metronidazole has been researched along with Dientamoeba fragilis Infection in 22 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole treatment had a short-term impact on the abundance of some bacterial genera, with most of these reverting to pretreatment levels 8 weeks after completed treatment." | 3.01 | Impact of Metronidazole Treatment and Dientamoeba Fragilis Colonization on Gut Microbiota Diversity. ( Andersen, LO; Gotfred-Rasmussen, H; Ingham, AC; Johannesen, TB; Nielsen, HV; Röser, D; Stensvold, CR, 2021) |
| "Metronidazole is a well-known and commonly used anti-protozoal agent, but another 5-nitroimidazole derivative, ornidazole, may be preferable, where available, because of its longer half-life and fewer side-effects." | 2.73 | A comparison of metronidazole and single-dose ornidazole for the treatment of dientamoebiasis. ( Balcioğlu, IC; Girginkardeşler, N; Kurt, O; Ok, UZ; Ozbilgin, A, 2008) |
| "Metronidazole was the therapeutic option in most cases, followed by paromomycin: 65." | 1.51 | Paromomycin is superior to metronidazole in Dientamoeba fragilis treatment. ( Abellana, R; Burgaña, A; García-Puig, R; Gonçalves, AQ; Hernández, CG; Kazan, R; Padilla, E; Pérez Ortiz, AM; Pérez, J; Perez-Porcuna, TM; Ramos, CC; Rivero, MM; Yordanov, SZ, 2019) |
| "Metronidazole treatment failure was significantly more frequent in patients with E." | 1.43 | Is the treatment of Enterobius vermicularis co-infection necessary to eradicate Dientamoeba fragilis infection? ( Boga, JA; Fernández, J; Iglesias, C; Martínez-Camblor, P; Rodríguez, M; Rodríguez-Guardado, A; Rojo, S; Vázquez, F, 2016) |
| "Recurrence of the symptoms and recurrence of the D." | 1.42 | [Dientamoeba fragilis infection as cause of severe abdominal discomfort and flatulence]. ( Halkjær, S; Petersen, AM; Stensvold, CR, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (13.64) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (27.27) | 29.6817 |
| 2010's | 10 (45.45) | 24.3611 |
| 2020's | 3 (13.64) | 2.80 |
| Authors | Studies |
|---|---|
| Montraveta-Querol, M | 1 |
| Bovo, MV | 1 |
| Roig-Abraham, N | 1 |
| Romaní, N | 1 |
| Alcaraz, A | 1 |
| Fernández-Rivas, G | 1 |
| Burgaña, A | 1 |
| Abellana, R | 1 |
| Yordanov, SZ | 1 |
| Kazan, R | 1 |
| Pérez Ortiz, AM | 1 |
| Ramos, CC | 1 |
| Hernández, CG | 1 |
| Rivero, MM | 1 |
| Gonçalves, AQ | 1 |
| Padilla, E | 1 |
| Pérez, J | 1 |
| García-Puig, R | 1 |
| Perez-Porcuna, TM | 1 |
| Clemente, L | 1 |
| Pasut, M | 1 |
| Carlet, R | 1 |
| Ruscio, M | 1 |
| Fontana, F | 1 |
| Gotfred-Rasmussen, H | 1 |
| Stensvold, CR | 5 |
| Ingham, AC | 1 |
| Johannesen, TB | 1 |
| Andersen, LO | 1 |
| Röser, D | 2 |
| Nielsen, HV | 4 |
| Menéndez, C | 1 |
| Fernández-Suarez, J | 1 |
| Boga Ribeiro, JA | 1 |
| Rodríguez-Pérez, M | 1 |
| Vázquez, F | 2 |
| Gonzalez-Sotorrios, N | 1 |
| Rodríguez-Guardado, A | 2 |
| Simonsen, J | 1 |
