metronidazole has been researched along with Neutropenia in 18 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Neutropenia: A decrease in the number of NEUTROPHILS found in the blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neutropenia was ameliorated with use of granulocyte colony-stimulating factor." | 5.37 | Infliximab- and azathioprine-related severe neutropenia and thrombocytopenia in a case with Crohn's disease. ( Alkim, C; Alkim, H; Altinkaya, E; Boğa, S; Buğdaci, MS; Köksal, AR; Özdoğan, O; Sökmen, M, 2011) |
| " The Hill dose-response model followed by curve-fitting analysis was used to calculate and compare primary and secondary PD parameters." | 1.38 | Therapeutic equivalence requires pharmaceutical, pharmacokinetic, and pharmacodynamic identities: true bioequivalence of a generic product of intravenous metronidazole. ( Agudelo, M; Vesga, O, 2012) |
| "Neutropenia was ameliorated with use of granulocyte colony-stimulating factor." | 1.37 | Infliximab- and azathioprine-related severe neutropenia and thrombocytopenia in a case with Crohn's disease. ( Alkim, C; Alkim, H; Altinkaya, E; Boğa, S; Buğdaci, MS; Köksal, AR; Özdoğan, O; Sökmen, M, 2011) |
| "Prepubertal periodontitis affects both primary and permanent dentition." | 1.30 | Subgingival microflora and treatment in prepubertal periodontitis associated with chronic idiopathic neutropenia. ( Kamma, JJ; Lygidakis, NA; Nakou, M, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (38.89) | 18.7374 |
| 1990's | 3 (16.67) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 3 (16.67) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Hosack, T | 1 |
| Mandal, AK | 1 |
| Griffiths, C | 1 |
| Missouris, CG | 1 |
| Khan, AY | 1 |
| Golewale, MH | 1 |
| Kahn, DA | 1 |
| Peel, T | 1 |
| Cheng, AC | 1 |
| Spelman, T | 1 |
| Huysmans, M | 1 |
| Spelman, D | 1 |
| Köksal, AR | 1 |
| Alkim, C | 1 |
| Altinkaya, E | 1 |
| Buğdaci, MS | 1 |
| Özdoğan, O | 1 |
| Boğa, S | 1 |
| Alkim, H | 1 |
| Sökmen, M | 1 |
| Agudelo, M | 1 |
| Vesga, O | 1 |
| Levenga, H | 1 |
| Donnelly, P | 1 |
| Blijlevens, N | 1 |
| Verweij, P | 1 |
| Shirango, H | 1 |
| de Pauw, B | 1 |
| Smith, JA | 1 |
| Barrett, AP | 2 |
| Schifter, M | 1 |
| Mani, V | 1 |
| Cartwright, K | 1 |
| Dooley, J | 1 |
| Swarbrick, E | 1 |
| Fairclough, P | 1 |
| Oakley, C | 1 |
| Kamma, JJ | 1 |
| Lygidakis, NA | 1 |
| Nakou, M | 1 |
| Miyazaki, S | 1 |
| Fujikawa, T | 1 |
| Kobayashi, I | 1 |
| Matsumoto, T | 1 |
| Tateda, K | 1 |
| Yamaguchi, K | 1 |
| Gorschlüter, M | 1 |
| Glasmacher, A | 1 |
| Hahn, C | 1 |
| Schakowski, F | 1 |
| Ziske, C | 1 |
| Molitor, E | 1 |
| Marklein, G | 1 |
| Sauerbruch, T | 1 |
| Schmidt-Wolf, IG | 1 |
| Guerre, J | 1 |
| Gaudric, M | 1 |
| Tual, JL | 1 |
| McKendrick, MW | 1 |
| Geddes, AM | 1 |
| Bergan, T | 1 |
| Windle, R | 1 |
| Macpherson, S | 1 |
| Bell, PR | 1 |
| Levrat, R | 1 |
| Joliot, AY | 1 |
| Vital Durand, D | 1 |
| Martin, D | 1 |
1 review available for metronidazole and Neutropenia
| Article | Year |
|---|---|
Fatal hemorrhagic pneumonia caused by infection due to Kytococcus sedentarius--a pathogen or passenger?
