metronidazole has been researched along with Infant, Newborn, Diseases in 23 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Infant, Newborn, Diseases: Diseases of newborn infants present at birth (congenital) or developing within the first month of birth. It does not include hereditary diseases not manifesting at birth or within the first 30 days of life nor does it include inborn errors of metabolism. Both HEREDITARY DISEASES and METABOLISM, INBORN ERRORS are available as general concepts.
| Excerpt | Relevance | Reference |
|---|---|---|
| "No antimicrobial regimen has been shown to be superior to ampicillin and gentamicin in decreasing mortality and preventing clinical deterioration in NEC." | 5.41 | Empirical Antimicrobial Therapy of Neonates with Necrotizing Enterocolitis: A Systematic Review. ( Aluvaala, J; Barbieri, E; Bonadies, L; Donà, D; English, M; Gastaldi, A, 2023) |
| "Sexually transmitted diseases were reduced: Trichomonas vaginalis (rate ratio, 0." | 2.70 | Randomized trial of presumptive sexually transmitted disease therapy during pregnancy in Rakai, Uganda. ( Abramowsky, C; Gray, RH; Kigozi, G; Meehan, M; Moulton, LH; O'Brien, KL; Quinn, TC; Robb, M; Serwadda, D; Sewankambo, NK; Wabwire-Mangen, F; Wawer, MJ, 2001) |
| "Bacterial meningitis is not considered a separate disease entity but a complication of bacteremia and sepsis." | 1.27 | [Chemotherapy of severe bacterial infections in pediatrics]. ( Guggenbichler, JP, 1983) |
| " No side effects of metronidazole were noted and its extended half life in neonates suggests that less frequent dosage would be appropriate." | 1.27 | Intravenous metronidazole in the newborn. ( Hall, P; Kaye, CM; McIntosh, N; Steele, J, 1983) |
| " Elimination half-life was inversely related to gestational age, and ranged from 22." | 1.26 | Pharmacokinetics and tissue distribution of metronidazole in the new born infant. ( Baird-Lambert, J; Buchanan, N; Cvejic, M; Doyle, PE; Jager-Roman, E, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (86.96) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (4.35) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Donà, D | 1 |
| Gastaldi, A | 1 |
| Barbieri, E | 1 |
| Bonadies, L | 1 |
| Aluvaala, J | 1 |
| English, M | 1 |
| Trintis, J | 1 |
| Epie, N | 1 |
| Boss, R | 1 |
| Riedel, S | 1 |
| DAGENAIS PERUSSE, P | 1 |
| BARIL, E | 1 |
| OUADAHI, S | 1 |
| BENER, R | 1 |
| NOE, A | 1 |
| Sander, C | 1 |
| Guggenbichler, JP | 1 |
| Hall, P | 1 |
| Kaye, CM | 1 |
| McIntosh, N | 1 |
| Steele, J | 1 |
| Jager-Roman, E | 1 |
| Doyle, PE | 1 |
| Baird-Lambert, J | 1 |
| Cvejic, M | 1 |
| Buchanan, N | 1 |
| Law, BJ | 1 |
| Marks, MI | 1 |
| Gray, RH | 1 |
| Wabwire-Mangen, F | 1 |
| Kigozi, G | 1 |
| Sewankambo, NK | 1 |
| Serwadda, D | 1 |
| Moulton, LH | 1 |
| Quinn, TC | 1 |
| O'Brien, KL | 1 |
| Meehan, M | 1 |
| Abramowsky, C | 1 |
| Robb, M | 1 |
| Wawer, MJ | 1 |
| McCormack, WM | 1 |
| Atias, A | 1 |
| Ruíz-Esquide, F | 1 |
| Escobar, E | 1 |
| Schilling, E | 1 |
| Berman, BW | 1 |
| King, FH | 1 |
| Rubenstein, DS | 1 |
| Long, SS | 1 |
| Schwarz, R | 1 |
| Rosegger, H | 1 |
| Trauner, F | 1 |
| Rom, S | 1 |
| Flynn, D | 1 |
| Noone, P | 1 |
| Feldman, WE | 1 |
| Hawkins, DF | 1 |
| Metze, H | 1 |
| Brandau, H | 1 |
| al-Salihi, FL | 1 |
| Curran, JP | 1 |
| Wang, J | 1 |
| Sokol, AB | 1 |
| Min, DS | 1 |
| Penza, J | 1 |
| Rankin, JS | 1 |
| Axton, JH | 1 |
| Robinson, SC | 1 |
| Mirchandani, G | 1 |
| Littlewood, JM | 1 |
| Kohler, HG | 1 |
4 reviews available for metronidazole and Infant, Newborn, Diseases
| Article | Year |
|---|---|
Empirical Antimicrobial Therapy of Neonates with Necrotizing Enterocolitis: A Systematic Review.