| Olsen, KE | 2 |
| Bytzer, P | 2 |
| Mølbak, K | 2 |
| de Jong, MJ | 1 |
| Korterink, JJ | 1 |
| Benninga, MA | 1 |
| Hilbink, M | 1 |
| Widdershoven, J | 1 |
| Deckers-Kocken, JM | 1 |
| Halkjær, S | 1 |
| Petersen, AM | 1 |
| Boga, JA | 1 |
| Rojo, S | 1 |
| Fernández, J | 1 |
| Rodríguez, M | 1 |
| Iglesias, C | 1 |
| Martínez-Camblor, P | 1 |
| Lewis, HC | 1 |
| Hammerum, AM | 1 |
| Porsbo, LJ | 1 |
| Nielsen, SS | 1 |
| Arendrup, MC | 1 |
| Lankester, F | 1 |
| Kiyang, JA | 1 |
| Bailey, W | 1 |
| Unwin, S | 1 |
| Banik, GR | 1 |
| Barratt, JL | 1 |
| Marriott, D | 1 |
| Harkness, J | 1 |
| Ellis, JT | 1 |
| Stark, D | 1 |
| Engsbro, AL | 1 |
| Schure, JM | 1 |
| de Vries, M | 1 |
| Weel, JF | 1 |
| van Roon, EN | 1 |
| Faber, TE | 1 |
| Girginkardeşler, N | 2 |
| Coşkun, S | 1 |
| Cüneyt Balcioğlu, I | 1 |
| Ertan, P | 1 |
| Ok, UZ | 2 |
| Norberg, A | 1 |
| Nord, CE | 1 |
| Evengård, B | 2 |
| Ito, R | 1 |
| Sakagami, J | 1 |
| Kataoka, K | 1 |
| Nakamura, H | 1 |
| Motoyoshi, T | 1 |
| Takada, R | 1 |
| Kanemitsu, D | 1 |
| Yasuda, H | 1 |
| Mitsufuji, S | 1 |
| Okanoue, T | 1 |
| Kurt, O | 1 |
| Balcioğlu, IC | 1 |
| Ozbilgin, A | 1 |
| Wolfe, MS | 1 |
| Lindström, J | 1 |
| Spencer, MJ | 1 |
| Garcia, LS | 1 |
| Chapin, MR | 1 |
| Turner, JA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Metronidazole for the Treatment of Dientamoebiasis in Children in Denmark - A Randomized, Placebo-controlled, Double-blinded Clinical Trial[NCT01314976] | Phase 4 | 100 participants (Anticipated) | Interventional | 2011-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for metronidazole and Dientamoeba fragilis Infection
| Article | Year |
|---|---|
The treatment of intestinal protozoan infections.
Topics: Amebicides; Antimalarials; Antiprotozoal Agents; Balantidiasis; Chloroquine; Coccidiosis; Dientamoeb | 1982 |
[Dientamoeba fragilis--an old parasite sparks new interest].
Topics: Animals; Antitrichomonal Agents; Dientamoeba; Dientamoebiasis; Feces; Humans; Metronidazole | 2001 |
Giardiasis and infections with Dientamoeba fragilis.
Topics: Adult; Amebiasis; Animals; Cats; Child; Child, Preschool; Dientamoeba; Dientamoebiasis; Dogs; Female | 1985 |
4 trials available for metronidazole and Dientamoeba fragilis Infection
| Article | Year |
|---|---|
Impact of Metronidazole Treatment and Dientamoeba Fragilis Colonization on Gut Microbiota Diversity.
Topics: Child; Dientamoeba; Dientamoebiasis; Feces; Gastrointestinal Microbiome; Humans; Metronidazole | 2021 |
Metronidazole therapy for treating dientamoebiasis in children is not associated with better clinical outcomes: a randomized, double-blinded and placebo-controlled clinical trial.
Topics: Anti-Infective Agents; Child; Child, Preschool; Denmark; Dientamoebiasis; Double-Blind Method; Femal | 2014 |
Dientamoeba fragilis, a neglected cause of diarrhea, successfully treated with secnidazole.
