delmopinol: structure in first source
ID Source | ID |
---|---|
PubMed CID | 57337 |
CHEMBL ID | 2104220 |
CHEBI ID | 135122 |
SCHEMBL ID | 120704 |
MeSH ID | M0199265 |
Synonym |
---|
79874-76-3 |
decapinol |
decapinolum |
CHEBI:135122 |
delmopinol |
2-[3-(4-propylheptyl)morpholin-4-yl]ethanol |
(rs)-2-(3-(4-propylheptyl)morpholino)ethanol |
4-morpholineethanol, 3-(4-propylheptyl)-, (+-)- |
delmopinol [inn] |
delmopinolum [inn-latin] |
delmopinolum |
dt67wl708f , |
unii-dt67wl708f |
(+-)-3-(4-propylheptyl)-4-morpholineethanol |
delmopinol hcl |
CHEMBL2104220 |
delmopinol [mi] |
(+/-)-3-(4-propylheptyl)-4-morpholineethanol |
delmopinol [who-dd] |
QSFOWAYMMZCQNF-UHFFFAOYSA-N |
4-(2-hydroxyethyl)-3-(4-propylheptyl)morpholine |
SCHEMBL120704 |
FT-0700717 |
Q13571783 |
2-(3-(4-propylheptyl)morpholino)ethanol hydrochloride |
2-[3-(4-propylheptyl)morpholin-4-yl]ethan-1-ol |
DTXSID10868552 |
Delmopinol is a tertiary amine surfactant that is used to counteract dental plaque formation. It is a morpholinoethanol derivative which, in mouthrinses used in the absence of normal oral hygiene, has been shown effective in inhibition of plaque and gingivitis.
Delmopinol has been shown to possess plaque inhibitory activity in several previous studies. It is considered a potential agent for the chemical control of plaque.
Excerpt | Reference | Relevance |
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"Delmopinol has been shown to possess plaque inhibitory activity in several previous studies." | ( The relative efficacy of 0.1% and 0.2% delmopinol mouthrinses in inhibiting the development of supragingival dental plaque and gingivitis in man. Abbott, DM; Gunsolley, JC; Koertge, TE; Payne, EL, 1994) | 1.28 |
"Delmopinol has been considered as a potential agent for the chemical control of plaque. " | ( A comparison of delmopinol and chlorhexidine on plaque regrowth over a 4-day period and salivary bacterial counts. Addy, M; Aström, M; Maynard, JH; Moran, J; Movert, R; Roberts, SE; Wade, WG, 1992) | 2.07 |
Excerpt | Reference | Relevance |
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"Delmopinol showed 22% lower plaque index scores than placebo after 3 months (p<0.01) and 13% lower scores after 6 months." | ( 6-month use of 0.2% delmopinol hydrochloride in comparison with 0.2% chlorhexidine digluconate and placebo. (I). Effect on plaque formation and gingivitis. Attström, R; Edwardsson, S; Hase, JC; Kelty, E; Kisch, J, 1998) | 1.34 |
Delmopinol hydrochloride treatment of the previously placebo-treated surfaces resulted in a decrease in the number of surfaces with visible plaque from 89.3% to 6% on day 14. The delmopinols-treated plaques lost 59% of their wet weight upon sonication, while the controls lost only 19%.
Excerpt | Reference | Relevance |
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"Delmopinol hydrochloride treatment of the previously placebo-treated surfaces resulted in a decrease in the number of surfaces with visible plaque from 89.3% on day 7 to 6% on day 14." | ( Effect of local application of delmopinol hydrochloride on developing and early established supragingival plaque in humans. Attström, R; Edwardsson, S; Klinge, B; Matsson, L; Sjödin, T, 1996) | 1.3 |
"The delmopinol-treated plaques lost 59% of their wet weight upon sonication, while the controls lost only 19%." | ( Effect of delmopinol on the cohesion of glucan-containing plaque formed by Streptococcus mutans in a flow cell system. Hansson, E; Petersson, L; Rundegren, J; Simonsson, T, 1992) | 1.17 |
To compare three different rinse times with delmopinol (15, 30 and 60 seconds) with respect to inhibition of plaque growth. To determine the pharmacokinetic parameters of delmop inol for these rinse times.
Excerpt | Reference | Relevance |
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"To compare three different rinse times with delmopinol (15, 30 and 60 seconds) with respect to inhibition of plaque growth and to determine the pharmacokinetic parameters of delmopinol for these rinse times." | ( Pharmacokinetics and clinical efficacy of delmopinol in an open rinse time study in healthy volunteers. Aström, M; Ekman, I; Håkansson, J; Sjödin, T; Sparre, B, 2011) | 0.89 |
" Plasma samples for the pharmacokinetic evaluation were also taken." | ( Pharmacokinetics and clinical efficacy of delmopinol in an open rinse time study in healthy volunteers. Aström, M; Ekman, I; Håkansson, J; Sjödin, T; Sparre, B, 2011) | 0.63 |
" Statistical analysis of the systemic exposure, in terms of the pharmacokinetic parameters AUC(12h) and C(max) showed a significant treatment effect." | ( Pharmacokinetics and clinical efficacy of delmopinol in an open rinse time study in healthy volunteers. Aström, M; Ekman, I; Håkansson, J; Sjödin, T; Sparre, B, 2011) | 0.63 |
Excerpt | Reference | Relevance |
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" Results indicate a very low bioavailability (1-3%) due to extensive first-pass metabolism of delmopinol after oral administration." | ( Pharmacokinetics of 14C-delmopinol in the healthy male volunteer. Eriksson, B; Gunnarsson, PO; Hallström, G; Ottersgård Brorsson, AK; Sjödin, T, 1998) | 0.83 |
The aim of this study was to investigate a possible dose-response effect of delmopinol hydrochloride, on the development of plaque and on the healing of gingivitis.
Excerpt | Relevance | Reference |
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"The aim of this study was to investigate a possible dose-response effect of delmopinol hydrochloride, on the development of plaque and on the healing of gingivitis." | ( The effect of delmopinol rinsing on dental plaque formation and gingivitis healing. Attström, R; Collaert, B; De Bruyn, H; Movert, R, 1992) | 0.87 |
"The aim of this study was to test a possible dose-response effect of topical application of delmopinol HCl on the salivary microbiology, the healing of a pre-established experimental gingivitis, plaque development, and supragingival plaque composition." | ( Short-term effect of topical application of delmopinol on salivary microbiology, plaque, and gingivitis. Aström, M; Attström, R; Collaert, B; Edwardsson, S; Hase, JC; Movert, R, 1994) | 0.77 |
Class | Description |
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morpholines | Any compound containing morpholine as part of its structure. |
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 35 (60.34) | 18.2507 |
2000's | 7 (12.07) | 29.6817 |
2010's | 10 (17.24) | 24.3611 |
2020's | 6 (10.34) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (26.80) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 21 (34.43%) | 5.53% |
Reviews | 4 (6.56%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 36 (59.02%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |