metronidazole has been researched along with Burns in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Burns: Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mallikarjuna Rao, C | 1 |
| Ghosh, A | 1 |
| Raghothama, C | 1 |
| Bairy, KL | 1 |
| Huang, X | 1 |
| Ma, E | 1 |
| Gong, L | 1 |
| Pandey, S | 1 |
| Basheer, M | 1 |
| Roy, S | 1 |
| Udupa, N | 1 |
| Ramakrishnan, KM | 1 |
| Jayaraman, V | 1 |
| Ramachandran, K | 1 |
| Madhivanan, T | 1 |
4 other studies available for metronidazole and Burns
| Article | Year |
|---|---|
Does metronidazole reduce lipid peroxidation in burn injuries to promote healing?
Topics: Animals; Anti-Infective Agents; Antioxidants; Burns; Disease Models, Animal; Lipid Peroxidation; Mal | 2002 |
[Clinical analysis of anaerobic septicemia in 26 patients with extensive burn].
Topics: Adolescent; Adult; Anti-Bacterial Agents; Bacteremia; Bacteroides fragilis; Bacteroides Infections; | 1995 |
Development and evaluation of transdermal formulations containing metronidazole and norfloxacin for the treatment of burn wound.
Topics: Administration, Cutaneous; Animals; Burns; Male; Metronidazole; Norfloxacin; Rats; Rats, Wistar | 1999 |
The management of anaerobic infection in extensive burns.
Topics: Adolescent; Adult; Bacteria, Anaerobic; Bacterial Infections; Burns; Child; Humans; Metronidazole; M | 1986 |