metronidazole has been researched along with Puerperal Disorders in 12 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Puerperal Disorders: Disorders or diseases associated with PUERPERIUM, the six-to-eight-week period immediately after PARTURITION in humans.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pathogenic anaerobic bacteria may be among the causes of puerperal mastitis which, therefore, was treated by the authors with metronidazole (Vagimid) and with antibiotics, such as penicillin, oxacillin, erythromycin, and oxytetracycline." | 7.66 | [Metronidazole for treatment of puerperal mastitis (author's transl)]. ( Amon, I; Amon, K; Scharp, H, 1982) |
| "Serum levels of tobramycin were determined with an enzyme immunoassay technique in 20 puerperal women with postcesarean endometritis who were being treated with metronidazole-tobramycin." | 3.67 | Tobramycin dosing in the puerperal patient. ( Pastorek, JG; Phelan, M; Ragan, FA, 1987) |
| "Pathogenic anaerobic bacteria may be among the causes of puerperal mastitis which, therefore, was treated by the authors with metronidazole (Vagimid) and with antibiotics, such as penicillin, oxacillin, erythromycin, and oxytetracycline." | 3.66 | [Metronidazole for treatment of puerperal mastitis (author's transl)]. ( Amon, I; Amon, K; Scharp, H, 1982) |
| "Bacterial vaginosis is associated with adverse sequelae, including late miscarriage, preterm prelabour rupture of the membranes, chorioamnionitis, postpartum endometritis and preterm labour and delivery." | 1.30 | Bacterial vaginosis: its importance in obstetrics. ( Lamont, RF; Woodrow, N, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (66.67) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Miller, L | 1 |
| Thomas, K | 1 |
| Hughes, JP | 1 |
| Holmes, KK | 1 |
| Stout, S | 1 |
| Eschenbach, DA | 1 |
| Steudel, HC | 1 |
| Gugler, R | 1 |
| Amon, I | 2 |
| Amon, K | 2 |
| Zschiesche, M | 1 |
| Haller, H | 1 |
| Golob, E | 1 |
| Scharp, H | 1 |
| Woodrow, N | 1 |
| Lamont, RF | 1 |
| Wagner, VP | 1 |
| Smale, LE | 1 |
| Lischke, JH | 1 |
| van den Bogaard, AE | 1 |
| Hazen, MJ | 1 |
| Kriele, CP | 1 |
| Oláh, KS | 1 |
| Gee, H | 1 |
| Sesti, F | 1 |
| Piccione, E | 1 |
| McCahill, ME | 1 |
| Braff, DL | 1 |
| Pastorek, JG | 1 |
| Ragan, FA | 1 |
| Phelan, M | 1 |
1 review available for metronidazole and Puerperal Disorders
| Article | Year |
|---|---|
[Current therapeutic aspects of Trichomonas vaginalis infections in gynecology].
Topics: Adult; Antitrichomonal Agents; Female; Humans; Metronidazole; Pregnancy; Pregnancy Complications, In | 1987 |
1 trial available for metronidazole and Puerperal Disorders
| Article | Year |
|---|---|
Randomised treatment trial of bacterial vaginosis to prevent post-abortion complication.
Topics: Abortion, Induced; Adult; Ambulatory Care; Double-Blind Method; Doxycycline; Drug Therapy, Combinati | 2004 |
10 other studies available for metronidazole and Puerperal Disorders
| Article | Year |
|---|---|
[Postpartum pseudomembranous colitis].
Topics: Adult; Cefotaxime; Colon; Colonoscopy; Drug Therapy, Combination; Enterocolitis, Pseudomembranous; F | 1984 |
[Pharmacokinetics of metronidazole during perioperative short-term prophylaxis in cesarean section].
Topics: Bacteroides Infections; Cesarean Section; Female; Humans; Kinetics; Metronidazole; Postoperative Com | 1983 |
[Prevention of infections after cesarean section].
Topics: Cesarean Section; Female; Fever; Humans; Infant, Newborn; Metronidazole; Pregnancy; Puerperal Disord | 1980 |
[Metronidazole for treatment of puerperal mastitis (author's transl)].
Topics: Anti-Bacterial Agents; Female; Humans; Mastitis; Metronidazole; Milk, Human; Pregnancy; Puerperal Di | 1982 |
Bacterial vaginosis: its importance in obstetrics.
Topics: Abortion, Spontaneous; Anti-Infective Agents; Chorioamnionitis; Endometritis; Female; Humans; Metron | 1998 |
Amebic abscess of the liver and spleen in pregnancy and the puerperium.
Topics: Adolescent; Adult; Amebiasis; Chloroquine; Emetine; Female; Humans; Infant, Newborn; Liver Abscess, | 1975 |
Rationale for treatment of retained placenta in cows with neomycin and metronidazole.
Topics: Animals; Bacteria, Aerobic; Bacteria, Anaerobic; Bacterial Infections; Cattle; Cattle Diseases; Drug | 1992 |
Postpartum haemolytic uraemic syndrome precipitated by antibiotics. Case report.
Topics: Adult; Ampicillin; Drug Therapy, Combination; Female; Hemolytic-Uremic Syndrome; Humans; Metronidazo | 1990 |
Atypical postpartum psychosis possibly associated with metronidazole therapy.
Topics: Adult; Dysentery, Amebic; Female; Humans; Infant, Newborn; Laos; Metronidazole; Pregnancy; Psychoses | 1988 |
Tobramycin dosing in the puerperal patient.
Topics: Cesarean Section; Drug Therapy, Combination; Endometritis; Female; Humans; Kinetics; Metronidazole; | 1987 |