metronidazole has been researched along with Foot Diseases in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Foot Diseases: Anatomical and functional disorders affecting the foot.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole has excellent tissue penetration; its antibacterial site of action is within anaerobic bacterial cells." | 2.38 | Vancomycin, metronidazole, and tetracyclines. ( Ellison, MJ, 1992) |
| "Radiography revealed septic arthritis of the distal interphalangeal joint and osteomyelitis of the distal and middle phalanges." | 1.29 | Use of antimicrobial-impregnated polymethyl methacrylate beads for treatment of chronic, refractory septic arthritis and osteomyelitis of the digit in a bull. ( Hendrickson, DA; Klohnen, AA; Stone, WC; Trostle, SS, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zimmerman, J | 1 |
| Silver, J | 1 |
| Shapiro, M | 1 |
| Friedman, G | 1 |
| Melmed, RN | 1 |
| Trostle, SS | 1 |
| Hendrickson, DA | 1 |
| Stone, WC | 1 |
| Klohnen, AA | 1 |
| Ellison, MJ | 1 |
| Djawari, D | 1 |
1 review available for metronidazole and Foot Diseases
| Article | Year |
|---|---|
Vancomycin, metronidazole, and tetracyclines.
Topics: Bacterial Infections; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance, Microbia | 1992 |
3 other studies available for metronidazole and Foot Diseases
| Article | Year |
|---|---|
Clindamycin unresponsive anaerobic osteomyelitis treated with oral metronidazole.
Topics: Administration, Oral; Bacterial Infections; Bacteroides fragilis; Clindamycin; Diabetes Complication | 1980 |
Use of antimicrobial-impregnated polymethyl methacrylate beads for treatment of chronic, refractory septic arthritis and osteomyelitis of the digit in a bull.
Topics: Actinomyces; Actinomycosis; Administration, Oral; Animals; Anti-Bacterial Agents; Anti-Inflammatory | 1996 |
[Cutaneous manifestation of Crohn disease].
Topics: Administration, Oral; Adult; Crohn Disease; Drug Administration Schedule; Female; Foot Diseases; Hum | 1990 |