Topics: Ampicillin; Anti-Bacterial Agents; Clinical Deterioration; Enterocolitis, Necrotizing; Female; Fetal | 2023 |
Neonatal Trichomonas vaginalis infection: a case report and review of literature.
Topics: Antiprotozoal Agents; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infectious Disease | 2010 |
Management of sexually transmissible infections during pregnancy.
Topics: Anti-Bacterial Agents; Candidiasis; Chlamydia Infections; Coitus; Condylomata Acuminata; Corynebacte | 1975 |
Infectious vaginopathies in pregnancy.
Topics: Antifungal Agents; Candidiasis, Vulvovaginal; Female; Glucocorticoids; Gonorrhea; Haemophilus Infect | 1970 |
2 trials available for metronidazole and Infant, Newborn, Diseases
| Article | Year |
|---|---|
Randomized trial of presumptive sexually transmitted disease therapy during pregnancy in Rakai, Uganda.
Topics: Azithromycin; Birth Weight; Cefixime; Drug Therapy, Combination; Endophthalmitis; Female; Folic Acid | 2001 |
Trichomonas vaginalis. V. Further observations on metronidazole (Flagyl) (including infant follow-up).
Topics: Abnormalities, Drug-Induced; Adult; Clinical Trials as Topic; Drug Resistance, Microbial; Female; Fe | 1965 |
17 other studies available for metronidazole and Infant, Newborn, Diseases
| Article | Year |
|---|---|
[TRICHOMONAS VAGINITIS IN INFANTS].
Topics: Drug Therapy; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Metronidazole; Tri | 1964 |
[Purulent vulvovaginitis in a newborn girl as a rare form of a trichomonas vaginalis infection and its treatment].
Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Metronidazole; Pregnancy; Trichomonas Va | 1967 |
[Chemotherapy of severe bacterial infections in pediatrics].
Topics: Aminoglycosides; Anti-Bacterial Agents; Bacterial Infections; Cefotaxime; Cephalosporins; Clindamyci | 1983 |
Intravenous metronidazole in the newborn.
Topics: Bacterial Infections; Female; Half-Life; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant, | 1983 |
Pharmacokinetics and tissue distribution of metronidazole in the new born infant.
Topics: Bacterial Infections; Betamethasone; Female; Gestational Age; Half-Life; Humans; Infant, Newborn; In | 1982 |
Excellent outcome of Bacteroides meningitis in a newborn treated with metronidazole.
Topics: Bacteroides fragilis; Bacteroides Infections; Humans; Infant, Newborn; Infant, Newborn, Diseases; Ma | 1980 |
[Invading intestinal amebiasis in infants (author's transl)].
Topics: Dysentery, Amebic; Entamoeba histolytica; Humans; Infant, Newborn; Infant, Newborn, Diseases; Metron | 1977 |
Bacteroides fragilis meningitis in a neonate successfully treated with metronidazole.
Topics: Bacteroides fragilis; Bacteroides Infections; Female; Humans; Infant, Newborn; Infant, Newborn, Dise | 1978 |
[Trichomoniasis in the newborn (author's transl)].
Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Metronidazole; Pregnancy; Pregnancy Comp | 1977 |
Anaerobic infection in a neonate. Early detection by gas liquid chromatography and response to metronidazole.
Topics: Bacterial Infections; Chromatography, Gas; Female; Gram-Negative Anaerobic Bacteria; Humans; Infant, | 1977 |
Bacteroides fragilis ventriculitis and meningitis. Report of two cases.
Topics: Ampicillin; Bacteroides fragilis; Bacteroides Infections; Cerebrospinal Fluid Shunts; Chloramphenico | 1976 |
Teratogens in the human: current problems.
Topics: Abnormalities, Drug-Induced; Barbiturates; Contraceptives, Oral; Ethanol; Female; Fetal Diseases; Hu | 1976 |
[Trichomonas colpitis in childhood].
Topics: Adolescent; Age Factors; Child; Child, Preschool; Estrogens; Female; Humans; Infant; Infant, Newborn | 1974 |
Neonatal Trichomonas vaginalis: report of three cases and review of the literature.
Topics: Age Factors; Culture Media; Feces; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; | 1974 |
Trichomonas cystitis in a six-week-old infant--effective treatment with oral metronidazole.
Topics: Administration, Oral; Cystitis; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Metronid | 1972 |
Amoebic proctocolitis and liver abscess in a neonate.
Topics: Colitis; Diarrhea, Infantile; Dysentery, Amebic; Female; Humans; Infant, Newborn; Infant, Newborn, D | 1972 |
Urinary tract infection by Trichomonas vaginalis in a newborn baby.
Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Metronidazole; Trichomonas Infections; U | 1966 |