metronidazole has been researched along with AIDS-Related Opportunistic Infections in 27 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
AIDS-Related Opportunistic Infections: Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A case of metronidazole- and albendazole-resistant giardiasis in a patient with the acquired immunodeficiency syndrome was successfully treated with nitazoxanide (1." | 7.71 | Successful treatment of metronidazole- and albendazole-resistant giardiasis with nitazoxanide in a patient with acquired immunodeficiency syndrome. ( Abboud, P; Ballet, JJ; Borsa-Lebas, F; Brasseur, P; Caron, F; Favennec, L; Gargala, G; Lemée, V, 2001) |
| "A case of metronidazole- and albendazole-resistant giardiasis in a patient with the acquired immunodeficiency syndrome was successfully treated with nitazoxanide (1." | 3.71 | Successful treatment of metronidazole- and albendazole-resistant giardiasis with nitazoxanide in a patient with acquired immunodeficiency syndrome. ( Abboud, P; Ballet, JJ; Borsa-Lebas, F; Brasseur, P; Caron, F; Favennec, L; Gargala, G; Lemée, V, 2001) |
| " With only partial compliance to local debridement, chlorhexidine oral rinses, and systemic metronidazole therapy, alveolar bone loss resulted in tooth mobility necessitating extraction of 2 involved teeth." | 3.70 | Rapid progression of bone loss in HIV-associated necrotizing ulcerative stomatitis. ( McKaig, R; Patton, LL, 1998) |
| "Treatment with albendazole led to clinical responses in six of 10 patients, and dietary manipulation resulted in clinical improvement in eight of nine patients." | 2.39 | Clinical features of microsporidiosis in patients with AIDS. ( Asmuth, DM; DeGirolami, PC; Desai, G; Ezratty, CR; Federman, M; Pleskow, DK; Wanke, CA, 1994) |
| "Histoplasmosis is a frequent complication of HIV infection and is usually the result of reactivation." | 2.39 | Oral histoplasmosis in a patient infected with HIV. A case report. ( Durham, T; Johansson, SL; Kaufman, L; Swindells, S, 1994) |
| "Cancrum oris (noma) is a gangrenous infection that develops in the mouth and spreads rapidly to other parts of the face." | 1.31 | Noma (cancrum oris): case report in a 4-year-old HIV-positive South African child. ( Chikte, UM; Naidoo, S, 2000) |
| "The clinical manifestations included amoebic colitis (13 patients), amoebic liver abscess (nine), both colitis and abscess (four), and pleural effusion (two)." | 1.30 | Invasive amoebiasis: an emerging parasitic disease in patients infected with HIV in an area endemic for amoebic infection. ( Chang, SC; Chen, MY; Chen, PJ; Fang, CT; Hsieh, SM; Hung, CC; Wong, JM, 1999) |
| "difficile diarrhea is at least as likely to resolve with antibiotic therapy in patients with AIDS as it is in those with the non-AIDS-related disorder." | 1.29 | Clostridium difficile diarrhea in patients with AIDS versus non-AIDS controls. Methods of treatment and clinical response to treatment. ( Borucki, MJ; Clench, MH; Cozart, JC; Kalangi, SS; Pollard, RB; Soloway, RD; Taylor, DR, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (48.15) | 18.2507 |
| 2000's | 6 (22.22) | 29.6817 |
| 2010's | 8 (29.63) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sherley, M | 1 |
| Martin, SJ | 1 |
| Tambe, S | 1 |
| Zambare, U | 1 |
| Nayak, C | 1 |
| Feagins, LA | 1 |
| Chan, V | 1 |
| Spechler, SJ | 1 |
| Kreft, B | 1 |
| Oehme, A | 1 |
| Lübbert, C | 1 |
| Marsch, WC | 1 |
| Kekulé, AS | 1 |
| Milánkovits, M | 1 |
| Gatski, M | 1 |
