvulsants; Back Pain; Critical Care Nursing; Critic | 2017 |
The Addition of Intravenous Metronidazole to Oral Vancomycin is Associated With Improved Mortality in Critically Ill Patients With Clostridium difficile Infection.
Topics: Administration, Intravenous; Administration, Oral; Adult; Aged; Anti-Infective Agents; Clostridioide | 2015 |
Fulminant amebic colitis mimicking pseudomembranous colitis.
Topics: Anastomosis, Surgical; Anti-Bacterial Agents; Appendectomy; Biopsy, Needle; Colonoscopy; Combined Mo | 2010 |
Spontaneous, nontraumatic gas gangrene due to Clostridium perfringens.
Topics: Amikacin; Anti-Bacterial Agents; Anti-Infective Agents; Blister; Ceftazidime; Clostridium perfringen | 2006 |