metronidazole has been researched along with Body Weight in 41 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with metronidazole reversed steatorrhea but exacerbated the gaseous distention of the small intestine, precipitating emergency surgical decompression and ileostomy." | 5.27 | Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin. ( Isaacs, P; Keshavarzian, A; McColl, I; Sladen, GE, 1983) |
| "Metronidazole (0." | 5.26 | Effect of metronidazole on the C3H/HeJ mouse and growth of the C3HBA mammary adenocarcinoma. ( Haynes, MJ; Inch, WR; McCredie, JA; Sutherland, RM, 1977) |
| "For 3 weeks, we administered oral AB (ciprofloxacin/metronidazole) or control treatment to homozygous ΔF508 (Δ/Δ), cystic fibrosis transmembrane conductance regulator (CFTR) knockout (-/-), and wild-type (WT) mice and quantified fat absorption using a 72-h fat balance test." | 3.78 | Effect of antibiotic treatment on fat absorption in mice with cystic fibrosis. ( Bijvelds, MJ; Burgerhof, JG; de Jonge, HR; De Lisle, RC; Verkade, HJ; Wouthuyzen-Bakker, M, 2012) |
| "Treatment with metronidazole and erythromycin reduced rates of premature delivery in women with bacterial vaginosis and an increased risk for preterm delivery." | 2.68 | Reduced incidence of preterm delivery with metronidazole and erythromycin in women with bacterial vaginosis. ( Andrews, WW; Copper, RL; DuBard, MB; Goldenberg, RL; Hauth, JC, 1995) |
| "Linking haemodynamic (HD) and pharmacokinetic (PK) parameters provides much insight into interrelations between circulatory system and drug disposition." | 1.46 | Models describing metronidazole pharmacokinetics in relation to hemodynamics in turkeys. ( Grabowski, T; Pasławska, U; Poźniak, B; Świtała, M, 2017) |
| " The authors evaluated the effect of cigarette smoking on the bioavailability of metronidazole in plasma and saliva." | 1.38 | The effect of smoking on the bioavailability of metronidazole in plasma and saliva. ( Bergamaschi, Cde C; Brito, RB; Groppo, FC; Haas, DA; Montalli, VA; Motta, RH; Nolasco, FP; Ramacciato, JC, 2012) |
| " Such aberrations were higher in smaller fish samples for a particular dosage of MTZ, as established by correlation analysis between fish body weight and MN/BN count at P<0." | 1.36 | Therapeutic efficacies of Coriandrum sativum aqueous extract against metronidazole-induced genotoxicity in Channa punctatus peripheral erythrocytes. ( Auddy, M; Dasgupta, S; Guha, G; Mukhopadhyay, A; Talapatra, SN, 2010) |
| "Colitis was induced by feeding male SD rats with a diet containing 3." | 1.31 | Prebiotic treatment of experimental colitis with germinated barley foodstuff: a comparison with probiotic or antibiotic treatment. ( Andoh, A; Araki, Y; Bamba, T; Fujiyama, Y; Fukuda, M; Fukuoka, M; Kanauchi, O; Matsumoto, Y; Mitsuyama, K; Sata, M; Takagi, K; Toyonaga, A, 2002) |
| "Metronidazole was administered at various dose rates by crop gavage or in drinking water to eight groups of five to ten finches each." | 1.30 | Cochlosoma infections in finches. ( Filippich, LJ; O'Donoghue, PJ, 1997) |
| "Treatment with metronidazole reversed steatorrhea but exacerbated the gaseous distention of the small intestine, precipitating emergency surgical decompression and ileostomy." | 1.27 | Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin. ( Isaacs, P; Keshavarzian, A; McColl, I; Sladen, GE, 1983) |