| Martin, DH | 1 |
| Levison, J | 1 |
| Mena, L | 1 |
| Clark, RA | 1 |
| Murphy, M | 1 |
| Henderson, H | 1 |
| Schmidt, N | 1 |
| Kissinger, P | 1 |
| Oakeshott, P | 1 |
| Ahmed, J | 1 |
| Hay, PE | 1 |
| Reid, F | 1 |
| Kerry, SR | 1 |
| Aghaizu, A | 1 |
| Tong, CY | 1 |
| Mahto, M | 1 |
| Evans-Jones, J | 1 |
| Mallinson, H | 1 |
| Ohnishi, K | 1 |
| Uchiyama-Nakamura, F | 1 |
| Niakara, A | 1 |
| Bougouma, A | 1 |
| Cisse, R | 1 |
| Naidoo, S | 1 |
| Chikte, UM | 1 |
| Martinez, MW | 1 |
| Petre, S | 1 |
| Wisinger, D | 1 |
| Temesgen, Z | 1 |
| Stephens, S | 1 |
| Brown, CD | 1 |
| Wiener, CM | 1 |
| Asmuth, DM | 1 |
| DeGirolami, PC | 1 |
| Federman, M | 1 |
| Ezratty, CR | 1 |
| Pleskow, DK | 1 |
| Desai, G | 1 |
| Wanke, CA | 1 |
| Lu, SS | 1 |
| Schwartz, JM | 1 |
| Simon, DM | 1 |
| Brandt, LJ | 1 |
| Swindells, S | 1 |
| Durham, T | 1 |
| Johansson, SL | 1 |
| Kaufman, L | 1 |
| Cappell, MS | 1 |
| Philogene, C | 1 |
| Cozart, JC | 1 |
| Kalangi, SS | 1 |
| Clench, MH | 1 |
| Taylor, DR | 1 |
| Borucki, MJ | 1 |
| Pollard, RB | 1 |
| Soloway, RD | 1 |
| Arranz-Caso, JA | 1 |
| Albarrán-Hernández, F | 1 |
| Cuadrado-Gómez, LM | 1 |
| Gonzalez-Palacios, R | 1 |
| Barrio, J | 1 |
| Lecona, M | 1 |
| Hernanz, JM | 1 |
| Sánchez, M | 1 |
| Gurbindo, MD | 1 |
| Lázaro, P | 1 |
| Barrio, JL | 1 |
| Laguna-del-Estal, P | 1 |
| Moya-Mir, MS | 1 |
| Patton, LL | 1 |
| McKaig, R | 1 |
| Dhawan, VK | 1 |
| Nachum, R | 1 |
| Bhat, N | 1 |
| Tolbert, L | 1 |
| Agrawal, M | 1 |
| Hung, CC | 1 |
| Chen, PJ | 1 |
| Hsieh, SM | 1 |
| Wong, JM | 1 |
| Fang, CT | 1 |
| Chang, SC | 1 |
| Chen, MY | 1 |
| von Gottberg, AM | 1 |
| Dini, LA | 1 |
| Frean, JA | 1 |
| Grimwood, AJ | 1 |
| Abboud, P | 1 |
| Lemée, V | 1 |
| Gargala, G | 1 |
| Brasseur, P | 1 |
| Ballet, JJ | 1 |
| Borsa-Lebas, F | 1 |
| Caron, F | 1 |
| Favennec, L | 1 |
| Bianco, R | 1 |
3 reviews available for metronidazole and AIDS-Related Opportunistic Infections
| Article | Year |
|---|---|
Clinical features of microsporidiosis in patients with AIDS.
Topics: Adult; AIDS-Related Opportunistic Infections; Albendazole; Animals; Boston; CD4-Positive T-Lymphocyt | 1994 |
Oral histoplasmosis in a patient infected with HIV. A case report.
Topics: Adult; AIDS-Related Opportunistic Infections; Fluconazole; Histoplasmosis; Humans; Male; Metronidazo | 1994 |
Rosacea-like demodicosis in an HIV-positive child.
Topics: AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Antitrichomonal Agents; Child, Prescho | 1996 |
3 trials available for metronidazole and AIDS-Related Opportunistic Infections
| Article | Year |
|---|---|
The influence of bacterial vaginosis on the response to Trichomonas vaginalis treatment among HIV-infected women.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Dose-Response Relationship, Dru | 2011 |
Metronidazole treatment for acute phase amoebic liver abscess in patients co-infected with HIV.
Topics: Adult; AIDS-Related Opportunistic Infections; Amebicides; CD4 Lymphocyte Count; Humans; Liver Absces | 2012 |
Clostridium difficile-associated diarrhea in patients with HIV positivity and AIDS: a prospective controlled study.
Topics: Adult; Aged; AIDS-Related Opportunistic Infections; Clostridioides difficile; Diarrhea; Enterocoliti | 1994 |
21 other studies available for metronidazole and AIDS-Related Opportunistic Infections
| Article | Year |
|---|---|
Multiple simultaneous infections in a patient with well-controlled HIV: when Occam's razor fails.
