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delmopinol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

delmopinol: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID57337
CHEMBL ID2104220
CHEBI ID135122
SCHEMBL ID120704
MeSH IDM0199265

Synonyms (27)

Synonym
79874-76-3
decapinol
decapinolum
CHEBI:135122
delmopinol
2-[3-(4-propylheptyl)morpholin-4-yl]ethanol
(rs)-2-(3-(4-propylheptyl)morpholino)ethanol
4-morpholineethanol, 3-(4-propylheptyl)-, (+-)-
delmopinol [inn]
delmopinolum [inn-latin]
delmopinolum
dt67wl708f ,
unii-dt67wl708f
(+-)-3-(4-propylheptyl)-4-morpholineethanol
delmopinol hcl
CHEMBL2104220
delmopinol [mi]
(+/-)-3-(4-propylheptyl)-4-morpholineethanol
delmopinol [who-dd]
QSFOWAYMMZCQNF-UHFFFAOYSA-N
4-(2-hydroxyethyl)-3-(4-propylheptyl)morpholine
SCHEMBL120704
FT-0700717
Q13571783
2-(3-(4-propylheptyl)morpholino)ethanol hydrochloride
2-[3-(4-propylheptyl)morpholin-4-yl]ethan-1-ol
DTXSID10868552

Research Excerpts

Overview

Delmopinol is a tertiary amine surfactant that is used to counteract dental plaque formation. It is a morpholinoethanol derivative which, in mouthrinses used in the absence of normal oral hygiene, has been shown effective in inhibition of plaque and gingivitis.

ExcerptReferenceRelevance
"Delmopinol is a tertiary amine surfactant that is used to counteract dental plaque formation. "( Adsorption of delmopinol at the solid/liquid interface--the role of the acid-base equilibrium.
Arnebrant, T; Halthur, T; Sjödin, T; Svensson, O, 2010
)
2.16
"Delmopinol is a third-generation anti-plaque agent used as a mouthwash to reduce plaque and alleviate gingivitis."( Meta-analyses of studies of 0.2% delmopinol mouth rinse as an adjunct to gingival health and plaque control measures.
Addy, M; Moran, J; Newcombe, RG, 2007
)
2.06
"Delmopinol is a new surface-active agent which can reduce plaque formation and gingivitis. "( Effects of delmopinol on antimicrobial peroxidase systems and lysozyme in vitro and in human whole saliva.
Hannuksela, S; Lenander-Lumikari, M; Tenovuo, J, 1995
)
2.12
"Delmopinol hydrochloride is a highly surface active substance which has been shown to reduce the amount of plaque in vitro and in vivo and the level of gingivitis in vivo. "( In vitro interactions of delmopinol hydrochloride with salivary films adsorbed at solid/liquid interfaces.
Arnebrant, T; Rundegren, J; Vassilakos, N, 1993
)
2.03
"Delmopinol is a morpholinoethanol derivative which, in mouthrinses used in the absence of normal oral hygiene, has been shown effective in the inhibition of plaque and gingivitis. "( A 6-month home-usage trial of 0.1% and 0.2% delmopinol mouthwashes (I). Effects on plaque, gingivitis, supragingival calculus and tooth staining.
Addy, M; Claydon, N; Hunter, L; Kelty, E; Moran, J; Movert, R; Wade, W, 1996
)
2
"Delmopinol is a new surface active anti-plaque agent that has demonstrated a low antimicrobial effect in vitro. "( Effect of 4 days of mouth rinsing with delmopinol or chlorhexidine on the vitality of plaque bacteria.
Aström, M; Hvid, EB; Johansson, M; Rundegren, J, 1992
)
2
"Delmopinol is a low molecular weight surface-active compound that has been shown to be effective against dental plaque both in vitro and in vivo and against gingivitis in vivo. "( Influence of delmopinol on bacterial zeta-potentials and on the colloidal stability of bacterial suspensions.
Arnebrant, T; Hvid, EB; Petersson, L; Simonsson, T, 1991
)
2.09

Effects

Delmopinol has been shown to possess plaque inhibitory activity in several previous studies. It is considered a potential agent for the chemical control of plaque.