Topics: Actinomycetales; Actinomycetales Infections; Acyclovir; Antineoplastic Combined Chemotherapy Protoco | 2004 |
17 other studies available for metronidazole and Neutropenia
| Article | Year |
|---|---|
Idiosyncratic metronidazole-induced neutropaenia in an older adult.
Topics: Aged; Humans; Metronidazole; Neutropenia | 2023 |
A case of chronic drug-induced neutropenia.
Topics: Anti-Anxiety Agents; Anti-Infective Agents; Anxiety Disorders; Chronic Disease; Female; Humans; Metr | 2008 |
Differing risk factors for vancomycin-resistant and vancomycin-sensitive enterococcal bacteraemia.
Topics: Adult; Age Factors; Aged; Bacteremia; Bone Marrow Transplantation; Case-Control Studies; Catheteriza | 2012 |
Infliximab- and azathioprine-related severe neutropenia and thrombocytopenia in a case with Crohn's disease.
Topics: Adult; Anti-Infective Agents; Anti-Inflammatory Agents; Antibodies, Monoclonal; Azathioprine; Crohn | 2011 |
Therapeutic equivalence requires pharmaceutical, pharmacokinetic, and pharmacodynamic identities: true bioequivalence of a generic product of intravenous metronidazole.
Topics: Animals; Anti-Bacterial Agents; Area Under Curve; Bacteroides fragilis; Bacteroides Infections; Chro | 2012 |
Neutropenia associated with metronidazole therapy.
Topics: Agranulocytosis; Female; Humans; Leukocyte Count; Metronidazole; Middle Aged; Neutropenia | 1980 |
Antibiotic strategy in orofacial/head and neck infections in severe neutropenia.
Topics: Adolescent; Adult; Aged; Aminoglycosides; Anti-Bacterial Agents; Bacterial Infections; Clinical Prot | 1994 |
Antibiotic prophylaxis in gastrointestinal endoscopy: a report by a Working Party for the British Society of Gastroenterology Endoscopy Committee.
Topics: Administration, Oral; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotic Prophyla | 1997 |
Subgingival microflora and treatment in prepubertal periodontitis associated with chronic idiopathic neutropenia.
Topics: Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin-Potassium Clavulanate C | 1998 |
Development of systemic bacteraemia after oral inoculation of vancomycin-resistant enterococci in mice.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Bacteremia; Bacterial | 2001 |
Clostridium difficile infection in patients with neutropenia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Antineoplastic Agents; Cross Infe | 2001 |
[Early neutropenia during treatment by metronidazole].
Topics: Adult; Agranulocytosis; Drug Hypersensitivity; Female; Humans; Metronidazole; Neutropenia | 1979 |
Neutropenia associated with metronidazole.
Topics: Aged; Agranulocytosis; Bacterial Infections; Humans; Male; Metronidazole; Neutropenia | 1979 |
Neutropenia associated with metronidazole.
Topics: Agranulocytosis; Azathioprine; Drug Therapy, Combination; Humans; Metronidazole; Neutropenia | 1979 |
Neutropenia associated with metronidazole.
Topics: Agranulocytosis; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Humans; Metronidazole; | 1979 |
[Prolonged neutropenia during treatment with metronidazole].
Topics: Agranulocytosis; Female; Humans; Metronidazole; Middle Aged; Neutropenia | 1978 |
Metronidazole in the management of anaerobic neck infection in acute leukemia.
Topics: Adult; Bacteria, Anaerobic; Bacterial Infections; Humans; Leukemia, Myeloid; Male; Metronidazole; Ne | 1988 |