Topics: Acquired Immunodeficiency Syndrome; Aftercare; AIDS-Related Opportunistic Infections; Anti-Retrovira | 2017 |
Nodulo-ulcerative and erythrodermic secondary syphilis in human immunodeficiency virus-infected individuals.
Topics: Administration, Oral; Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Chancre; | 2019 |
A case of duodenal Entamoeba histolytica.
Topics: Adult; AIDS-Related Opportunistic Infections; Amebicides; Animals; Biopsy; Drug Administration Sched | 2009 |
[37-year old patient with fever, diarrhea and lymphadenopathy].
Topics: Adult; AIDS Serodiagnosis; AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Antifungal | 2010 |
[Combined local and vaginal therapy in Buruli ulcer].
Topics: Adolescent; Age Distribution; Aged; AIDS-Related Opportunistic Infections; Amikacin; Anti-Infective | 2010 |
Trichomonas vaginalis among multiethnic female UK students.
Topics: AIDS-Related Opportunistic Infections; Anti-Infective Agents; Female; Humans; Metronidazole; Trichom | 2011 |
Response to 'Trichomonas vaginalis among multiethnic female UK students'.
Topics: AIDS-Related Opportunistic Infections; Anti-Infective Agents; Female; Humans; Metronidazole; Trichom | 2011 |
[A case of pneumopericardium complicating a liver abscess in a patient infected with HIV].
Topics: Adult; AIDS-Related Opportunistic Infections; Amoxicillin; Anemia; Anti-Infective Agents; Blood Tran | 1999 |
Noma (cancrum oris): case report in a 4-year-old HIV-positive South African child.
Topics: AIDS-Related Opportunistic Infections; Anti-Infective Agents; Child, Preschool; Female; HIV Seroposi | 2000 |
Intestinal spirochetosis and diarrhea, commensal or causal.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Biopsy; Colitis, Microscopic; D | 2004 |
Host to an intruder.
Topics: Adult; AIDS-Related Opportunistic Infections; Animals; Antiprotozoal Agents; Diarrhea; Giardia lambl | 2005 |
Clostridium difficile infection is a treatable cause of diarrhea in patients with advanced human immunodeficiency virus infection: a study of seven consecutive patients admitted from 1986 to 1992 to a university teaching hospital.
Topics: Adult; AIDS-Related Opportunistic Infections; Clostridioides difficile; Diarrhea; Enterocolitis, Pse | 1993 |
Clostridium difficile diarrhea in patients with AIDS versus non-AIDS controls. Methods of treatment and clinical response to treatment.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Bacterial Toxins; Case-Control | 1993 |
Metronidazole treatment in a patient with AIDS and visceral leishmaniasis.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Humans; Leishmania | 1995 |
Prophylaxis of visceral leishmaniasis in human immunodeficiency virus-infected patients.
Topics: AIDS-Related Opportunistic Infections; Antiprotozoal Agents; Humans; Leishmaniasis, Visceral; Metron | 1997 |
Rapid progression of bone loss in HIV-associated necrotizing ulcerative stomatitis.
Topics: Adult; AIDS-Related Opportunistic Infections; Alveolar Bone Loss; Anti-Infective Agents; Anti-Infect | 1998 |
Vancomycin-resistant enterococcal colonization in nonhospitalized HIV-infected patients.
Topics: Adult; AIDS-Related Opportunistic Infections; Amoxicillin; Anti-Bacterial Agents; Bisexuality; Black | 1998 |
Invasive amoebiasis: an emerging parasitic disease in patients infected with HIV in an area endemic for amoebic infection.
Topics: Adult; AIDS-Related Opportunistic Infections; Animals; Anti-Infective Agents; Antibodies, Protozoan; | 1999 |
Confirmation of transmission of the microsporidian parasite Enterocytozoon bieneusi in South Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Albendazole; Animals; Anti-Bacterial Agents; Antinemat | 2000 |
Successful treatment of metronidazole- and albendazole-resistant giardiasis with nitazoxanide in a patient with acquired immunodeficiency syndrome.
Topics: Adult; AIDS-Related Opportunistic Infections; Albendazole; Animals; Antiprotozoal Agents; Drug Resis | 2001 |
HIV-related gingival and periodontal disorders.
Topics: AIDS-Related Opportunistic Infections; Gingivitis; HIV Infections; Humans; Metronidazole; Periodonti | 1992 |