Topics: Adolescent; Adult; Animals; Antiprotozoal Agents; Child; Child, Preschool; Diarrhea; Dientamoeba; Di | 2003 |
A comparison of metronidazole and single-dose ornidazole for the treatment of dientamoebiasis.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Amebicides; Animals; Antiprotozoal | 2008 |
15 other studies available for metronidazole and Dientamoeba fragilis Infection
| Article | Year |
|---|---|
Should Dientamoeba fragillis be looked for in pediatric digestive pathology of an unknown cause? A proposed pilot case-control study.
Topics: Case-Control Studies; Child; Dientamoeba; Dientamoebiasis; Humans; Metronidazole; Real-Time Polymera | 2022 |
Paromomycin is superior to metronidazole in Dientamoeba fragilis treatment.
Topics: Adolescent; Adult; Antiprotozoal Agents; Child; Dientamoeba; Dientamoebiasis; Feces; Female; Humans; | 2019 |
Dientamoeba fragilis in the North-East of Italy: Prevalence study and treatment.
Topics: Adolescent; Adult; Aged; Antiprotozoal Agents; Child; Child, Preschool; Cross-Sectional Studies; Die | 2021 |
Epidemiological and clinical characteristics of Dientamoeba fragilis infection.
Topics: Adult; Antiprotozoal Agents; Dientamoebiasis; Female; Humans; Male; Metronidazole; Middle Aged; Paro | 2019 |
Dientamoeba fragilis and chronic abdominal pain in children: a case-control study.
Topics: Abdominal Pain; Adolescent; Antiprotozoal Agents; Case-Control Studies; Child; Chronic Disease; Clio | 2014 |
[Dientamoeba fragilis infection as cause of severe abdominal discomfort and flatulence].
Topics: Adolescent; Dientamoeba; Dientamoebiasis; Feces; Flatulence; Humans; Male; Metronidazole; Recurrence | 2015 |
Is the treatment of Enterobius vermicularis co-infection necessary to eradicate Dientamoeba fragilis infection?
Topics: Adolescent; Adult; Aged; Animals; Anthelmintics; Antiprotozoal Agents; Child; Child, Preschool; Coin | 2016 |
Blastocystis: unravelling potential risk factors and clinical significance of a common but neglected parasite.
Topics: Adolescent; Adult; Aged; Animals; Antiparasitic Agents; Blastocystis; Blastocystis Infections; Child | 2009 |
Dientamoeba fragilis: initial evidence of pathogenicity in the western lowland gorilla (Gorilla gorilla gorilla).
Topics: Animals; Antiprotozoal Agents; Ape Diseases; Dientamoeba; Dientamoebiasis; Feces; Female; Gorilla go | 2010 |
A case-controlled study of Dientamoeba fragilis infections in children.
Topics: Abdominal Pain; Adolescent; Antiprotozoal Agents; Australia; Case-Control Studies; Child; Child, Pre | 2011 |
Treatment of Dientamoeba fragilis in patients with irritable bowel syndrome.
Topics: Adult; Antiprotozoal Agents; Denmark; Dientamoeba; Dientamoebiasis; Feces; Female; Humans; Irritable | 2012 |
Symptoms and treatment of Dientamoeba fragilis infection in children, a retrospective study.
Topics: Adolescent; Antiprotozoal Agents; Child; Child, Preschool; Clioquinol; Dientamoebiasis; Feces; Femal | 2013 |
Dientamoeba fragilis--a protozoal infection which may cause severe bowel distress.
Topics: Adolescent; Adult; Aged; Animals; Anti-Infective Agents; Child; Child, Preschool; Diarrhea; Dientamo | 2003 |
Chronic diarrhea and protein-losing gastroenteropathy caused by Dientamoeba fragilis.
Topics: Aged; Antiprotozoal Agents; Biopsy; Chronic Disease; Colon; Diarrhea; Dientamoebiasis; Feces; Female | 2004 |
Dientamoeba fragilis. An intestinal pathogen in children?
Topics: Amebiasis; Child; Child, Preschool; Dientamoebiasis; Female; Gastrointestinal Diseases; Humans; Infa | 1979 |