| " The dosage of metronidazole was about 10 or 20 mg/kg b." | 1.27 | Disposition kinetics of metronidazole in children. ( Amon, I; Amon, K; Franke, G; Nagel, F; Scharp, H, 1983) |
| "6." | 1.27 | Metronidazole excretion in human milk and its effect on the suckling neonate. ( D'Arcy, PF; McElnay, JC; Passmore, CM; Rainey, EA, 1988) |
| "Xylose absorption was abnormal in five of the 10 patients." | 1.27 | Iron malabsorption in giardiasis. ( Acampora, A; Cucchiara, S; De Vizia, B; Poggi, V; Vajro, P, 1985) |
| "Pneumatosis cystoides intestinalis was a sequal in two patients." | 1.26 | Bypass enteropathy: an inflammatory process in the excluded segment with systemic complications. ( Ament, ME; Drenick, EJ; Finegold, SM; Passaro, E, 1977) |
| "Metronidazole (0." | 1.26 | Effect of metronidazole on the C3H/HeJ mouse and growth of the C3HBA mammary adenocarcinoma. ( Haynes, MJ; Inch, WR; McCredie, JA; Sutherland, RM, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (46.34) | 18.7374 |
| 1990's | 8 (19.51) | 18.2507 |
| 2000's | 5 (12.20) | 29.6817 |
| 2010's | 9 (21.95) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Grabowski, T | 1 |
| Pasławska, U | 1 |
| Poźniak, B | 1 |
| Świtała, M | 1 |
| Zarrinpar, A | 1 |
| Chaix, A | 1 |
| Xu, ZZ | 1 |
| Chang, MW | 1 |
| Marotz, CA | 1 |
| Saghatelian, A | 1 |
| Knight, R | 1 |
| Panda, S | 1 |
| Nagaoka, K | 1 |
| Yanagihara, K | 1 |
| Harada, Y | 1 |
| Yamada, K | 1 |
| Migiyama, Y | 1 |
| Morinaga, Y | 1 |
| Izumikawa, K | 1 |
| Kakeya, H | 1 |
| Nakashima, M | 1 |
| Nishimura, M | 1 |
| Kohno, S | 1 |
| Ogut, H | 1 |
| Parlak, R | 1 |
| Bezagio, RC | 1 |
| Colli, CM | 1 |
| Romera, LI | 1 |
| Ferreira, ÉC | 1 |
| Falavigna-Guilherme, AL | 1 |
| Gomes, ML | 1 |
| Tian, J | 1 |
| Hao, L | 1 |
| Chandra, P | 1 |
| Jones, DP | 1 |
| Willams, IR | 1 |
| Gewirtz, AT | 1 |
| Ziegler, TR | 1 |
| Noorafshan, A | 1 |
| Karbalay-Doust, S | 1 |
| Valizadeh, A | 1 |
| Aliabadi, E | 1 |
| Talapatra, SN | 1 |
| Dasgupta, S | 1 |
| Guha, G | 1 |
| Auddy, M | 1 |
| Mukhopadhyay, A | 1 |
| Wouthuyzen-Bakker, M | 1 |
| Bijvelds, MJ | 1 |
| de Jonge, HR | 1 |
| De Lisle, RC | 1 |
| Burgerhof, JG | 1 |
| Verkade, HJ | 1 |
| Montalli, VA | 1 |
| Bergamaschi, Cde C | 1 |
| Ramacciato, JC | 1 |
| Nolasco, FP | 1 |
| Groppo, FC | 1 |
| Brito, RB | 1 |
| Haas, DA | 1 |
| Motta, RH | 1 |
| Fararjeh, M | 1 |
| Mohammad, MK | 1 |
| Bustanji, Y | 1 |
| Alkhatib, H | 1 |
| Abdalla, S | 1 |
| Keshavarzian, A | 1 |
| Isaacs, P | 1 |
| McColl, I | 1 |
| Sladen, GE | 1 |
| Drenick, EJ | 2 |
| Fisler, J | 1 |
| Johnson, D | 1 |
| Banwell, JG | 1 |
| Boldt, DH | 1 |
| Meyers, J | 1 |
| Weber, FL | 1 |
| Amon, I | 1 |
| Amon, K | 1 |
| Scharp, H | 1 |
| Franke, G | 1 |
| Nagel, F | 1 |
| Hayes, JG | 1 |
| Austin, TW | 1 |
| Smith, EA | 1 |
| Darwish, R | 1 |
| Ralph, ED | 1 |
| Pattison, FL | 1 |
| Ludwig, E | 1 |
| Magyar, T | 1 |
| Csiba, A | 1 |
| Kardos, J | 1 |
| Graber, H | 1 |
| Tannock, IF | 2 |
| Hauth, JC | 1 |
| Goldenberg, RL | 1 |
| Andrews, WW | 1 |
| DuBard, MB | 1 |
| Copper, RL | 1 |
| Gardiner, KR | 1 |
| Anderson, NH | 1 |
| McCaigue, MD | 1 |
| Erwin, PJ | 1 |
| Halliday, MI | 1 |
| Rowlands, BJ | 1 |
| Filippich, LJ | 1 |
| O'Donoghue, PJ | 1 |