ExcerptReferenceRelevance
"Delmopinol has been shown to possess plaque inhibitory activity in several previous studies."( The relative efficacy of 0.1% and 0.2% delmopinol mouthrinses in inhibiting the development of supragingival dental plaque and gingivitis in man.
Abbott, DM; Gunsolley, JC; Koertge, TE; Payne, EL, 1994
)
1.28
"Delmopinol has been considered as a potential agent for the chemical control of plaque. "( A comparison of delmopinol and chlorhexidine on plaque regrowth over a 4-day period and salivary bacterial counts.
Addy, M; Aström, M; Maynard, JH; Moran, J; Movert, R; Roberts, SE; Wade, WG, 1992
)
2.07

Actions

ExcerptReferenceRelevance
"Delmopinol showed 22% lower plaque index scores than placebo after 3 months (p<0.01) and 13% lower scores after 6 months."( 6-month use of 0.2% delmopinol hydrochloride in comparison with 0.2% chlorhexidine digluconate and placebo. (I). Effect on plaque formation and gingivitis.
Attström, R; Edwardsson, S; Hase, JC; Kelty, E; Kisch, J, 1998
)
1.34

Treatment

Delmopinol hydrochloride treatment of the previously placebo-treated surfaces resulted in a decrease in the number of surfaces with visible plaque from 89.3% to 6% on day 14. The delmopinols-treated plaques lost 59% of their wet weight upon sonication, while the controls lost only 19%.

ExcerptReferenceRelevance
"Delmopinol hydrochloride treatment of the previously placebo-treated surfaces resulted in a decrease in the number of surfaces with visible plaque from 89.3% on day 7 to 6% on day 14."( Effect of local application of delmopinol hydrochloride on developing and early established supragingival plaque in humans.
Attström, R; Edwardsson, S; Klinge, B; Matsson, L; Sjödin, T, 1996
)
1.3
"The delmopinol-treated plaques lost 59% of their wet weight upon sonication, while the controls lost only 19%."( Effect of delmopinol on the cohesion of glucan-containing plaque formed by Streptococcus mutans in a flow cell system.
Hansson, E; Petersson, L; Rundegren, J; Simonsson, T, 1992
)
1.17

Pharmacokinetics

To compare three different rinse times with delmopinol (15, 30 and 60 seconds) with respect to inhibition of plaque growth. To determine the pharmacokinetic parameters of delmop inol for these rinse times.

ExcerptReferenceRelevance
"To compare three different rinse times with delmopinol (15, 30 and 60 seconds) with respect to inhibition of plaque growth and to determine the pharmacokinetic parameters of delmopinol for these rinse times."( Pharmacokinetics and clinical efficacy of delmopinol in an open rinse time study in healthy volunteers.
Aström, M; Ekman, I; Håkansson, J; Sjödin, T; Sparre, B, 2011
)
0.89
" Plasma samples for the pharmacokinetic evaluation were also taken."( Pharmacokinetics and clinical efficacy of delmopinol in an open rinse time study in healthy volunteers.
Aström, M; Ekman, I; Håkansson, J; Sjödin, T; Sparre, B, 2011
)
0.63
" Statistical analysis of the systemic exposure, in terms of the pharmacokinetic parameters AUC(12h) and C(max) showed a significant treatment effect."( Pharmacokinetics and clinical efficacy of delmopinol in an open rinse time study in healthy volunteers.
Aström, M; Ekman, I; Håkansson, J; Sjödin, T; Sparre, B, 2011
)
0.63

Bioavailability

ExcerptReferenceRelevance
" Results indicate a very low bioavailability (1-3%) due to extensive first-pass metabolism of delmopinol after oral administration."( Pharmacokinetics of 14C-delmopinol in the healthy male volunteer.
Eriksson, B; Gunnarsson, PO; Hallström, G; Ottersgård Brorsson, AK; Sjödin, T, 1998
)
0.83

Dosage Studied

The aim of this study was to investigate a possible dose-response effect of delmopinol hydrochloride, on the development of plaque and on the healing of gingivitis.

ExcerptRelevanceReference
"The aim of this study was to investigate a possible dose-response effect of delmopinol hydrochloride, on the development of plaque and on the healing of gingivitis."( The effect of delmopinol rinsing on dental plaque formation and gingivitis healing.
Attström, R; Collaert, B; De Bruyn, H; Movert, R, 1992
)
0.87
"The aim of this study was to test a possible dose-response effect of topical application of delmopinol HCl on the salivary microbiology, the healing of a pre-established experimental gingivitis, plaque development, and supragingival plaque composition."( Short-term effect of topical application of delmopinol on salivary microbiology, plaque, and gingivitis.
Aström, M; Attström, R; Collaert, B; Edwardsson, S; Hase, JC; Movert, R, 1994
)
0.77
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
morpholinesAny compound containing morpholine as part of its structure.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (58)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's35 (60.34)18.2507
2000's7 (12.07)29.6817
2010's10 (17.24)24.3611
2020's6 (10.34)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 26.80

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index26.80 (24.57)
Research Supply Index4.42 (2.92)
Research Growth Index4.62 (4.65)
Search Engine Demand Index61.43 (26.88)
Search Engine Supply Index3.95 (0.95)

This Compound (26.80)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials21 (34.43%)5.53%
Reviews4 (6.56%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other36 (59.02%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]