metronidazole has been researched along with Acute Brain Injuries in 5 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A large traumatic brain abscess in a 9-year-old white boy was successfully treated conservatively with antibiotics, including metronidazole and ampicillin." | 3.67 | Nonsurgical treatment of a traumatic brain abscess in a child. ( Bartholdy, NJ; Haase, J; Sandermann, J; Udesen, H, 1986) |
| "The changes in management of intradural brain abscess at Groote Schuur Hospital for the 35 years 1952-1986 are reviewed." | 1.28 | Cranial intradural abscess management of 641 patients during the 35 years from 1952 to 1986. ( Keet, PC, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Frasca, D | 2 |
| Dahyot-Fizelier, C | 2 |
| Adier, C | 2 |
| Mimoz, O | 2 |
| Debaene, B | 2 |
| Couet, W | 2 |
| Marchand, S | 2 |
| Knerlich, F | 1 |
| Verheggen, R | 1 |
| Keet, PC | 1 |
| Sandermann, J | 1 |
| Haase, J | 1 |
| Bartholdy, NJ | 1 |
| Udesen, H | 1 |
5 other studies available for metronidazole and Acute Brain Injuries
| Article | Year |
|---|---|
Metronidazole and hydroxymetronidazole central nervous system distribution: 1. microdialysis assessment of brain extracellular fluid concentrations in patients with acute brain injury.
Topics: Aged; Anti-Infective Agents; Area Under Curve; Biotransformation; Blood-Brain Barrier; Brain; Brain | 2014 |
Metronidazole and hydroxymetronidazole central nervous system distribution: 2. cerebrospinal fluid concentration measurements in patients with external ventricular drain.
Topics: Aged; Anti-Infective Agents; Area Under Curve; Biotransformation; Blood-Brain Barrier; Brain Injurie | 2014 |
Neurological picture. Feeding cats might be dangerous: penetrating orbital and brain injury without neurological deficits.
Topics: Aged; Amoxicillin-Potassium Clavulanate Combination; Animals; Antifungal Agents; Brain Injuries; Cat | 2005 |
Cranial intradural abscess management of 641 patients during the 35 years from 1952 to 1986.
Topics: Brain Abscess; Brain Injuries; Glasgow Coma Scale; Humans; Metronidazole; Otitis Media; Prognosis; T | 1990 |
Nonsurgical treatment of a traumatic brain abscess in a child.
Topics: Ampicillin; Brain Abscess; Brain Injuries; Child; Chloramphenicol; Diagnosis, Differential; Drug The | 1986 |