| Ivnitskiĭ, IuIu | 1 |
| Malakhovskiĭ, VN | 1 |
| Hans, W | 1 |
| Schölmerich, J | 1 |
| Gross, V | 1 |
| Falk, W | 1 |
| Fukuda, M | 1 |
| Kanauchi, O | 1 |
| Araki, Y | 1 |
| Andoh, A | 1 |
| Mitsuyama, K | 1 |
| Takagi, K | 1 |
| Toyonaga, A | 1 |
| Sata, M | 1 |
| Fujiyama, Y | 1 |
| Fukuoka, M | 1 |
| Matsumoto, Y | 1 |
| Bamba, T | 1 |
| Ament, ME | 1 |
| Finegold, SM | 1 |
| Passaro, E | 1 |
| Inch, WR | 1 |
| McCredie, JA | 1 |
| Haynes, MJ | 1 |
| Sutherland, RM | 1 |
| Eakins, MN | 1 |
| Conroy, PJ | 1 |
| Searle, AJ | 1 |
| Slater, TF | 1 |
| Willson, RL | 1 |
| Loft, S | 2 |
| Otte, J | 1 |
| Poulsen, HE | 1 |
| Sørensen, H | 1 |
| Sullivan, PB | 1 |
| Lunn, PG | 1 |
| Northrop-Clewes, C | 1 |
| Crowe, PT | 1 |
| Marsh, MN | 1 |
| Neale, G | 1 |
| Bolin, TD | 1 |
| Duncombe, VM | 1 |
| Pereira, SP | 1 |
| Linklater, JM | 1 |
| Hamberg, O | 1 |
| Ovesen, L | 1 |
| Dorfeldt, A | 1 |
| Sonne, J | 1 |
| Passmore, CM | 1 |
| McElnay, JC | 1 |
| Rainey, EA | 1 |
| D'Arcy, PF | 1 |
| Spence, JA | 1 |
| Aitchison, GU | 1 |
| Fraser, J | 1 |
| Lewin, MR | 1 |
| Araujo, JG | 1 |
| Sarmiento, JL | 1 |
| Barton, TP | 1 |
| Jayaraj, AP | 1 |
| Harrison, RA | 1 |
| De Vizia, B | 1 |
| Poggi, V | 1 |
| Vajro, P | 1 |
| Cucchiara, S | 1 |
| Acampora, A | 1 |
| Powell, SJ | 1 |
| Elsdon-Dew, R | 1 |
| Heap, T | 1 |
| Potts, GO | 1 |
| Beyler, AL | 1 |
| Schane, HP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase III Trial of Antibiotics to Reduce Chorioamnionitis-Related Perinatal HIV Transmission[NCT00021671] | Phase 3 | 3,720 participants | Interventional | Completed | |||
| Clindamycin to Reduce Preterm Birth in a Low Resource Setting: A Randomized Placebo-controlled Trial[NCT01800825] | Phase 4 | 1,726 participants (Actual) | Interventional | 2013-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for metronidazole and Body Weight
| Article | Year |
|---|---|
Metronidazole in a single dose for the treatment of trichomoniasis. Failure of a 1-g single dose.
Topics: Adolescent; Adult; Body Weight; Clinical Trials as Topic; Drug Administration Schedule; Female; Huma | 1982 |
Reduced incidence of preterm delivery with metronidazole and erythromycin in women with bacterial vaginosis.
Topics: Adult; Anti-Bacterial Agents; Antitrichomonal Agents; Body Weight; Double-Blind Method; Erythromycin | 1995 |
Reduced incidence of preterm delivery with metronidazole and erythromycin in women with bacterial vaginosis.
Topics: Adult; Anti-Bacterial Agents; Antitrichomonal Agents; Body Weight; Double-Blind Method; Erythromycin | 1995 |
Reduced incidence of preterm delivery with metronidazole and erythromycin in women with bacterial vaginosis.
Topics: Adult; Anti-Bacterial Agents; Antitrichomonal Agents; Body Weight; Double-Blind Method; Erythromycin | 1995 |
Reduced incidence of preterm delivery with metronidazole and erythromycin in women with bacterial vaginosis.
Topics: Adult; Anti-Bacterial Agents; Antitrichomonal Agents; Body Weight; Double-Blind Method; Erythromycin | 1995 |
Effect of short-term intermittent antibiotic treatment on growth of Burmese (Myanmar) village children.
Topics: Age Factors; Amoxicillin; Bacterial Infections; Body Height; Body Weight; Breath Tests; Child, Presc | 1990 |
The effect of dietary energy and protein deficiency on drug metabolism.
