metronidazole has been researched along with Experimental Mammary Neoplasms in 20 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole (0." | 5.26 | Effect of metronidazole on the C3H/HeJ mouse and growth of the C3HBA mammary adenocarcinoma. ( Haynes, MJ; Inch, WR; McCredie, JA; Sutherland, RM, 1977) |
| "The comparative radiosensitizing effects of camphor and metronidazole on murine transplantable mammary adenocarcinoma are reported." | 3.67 | Radiosensitizing effect of camphor on transplantable mammary adenocarcinoma in mice. ( Goel, HC; Roa, AR, 1988) |
| "Metronidazole (0." | 1.26 | Effect of metronidazole on the C3H/HeJ mouse and growth of the C3HBA mammary adenocarcinoma. ( Haynes, MJ; Inch, WR; McCredie, JA; Sutherland, RM, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (85.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 1 (5.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rossini, A | 1 |
| Rumio, C | 1 |
| Sfondrini, L | 1 |
| Tagliabue, E | 1 |
| Morelli, D | 1 |
| Miceli, R | 1 |
| Mariani, L | 1 |
| Palazzo, M | 1 |
| Ménard, S | 1 |
| Balsari, A | 1 |
| Cavaliere, A | 1 |
| Bacci, M | 1 |
| Vitali, R | 1 |
| Magdon, E | 2 |
| Schröder, E | 2 |
| Tannock, IF | 2 |
| Yang, DJ | 1 |
| Ilgan, S | 1 |
| Higuchi, T | 1 |
| Zareneyrizi, F | 1 |
| Oh, CS | 1 |
| Liu, CW | 1 |
| Kim, EE | 1 |
| Podoloff, DA | 1 |
| Fowler, JF | 2 |
| Rustia, M | 1 |
| Shubik, P | 1 |
| Inch, WR | 2 |
| McCredie, JA | 1 |
| Haynes, MJ | 2 |
| Sutherland, RM | 1 |
| Adams, GE | 1 |
| Denekamp, J | 2 |
| Harris, SR | 1 |
| Stone, HB | 2 |
| Withers, HR | 2 |
| Hentschel, M | 1 |
| Schmidt, W | 1 |
| Goel, HC | 1 |
| Roa, AR | 1 |
| Noker, PE | 1 |
| Simpson-Herren, L | 1 |
| Wagoner, SD | 1 |
| Rockwell, S | 1 |
| Irvin, CG | 1 |
| Nierenburg, M | 1 |
| Amon, I | 1 |
| Peters, R | 1 |
| Begg, AC | 1 |
| Sheldon, PW | 1 |
| Foster, JL | 1 |
20 other studies available for metronidazole and Experimental Mammary Neoplasms
| Article | Year |
|---|---|
Influence of antibiotic treatment on breast carcinoma development in proto-neu transgenic mice.
Topics: Animals; Anti-Infective Agents; Cell Growth Processes; Ciprofloxacin; Cocarcinogenesis; Female; Gene | 2006 |
Induction of mammary tumors with metronidazole in female Sprague-Dawley rats.
Topics: Adenocarcinoma; Adenofibroma; Animals; Female; Mammary Neoplasms, Experimental; Metronidazole; Rats; | 1984 |
[Comparative studies on the radiosensitizing action of 4-nitroimidazole and metronidazole (author's transl)].
Topics: Adenocarcinoma; Animals; Cell Survival; DNA, Neoplasm; Female; Leukemia L5178; Mammary Neoplasms, Ex | 1981 |
In vivo interaction of anti-cancer drugs with misonidazole or metronidazole: methotrexate, 5-fluorouracil and adriamycin.
Topics: Animals; Body Weight; Doxorubicin; Drug Therapy, Combination; Fibrosarcoma; Fluorouracil; Leukocyte | 1980 |
In vivo interaction of anti-cancer drugs with misonidazole or metronidazole: cyclophosphamide and BCNU.