Topics: Adult; Antipyrine; Biotransformation; Body Weight; Diet; Energy Metabolism; Glucuronates; Humans; Ma | 1990 |
37 other studies available for metronidazole and Body Weight
| Article | Year |
|---|---|
Models describing metronidazole pharmacokinetics in relation to hemodynamics in turkeys.
Topics: Aging; Animals; Anti-Infective Agents; Body Weight; Hemodynamics; Metronidazole; Models, Biological; | 2017 |
Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism.
Topics: Amphotericin B; Ampicillin; Animals; Anti-Bacterial Agents; Bile Acids and Salts; Blood Glucose; Bod | 2018 |
Establishment of a new murine model of liver abscess induced by Fusobacterium necrophorum injected into the caudal vein.
Topics: Administration, Intravenous; Animals; Anti-Bacterial Agents; Bacterial Load; Body Weight; Disease Mo | 2013 |
Hexamitiasis leads to lower metabolic rates in rainbow trout Oncorhynchus mykiss (Walbaum) juveniles.
Topics: Animals; Antiparasitic Agents; Body Weight; Diplomonadida; Disease Susceptibility; Fish Diseases; In | 2014 |
Synergistic effects of fenbendazole and metronidazole against Giardia muris in Swiss mice naturally infected.
Topics: Animals; Antiprotozoal Agents; Body Weight; Drug Synergism; Feces; Female; Fenbendazole; Giardia; Gi | 2017 |
Dietary glutamine and oral antibiotics each improve indexes of gut barrier function in rat short bowel syndrome.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Antibodies, Bacterial; Bacterial Translocation | 2009 |
Ameliorative effects of curcumin on the structural parameters of seminiferous tubules and Leydig cells in metronidazole-treated mice: a stereological approach.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antiprotozoal Agents; Body Weight; Cell Count; Cur | 2011 |
Therapeutic efficacies of Coriandrum sativum aqueous extract against metronidazole-induced genotoxicity in Channa punctatus peripheral erythrocytes.
Topics: Animals; Antimutagenic Agents; Antitrichomonal Agents; Body Weight; Cell Nucleus; Coriandrum; Erythr | 2010 |
Effect of antibiotic treatment on fat absorption in mice with cystic fibrosis.
Topics: Animals; Anti-Bacterial Agents; Bile Acids and Salts; Body Weight; Ciprofloxacin; Cystic Fibrosis; C | 2012 |
The effect of smoking on the bioavailability of metronidazole in plasma and saliva.
Topics: Adolescent; Anti-Infective Agents; Area Under Curve; Biological Availability; Body Height; Body Mass | 2012 |
Evaluation of immunosuppression induced by metronidazole in Balb/c mice and human peripheral blood lymphocytes.
Topics: Adult; Animals; Body Weight; Female; Humans; Immunosuppressive Agents; Lymphocyte Activation; Lympho | 2008 |
Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin.
Topics: Adult; Body Weight; Constipation; Humans; Ileostomy; Indomethacin; Intestinal Obstruction; Intestina | 1983 |
Hepatic steatosis after intestinal bypass--prevention and reversal by metronidazole, irrespective of protein-calorie malnutrition.
Topics: Adult; Amino Acids; Body Weight; Fatty Liver; Female; Humans; Ileum; Jejunum; Liver; Male; Metronida | 1982 |
Phytohemagglutinin derived from red kidney bean (Phaseolus vulgaris): a cause for intestinal malabsorption associated with bacterial overgrowth in the rat.
Topics: Animals; Body Weight; Dietary Fats; Dietary Proteins; Germ-Free Life; Intestinal Absorption; Intesti | 1983 |
Disposition kinetics of metronidazole in children.
Topics: Adolescent; Aging; Body Weight; Child; Child, Preschool; Drug Administration Schedule; Female; Human | 1983 |
Amoebic liver abscess: clinical presentation and diagnosis.
Topics: Abdomen; Adult; Aged; Anorexia; Body Weight; Female; Fever; Humans; Liver Abscess, Amebic; Male; Met | 1980 |
[Pharmacokinetics of metronidazole (Klion) in relation to age].
Topics: Adult; Age Factors; Aged; Body Weight; Dose-Response Relationship, Drug; Humans; Kinetics; Metronida | 1981 |
In vivo interaction of anti-cancer drugs with misonidazole or metronidazole: methotrexate, 5-fluorouracil and adriamycin.