Topics: Animals; Body Weight; Carmustine; Cyclophosphamide; Drug Therapy, Combination; Fibrosarcoma; Leukocy | 1980 |
Noninvasive assessment of tumor hypoxia with 99mTc labeled metronidazole.
Topics: Animals; Autoradiography; Cell Hypoxia; Cysteine; Female; Fluorine Radioisotopes; Iodine Radioisotop | 1999 |
Developments in radiotherapy other than heavy particle beams.
Topics: Animals; Brain Neoplasms; Energy Transfer; Fast Neutrons; Female; Glioblastoma; Hot Temperature; Hum | 1977 |
Experimental induction of hepatomas, mammary tumors, and other tumors with metronidazole in noninbred Sas:MRC(WI)BR rats.
Topics: Animals; Carcinogens; Female; Liver Neoplasms, Experimental; Male; Mammary Neoplasms, Experimental; | 1979 |
Effect of metronidazole on the C3H/HeJ mouse and growth of the C3HBA mammary adenocarcinoma.
Topics: Adenocarcinoma; Animals; Blood Chemical Analysis; Body Weight; Mammary Neoplasms, Experimental; Metr | 1977 |
Effect of metronidazole on the radiocurability and oxygenation of the C3HBA tumor.
Topics: Animals; Dose-Response Relationship, Radiation; Female; Mammary Neoplasms, Experimental; Metronidazo | 1976 |
Radiosensitizers of hypoxic cells in solid tumors.
Topics: Animals; Cells, Cultured; Cricetinae; Dose-Response Relationship, Drug; Fast Neutrons; Mammary Neopl | 1976 |
Tests of two electron-affinic radiosensitizers in vivo using regrowth of an experimental carcinoma.
Topics: Animals; Dose-Response Relationship, Radiation; Male; Mammary Neoplasms, Experimental; Metronidazole | 1975 |
Metronidazole: effect on radiosensitivity of tumor and normal tissues in mice.
Topics: Animals; Dose-Response Relationship, Radiation; Jejunum; Mammary Neoplasms, Experimental; Metronidaz | 1975 |
Pharmacokinetics of isometronidazole. Basic model and estimation of the kinetic parameters from experimental data.
Topics: Animals; Humans; Mammary Neoplasms, Experimental; Metronidazole; Mice; Mice, Inbred C3H; Models, Bio | 1992 |
Radiosensitizing effect of camphor on transplantable mammary adenocarcinoma in mice.
Topics: Adenocarcinoma; Animals; Camphor; Male; Mammary Neoplasms, Experimental; Metronidazole; Mice; Mice, | 1988 |
Distribution of nitroimidazoles and L-phenylalanine mustard in mammary adenocarcinoma 16/C tumors.
Topics: Adenocarcinoma; Animals; Female; Lissamine Green Dyes; Mammary Neoplasms, Experimental; Melphalan; M | 1987 |
Effect of 1-methyl-5-sulfonamide-4-nitroimidazole and 1-methyl-5-bromide-4-nitroimidazole on the radiosensitivity of EMT6 tumor cells.
Topics: Animals; Cell Line; Cell Survival; Female; Mammary Neoplasms, Experimental; Metronidazole; Mice; Mic | 1986 |
[Tissue distribution of iso-metronidazole and metronidazole in tumor-bearing C3H inbred mice].
Topics: Adenocarcinoma; Animals; Brain Chemistry; Mammary Neoplasms, Experimental; Metronidazole; Mice; Mice | 1985 |
Tumor and normal tissue response to metronidazole and irradiation in mice.
Topics: Animals; Carcinoma; Cesium Isotopes; Dose-Response Relationship, Radiation; Epithelium; Female; Hypo | 1974 |
Demonstration of radiosensitization of hypoxic cells in solid tumours by metronidazole.
Topics: Animals; Dose-Response Relationship, Radiation; Hypoxia; Iodine Radioisotopes; Mammary Neoplasms, Ex | 1974 |