Topics: Animals; Body Weight; Doxorubicin; Drug Therapy, Combination; Fibrosarcoma; Fluorouracil; Leukocyte | 1980 |
In vivo interaction of anti-cancer drugs with misonidazole or metronidazole: cyclophosphamide and BCNU.
Topics: Animals; Body Weight; Carmustine; Cyclophosphamide; Drug Therapy, Combination; Fibrosarcoma; Leukocy | 1980 |
Enteral and parenteral anti-endotoxin treatment in experimental colitis.
Topics: Animals; Anti-Infective Agents, Local; Antitoxins; Body Weight; Cefuroxime; Colitis; Endotoxins; Ent | 1994 |
Cochlosoma infections in finches.
Topics: Animals; Animals, Domestic; Antiprotozoal Agents; Bird Diseases; Birds; Body Weight; Colon; Data Col | 1997 |
[Gas exchange as a factor of the body radiation resistance].
Topics: Animals; Blood Gas Analysis; Body Weight; Cerebrovascular Circulation; Hypoxia; Male; Metronidazole; | 1998 |
The role of the resident intestinal flora in acute and chronic dextran sulfate sodium-induced colitis in mice.
Topics: Acute Disease; Animals; Anti-Bacterial Agents; Biopsy; Body Weight; Chronic Disease; Ciprofloxacin; | 2000 |
Case problem: medical nutrition therapy for a patient with Crohn's disease.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Body Weight; Ciprofloxacin; Crohn Disease; Diarrhea | 2000 |
Prebiotic treatment of experimental colitis with germinated barley foodstuff: a comparison with probiotic or antibiotic treatment.
Topics: Animal Feed; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Body Weight; Colitis; Diet; Dise | 2002 |
Bypass enteropathy: an inflammatory process in the excluded segment with systemic complications.
Topics: Adult; Albumins; Arthritis; Body Weight; Dermatitis; Diarrhea; Female; Humans; Ileum; Inflammation; | 1977 |
Effect of metronidazole on the C3H/HeJ mouse and growth of the C3HBA mammary adenocarcinoma.
Topics: Adenocarcinoma; Animals; Blood Chemical Analysis; Body Weight; Mammary Neoplasms, Experimental; Metr | 1977 |
Metronidazole (Flagyl), a radiosensitiser of possible clinical use in cancer chemotherapy: some biochemical and pharmacological considerations.
Topics: Anaerobiosis; Animals; Bacteria; Blood Cell Count; Body Weight; Endoplasmic Reticulum; Female; Kinet | 1976 |
Influence of intact and myrosinase-treated indolyl glucosinolates on the metabolism in vivo of metronidazole and antipyrine in the rat.
Topics: Animals; Antipyrine; Body Weight; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucosinolates; | 1992 |
Persistent diarrhea and malnutrition--the impact of treatment on small bowel structure and permeability.
Topics: Anti-Bacterial Agents; Antifungal Agents; Blood Proteins; Body Weight; Cell Membrane Permeability; C | 1992 |
Metronidazole excretion in human milk and its effect on the suckling neonate.
Topics: Adult; Body Weight; Female; Humans; Infant; Infant, Newborn; Male; Metronidazole; Milk, Human | 1988 |
Development of periodontal disease in a single flock of sheep: clinical signs, morphology of subgingival plaque and influence of antimicrobial agents.
Topics: Animals; Body Weight; Dental Plaque; Female; Gingiva; Metronidazole; Oxytetracycline; Periodontal Di | 1988 |
Bypass induced liver disease: an experimental study of the effect of post-operative protein supplementation and metronidazole therapy in an animal model.
Topics: Animals; Body Weight; Dietary Proteins; Female; Jejunoileal Bypass; Liver; Liver Diseases; Liver Fun | 1987 |
Iron malabsorption in giardiasis.
Topics: Anemia, Hypochromic; Body Weight; Child; Child, Preschool; Ferrous Compounds; Giardiasis; Hemoglobin | 1985 |
Evaluation of metronidazole and MK-910 in invasive amebiasis.
Topics: Administration, Oral; Body Weight; Dysentery, Amebic; Entamoeba histolytica; Feces; Fluorine; Humans | 1971 |
Giardiasis: a common cause of prolonged diarrhoea in adults.
Topics: Adult; Aged; Biopsy; Body Weight; Diarrhea; Female; Giardiasis; Humans; Intestinal Mucosa; Malabsorp | 1974 |
Pituitary gonadotropin inhibitory activity of danazol.
Topics: Adrenal Glands; Androgens; Animals; Body Weight; Castration; Contraceptives, Oral; Depression, Chemi | 1974 |